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Role of tumor suppressor molecules in genomic perturbations and damaged DNA repair involved in the pathogenesis of cancer and neurodegeneration (Review)

  • Authors:
    • Satoru Matsuda
    • Mutsumi Murakami
    • Yuka Ikeda
    • Yukie Nakagawa
    • Ai Tsuji
    • Yasuko Kitagishi
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    Affiliations: Department of Food Science and Nutrition, Nara Women's University, Nara 630‑8506, Japan
    Copyright: © Matsuda et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 10
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    Published online on: June 17, 2020
       https://doi.org/10.3892/br.2020.1317
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Abstract

Genomic perturbations due to inaccurate DNA replication, including inappropriate chromosomal segregation often underlie the development of cancer and neurodegenerative diseases. The incidence of these two diseases increases with age and exhibits an inverse association. Therefore, elderly subjects with cancer exhibit a reduced risk of a neurodegenerative disease, and vice versa. Both of these diseases are associated with aging and share several risk factors. Cells have multiple mechanisms to repair DNA damage and inaccurate replication. Previous studies have demonstrated that tumor suppressor proteins serve a critical role in the DNA damage response, which may result in genomic instability and thus induction of cellular apoptosis. Tumor suppressor genes, such as phosphatase and tensin homologue deleted on chromosome 10 (PTEN), breast cancer susceptibility gene 1 (BRCA1) and TP53 reduce genomic susceptibility to cancer by repairing the damaged DNA. In addition, these genes work cooperatively to ensure the inhibition of the development of several types of cancer. PTEN, BRCA1 and TP53 have been recognized as the most frequently deleted and/or mutated genes in various types of human cancer. Recently, tumor suppressor genes have also been shown to be involved in the development of neurodegenerative diseases. The present review summarizes the recent findings of the functions of these tumor suppressors that are associated with genomic stability, and are involved in carcinogenic and neurodegenerative cell signaling. A summary is presented regarding the interactions of these tumor suppressors with their partners which results in transduction of downstream signals. The implications of these functions for cancer and neurodegenerative disease‑associated biology are also highlighted.
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1 

Awasthi P, Foiani M and Kumar A: ATM and ATR signaling at a glance. J Cell Sci. 128:4255–4262. 2015.PubMed/NCBI View Article : Google Scholar

2 

Van Haaften G, Plasterk RH and Tijsterman M: Genomic instability and cancer: Scanning the Caenorhabditis elegans genome for tumor suppressors. Oncogene. 23:8366–8375. 2004.PubMed/NCBI View Article : Google Scholar

3 

Ghezzi EM and Ship JA: Systemic diseases and their treatments in the elderly: Impact on oral health. J Public Health Dent. 60:289–296. 2000.PubMed/NCBI View Article : Google Scholar

4 

Zhang Q, Guo S, Zhang X, Tang S, Shao W, Han X, Wang L and Du Y: Inverse relationship between cancer and Alzheimer's disease: A systemic review meta-analysis. Neurol Sci. 36:1987–1994. 2015.PubMed/NCBI View Article : Google Scholar

5 

Musicco M, Adorni F, Di Santo S, Prinelli F, Pettenati C, Caltagirone C, Palmer K and Russo A: Inverse occurrence of cancer and Alzheimer disease: A population-based incidence study. Neurology. 81:322–328. 2013.PubMed/NCBI View Article : Google Scholar

6 

Nudelman KN, Risacher SL, West JD, McDonald BC, Gao S and Saykin AJ: Alzheimer's disease neuroimaging initiative. Association of cancer history with Alzheimer's disease onset and structural brain changes. Front Physiol. 5(423)2014.PubMed/NCBI View Article : Google Scholar

7 

Liu Y, Chen Q and Zhang JT: Tumor suppressor gene 14-3-3sigma is down-regulated whereas the proto-oncogene translation elongation factor 1delta is up-regulated in non-small cell lung cancers as identified by proteomic profiling. J Proteome Res. 3:728–735. 2004.PubMed/NCBI View Article : Google Scholar

8 

Boiko AD, Porteous S, Razorenova OV, Krivokrysenko VI, Williams BR and Gudkov AV: A systematic search for downstream mediators of tumor suppressor function of p53 reveals a major role of BTG2 in suppression of Ras-induced transformation. Genes Dev. 20:236–252. 2006.PubMed/NCBI View Article : Google Scholar

