Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Biomedical Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9434 Online ISSN: 2049-9442
Journal Cover
May-2020 Volume 12 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-2020 Volume 12 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Examination of associations between personality traits, and polymorphisms of MAO‑A and 5‑HTT with the severity of menopausal symptoms and depression levels

  • Authors:
    • Sedighe Esmaeilzadeh
    • Mouloud Agajani Delavar
    • Hamidreza Nouri
    • Sepideh Mashayekh‑Amiri
    • Niloufar Ahmadi
    • Reza Namdar
  • View Affiliations / Copyright

    Affiliations: Infertility and Reproductive Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Mazandaran 47135‑547, Iran, Cellular and Molecular Biology Research Center, Babol University of Medical Sciences, Babol, Mazandaran 47135‑547, Iran, Student Committee Research, Babol University of Medical Sciences, Babol, Mazandaran 47135‑547, Iran, Shahid Yahya Nezhad Hospital, Babol University of Medical Sciences, Babol, Mazandaran 47135‑547, Iran
  • Pages: 259-266
    |
    Published online on: March 4, 2020
       https://doi.org/10.3892/br.2020.1287
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of the present study was to investigate the association between different personality traits with monoamine oxidase A (MAO‑A) and serotonin transporter (5‑HTT), and to examine their effects on the severity of menopause symptoms as well as the levels of depression in menopausal women. The study was designed as an analytical cross‑sectional study, performed on 132 healthy post‑menopausal women in Iran. Personality was assessed using the Revised Edition of the NEO Personality Index (Neuroticism‑Extroversion‑Openness‑Five Factor Inventory). The symptoms score sheet, used for measuring menopausal symptoms, was used to classify the participants according to their menopausal symptoms. Furthermore, Beck Depression Inventory short version was also used to assess depressive symptoms. Examination of blood samples taken from all participants was to identify DNA polymorphisms of 5‑HTT using PCR. The results of the present study showed that a high level of neuroticism (P<0.0001), low levels of extroversion (P<0.002), an openness to experience (P=0.039) and conscientiousness (P=0.001) were all positively associated with the severity of menopausal symptoms. In addition, a high level of neuroticism (P<0.0001), low levels of extroversion (P<0.0001), and a low level of agreeableness (P<0.024) and conscientiousness (P<0.0001) were all positively associated with depressive symptoms. There was no statistically significant association between MAO‑A and 5‑HTT polymorphisms with menopause and depression scores. Based on these results, there appears to be a significant association between personality traits with both depression and menopausal symptoms. Identification of homogeneous groups of women who are predisposed to depression and severe menopausal symptoms may allow for the implementation of early prevention programs.
View Figures
View References

1 

Hickey M, Bryant C and Judd F: Evaluation and management of depressive and anxiety symptoms in midlife. Climacteric. 15:3–9. 2012.PubMed/NCBI View Article : Google Scholar

2 

Catalano A, Martino G, Bellone F, Gaudio A, Lasco C, Langher V, Lasco A and Morabito N: Anxiety levels predict fracture risk in postmenopausal women assessed for osteoporosis. Menopause. 25:1110–1115. 2018.PubMed/NCBI View Article : Google Scholar

3 

Kaunitz AM and Manson JE: Management of menopausal symptoms. Obstet Gynecol. 126:859–876. 2015.PubMed/NCBI View Article : Google Scholar

4 

Dalal PK and Agarwal M: Postmenopausal syndrome. Indian J Psychiatry. 57(Suppl 2):S222–S232. 2015.PubMed/NCBI View Article : Google Scholar

5 

Labouvie-Vief G, Diehl M, Tarnowski A and Shen J: Age differences in adult personality: Findings from the United States and China. Gerontol B Psychol Sci Soc Sci. 55(1):4–17. 2000.PubMed/NCBI View Article : Google Scholar

6 

Lin MF, Ko HC, Wu JY and Chang FM: The impact of extroversion or menopause status on depressive symptoms among climacteric women in Taiwan: Neuroticism as moderator or mediator? Menopause. 15:138–143. 2008.PubMed/NCBI View Article : Google Scholar

7 

Elavsky S and McAuley E: Personality, menopausal symptoms, and physical activity outcomes in middle-aged women. Pers Individ Dif. 46:123–128. 2009.PubMed/NCBI View Article : Google Scholar

8 

Jahromi M, Moeen L and Yazdani L: Relationship between personality traits and marital satisfaction in women Kazeroun city. SID. 1:143–162. 2011.

