Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Biomedical Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9434 Online ISSN: 2049-9442
Journal Cover
November-2020 Volume 13 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2020 Volume 13 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article Open Access

Association of polymorphism genes LPL, ADRB2, AGT and AGTR1 with risk of hyperinsulinism and insulin resistance in the Kazakh population

  • Authors:
    • Aizhan Shakhanova
    • Nurlan Aukenov
    • Alma Nurtazina
    • Meruyert Massabayeva
    • Dmitriy Babenko
    • Madina Adiyeva
    • Nurlan Shaimardonov
  • View Affiliations / Copyright

    Affiliations: Department of Propaedeutic of Internal Diseases, Semey Medical University, Semey, East Kazakhstan Region F17G0D3, Kazakhstan, Department of Health and Human Resources, Ministry of Health of the Republic of Kazakhstan, Nur‑Sultan, East Kazakhstan Region Z05K5K8, Kazakhstan, Scientific and Research Center, Karaganda Medical University, Karaganda, East Kazakhstan Region M01K6T3, Kazakhstan
    Copyright: © Shakhanova et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 35
    |
    Published online on: August 7, 2020
       https://doi.org/10.3892/br.2020.1342
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Hyperinsulinism and insulin resistance are closely associated with several common diseases including type 2 of diabetes, cardiovascular diseases, and metabolic syndrome. The present study aimed to determine the association between hyperinsulinism, insulin resistance and the polymorphism of genes, including angiotensin II receptor type 1 (AGTR1), angiotensinogen (AGT), β2‑adrenoreceptor (ADRB2) and lipoprotein lipase (LPL), in the Kazakh population. The design of the current research was a case‑control study, involving 460 subjects (age range, 18‑65 years). For every subject, plasma glucose, insulin, total cholesterol, triglycerides, high‑density lipoprotein, low‑density lipoprotein, apolipoprotein B and apolipoprotein A1 were examined. Moreover, reverse transcription‑quantitative PCR was conducted to detect the polymorphism genes LPL Ser447Ter, ADRB2 Gln27Glu, AGT Thr174Met and AGTR1 A1166C. Hyperinsulinism was considered when the insulin level was elevated >24.9 IU/ml. The homeostasis model assessment insulin resistance (HOMA‑IR) was used to evaluate insulin resistance. The subjects were divided into hyperinsulinism (17 men and 24 women) and normal level insulin (214 men and 205 women) groups, which were also split into insulin resistance group (HOMA‑IR >2.7; 80 men and 105 women) and those without insulin resistance group (151 men and 124 women). The results suggested that LPL Ser447Ter (rs328) allele G was associated with a lower risk of hyperinsulinism (P=0.037). Furthermore, polymorphisms of genes ADRB2 Gln27Glu (rs1042714), AGT Thr174Met (rs4762) and AGTR1 A1166C (rs5186) were not associated with hyperinsulinism and insulin resistance in the Kazakh population. No interaction was identified between LPL Ser447Ter, ADRB2 Gln27Glu, AGT Thr174Met and AGTR1 A1166C. Therefore, the results indicated that haplotype combinations were not associated with insulin resistance.
View Figures
View References

1 

Alberti G, Zimmet P, Shaw J and Grundy SM: The IDF consensus worldwide definition of the metabolic syndrome. International Diabetes Federation, Brussels, Belgium, 2006.

2 

Schenk S, Saberi M and Olefsky JM: Insulin sensitivity: Modulation by nutrients and inflammation. J Clin Invest. 118:2992–3002. 2008.PubMed/NCBI View Article : Google Scholar

3 

Beisiegel U: Lipoprotein metabolism. Eur Heart J. 19 (Suppl A):A20–A23. 1998.PubMed/NCBI

4 

Muñoz-Barrios S, Guzmán-Guzmán IP, José Francisco JF, Salgado-Bernabé AB, Salgado-Goytia L and Parra-Rojas I: Association of the HindIII and S447X polymorphisms in LPL gene with hypertension and type 2 diabetes in Mexican families. Dis Markers. 33:313–320. 2012.PubMed/NCBI View Article : Google Scholar

5 

Xie C, Wang ZC, Liu XF and Yang MS: The common biological basis for common complex diseases: Evidence from lipoprotein lipase gene. Eur J Hum Genet. 18:3–7. 2010.PubMed/NCBI View Article : Google Scholar

