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Effect of procalcitonin on the prognosis of patients with COPD

  • Authors:
    • Chen Gong
    • Ying Yang
    • Minli Chen
    • Zhengfu Xie
  • View Affiliations / Copyright

    Affiliations: Geriatrics Respiratory Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P.R. China
    Copyright: © Gong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 313-318
    |
    Published online on: April 22, 2020
       https://doi.org/10.3892/br.2020.1298
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Abstract

The aim of the present study was to investigate the effect of procalcitonin levels on the prognosis of chronic obstructive pulmonary disease (COPD), and its relationship with other indices of infection. Inpatients diagnosed with acute aggravation of COPD between January 2017 and June 2018 were enrolled in the present study. Troponin, C‑reactive protein (CRP), erythrocyte sedimentation rate (ESR), white blood cell (WBC) count, percentage of neutrophils (NE%), hospitalization days and hospitalization expenses were collected and followed up for half a year to observe the survival rate in patients with COPD and the risk of acute aggravation. There were 246 patients with procalcitonin (PCT) levels <0.1 ng/ml, among whom 55 were randomly selected and assigned to a PCT negative group; and another 55 patients with PCT levels ≥0.1 ng/ml were assigned to a PCT positive group. The serum CRP, ESR, WBC count, NE% and hospitalization expenses in the PCT positive group were significantly higher compared with the PCT negative group (P<0.05). There was a positive association between PCT levels and CRP, WBC, NE% and hospitalization expenses, but not between PCT and ESR. The number of AECOPD events occurring within half a year between the two groups was statistically significant (χ²=5.923; P<0.05), and there was no significant correlation between PCT and recurrence frequency. Together, the results of the present study suggest that the levels of PCT in patients with acute aggravation may reflect the severity of COPD and may be used as a reference value for prognostic risk assessment. Serum PCT levels may be used as an indicator to predict duration and cost of hospitalization.
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1 

Flattet Y, Garin N, Serratrice J, Perrier A, Stirnemann J and Carballo S: Determining prognosis in acute exacerbation of COPD. Int J Chron Obstruct Pulmon Dis. 12:467–475. 2017.PubMed/NCBI View Article : Google Scholar

2 

Dixit D, Bridgeman MB, Andrews LB, Narayanan N, Radbel J, Parikh A and Sunderram J: Acute exacerbations of chronic obstructive pulmonary disease: Diagnosis, management, and prevention in critically ill patients. Pharmacotherapy. 35:631–648. 2015.PubMed/NCBI View Article : Google Scholar

3 

Sethi S: Infectious etiology of acute exacerbations of chronic bronchitis. Chest. 117 (5 Suppl 2):380S–385S. 2000.PubMed/NCBI View Article : Google Scholar

4 

Holden V, Slack III D and McCurdy MT: Diagnosis and management of acute exacerbations of chronic obstructive pulmonary disease. Emerg Med Pract. 19:1–24. 2017.PubMed/NCBI

5 

Hakamy A, McKeever TM, Steiner MC, Roberts CM, Singh SJ and Bolton CE: The use of the practice walk test in pulmonary rehabilitation program: National COPD audit pulmonary rehabilitation workstream. Int J Chron Obstruct Pulmon Dis. 12:2681–2686. 2017.PubMed/NCBI View Article : Google Scholar

6 

Miravitlles M and Anzueto A: Role of infection in exacerbations of chronic obstructive pulmonary disease. Curr Opin Pulm Med. 21:278–283. 2015.PubMed/NCBI View Article : Google Scholar

7 

Cazzola M, MacNee W, Martinez FJ, Rabe KF, Franciosi LG, Barnes PJ, Brusasco V, Burge PS, Calverley PM, Celli BR, et al: Outcomes for COPD pharmacological trials: From lung function to biomarkers. Eur Respir J. 31:416–469. 2008.PubMed/NCBI View Article : Google Scholar

8 

Biomarkers Definitions Working Group. Biomarkers and surrogate endpoints: Preferred definitions and conceptual framework. Clin Pharmacol Ther. 69:89–95. 2001.PubMed/NCBI View Article : Google Scholar

9 

Miller M, Cho JY, Pham A, Ramsdell J and Broide DH: Adiponectin and functional adiponectin receptor 1 are expressed by airway epithelial cells in chronic obstructive pulmonary disease. J Immunol. 182:684–691. 2009.PubMed/NCBI View Article : Google Scholar

10 

Liu YJ, Du P and Rao J: Procalcitonin as a diagnostic and prognostic marker for sepsis caused by intestinal infection: A case report. Eur Rev Med Pharmacol Sci. 17:1311–1313. 2013.PubMed/NCBI

11 

Irusen EM: Deciphering the new global initiative for chronic obstructive lung disease (GOLD) guideline. Curr Respir Care Rep. 1:183–188. 2012.