9 

Martino G, Catalano A, Bellone F, Langher V, Lasco C, Penna A, Nicocia G and Morabito N: Quality of life in postmenopausal women: Which role for vitamin D? Mediterranean J Clin Psychol (MJCP). 6(14)2018.

10 

Martino G, Catalano A, Bellone F, Sardella A, Lasco C, Caprì T, Langher V, Caputo A, Fabio RA and Morabito N: Vitamin D status is associated with anxiety levels in postmenopausal women evaluated for osteoporosis. Mediterranean J Clin Psychol (MJCP). 6:2018.

11 

McCrae RR and Costa PT: The five-factor model of personality: Theoretical perspectives. Wiggins JS (ed). Guilford Press, New York, NY, pp51.87, 1996.

12 

Costa PT Jr, Fagan PJ, Piedmont RL, Ponticas Y and Wise TN: The five-factor model of personality and sexual functioning in outpatient men and women. Psychiatr Med. 10:199–215. 1992.PubMed/NCBI

13 

Jang KL, Livesley WJ and Vernon PA: Heritability of the big five personality dimensions and their facets: A twin study. J Pers. 64:577–591. 1996.PubMed/NCBI View Article : Google Scholar

14 

Power RA and Pluess M: Heritability estimates of the Big Five personality traits based on common genetic variants. Transl Psychiatry. 5(e604)2015.PubMed/NCBI View Article : Google Scholar

15 

Leonardo ED and Hen R: Genetics of affective and anxiety disorders. Annu Rev Psychol. 57:117–137. 2006.PubMed/NCBI View Article : Google Scholar

16 

Lieben CK, Blokland A, Westerink B and Deutz NE: Acute tryptophan and serotonin depletion using an optimized tryptophan-free protein-carbohydrate mixture in the adult rat. Neurochem Int. 44:9–16. 2004.PubMed/NCBI View Article : Google Scholar

17 

Maes M, Leonard BE, Myint AM, Kubera M and Verkerk R: The new ‘5-HT’ hypothesis of depression: Cell-mediated immune activation induces indoleamine 2,3-dioxygenase, which leads to lower plasma tryptophan and an increased synthesis of detrimental tryptophan catabolites (TRYCATs), both of which contribute to the onset of depression. Prog Neuropsychopharmacol Biol Psychiatry. 35:702–721. 2011.PubMed/NCBI View Article : Google Scholar

18 

Maes M, Ringel K, Kubera M, Berk M and Rybakowski J: Increased autoimmune activity against 5-HT: A key component of depression that is associated with inflammation and activation of cell-mediated immunity, and with severity and staging of depression. J Affect Disord. 136:386–392. 2012.PubMed/NCBI View Article : Google Scholar

19 

Słopień R, Słopień A, Różycka A, Warenik-Szymankiewicz A, Lianeri M and Jagodziński P: The c. 1460C>T polymorphism of MAO-A is associated with the risk of depression in postmenopausal women. ScientificWorldJournal. 2012(194845)2012.PubMed/NCBI View Article : Google Scholar

20 

Jurczak A, Szkup M, Wieder-Huszla S, Grzywacz A, Samochowiec A, Karakiewicz B, Samochowiec J and Grochans E: The assessment of the relationship between personality, the presence of the 5HTT and MAO-A polymorphisms, and the severity of climacteric and depressive symptoms in postmenopausal women. Arch Womens Ment Health. 18:613–621. 2015.PubMed/NCBI View Article : Google Scholar

21 

Grochans E, Grzywacz A, Jurczak A, Samochowiec A, Karakiewicz B, Brodowska A, Starczewski A and Samochowiec J: The 5HTT and MAO-A polymorphisms associate with depressive mood and climacteric symptoms in postmenopausal women. Prog Neuropsychopharmacol Biol Psychiatry. 45:125–130. 2013.PubMed/NCBI View Article : Google Scholar

22 

Broekmans FJ, Soules MR and Fauser BC: Ovarian aging: Mechanisms and clinical consequences. Endocr Rev. 30:465–493. 2009.PubMed/NCBI View Article : Google Scholar

23 

Henderson VW and Sherwin BB: Surgical versus natural menopause: Cognitive issues. Menopause. 14:572–579. 2007.PubMed/NCBI View Article : Google Scholar

24 

Thurston RC, Matthews KA, Hernandez J and De La Torre F: Improving the performance of physiologic hot flash measures with support vector machines. Psychophysiology. 46:285–292. 2009.PubMed/NCBI View Article : Google Scholar