9 

Payne CM, Bernstein C, Dvorak K and Bernstein H: Hydrophobic bile acids, genomic instability, Darwinian selection, and colon carcinogenesis. Clin Exp Gastroenterol. 1:19–47. 2008.PubMed/NCBI View Article : Google Scholar

10 

Fujikake N, Shin M and Shimizu S: Association between autophagy and neurodegenerative diseases. Front Neurosci. 12(255)2018.PubMed/NCBI View Article : Google Scholar

11 

Madabhushi R, Pan L and Tsai LH: DNA damage and its links to neurodegeneration. Neuron. 83:266–282. 2014.PubMed/NCBI View Article : Google Scholar

12 

Bradley-Whitman MA, Timmons MD, Beckett TL, Murphy MP, Lynn BC and Lovell MA: Nucleic acid oxidation: An early feature of Alzheimer's disease. J Neurochem. 128:294–304. 2014.PubMed/NCBI View Article : Google Scholar

13 

Canugovi C, Shamanna RA, Croteau DL and Bohr VA: Base excision DNA repair levels in mitochondrial lysates of Alzheimer's disease. Neurobiol Aging. 35:1293–1300. 2014.PubMed/NCBI View Article : Google Scholar

14 

Chen W, Zou P, Zhao Z, Chen X, Fan X, Vinothkumar R, Cui R, Wu F, Zhang Q, Liang G and Ji J: Synergistic antitumor activity of rapamycin and EF24 via increasing ROS for the treatment of gastric cancer. Redox Biol. 10:78–89. 2016.PubMed/NCBI View Article : Google Scholar

15 

Zhao L, Wang JL, Wang YR and Fa XZ: Apigenin attenuates copper-mediated β-amyloid neurotoxicity through antioxidation, mitochondrion protection and MAPK signal inactivation in an AD cell model. Brain Res. 1492:33–45. 2013.PubMed/NCBI View Article : Google Scholar

16 

Wang Y, Branicky R, Noë A and Hekimi S: Superoxide dismutases: Dual roles in controlling ROS damage and regulating ROS signaling. J Cell Biol. 217:1915–1928. 2018.PubMed/NCBI View Article : Google Scholar

17 

Pong K: Oxidative stress in neurodegenerative diseases: Therapeutic implications for superoxide dismutase mimetics. Expert Opin Biol Ther. 3:127–139. 2003.PubMed/NCBI View Article : Google Scholar

18 

Nazıroğlu M, Muhamad S and Pecze L: Nanoparticles as potential clinical therapeutic agents in Alzheimer's disease: Focus on selenium nanoparticles. Expert Rev Clin Pharmacol. 10:773–782. 2017.PubMed/NCBI View Article : Google Scholar

19 

Cudkowicz ME, Pastusza KA, Sapp PC, Mathews RK, Leahy J, Pasinelli P, Francis JW, Jiang D, Andersen JK and Brown RH Jr: Survival in transgenic ALS mice does not vary with CNS glutathione peroxidase activity. Neurology. 59:729–734. 2002.PubMed/NCBI View Article : Google Scholar

20 

Sangwan S and Eisenberg DS: Perspective on SOD1 mediated toxicity in Amyotrophic Lateral Sclerosis. Postepy Biochem. 62:362–369. 2016.PubMed/NCBI

21 

Kostrominova TY: Advanced age-related denervation and fiber-type grouping in skeletal muscle of SOD1 knockout mice. Free Radic Biol Med. 49:1582–1593. 2010.PubMed/NCBI View Article : Google Scholar

22 

Kang SW: Superoxide dismutase 2 gene and cancer risk: Evidence from an updated meta-analysis. Int J Clin Exp Med. 8:14647–14655. 2015.PubMed/NCBI

23 

Flynn JM and Melov S: SOD2 in mitochondrial dysfunction and neurodegeneration. Free Radic Biol Med. 62:4–12. 2013.PubMed/NCBI View Article : Google Scholar

24 

Hroudová J, Singh N and Fišar Z: Mitochondrial dysfunctions in neurodegenerative diseases: Relevance to Alzheimer's disease. Biomed Res Int. 2014(175062)2014.PubMed/NCBI View Article : Google Scholar