12 

Müller B and Becker KL: Procalcitonin: How a hormone became a marker and mediator of sepsis. Swiss Med Wkly. 131:595–602. 2001.PubMed/NCBI

13 

Bohuon C: A brief history of procalcitonin. Intensive Care Med. 26 (Suppl 2):S146–S147. 2008.

14 

Fisher LA, Kikkawa DO, Rivier JE, Amara SG, Evans RM, Rosenfeld MG, Vale WW and Brown MR: Stimulation of noradrenergic sympathetic outflow by calcitonin gene-related peptide. Nature. 305:534–536. 1983.PubMed/NCBI View Article : Google Scholar

15 

Snider RH Jr, Nylen ES and Becker KL: Procalcitonin and its component peptides in systemic inflammation: Immunochemical characterization. J Investig Med. 45:552–560. 1997.PubMed/NCBI

16 

Julie D: Procalcitonin. J Clin Pathol. 68:675–679. 2015.PubMed/NCBI View Article : Google Scholar

17 

Gilbert DN: Procalcitonin as a biomarker in respiratory tract infection. Clin Infect Dis. 52 (Suppl 4):S346–S350. 2011.PubMed/NCBI View Article : Google Scholar

18 

Park JH, Wee JH, Choi SP and Oh SH: The value of procalcitonin level in community-acquired pneumonia in the ED. Am J Emerg Med. 30:1248–1254. 2012.PubMed/NCBI View Article : Google Scholar

19 

Clyne B and Olshaker JS: The C-reactive protein. J Emerg Med. 17:1019–1025. 1999.PubMed/NCBI View Article : Google Scholar

20 

O'Donnell RA, Peebles C, Ward JA, Daraker A, Angco G, Broberg P, Pierrou S, Lund J, Holgate ST, Davies DE, et al: Relationship between peripheral airway dysfunction, airway obstruction, and neutrophilic inflammation in COPD. Thorax. 59:837–842. 2004.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Gong C, Yang Y, Chen M and Xie Z: Effect of procalcitonin on the prognosis of patients with COPD. Biomed Rep 12: 313-318, 2020.
APA
Gong, C., Yang, Y., Chen, M., & Xie, Z. (2020). Effect of procalcitonin on the prognosis of patients with COPD. Biomedical Reports, 12, 313-318. https://doi.org/10.3892/br.2020.1298
MLA
Gong, C., Yang, Y., Chen, M., Xie, Z."Effect of procalcitonin on the prognosis of patients with COPD". Biomedical Reports 12.6 (2020): 313-318.
Chicago
Gong, C., Yang, Y., Chen, M., Xie, Z."Effect of procalcitonin on the prognosis of patients with COPD". Biomedical Reports 12, no. 6 (2020): 313-318. https://doi.org/10.3892/br.2020.1298
Copy and paste a formatted citation
x
Spandidos Publications style
Gong C, Yang Y, Chen M and Xie Z: Effect of procalcitonin on the prognosis of patients with COPD. Biomed Rep 12: 313-318, 2020.
APA
Gong, C., Yang, Y., Chen, M., & Xie, Z. (2020). Effect of procalcitonin on the prognosis of patients with COPD. Biomedical Reports, 12, 313-318. https://doi.org/10.3892/br.2020.1298
MLA
Gong, C., Yang, Y., Chen, M., Xie, Z."Effect of procalcitonin on the prognosis of patients with COPD". Biomedical Reports 12.6 (2020): 313-318.
Chicago
Gong, C., Yang, Y., Chen, M., Xie, Z."Effect of procalcitonin on the prognosis of patients with COPD". Biomedical Reports 12, no. 6 (2020): 313-318. https://doi.org/10.3892/br.2020.1298
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