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Article Open Access

Diagnostic value of circular RNAs in female reproductive system diseases: A PRISMA‑compliant meta‑analysis

  • Authors:
    • Jin Ding
    • Yuanyuan Lyu
    • Nan Guo
    • Qingwei Wang
    • Lina Li
    • Guantai Ni
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui 241001, P.R. China
    Copyright: © Ding et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 171-177
    |
    Published online on: February 12, 2020
       https://doi.org/10.3892/br.2020.1278
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Abstract

Circular RNAs (circRNAs) are novel non‑coding RNAs that have been reported to be involved in the progression of numerous diseases. However, the clinical diagnostic value of circRNAs in female reproductive system diseases remains unknown. The present study is a systemic review and meta‑analysis of the available literature on circRNAs as novel biomarkers for female reproductive system diseases. Relevant studies were systematically searched using the PubMed, Embase, Web of Science and Cochrane Library databases. The data obtained from the included studies were analyzed by RevMan5.3 and STATA 14.2. A total of six studies involving 613 individuals across three types of disease examined the diagnostic capabilities of circRNAs. Within these publications, the pooled sensitivity of circRNAs was 0.70 (95% CI, 0.64‑0.76), and the pooled specificity was 0.70 (95% CI, 0.64‑0.75). The pooled positive likelihood ratio and negative likelihood ratio were 2.33 and 0.42, respectively. The diagnostic score was 1.70 and the pooled diagnostic odds ratio was 5.48. The area under the summary receiver operator characteristic curve was 0.76 (95% CI, 0.72‑0.79), indicating that circRNAs exhibited a moderate diagnostic value for female reproductive system diseases and may function as potential diagnostic biomarkers. However, further studies are required to verify the clinical applications of circRNAs.
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1 

Zhao S, Mei Y, Wang Y, Zhu J, Zheng G and Ma R: Levels of CEA, CA153, CA199, CA724 and AFP in nipple discharge of breast cancer patients. Int J Clin Exp Med. 8:20837–20844. 2015.PubMed/NCBI

2 

Wang HF, Li LF, Guo SH, Zeng QY, Ning F, Liu WL and Zhang G: Evaluation of antibody level against Fusobacterium nucleatum in the serological diagnosis of colorectal cancer. Sci Rep. 6(33440)2016.PubMed/NCBI View Article : Google Scholar

3 

Beermann J, Piccoli MT, Viereck J and Thum T: Non-coding RNAs in development and disease: Background, mechanisms, and therapeutic approaches. Physiol Rev. 96:1297–1325. 2016.PubMed/NCBI View Article : Google Scholar

4 

Salzman J: Circular RNA expression: Its potential regulation and function. Trends Genet. 32:309–316. 2016.PubMed/NCBI View Article : Google Scholar

5 

Hsiao KY, Sun HS and Tsai SJ: Circular RNA-New member of noncoding RNA with novel functions. Exp Biol Med (Maywood). 242:1136–1141. 2017.PubMed/NCBI View Article : Google Scholar

6 

Shen F, Liu P, Xu Z, Li N, Yi Z, Tie X, Zhang Y and Gao L: CircRNA_001569 promotes cell proliferation through absorbing miR-145 in gastric cancer. J Biochem. 165:27–36. 2019.PubMed/NCBI View Article : Google Scholar

7 

Han D, Li J, Wang H, Su X, Hou J, Gu Y, Qian C, Lin Y, Liu X, Huang M, et al: Circular RNA circMTO1 acts as the sponge of microRNA-9 to suppress hepatocellular carcinoma progression. Hepatology. 66:1151–1164. 2017.PubMed/NCBI View Article : Google Scholar

8 

Qu D, Yan B, Xin R and Ma T: A novel circular RNA hsa_circ_0020123 exerts oncogenic properties through suppression of miR-144 in non-small cell lung cancer. Am J Cancer Res. 8:1387–1402. 2018.PubMed/NCBI

9 

Zhang HD, Jiang LH, Hou JC, Zhou SY, Zhong SL, Zhu LP, Wang DD, Yang SJ, He YJ, Mao CF, et al: Circular RNA hsa_circ_0072995 promotes breast cancer cell migration and invasion through sponge for miR-30c-2-3p. Epigenomics. 10:1229–1242. 2018.PubMed/NCBI View Article : Google Scholar