6 

Blain JF, Aumont N, Théroux L, Dea D and Poirier J: A polymorphism in lipoprotein lipase affects the severity of Alzheimer's disease pathophysiology. Eur J Neurosci. 24:1245–1251. 2006.PubMed/NCBI View Article : Google Scholar

7 

Socquard E, Durlach A, Clavel C, Nazeyrollas P and Durlach V: Association of HindIII and PvuII genetic polymorphisms of lipoprotein lipase with lipid metabolism and macrovascular events in type 2 diabetic patients. Diabetes Metab. 32:262–269. 2006.PubMed/NCBI View Article : Google Scholar

8 

Goodarzi MO, Guo X, Taylor KD, Quiñones MJ, Saad MF, Yang H, Hsueh WA and Rotter JI: Lipoprotein lipase is a gene for insulin resistance in Mexican Americans. Diabetes. 53:214–220. 2004.PubMed/NCBI View Article : Google Scholar

9 

Tellechea ML, Muzzio DO, Iglesias Molli AE, Belli SH, Graffigna MN, Levalle OA, Frechtel GD and Cerrone GE: Association between β2-adrenoceptor (ADRB2) haplotypes and insulin resistance in PCOS. Clin Endocrinol (Oxf). 78:600–606. 2013.PubMed/NCBI View Article : Google Scholar

10 

Skov J, Persson F, Frøkiær J and Christiansen JS: Tissue renin-angiotensin systems: A unifying hypothesis of metabolic disease. Front Endocrinol (Lausanne). 5(23)2014.PubMed/NCBI View Article : Google Scholar

11 

Underwood PC and Adler GK: the renin angiotensin aldosterone system and insulin resistance in humans. Curr Hypertens Rep. 15:59–70. 2013.PubMed/NCBI View Article : Google Scholar

12 

Musso G, Saba F, Cassader M, Paschetta E, De Michieli F, Pinach S, Framarin L, Berrutti M, Leone N, Parente R, et al: Angiotensin II type 1 receptor rs5186 gene variant predicts incident NAFLD and associated hypertension: Role of dietary fat-induced pro-inflammatory cell activation. Am J Gastroenterol. 114:607–619. 2019.PubMed/NCBI View Article : Google Scholar

13 

Sikhayeva N, Talzhanov Y, Iskakova A, Dzharmukhanov J, Nugmanova R, Zholdybayeva E and Ramanculov E: Type 2 diabetes mellitus: Distribution of genetic markers in Kazakh population. Clin Interv Aging. 13:377–388. 2018.PubMed/NCBI View Article : Google Scholar

14 

Guo Y, Chen C, Jin X, Cui W, Wei Y, Wang H, Kong T, Mu Y and Zhu B: Autosomal DIPs for population genetic structure and differentiation analyses of Chinese Xinjiang Kyrgyz ethnic group. Sci Rep. 8(11054)2018.PubMed/NCBI View Article : Google Scholar

15 

Zhuo ZJ, Liu W, Zhang J, Zhu J, Zhang R, Tang J, Yang T, Zou Y, He J and Xia H: Functional polymorphisms at ERCC1/XPF genes confer neuroblastoma risk in Chinese children. EBioMedicine. 30:113–119. 2018.PubMed/NCBI View Article : Google Scholar

16 

Zhuo ZJ, Zhang R, Zhang J, Zhu J, Yang T, Zou Y, He J and Xia H: Associations between lncRNA MEG3 polymorphisms and neuroblastoma risk in Chinese children. Aging (Albany NY). 10:481–491. 2018.PubMed/NCBI View Article : Google Scholar

17 

Dai HJ, Wu JC, Tsai RT, Pan WH and Hsu WL: T-HOD: A literature-based candidate gene database for hypertension, obesity and diabetes. Database. 2013(bas061)2013.PubMed/NCBI View Article : Google Scholar

18 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

19 

Chan YH: Biostatistics 102 : Quantitative data-parametric & non-parametric tests. Singapore Med J. 44:391–396. 2003.PubMed/NCBI

20 

Chan YH: Biostatistics 103: Qualitative data-tests of independence. Singapore Med J. 44:498–503. 2003.PubMed/NCBI

21 

Yang T, Pang C, Tsang M, Lam CW, Poon PM, Chan LY, Wu XQ, Tomlinson B and Baum L: Pathogenic mutations of the lipoprotein lipase gene in Chinese patients with hypertriglyceridemic type 2 diabetes. Hum Mutat. 21:453. 2003.PubMed/NCBI View Article : Google Scholar