25 

Schneider-Matyka D, Jurczak A, Samochowiec A, Karakiewicz B, Szkup M, Grzywacz A and Grochans E: Analysis of personality traits and their influence on the quality of life of postmenopausal women with regard to genetic factors. Ann Gen Psychiatry. 15(25)2016.PubMed/NCBI View Article : Google Scholar

26 

Grochans E, Szkup M, Kotwas A, Kopec J, Karakiewicz B and Jurczak A: Analysis of sociodemographic, psychological, and genetic factors contributing to depressive symptoms in pre-, peri- and postmenopausal women. Int J Environ Res Public Health. 15(E712)2018.PubMed/NCBI View Article : Google Scholar

27 

Nathanson V: Revising the declaration of helsinki. BMJ. 346(f2837)2013.PubMed/NCBI View Article : Google Scholar

28 

Garcia-Diz L, Goñi I and Varela G: Use of the calculation of anthropometric values with microprocessors for nutritional diagnosis. Arch Latinoam Nutr. 35:48–62. 1985.PubMed/NCBI(In Spanish).

29 

Higgins D: Patient assessment part 5-measuring pulse. Nurs Times. 104:24–25. 2008.PubMed/NCBI

30 

Sherman S: Defining the menopausal transition. Am J Med. 12B (Suppl 188):3–7. 2005.PubMed/NCBI View Article : Google Scholar

31 

Australasian Menopause Society: Diagnosing Menopause, AMS Diagnosing Menopause Symptom score sheet. http://www.menopause.org.au/hp/information-sheets/420-diagnosing-menopause.

32 

Greene JG: Constructing a standard climacteric scale. Maturitas. 29:25–31. 1998.PubMed/NCBI View Article : Google Scholar

33 

Greene JG: Constructing a standard climacteric scale. Maturitas. 61:78–84. 2008.PubMed/NCBI View Article : Google Scholar

34 

Derman RJ, Dawood MY and Stone S: Quality of life during sequential hormone replacement therapy-a placebo-controlled study. Int J Fertil Menopausal Stud. 40:73–78. 1995.PubMed/NCBI

35 

Alder EM, Bancroft J and Livingstone J: Estradiol implants, hormone levels and reported symptoms. J Psychosomatic Obstetrics Gynecol. 13:223–235. 1992.

36 

Delavar MA and Hajiahmadi M: Age at menopause and measuring symptoms at midlife in a community in Babol, Iran. Menopause. 18:1213–1218. 2011.PubMed/NCBI View Article : Google Scholar

37 

Beck AT and Beck RW: Screening depressed patients in family practice A rapid technic. Postgrad Med. 52:81–85. 1972.PubMed/NCBI View Article : Google Scholar

38 

Edelstein BA, Drozdick LW and Ciliberti CM: Assessment of depression and bereavement in older adults. In: Handbook of Assessment in Clinical Gerontology. Elsevier Academic Press, Cambridge, MA, pp3-43, 2010.

39 

Rajabi GR: Psychometric properties of Beck depression inventory short form items (BDI-13). J Iran Psychologists. 1:291–298. 2005.

40 

Costa PT Jr and McCrae RR: Revised NEO personality inventory (NEO-PI-R) and NEO five-factor (NEO-FFI) inventory professional manual. Boyle GJ, Matthews G and Saklofske DH (eds). PAR, Odessa, FL, 1992.

41 

Garousi Farshi MT, Mehryar AH and Ghazi Tabatabaie MG: Application of the NEO PIR test and analytic evaluation of its characteristics and factorial structure among Iranian university students. Sci Information Database. 11:173–198. 2001.

42 

Miller SA, Dykes DD and Polesky HF: A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res. 16(1215)1988.PubMed/NCBI View Article : Google Scholar

43 

Edgnulu TG, Ozge A, Erdal N, Kuru O and Erdal ME: Association analysis of the functional MAOA gene promoter and MAOB gene intron 13 polymorphisms in tension type headache patients. Adv Clin Exp Med. 23:901–906. 2014.PubMed/NCBI View Article : Google Scholar

44 

Zhang X, Wang L, Huang F, Li J, Xiong L, Xue H and Zhang Y: Evaluation of the promoter region polymorphism (5-HTTLPR) in the serotonin transporter gene in females with postpartum depression. Exp Ther Med. 9:245–249. 2015.PubMed/NCBI View Article : Google Scholar

