Citrulline cooperatively exerts an anti‑inflammatory effect on synovial cells with glucosamine and N‑acetylglucosamine

  • Authors:
    • Yoshie Yamagishi
    • Akimasa Someya
    • Isao Nagaoka
  • View Affiliations

  • Published online on: May 12, 2020     https://doi.org/10.3892/br.2020.1304
  • Pages: 37-42
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Abstract

The aim of the present study was to evaluate the anti‑inflammatory effects of citrulline (Cit), glucosamine (GlcN) and N‑acetylglucosamine (GlcNAc) on synovial cells, which are primarily involved in inflammatory joint diseases. The combined effect of Cit, GlcN and GlcNAc on synovial cell inflammation was assessed by measuring IL‑1β‑induced IL‑6 production. GlcN and GlcNAc (0.5 mM each) alone did not suppress IL‑6 production, whereas Cit (0.5 mM) did significantly suppress IL‑6 production. Furthermore, the combined effect of Cit, GlcNAc and GlcN was examined; Cit + GlcN and Cit + GlcNAc significantly suppressed not only IL‑6 production, but also phosphorylation of ERK1/2. Similarly, combination of GlcN + GlcNAc significantly suppressed IL‑6 production and phosphorylation of ERK1/2. These observations suggest that among Cit, GlcNAc and GlcN, the combination of Cit with GlcN or GlcNAc exerts a synergistic anti‑inflammatory effect on synovial cells, thereby possibly exhibiting chondroprotective effects and alleviating inflammatory joint diseases.

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July 2020
Volume 13 Issue 1

Print ISSN: 2049-9434
Online ISSN:2049-9442

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APA
Yamagishi, Y., Someya, A., & Nagaoka, I. (2020). Citrulline cooperatively exerts an anti‑inflammatory effect on synovial cells with glucosamine and N‑acetylglucosamine. Biomedical Reports, 13, 37-42. https://doi.org/10.3892/br.2020.1304
MLA
Yamagishi, Y., Someya, A., Nagaoka, I."Citrulline cooperatively exerts an anti‑inflammatory effect on synovial cells with glucosamine and N‑acetylglucosamine". Biomedical Reports 13.1 (2020): 37-42.
Chicago
Yamagishi, Y., Someya, A., Nagaoka, I."Citrulline cooperatively exerts an anti‑inflammatory effect on synovial cells with glucosamine and N‑acetylglucosamine". Biomedical Reports 13, no. 1 (2020): 37-42. https://doi.org/10.3892/br.2020.1304