22 

Alinaghian N, Abdollahi E, Torab M, Khodaparast M, Zamani F and Rahimi-Moghaddam P: Gender-related relation between metabolic syndrome and S447X and HindIII polymorphisms of lipoprotein lipase gene in northern Iran. Gene. 706:13–18. 2019.PubMed/NCBI View Article : Google Scholar

23 

Vishram JK, Hansen TW, Torp-Pedersen C, Madsbad S, Jørgensen T, Fenger M, Lyngbæk S and Jeppesen J: Relationship between two common lipoprotein lipase variants and the metabolic syndrome and its individual components. Metab Syndr Relat Disord. 14:442–448. 2016.PubMed/NCBI View Article : Google Scholar

24 

Apalasamy YD, Ming MF, Rampal S, Bulgiba A and Mohamed Z: Gender-dependent association of a β(2)-adrenergic gene variant with obesity parameters in Malaysian Malays. Asia Pacific J Public Heal. 27:NP154–NP165. 2015.PubMed/NCBI View Article : Google Scholar

25 

González Sánchez JL, Proenza AM, Martínez Larrad MT, Ramis JM, Fernández Pérez C, Palou A and Serrano Ríos M: The glutamine 27 glutamic acid polymorphism of the beta2-adrenoceptor gene is associated with abdominal obesity and greater risk of impaired glucose tolerance in men but not in women: A population-based study in Spain. Clin Endocrinol (Oxf). 59:476–481. 2003.PubMed/NCBI View Article : Google Scholar

26 

Wang T, Zhang Y, Wang N, Liu Q, Wang Z, Liu B and Niu K: Synergistical action of the β2 adrenoceptor and fatty acid binding protein 2 polymorphisms on the loss of glomerular filtration rate in Chinese patients with type 2 diabetic nephropathy. Int Urol Nephrol. 50:715–723. 2018.PubMed/NCBI View Article : Google Scholar

27 

Kalupahana NS and Moustaid-Moussa N: The renin-angiotensin system: A link between obesity, inflammation and insulin resistance. Obes Rev. 13:136–149. 2012.PubMed/NCBI View Article : Google Scholar

28 

Hsiao CF, Sheu WW, Hung YJ, Lin MW, Curb D, Ranadex K, Quertermous T, Chen YM, Chen IY and Wu KD: The effects of the renin-angiotensin-aldosterone system gene polymorphisms on insulin resistance in hypertensive families. J Renin Angiotensin Aldosterone Syst. 13:446–454. 2012.PubMed/NCBI View Article : Google Scholar

29 

Liu N and Wang Y: Association between angiotensinogen T174M polymorphism and the risk of diabetic nephropathy: A meta-analysis. J Renin Angiotensin Aldosterone Syst. 20(1470320318823927)2019.PubMed/NCBI View Article : Google Scholar

30 

Moussa A, Triki S, Hamdouni H, Fekih O, Ajmi M, hajMbarek IB, Koubaa A, Neffati F, Omezzine A, Najjar MF and Bouslama A: Genetic variation in the renin-angiotensin system and diabetic nephropathy in the Tunisian population. Clin Lab. 63:2368–2371. 2017.PubMed/NCBI View Article : Google Scholar

31 

Makuc J, Šeruga M, Završnik M, Cilenšek I and Petrovič D: Angiotensinogen (AGT) gene missense polymorphisms (rs699 and rs4762) and diabetic nephropathy in Caucasians with type 2 diabetes mellitus. Bosn J Basic Med Sci. 17:262–267. 2017.PubMed/NCBI View Article : Google Scholar

32 

Procopciuc LM, Sitar-Tăut A, Pop D, Sitar-Tăut D-A, Olteanu I and Zdrenghea D: Renin angiotensin system polymorphisms in patients with metabolic syndrome (MetS). Eur J Intern Med. 21:414–418. 2010.PubMed/NCBI View Article : Google Scholar

33 

Goulart AC, Rexrode KM, Cheng S, Rose L, Buring JE, Ridker PM and Zee RYL: Association of genetic variants with the metabolic syndrome in 20,806 white women: The women's health genome study. Am Heart J. 158:257–262.e1. 2009.PubMed/NCBI View Article : Google Scholar

34 

Herrera CL, Castillo W, Estrada P, Mancilla B, Reyes G, Saavedra N, Guzmán N, Serón P, Lanas F and Salazar LA: Association of polymorphisms within the Renin-Angiotensin System with metabolic syndrome in a cohort of Chilean subjects. Arch Endocrinol Metab. 60:190–198. 2016.PubMed/NCBI View Article : Google Scholar