10 

Liu L, Li L, Ma X, Yue F, Wang Y, Wang L, Jin P and Zhang X: Altered circular RNA expression in patients with repeated implantation failure. Cell Physiol Biochem. 44:303–313. 2017.PubMed/NCBI View Article : Google Scholar

11 

Zhang YG, Yang HL, Long Y and Li WL: Circular RNA in blood corpuscles combined with plasma protein factor for early prediction of pre-eclampsia. BJOG. 123:2113–2118. 2016.PubMed/NCBI View Article : Google Scholar

12 

Xu XX, Jia SZ, Dai Y, Zhang JJ, Li XY, Shi JH, Leng JH and Lang JH: Identification of circular RNAs as a novel biomarker for ovarian endometriosis. Chin Med J (Engl). 131:559–566. 2018.PubMed/NCBI View Article : Google Scholar

13 

Nagini S: Breast Cancer: Current molecular therapeutic targets and new players. Anticancer Agents Med Chem. 17:152–163. 2017.PubMed/NCBI View Article : Google Scholar

14 

Whiting PF, Rutjes AW, Westwood ME, Mallett S, Deeks JJ, Reitsma JB, Leeflang MM, Sterne JA and Bossuyt PM: QUADAS-2 Group: QUADAS-2: A revised tool for the quality assessment of diagnostic accuracy studies. Ann Intern Med. 155:529–536. 2011.PubMed/NCBI View Article : Google Scholar

15 

Wang YM, Huang LM, Li DR, Shao JH, Xiong SL, Wang CM and Lu SM: Hsa_circ_0101996 combined with hsa_circ_0101119 in peripheral whole blood can serve as the potential biomarkers for human cervical squamous cell carcinoma. Int J Clin Exp Pathol. 10:11924–11931. 2017.PubMed/NCBI

16 

Bai Y, Rao H, Chen W, Luo X, Tong C and Qi H: Profiles of circular RNAs in human placenta and their potential roles related to preeclampsia. Biol Reprod. 98:705–712. 2018.PubMed/NCBI View Article : Google Scholar

17 

Hu X, Ao J, Li X, Zhang H, Wu J and Cheng W: Competing endogenous RNA expression profiling in pre-eclampsia identifies hsa_circ_0036877 as a potential novel blood biomarker for early pre-eclampsia. Clin Epigenetics. 10(48)2018.PubMed/NCBI View Article : Google Scholar

18 

Jiang M, Lash GE, Zhao X, Long Y, Guo C and Yang H: CircRNA-0004904, CircRNA-0001855, and PAPP-A: Potential novel biomarkers for the prediction of preeclampsia. Cell Physiol Biochem. 46:2576–2586. 2018.PubMed/NCBI View Article : Google Scholar

19 

Yin WB, Yan MG, Fang X, Guo JJ, Xiong W and Zhang RP: Circulating circular RNA hsa_circ_0001785 acts as a diagnostic biomarker for breast cancer detection. Clin Chim Acta. 487:363–368. 2018.PubMed/NCBI View Article : Google Scholar

20 

Lü L, Sun J, Shi P, Kong W, Xu K, He B, Zhang S and Wang J: Identification of circular RNAs as a promising new class of diagnostic biomarkers for human breast cancer. Oncotarget. 8:44096–44107. 2017.PubMed/NCBI View Article : Google Scholar

21 

Jeck WR and Sharpless NE: Detecting and characterizing circular RNAs. Nat Biotechnol. 32:453–461. 2014.PubMed/NCBI View Article : Google Scholar

22 

Gao YL, Zhang MY, Xu B, Han LJ, Lan SF, Chen J, Dong YJ and Cao LL: Circular RNA expression profiles reveal that hsa_circ_0018289 is up-regulated in cervical cancer and promotes the tumorigenesis. Oncotarget. 8:86625–86633. 2017.PubMed/NCBI View Article : Google Scholar

23 

Chen Q, Zhang J, He Y and Wang Y: hsa_circ_0061140 knockdown reverses FOXM1-mediated cell growth and metastasis in ovarian cancer through miR-370 sponge activity. Mol Ther Nucleic Acids. 13:55–63. 2018.PubMed/NCBI View Article : Google Scholar

24 

Chen BJ, Byrne FL, Takenaka K, Modesitt SC, Olzomer EM, Mills JD, Farrell R, Hoehn KL and Janitz M: Analysis of the circular RNA transcriptome in endometrial cancer. Oncotarget. 9:5786–5796. 2017.PubMed/NCBI View Article : Google Scholar

