Examination of associations between personality traits, and polymorphisms of MAO‑A and 5‑HTT with the severity of menopausal symptoms and depression levels

  • Authors:
    • Sedighe Esmaeilzadeh
    • Mouloud Agajani Delavar
    • Hamidreza Nouri
    • Sepideh Mashayekh‑Amiri
    • Niloufar Ahmadi
    • Reza Namdar
  • View Affiliations

  • Published online on: March 4, 2020     https://doi.org/10.3892/br.2020.1287
  • Pages: 259-266
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The aim of the present study was to investigate the association between different personality traits with monoamine oxidase A (MAO‑A) and serotonin transporter (5‑HTT), and to examine their effects on the severity of menopause symptoms as well as the levels of depression in menopausal women. The study was designed as an analytical cross‑sectional study, performed on 132 healthy post‑menopausal women in Iran. Personality was assessed using the Revised Edition of the NEO Personality Index (Neuroticism‑Extroversion‑Openness‑Five Factor Inventory). The symptoms score sheet, used for measuring menopausal symptoms, was used to classify the participants according to their menopausal symptoms. Furthermore, Beck Depression Inventory short version was also used to assess depressive symptoms. Examination of blood samples taken from all participants was to identify DNA polymorphisms of 5‑HTT using PCR. The results of the present study showed that a high level of neuroticism (P<0.0001), low levels of extroversion (P<0.002), an openness to experience (P=0.039) and conscientiousness (P=0.001) were all positively associated with the severity of menopausal symptoms. In addition, a high level of neuroticism (P<0.0001), low levels of extroversion (P<0.0001), and a low level of agreeableness (P<0.024) and conscientiousness (P<0.0001) were all positively associated with depressive symptoms. There was no statistically significant association between MAO‑A and 5‑HTT polymorphisms with menopause and depression scores. Based on these results, there appears to be a significant association between personality traits with both depression and menopausal symptoms. Identification of homogeneous groups of women who are predisposed to depression and severe menopausal symptoms may allow for the implementation of early prevention programs.

Related Articles

Journal Cover

May 2020
Volume 12 Issue 5

Print ISSN: 2049-9434
Online ISSN:2049-9442

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
APA
Esmaeilzadeh, S., Delavar, M.A., Nouri, H., Mashayekh‑Amiri, S., Ahmadi, N., & Namdar, R. (2020). Examination of associations between personality traits, and polymorphisms of MAO‑A and 5‑HTT with the severity of menopausal symptoms and depression levels. Biomedical Reports, 12, 259-266. https://doi.org/10.3892/br.2020.1287
MLA
Esmaeilzadeh, S., Delavar, M. A., Nouri, H., Mashayekh‑Amiri, S., Ahmadi, N., Namdar, R."Examination of associations between personality traits, and polymorphisms of MAO‑A and 5‑HTT with the severity of menopausal symptoms and depression levels". Biomedical Reports 12.5 (2020): 259-266.
Chicago
Esmaeilzadeh, S., Delavar, M. A., Nouri, H., Mashayekh‑Amiri, S., Ahmadi, N., Namdar, R."Examination of associations between personality traits, and polymorphisms of MAO‑A and 5‑HTT with the severity of menopausal symptoms and depression levels". Biomedical Reports 12, no. 5 (2020): 259-266. https://doi.org/10.3892/br.2020.1287