25 

Hinerfeld D, Traini MD, Weinberger RP, Cochran B, Doctrow SR, Harry J and Melov S: Endogenous mitochondrial oxidative stress: Neurodegeneration, proteomic analysis, specific respiratory chain defects, and efficacious antioxidant therapy in superoxide dismutase 2 null mice. J Neurochem. 88:657–667. 2004.PubMed/NCBI View Article : Google Scholar

26 

Papa L, Hahn M, Marsh EL, Evans BS and Germain D: SOD2 to SOD1 switch in breast cancer. Biol Chem. 289:5412–5416. 2014.PubMed/NCBI View Article : Google Scholar

27 

Teoh-Fitzgerald ML, Fitzgerald MP, Jensen TJ, Futscher BW and Domann FE: Genetic and epigenetic inactivation of extracellular superoxide dismutase promotes an invasive phenotype in human lung cancer by disrupting ECM homeostasis. Mol Cancer Res. 10:40–51. 2012.PubMed/NCBI View Article : Google Scholar

28 

Baluchnejadmojarad T, Mansouri M, Ghalami J, Mokhtari Z and Roghani M: Sesamin imparts neuroprotection against intrastriatal 6-hydroxydopamine toxicity by inhibition of astroglial activation, apoptosis, and oxidative stress. Biomed Pharmacother. 88:754–761. 2017.PubMed/NCBI View Article : Google Scholar

29 

Petro M, Jaffer H, Yang J, Kabu S, Morris VB and Labhasetwar V: Tissue plasminogen activator followed by antioxidant-loaded nanoparticle delivery promotes activation/mobilization of progenitor cells in infarcted rat brain. Biomaterials. 81:169–180. 2016.PubMed/NCBI View Article : Google Scholar

30 

Dilawari A, Cangiarella J, Smith J, Huang A, Downey A and Muggia F: Co-existence of breast and ovarian cancers in BRCA germ-line mutation carriers. Ecancermedicalscience. 2(109)2008.PubMed/NCBI View Article : Google Scholar

31 

Modena A, Iacovelli R, Scarpa A, Brunelli M, Ciccarese C, Fantinel E, Bimbatti D, Massari F, Martignoni G and Tortora G: Investigating BRCA mutations: A breakthrough in precision medicine of castration-resistant prostate cancer. Target Oncol. 11:569–577. 2016.PubMed/NCBI View Article : Google Scholar

32 

Guirouilh-Barbat JK, Wilhelm T and Lopez BS: AKT1/BRCA1 in the control of homologous recombination and genetic stability: The missing link between hereditary and sporadic breast cancers. Oncotarget. 1:691–699. 2010.PubMed/NCBI View Article : Google Scholar

33 

Ogino M, Ichimura M, Nakano N, Minami A, Kitagishi Y and Matsuda S: Roles of PTEN with DNA repair in Parkinson's disease. Int J Mol Sci. 17(954)2016.PubMed/NCBI View Article : Google Scholar

34 

Gonzalez ME, Li X, Toy K, DuPrie M, Ventura AC, Banerjee M, Ljungman M, Merajver SD and Kleer CG: Downregulation of EZH2 decreases growth of estrogen receptor-negative invasive breast carcinoma and requires BRCA1. Oncogene. 28:843–853. 2009.PubMed/NCBI View Article : Google Scholar

35 

Suberbielle E, Djukic B, Evans M, Kim DH, Taneja P, Wang X, Finucane M, Knox J, Ho K, Devidze N, et al: DNA repair factor BRCA1 depletion occurs in Alzheimer brains and impairs cognitive function in mice. Nat Commun. 6(8897)2015.PubMed/NCBI View Article : Google Scholar

36 

Brown EJ: Analysis of cell cycle progression and genomic integrity in early lethal knockouts. Methods Mol Biol. 280:201–212. 2004.PubMed/NCBI View Article : Google Scholar

37 

Jacobsen E, Beach T, Shen Y, Li R and Chang Y: Deficiency of the Mre11 DNA repair complex in Alzheimer's disease brains. Brain Res Mol Brain Res. 128:1–7. 2004.PubMed/NCBI View Article : Google Scholar