45 

Nilsson KW, Comasco E, Aslund C, Nordquist N, Leppert J and Oreland L: MAOA genotype, family relations and sexual abuse in relation to adolescent alcohol consumption. Addict Biol. 16:347–355. 2011.PubMed/NCBI View Article : Google Scholar

46 

Oreland L, Nilsson K, Damberg M and Hallman J: Monoamine oxidases: Activities, genotypes and the shaping of behaviour. J Neural Transm (Vienna). 114:817–822. 2007.PubMed/NCBI View Article : Google Scholar

47 

Zimmermann-Peruzatto JM, Almeida S, Lucion AB, Oses JP, Quevedo LA, Pinheiro KA, da Silva RA and Pinheiro RT: Evaluation of the 5-HTTLPR and 5-HTTVNTR polymorphisms in the serotonin transporter gene in women with postpartum depression. Neurosci Med. 3:275–280. 2012.

48 

Ghorbani M, Azhari S, Esmaily HA and GhanbariHashemabadi BA: Investigation of the relationship between personality characteristics and vasomotor symptoms in menopausal women. Iran J Nurs Midwifery Res. 21:441–447. 2016.PubMed/NCBI View Article : Google Scholar

49 

Bromberger JT and Epperson CN: Depression during and after the perimenopause: Impact of hormones, genetics, and environmental determinants of disease. Obstet Gynecol Clin North Am. 45:663–678. 2018.PubMed/NCBI View Article : Google Scholar

50 

Hakulinen C, Elovainio M, Pulkki-Raback L, Virtanen M, Kivimaki M and Jokela M: Personality and depressive symptoms: Individual-participant meta-analysis of 10 cohort studies. Depress Anxiety. 32:461–470. 2015.PubMed/NCBI View Article : Google Scholar

51 

Vink D, Aartsen MJ, Comijs HC, Heymans MW, Penninx BW, Stek ML, Deeg DJ and Beekman AT: Onset of anxiety and depression in the aging population: Comparison of risk factors in a 9-year prospective study. Am J Geriatr Psychiatry. 17:642–652. 2009.PubMed/NCBI View Article : Google Scholar

52 

Hayward RD, Taylor WD, Smoski MJ, Steffens DC and Payne ME: Association of five-factor model personality domains and facets with presence, onset, and treatment outcomes of major depression in older adults. Am J Geriatr Psychiatry. 21:88–96. 2013.PubMed/NCBI View Article : Google Scholar

53 

Weber K, Giannakopoulos P, Delaloye C, de Bilbao F, Moy G, Moussa A, Rubio MM, Ebbing K, Meuli R, Lazeyras F, et al: Volumetric MRI changes, cognition and personality traits in old age depression. J Affect Disord. 124:275–282. 2010.PubMed/NCBI View Article : Google Scholar

54 

Bosworth HB, Bastian LA, Rimer BK and Siegler IC: Coping styles and personality domains related to menopausal stress. Womens Health Issues. 13:32–38. 2003.PubMed/NCBI View Article : Google Scholar

55 

van der Veen DC, van Dijk SD, Comijs HC, van Zelst WH, Schoevers RA and Oude Voshaar RC: The importance of personality and life-events in anxious depression: From trait to state anxiety. Aging Ment Health. 21:1177–1183. 2017.PubMed/NCBI View Article : Google Scholar

56 

Cohen LS, Soares CN, Vitonis AF, Otto MW and Harlow BL: Risk for new onset of depression during the menopausal transition: The Harvard study of moods and cycles. Arch Gen Psychiatry. 63:385–390. 2006.PubMed/NCBI View Article : Google Scholar

57 

Petito A, Altamura M, Iuso S, Padalino FA, Sessa F, D'Andrea G, Margaglione M and Bellomo A: The relationship between personality traits, the 5HTT polymorphisms, and the occurrence of anxiety and depressive symptoms in elite athletes. PLoS One. 11(e0156601)2016.PubMed/NCBI View Article : Google Scholar

58 

Plieger T, Montag C, Felten A and Reuter M: The serotonin transporter polymorphism (5-HTTLPR) and personality: Response style as a new endophenotype for anxiety. Int J Neuropsychopharmacol. 17:851–858. 2014.PubMed/NCBI View Article : Google Scholar

59 

Paaver M, Kurrikoff T, Nordquist N, Oreland L and Harro J: The effect of 5-HTT gene promoter polymorphism on impulsivity depends on family relations in girls. Prog Neuropsychopharmacol Biol Psychiatry. 32:1263–1268. 2008.PubMed/NCBI View Article : Google Scholar

