Open Access

Diagnostic value of circular RNAs in female reproductive system diseases: A PRISMA‑compliant meta‑analysis

  • Authors:
    • Jin Ding
    • Yuanyuan Lyu
    • Nan Guo
    • Qingwei Wang
    • Lina Li
    • Guantai Ni
  • View Affiliations

  • Published online on: February 12, 2020     https://doi.org/10.3892/br.2020.1278
  • Pages: 171-177
  • Copyright: © Ding et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Circular RNAs (circRNAs) are novel non‑coding RNAs that have been reported to be involved in the progression of numerous diseases. However, the clinical diagnostic value of circRNAs in female reproductive system diseases remains unknown. The present study is a systemic review and meta‑analysis of the available literature on circRNAs as novel biomarkers for female reproductive system diseases. Relevant studies were systematically searched using the PubMed, Embase, Web of Science and Cochrane Library databases. The data obtained from the included studies were analyzed by RevMan5.3 and STATA 14.2. A total of six studies involving 613 individuals across three types of disease examined the diagnostic capabilities of circRNAs. Within these publications, the pooled sensitivity of circRNAs was 0.70 (95% CI, 0.64‑0.76), and the pooled specificity was 0.70 (95% CI, 0.64‑0.75). The pooled positive likelihood ratio and negative likelihood ratio were 2.33 and 0.42, respectively. The diagnostic score was 1.70 and the pooled diagnostic odds ratio was 5.48. The area under the summary receiver operator characteristic curve was 0.76 (95% CI, 0.72‑0.79), indicating that circRNAs exhibited a moderate diagnostic value for female reproductive system diseases and may function as potential diagnostic biomarkers. However, further studies are required to verify the clinical applications of circRNAs.

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April 2020
Volume 12 Issue 4

Print ISSN: 2049-9434
Online ISSN:2049-9442

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APA
Ding, J., Lyu, Y., Guo, N., Wang, Q., Li, L., & Ni, G. (2020). Diagnostic value of circular RNAs in female reproductive system diseases: A PRISMA‑compliant meta‑analysis. Biomedical Reports, 12, 171-177. https://doi.org/10.3892/br.2020.1278
MLA
Ding, J., Lyu, Y., Guo, N., Wang, Q., Li, L., Ni, G."Diagnostic value of circular RNAs in female reproductive system diseases: A PRISMA‑compliant meta‑analysis". Biomedical Reports 12.4 (2020): 171-177.
Chicago
Ding, J., Lyu, Y., Guo, N., Wang, Q., Li, L., Ni, G."Diagnostic value of circular RNAs in female reproductive system diseases: A PRISMA‑compliant meta‑analysis". Biomedical Reports 12, no. 4 (2020): 171-177. https://doi.org/10.3892/br.2020.1278