38 

Jhanwar-Uniyal M: BRCA1 in cancer, cell cycle and genomic stability. Front Biosci. 8 (Suppl):S1107–S1117. 2003.PubMed/NCBI View Article : Google Scholar

39 

Hradek AC, Lee HP, Siedlak SL, Torres SL, Jung W, Han AH and Lee HG: Distinct chronology of neuronal cell cycle re-entry and tau pathology in the 3xTg-AD mouse model and Alzheimer's disease patients. J Alzheimers Dis. 4:57–65. 2015.PubMed/NCBI View Article : Google Scholar

40 

Padmanabhan J, Brown K and Shelanski ML: Cell cycle inhibition and retinoblastoma protein overexpression prevent Purkinje cell death in organotypic slice cultures. Dev Neurobiol. 67:818–826. 2007.PubMed/NCBI View Article : Google Scholar

41 

Delobel P, Lavenir I, Ghetti B, Holzer M and Goedert M: Cell-cycle markers in a transgenic mouse model of human tauopathy: Increased levels of cyclin-dependent kinase inhibitors p21Cip1 and p27Kip1. Am J Pathol. 168:878–887. 2006.PubMed/NCBI View Article : Google Scholar

42 

Bialopiotrowicz E, Szybinska A, Kuzniewska B, Buizza L, Uberti D, Kuznicki J and Wojda U: Highly pathogenic Alzheimer's disease presenilin 1 P117R mutation causes a specific increase in p53 and p21 protein levels and cell cycle dysregulation in human lymphocytes. J Alzheimers Dis. 32:397–415. 2012.PubMed/NCBI View Article : Google Scholar

43 

Yin Y and Shen WH: PTEN: A new guardian of the genome. Oncogene. 27:5443–5453. 2008.PubMed/NCBI View Article : Google Scholar

44 

Wise HM, Hermida MA and Leslie NR: Prostate cancer, PI3K, PTEN and prognosis. Clin Sci (Lond). 131:197–210. 2017.PubMed/NCBI View Article : Google Scholar

45 

Yakubov E, Ghoochani A, Buslei R, Buchfelder M, Eyüpoglu IY and Savaskan N: Hidden association of Cowden syndrome, PTEN mutation and meningioma frequency. Oncoscience. 3:149–155. 2016.PubMed/NCBI View Article : Google Scholar

46 

Hou SQ, Ouyang M, Brandmaier A, Hao H and Shen WH: PTEN in the maintenance of genome integrity: From DNA replication to chromosome segregation. Bioessays:. 39(1700082)2017.PubMed/NCBI View Article : Google Scholar

47 

Ming M and He YY: PTEN in DNA damage repair. Cancer Lett. 319:125–129. 2012.PubMed/NCBI View Article : Google Scholar

48 

Fiandalo MV and Kyprianou N: Caspase control: Protagonists of cancer cell apoptosis. Exp Oncol. 34:165–175. 2012.PubMed/NCBI

49 

Krishnan A and Zochodne DW: Is cytoplasmic PTEN a specific target for neuronal survival? Mol Neurobiol. 52:1758–1764. 2015.PubMed/NCBI View Article : Google Scholar

50 

Asua D, Bougamra G, Calleja-Felipe M, Morales M and Knafo S: Peptides acting as cognitive enhancers. Neuroscience. 370:81–87. 2018.PubMed/NCBI View Article : Google Scholar

51 

Frere S and Slutsky I: Targeting PTEN interactions for Alzheimer's disease. Nat Neurosci. 19:416–418. 2016.PubMed/NCBI View Article : Google Scholar

52 

Knafo S, Sánchez-Puelles C, Palomer E, Delgado I, Draffin JE, Mingo J, Wahle T, Kaleka K, Mou L, Pereda-Perez I, et al: PTEN recruitment controls synaptic and cognitive function in Alzheimer's models. Nat Neurosci. 19:443–453. 2016.PubMed/NCBI View Article : Google Scholar

53 

Zhang YY, Huang J, Yang M, Gu LJ, Ji JY, Wang LJ and Yuan WJ: Effect of a low-protein diet supplemented with Keto-acids on autophagy and inflammation in 5/6 nephrectomized rats. Biosci Rep. 35(e00263)2015.PubMed/NCBI View Article : Google Scholar

