Open Access

Total flavonoids of Selaginella pulvinata alleviates cognitive impairment in mice

  • Authors:
    • Lianzhu Zhang
    • Yang Zhang
    • Yating Hou
    • Haiyan Li
    • Chikun Li
    • Jile Xin
    • Nana Zhou
    • Qingjie Li
    • Yu Song
    • Zhengyao Zhang
  • View Affiliations

  • Published online on: June 9, 2020     https://doi.org/10.3892/br.2020.1315
  • ArticleNumber: 8
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Cognitive impairment (CI) refers to dysfunctional cognition, which encompasses a spectrum of disorders, ranging from mild cognitive impairment to dementia. Any factor that results in cortical damage may cause CI. Total flavonoids of of Selaginella pulvinata (TFSP), have shown promising antioxidant and protective effects in animal models. In the present study, mice were intraperitoneally treated with scopolamine, sodium nitrite or 45% ethanol to induce memory impairment, and the effects were assessed using a step-down test. After performing the behavioural test, hippocampal sections were collected for anatomical analysis, and the brain and serum levels of memory-related molecules were evaluated. The results showed that TFSP improved memory in a mouse model of CI significantly. Serum data were consistent with the behavioural results: TFSP increased blood acetylcholine levels through modulation of the acetylcholinesterase and choline acetyltransferase levels. It also ameliorated oxidative stress in neurons, increasing superoxide dismutase, glutathione peroxidase and inhibiting nitric oxide synthase levels in the brain. These results suggest that TFSP may exhibit potential as a clinical treatment for neurodegenerative diseases, including Parkinson's disease, Alzheimer's disease, and senile dementia.
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August-2020
Volume 13 Issue 2

Print ISSN: 2049-9434
Online ISSN:2049-9442

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Spandidos Publications style
Zhang L, Zhang Y, Hou Y, Li H, Li C, Xin J, Zhou N, Li Q, Song Y, Zhang Z, Zhang Z, et al: Total flavonoids of Selaginella pulvinata alleviates cognitive impairment in mice. Biomed Rep 13: 8, 2020
APA
Zhang, L., Zhang, Y., Hou, Y., Li, H., Li, C., Xin, J. ... Zhang, Z. (2020). Total flavonoids of Selaginella pulvinata alleviates cognitive impairment in mice. Biomedical Reports, 13, 8. https://doi.org/10.3892/br.2020.1315
MLA
Zhang, L., Zhang, Y., Hou, Y., Li, H., Li, C., Xin, J., Zhou, N., Li, Q., Song, Y., Zhang, Z."Total flavonoids of Selaginella pulvinata alleviates cognitive impairment in mice". Biomedical Reports 13.2 (2020): 8.
Chicago
Zhang, L., Zhang, Y., Hou, Y., Li, H., Li, C., Xin, J., Zhou, N., Li, Q., Song, Y., Zhang, Z."Total flavonoids of Selaginella pulvinata alleviates cognitive impairment in mice". Biomedical Reports 13, no. 2 (2020): 8. https://doi.org/10.3892/br.2020.1315