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Article

Human NINEIN polymorphism at codon 1111 is associated with the risk of colorectal cancer

  • Authors:
    • Yukiko Yasuda
    • Akiko Sakai
    • Sachio Ito
    • Kaori Sasai
    • Akisada Ishizaki
    • Yoshiya Okano
    • Seito Kawahara
    • Yoshimi Jitsumori
    • Hiromasa Yamamoto
    • Nagahide Matsubara
    • Kenji Shimizu
    • Hiroshi Katayama
  • View Affiliations / Copyright

    Affiliations: Department of Molecular Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700‑8558, Japan, Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700‑8558, Japan, Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700‑8558, Japan
  • Article Number: 45
    |
    Published online on: August 27, 2020
       https://doi.org/10.3892/br.2020.1352
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Abstract

NINEIN serves an essential role in centrosome function as a microtubule organizing center, and in the reformation of the interphase centrosome architecture following mitosis. In the present study, the association between NINEIN Pro1111Ala (rs2236316), a missense single nucleotide polymorphism, and the risk of colorectal cancer (CRC), related to smoking and alcohol consumption habits in 200 patients with CRC and 1,141 cancer‑free control participants were assessed in a case‑control study performed in Japan. The results showed that the NINEIN Ala/Ala genotype compared with the Pro/Pro genotype was significantly more associated with an increased risk of CRC, and the males with the Ala/Ala genotype exhibited a significantly increased risk of CRC compared with those with Pro/Pro and Pro/Ala genotypes. Stratified analyses of the Ala/Ala genotype with CRC risk further showed an increased association in never/light drinkers (<23 g of ethanol/day), in male never/light drinkers and in male patients with rectal cancer. These findings suggest that the genetic variant of the NINEIN Pro1111Ala polymorphism has a significant effect on CRC susceptibility in the Japanese population.
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Copy and paste a formatted citation
Spandidos Publications style
Yasuda Y, Sakai A, Ito S, Sasai K, Ishizaki A, Okano Y, Kawahara S, Jitsumori Y, Yamamoto H, Matsubara N, Matsubara N, et al: Human NINEIN polymorphism at codon 1111 is associated with the risk of colorectal cancer. Biomed Rep 13: 45, 2020.
APA
Yasuda, Y., Sakai, A., Ito, S., Sasai, K., Ishizaki, A., Okano, Y. ... Katayama, H. (2020). Human NINEIN polymorphism at codon 1111 is associated with the risk of colorectal cancer. Biomedical Reports, 13, 45. https://doi.org/10.3892/br.2020.1352
MLA
Yasuda, Y., Sakai, A., Ito, S., Sasai, K., Ishizaki, A., Okano, Y., Kawahara, S., Jitsumori, Y., Yamamoto, H., Matsubara, N., Shimizu, K., Katayama, H."Human NINEIN polymorphism at codon 1111 is associated with the risk of colorectal cancer". Biomedical Reports 13.5 (2020): 45.
Chicago
Yasuda, Y., Sakai, A., Ito, S., Sasai, K., Ishizaki, A., Okano, Y., Kawahara, S., Jitsumori, Y., Yamamoto, H., Matsubara, N., Shimizu, K., Katayama, H."Human NINEIN polymorphism at codon 1111 is associated with the risk of colorectal cancer". Biomedical Reports 13, no. 5 (2020): 45. https://doi.org/10.3892/br.2020.1352
Copy and paste a formatted citation
x
Spandidos Publications style
Yasuda Y, Sakai A, Ito S, Sasai K, Ishizaki A, Okano Y, Kawahara S, Jitsumori Y, Yamamoto H, Matsubara N, Matsubara N, et al: Human NINEIN polymorphism at codon 1111 is associated with the risk of colorectal cancer. Biomed Rep 13: 45, 2020.
APA
Yasuda, Y., Sakai, A., Ito, S., Sasai, K., Ishizaki, A., Okano, Y. ... Katayama, H. (2020). Human NINEIN polymorphism at codon 1111 is associated with the risk of colorectal cancer. Biomedical Reports, 13, 45. https://doi.org/10.3892/br.2020.1352
MLA
Yasuda, Y., Sakai, A., Ito, S., Sasai, K., Ishizaki, A., Okano, Y., Kawahara, S., Jitsumori, Y., Yamamoto, H., Matsubara, N., Shimizu, K., Katayama, H."Human NINEIN polymorphism at codon 1111 is associated with the risk of colorectal cancer". Biomedical Reports 13.5 (2020): 45.
Chicago
Yasuda, Y., Sakai, A., Ito, S., Sasai, K., Ishizaki, A., Okano, Y., Kawahara, S., Jitsumori, Y., Yamamoto, H., Matsubara, N., Shimizu, K., Katayama, H."Human NINEIN polymorphism at codon 1111 is associated with the risk of colorectal cancer". Biomedical Reports 13, no. 5 (2020): 45. https://doi.org/10.3892/br.2020.1352
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