54 

Estevez AO, Morgan KL, Szewczyk NJ, Gems D and Estevez M: The neurodegenerative effects of selenium are inhibited by FOXO and PINK1/PTEN regulation of insulin/insulin-like growth factor signaling in Caenorhabditis elegans. Neurotoxicology. 41:28–43. 2014.PubMed/NCBI View Article : Google Scholar

55 

Machado-Silva A, Perrier S and Bourdon JC: p53 family members in cancer diagnosis and treatment. Semin Cancer Biol. 20:57–62. 2010.PubMed/NCBI View Article : Google Scholar

56 

Stewart-Ornstein J and Lahav G: p53 dynamics in response to DNA damage vary across cell lines and are shaped by efficiency of DNA repair and activity of the kinase ATM. Sci Signal. 10(eaah6671)2017.PubMed/NCBI View Article : Google Scholar

57 

Zhang XP, Liu F, Cheng Z and Wang W: Cell fate decision mediated by p53 pulses. Version 2. Proc Natl Acad Sci USA. 106:12245–50. 2009.PubMed/NCBI View Article : Google Scholar

58 

Bénard J, Douc-Rasy S and Ahomadegbe JC: TP53 family members and human cancers. Hum Mutat. 21:182–191. 2003.PubMed/NCBI View Article : Google Scholar

59 

Varley JM: Germline TP53 mutations and Li-Fraumeni syndrome. Hum Mutat. 21:313–320. 2003.PubMed/NCBI View Article : Google Scholar

60 

Zhao J, Lammers P, Torrance CJ and Bader AG: TP53-independent function of miR-34a via HDAC1 and p21(CIP1/WAF1.). Mol Ther. 21:1678–1686. 2013.PubMed/NCBI View Article : Google Scholar

61 

O'Neil N and Rose A: DNA repair. WormBook. Jan, 13:1–12. 2006.PubMed/NCBI View Article : Google Scholar

62 

Golubnitschaja O: Cell cycle checkpoints: The role and evaluation for early diagnosis of senescence, cardiovascular, cancer, and neurodegenerative diseases. Amino Acids. 32:359–371. 2007.PubMed/NCBI View Article : Google Scholar

63 

Hazan I, Hofmann TG and Aqeilan RI: Tumor suppressor genes within common fragile sites are active players in the DNA damage response. PLoS Genet. 12(e1006436)2016.PubMed/NCBI View Article : Google Scholar

64 

Thurn KT, Thomas S, Raha P, Qureshi I and Munster PN: Histone deacetylase regulation of ATM-mediated DNA damage signaling. Mol Cancer Ther. 12:2078–2087. 2013.PubMed/NCBI View Article : Google Scholar

65 

Le Corre L, Fustier P, Chalabi N, Bignon YJ and Bernard-Gallon D: Effects of resveratrol on the expression of a panel of genes interacting with the BRCA1 oncosuppressor in human breast cell lines. Clin Chim Acta. 344:115–121. 2004.PubMed/NCBI View Article : Google Scholar

66 

Matsuda S, Nakagawa Y, Kitagishi Y, Nakanishi A and Murai T: Reactive oxygen species, superoxide dimutases, and PTEN-p53-AKT-MDM2 signaling loop network in mesenchymal Stem/Stromal cells regulation. Cells. 7(36)2018.PubMed/NCBI View Article : Google Scholar

67 

Hair JM, Terzoudi GI, Hatzi VI, Lehockey KA, Srivastava D, Wang W, Pantelias GE and Georgakilas AG: BRCA1 role in the mitigation of radiotoxicity and chromosomal instability through repair of clustered DNA lesions. Chem Biol Interact. 188:350–358. 2010.PubMed/NCBI View Article : Google Scholar

68 

Liu W, Zhou Y, Reske SN and Shen C: PTEN mutation: Many birds with one stone in tumorigenesis. Anticancer Res. 28:3613–3619. 2008.PubMed/NCBI

69 

Kobayashi H, Ogawa K, Kawahara N, Iwai K, Niiro E, Morioka S and Yamada Y: Sequential molecular changes and dynamic oxidative stress in high-grade serous ovarian carcinogenesis. Free Radic Res. 51:755–764. 2017.PubMed/NCBI View Article : Google Scholar