25 

Ning L, Long B, Zhang W, Yu M, Wang S, Cao D, Yang J, Shen K, Huang Y and Lang J: Circular RNA profiling reveals circEXOC6B and circN4BP2L2 as novel prognostic biomarkers in epithelial ovarian cancer. Int J Oncol. 53:2637–2646. 2018.PubMed/NCBI View Article : Google Scholar

26 

Bartl T, Schwameis R, Stift A, Bachleitner-Hofmann T, Reinthaller A, Grimm C and Polterauer S: Predictive and prognostic implication of bowel resections during primary cytoreductive surgery in advanced epithelial ovarian cancer. Int J Gynecol Cancer. 28:1664–1671. 2018.PubMed/NCBI View Article : Google Scholar

27 

Ahmed I, Karedath T, Andrews SS, Al-Azwani IK, Mohamoud YA, Querleu D, Rafii A and Malek JA: Altered expression pattern of circular RNAs in primary and metastatic sites of epithelial ovarian carcinoma. Oncotarget. 7:36366–36381. 2016.PubMed/NCBI View Article : Google Scholar

28 

Hang W, Feng Y, Sang Z, Yang Y, Zhu Y, Huang Q and Xi X: Downregulation of miR-145-5p in cancer cells and their derived exosomes may contribute to the development of ovarian cancer by targeting CT. Int J Mol Med. 43:256–266. 2019.PubMed/NCBI View Article : Google Scholar

29 

Hou J, Jiang W, Zhu L, Zhong S, Zhang H, Li J, Zhou S, Yang S, He Y, Wang D, et al: Circular RNAs and exosomes in cancer: A mysterious connection. Clin Transl Oncol. 20:1109–1116. 2018.PubMed/NCBI View Article : Google Scholar

30 

Li S, Li Y, Chen B, Zhao J, Yu S, Tang Y, Zheng Q, Li Y, Wang P, He X and Huang S: ExoRBase: A database of circRNA, lncRNA and mRNA in human blood exosomes. Nucleic Acids Res. 46:D106–D112. 2018.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Ding J, Lyu Y, Guo N, Wang Q, Li L and Ni G: Diagnostic value of circular RNAs in female reproductive system diseases: A PRISMA‑compliant meta‑analysis. Biomed Rep 12: 171-177, 2020.
APA
Ding, J., Lyu, Y., Guo, N., Wang, Q., Li, L., & Ni, G. (2020). Diagnostic value of circular RNAs in female reproductive system diseases: A PRISMA‑compliant meta‑analysis. Biomedical Reports, 12, 171-177. https://doi.org/10.3892/br.2020.1278
MLA
Ding, J., Lyu, Y., Guo, N., Wang, Q., Li, L., Ni, G."Diagnostic value of circular RNAs in female reproductive system diseases: A PRISMA‑compliant meta‑analysis". Biomedical Reports 12.4 (2020): 171-177.
Chicago
Ding, J., Lyu, Y., Guo, N., Wang, Q., Li, L., Ni, G."Diagnostic value of circular RNAs in female reproductive system diseases: A PRISMA‑compliant meta‑analysis". Biomedical Reports 12, no. 4 (2020): 171-177. https://doi.org/10.3892/br.2020.1278
Copy and paste a formatted citation
x
Spandidos Publications style
Ding J, Lyu Y, Guo N, Wang Q, Li L and Ni G: Diagnostic value of circular RNAs in female reproductive system diseases: A PRISMA‑compliant meta‑analysis. Biomed Rep 12: 171-177, 2020.
APA
Ding, J., Lyu, Y., Guo, N., Wang, Q., Li, L., & Ni, G. (2020). Diagnostic value of circular RNAs in female reproductive system diseases: A PRISMA‑compliant meta‑analysis. Biomedical Reports, 12, 171-177. https://doi.org/10.3892/br.2020.1278
MLA
Ding, J., Lyu, Y., Guo, N., Wang, Q., Li, L., Ni, G."Diagnostic value of circular RNAs in female reproductive system diseases: A PRISMA‑compliant meta‑analysis". Biomedical Reports 12.4 (2020): 171-177.
Chicago
Ding, J., Lyu, Y., Guo, N., Wang, Q., Li, L., Ni, G."Diagnostic value of circular RNAs in female reproductive system diseases: A PRISMA‑compliant meta‑analysis". Biomedical Reports 12, no. 4 (2020): 171-177. https://doi.org/10.3892/br.2020.1278
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