60 

Serretti A, Calati R, Mandelli L and De Ronchi D: Serotonin transporter gene variants and behavior: A comprehensive review. Curr Drug Targets. 7:1659–1669. 2006.PubMed/NCBI View Article : Google Scholar

61 

Wilhelm K, Mitchell PB, Niven H, Finch A, Wedgwood L, Scimone A, Blair IP, Parker G and Schofield PR: Life events, first depression onset and the serotonin transporter gene. Br J Psychiatry. 188:210–215. 2006.PubMed/NCBI View Article : Google Scholar

62 

Grochans E, Jurczak A, Szkup M, Samochowiec A, Wloszczak-Szubzda A, Karakiewicz B, Grzywacz A, Brodowska A and Samochowiec J: Evaluation of the relationship between 5-HTT and MAO gene polymorphisms, mood and level of anxiety among postmenopausal women. Int J Environ Res Public Health. 12:268–281. 2014.PubMed/NCBI View Article : Google Scholar

63 

Middeldorp CM, de Geus EJ, Willemsen G, Hottenga JJ, Slagboom PE and Boomsma DI: The serotonin transporter gene length polymorphism (5-HTTLPR) and life events: No evidence for an interaction effect on neuroticism and anxious depressive symptoms. Twin Res Hum Genet. 13:544–549. 2010.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Esmaeilzadeh S, Delavar MA, Nouri H, Mashayekh‑Amiri S, Ahmadi N and Namdar R: Examination of associations between personality traits, and polymorphisms of MAO‑A and 5‑HTT with the severity of menopausal symptoms and depression levels. Biomed Rep 12: 259-266, 2020.
APA
Esmaeilzadeh, S., Delavar, M.A., Nouri, H., Mashayekh‑Amiri, S., Ahmadi, N., & Namdar, R. (2020). Examination of associations between personality traits, and polymorphisms of MAO‑A and 5‑HTT with the severity of menopausal symptoms and depression levels. Biomedical Reports, 12, 259-266. https://doi.org/10.3892/br.2020.1287
MLA
Esmaeilzadeh, S., Delavar, M. A., Nouri, H., Mashayekh‑Amiri, S., Ahmadi, N., Namdar, R."Examination of associations between personality traits, and polymorphisms of MAO‑A and 5‑HTT with the severity of menopausal symptoms and depression levels". Biomedical Reports 12.5 (2020): 259-266.
Chicago
Esmaeilzadeh, S., Delavar, M. A., Nouri, H., Mashayekh‑Amiri, S., Ahmadi, N., Namdar, R."Examination of associations between personality traits, and polymorphisms of MAO‑A and 5‑HTT with the severity of menopausal symptoms and depression levels". Biomedical Reports 12, no. 5 (2020): 259-266. https://doi.org/10.3892/br.2020.1287
Copy and paste a formatted citation
x
Spandidos Publications style
Esmaeilzadeh S, Delavar MA, Nouri H, Mashayekh‑Amiri S, Ahmadi N and Namdar R: Examination of associations between personality traits, and polymorphisms of MAO‑A and 5‑HTT with the severity of menopausal symptoms and depression levels. Biomed Rep 12: 259-266, 2020.
APA
Esmaeilzadeh, S., Delavar, M.A., Nouri, H., Mashayekh‑Amiri, S., Ahmadi, N., & Namdar, R. (2020). Examination of associations between personality traits, and polymorphisms of MAO‑A and 5‑HTT with the severity of menopausal symptoms and depression levels. Biomedical Reports, 12, 259-266. https://doi.org/10.3892/br.2020.1287
MLA
Esmaeilzadeh, S., Delavar, M. A., Nouri, H., Mashayekh‑Amiri, S., Ahmadi, N., Namdar, R."Examination of associations between personality traits, and polymorphisms of MAO‑A and 5‑HTT with the severity of menopausal symptoms and depression levels". Biomedical Reports 12.5 (2020): 259-266.
Chicago
Esmaeilzadeh, S., Delavar, M. A., Nouri, H., Mashayekh‑Amiri, S., Ahmadi, N., Namdar, R."Examination of associations between personality traits, and polymorphisms of MAO‑A and 5‑HTT with the severity of menopausal symptoms and depression levels". Biomedical Reports 12, no. 5 (2020): 259-266. https://doi.org/10.3892/br.2020.1287
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team