70 

Bankoglu EE, Tschopp O, Schmitt J, Burkard P, Jahn D, Geier A and Stopper H: Role of PTEN in oxidative stress and DNA damage in the liver of whole-body Pten Haplodeficient mice. PLoS One. 11(e0166956)2016.PubMed/NCBI View Article : Google Scholar

71 

Armstrong CW, Maxwell PJ, Ong CW, Redmond KM, McCann C, Neisen J, Ward GA, Chessari G, Johnson C, Crawford NT, et al: PTEN deficiency promotes macrophage infiltration and hypersensitivity of prostate cancer to IAP antagonist/radiation combination therapy. Oncotarget. 7:7885–7898. 2016.PubMed/NCBI View Article : Google Scholar

72 

Zhang R, Zhu L, Zhang L, Xu A, Li Z, Xu Y, He P, Wu M, Wei F and Wang C: PTEN enhances G2/M arrest in Etoposide-treated MCF-7 cells through activation of the ATM pathway. Oncol Rep. 35:2707–2714. 2016.PubMed/NCBI View Article : Google Scholar

73 

Yin H, Zhou Y, Wen C, Zhou C, Zhang W, Hu X, Wang L, You C and Shao J: Curcumin sensitizes glioblastoma to temozolomide by simultaneously generating ROS and disrupting AKT/mTOR signaling. Oncol Rep. 32:1610–1616. 2014.PubMed/NCBI View Article : Google Scholar

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Spandidos Publications style
Matsuda S, Murakami M, Ikeda Y, Nakagawa Y, Tsuji A and Kitagishi Y: Role of tumor suppressor molecules in genomic perturbations and damaged DNA repair involved in the pathogenesis of cancer and neurodegeneration (Review). Biomed Rep 13: 10, 2020.
APA
Matsuda, S., Murakami, M., Ikeda, Y., Nakagawa, Y., Tsuji, A., & Kitagishi, Y. (2020). Role of tumor suppressor molecules in genomic perturbations and damaged DNA repair involved in the pathogenesis of cancer and neurodegeneration (Review). Biomedical Reports, 13, 10. https://doi.org/10.3892/br.2020.1317
MLA
Matsuda, S., Murakami, M., Ikeda, Y., Nakagawa, Y., Tsuji, A., Kitagishi, Y."Role of tumor suppressor molecules in genomic perturbations and damaged DNA repair involved in the pathogenesis of cancer and neurodegeneration (Review)". Biomedical Reports 13.3 (2020): 10.
Chicago
Matsuda, S., Murakami, M., Ikeda, Y., Nakagawa, Y., Tsuji, A., Kitagishi, Y."Role of tumor suppressor molecules in genomic perturbations and damaged DNA repair involved in the pathogenesis of cancer and neurodegeneration (Review)". Biomedical Reports 13, no. 3 (2020): 10. https://doi.org/10.3892/br.2020.1317
Copy and paste a formatted citation
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Spandidos Publications style
Matsuda S, Murakami M, Ikeda Y, Nakagawa Y, Tsuji A and Kitagishi Y: Role of tumor suppressor molecules in genomic perturbations and damaged DNA repair involved in the pathogenesis of cancer and neurodegeneration (Review). Biomed Rep 13: 10, 2020.
APA
Matsuda, S., Murakami, M., Ikeda, Y., Nakagawa, Y., Tsuji, A., & Kitagishi, Y. (2020). Role of tumor suppressor molecules in genomic perturbations and damaged DNA repair involved in the pathogenesis of cancer and neurodegeneration (Review). Biomedical Reports, 13, 10. https://doi.org/10.3892/br.2020.1317
MLA
Matsuda, S., Murakami, M., Ikeda, Y., Nakagawa, Y., Tsuji, A., Kitagishi, Y."Role of tumor suppressor molecules in genomic perturbations and damaged DNA repair involved in the pathogenesis of cancer and neurodegeneration (Review)". Biomedical Reports 13.3 (2020): 10.
Chicago
Matsuda, S., Murakami, M., Ikeda, Y., Nakagawa, Y., Tsuji, A., Kitagishi, Y."Role of tumor suppressor molecules in genomic perturbations and damaged DNA repair involved in the pathogenesis of cancer and neurodegeneration (Review)". Biomedical Reports 13, no. 3 (2020): 10. https://doi.org/10.3892/br.2020.1317
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