35 

Akasaka H, Katsuya T, Saitoh S, Sugimoto K, Fu Y, Takagi S, Ohnishi H, Rakugi H, Ura N, Shimamoto K and Ogihara T: Effects of angiotensin II type 1 receptor gene polymorphisms on insulin resistance in a Japanese general population: The Tanno-Sobetsu study. Hypertens Res. 29:961–967. 2006.PubMed/NCBI View Article : Google Scholar

36 

Wang Y, Zhang J, Ma Y, Song X, Li S, Zhan X and Wu L: Different lipid profiles, insulin sensitivity, and insulin resistance among Han, Uygur, and Kazak men with normal glucose tolerance in Xinjiang, China. Lipids Health Dis. 17(209)2018.PubMed/NCBI View Article : Google Scholar

37 

Mach F, Baigent C, Catapano AL, Koskinas KC, Casula M, Badimon L, Chapman MJ, De Backer GG, Delgado V, Ference B, et al: 2019 ESC/EAS Guidelines for the management of dyslipidaemias: Lipid modification to reduce cardiovascular risk. Eur Heart J. 41:111–188. 2020.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Shakhanova A, Aukenov N, Nurtazina A, Massabayeva M, Babenko D, Adiyeva M and Shaimardonov N: Association of polymorphism genes <em>LPL, ADRB2, AGT</em> and <em>AGTR1</em> with risk of hyperinsulinism and insulin resistance in the Kazakh population. Biomed Rep 13: 35, 2020.
APA
Shakhanova, A., Aukenov, N., Nurtazina, A., Massabayeva, M., Babenko, D., Adiyeva, M., & Shaimardonov, N. (2020). Association of polymorphism genes <em>LPL, ADRB2, AGT</em> and <em>AGTR1</em> with risk of hyperinsulinism and insulin resistance in the Kazakh population. Biomedical Reports, 13, 35. https://doi.org/10.3892/br.2020.1342
MLA
Shakhanova, A., Aukenov, N., Nurtazina, A., Massabayeva, M., Babenko, D., Adiyeva, M., Shaimardonov, N."Association of polymorphism genes <em>LPL, ADRB2, AGT</em> and <em>AGTR1</em> with risk of hyperinsulinism and insulin resistance in the Kazakh population". Biomedical Reports 13.5 (2020): 35.
Chicago
Shakhanova, A., Aukenov, N., Nurtazina, A., Massabayeva, M., Babenko, D., Adiyeva, M., Shaimardonov, N."Association of polymorphism genes <em>LPL, ADRB2, AGT</em> and <em>AGTR1</em> with risk of hyperinsulinism and insulin resistance in the Kazakh population". Biomedical Reports 13, no. 5 (2020): 35. https://doi.org/10.3892/br.2020.1342
Copy and paste a formatted citation
x
Spandidos Publications style
Shakhanova A, Aukenov N, Nurtazina A, Massabayeva M, Babenko D, Adiyeva M and Shaimardonov N: Association of polymorphism genes <em>LPL, ADRB2, AGT</em> and <em>AGTR1</em> with risk of hyperinsulinism and insulin resistance in the Kazakh population. Biomed Rep 13: 35, 2020.
APA
Shakhanova, A., Aukenov, N., Nurtazina, A., Massabayeva, M., Babenko, D., Adiyeva, M., & Shaimardonov, N. (2020). Association of polymorphism genes <em>LPL, ADRB2, AGT</em> and <em>AGTR1</em> with risk of hyperinsulinism and insulin resistance in the Kazakh population. Biomedical Reports, 13, 35. https://doi.org/10.3892/br.2020.1342
MLA
Shakhanova, A., Aukenov, N., Nurtazina, A., Massabayeva, M., Babenko, D., Adiyeva, M., Shaimardonov, N."Association of polymorphism genes <em>LPL, ADRB2, AGT</em> and <em>AGTR1</em> with risk of hyperinsulinism and insulin resistance in the Kazakh population". Biomedical Reports 13.5 (2020): 35.
Chicago
Shakhanova, A., Aukenov, N., Nurtazina, A., Massabayeva, M., Babenko, D., Adiyeva, M., Shaimardonov, N."Association of polymorphism genes <em>LPL, ADRB2, AGT</em> and <em>AGTR1</em> with risk of hyperinsulinism and insulin resistance in the Kazakh population". Biomedical Reports 13, no. 5 (2020): 35. https://doi.org/10.3892/br.2020.1342
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team