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Article

Role of skeletal macrophages in fracture repair: A systematic review

  • Authors:
    • Zihao Wan
    • Lih-Ying Shin
    • Yu-Fan Wang
    • Zhihao Huang
    • Yanjing Dong
    • Chien-Wei Lee
    • Shekhar-Madhukar Kumta
    • Oscar Kuang‑Sheng Lee
  • View Affiliations / Copyright

    Affiliations: Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Sha Tin, Hong Kong, SAR 999077, P.R. China, Division of General Surgery, Peking University First Hospital, Peking University, Beijing 100000, P.R. China, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou, Guangdong 510005, P.R. China, Institute for Tissue Engineering and Regenerative Medicine, The Chinese University of Hong Kong, Sha Tin, Hong Kong, SAR 999077, P.R. China
  • Article Number: 53
    |
    Published online on: September 29, 2020
       https://doi.org/10.3892/br.2020.1360
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Abstract

In the field of bone research, the importance of the function of skeletal macrophages (sMΦ) and their crucial role in immune homeostasis and bone regeneration has been extensively studied. The aim of the present systematic review was to summarize the role of sMΦ in bone fracture healing and to evaluate their potential for immunoregulatory therapy in bone regeneration. A systematic literature search of PubMed and Embase® was performed to retrieve studies on the role of sMΦ in bone injury repair. The Systematic Review Centre for Laboratory animal Experimentation tool was used to assess the risk of bias of the studies included. A total of four articles were included in the present review. A relatively high risk of bias was identified in the included articles as none of the assessors in these studies were blinded. sMΦ were defined by the surface markers F4/80+, Mac‑2‑/low, TRAP‑, CD169+, Ly6G‑ and CD115low. All of the studies provided support for the essential role of sMΦ in intramembranous ossification or endochondral ossification during fracture healing. F4/80+Mac‑2‑CD169+ sMΦ are a promising therapeutic target for immunoregulatory therapy of bone repair due to their essential role in bone formation and homeostasis. Future studies aimed at profiling and modulating sMΦ to promote bone regeneration are required.
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1 

Chen W, Lv H, Liu S, Liu B, Zhu Y, Chen X, Yang G, Liu L, Zhang T, Wang H, et al: National incidence of traumatic fractures in China: A retrospective survey of 512 187 individuals. Lancet Glob Heal. 5:e807–e817. 2017.PubMed/NCBI View Article : Google Scholar

2 

Schneider E, Goldhahn J and Burckhardt P: The challenge: Fracture treatment in osteoporotic bone. Osteoporos Int. 16:1–2. 2005.PubMed/NCBI View Article : Google Scholar

3 

Holmes D: Non-union bone fracture: A quicker fix. Nature. 550(S193)2017.PubMed/NCBI View Article : Google Scholar

4 

Loi F, Córdova LA, Pajarinen J, Lin TH, Yao Z and Goodman SB: Inflammation, fracture and bone repair. Bone. 86:119–130. 2016.PubMed/NCBI View Article : Google Scholar

5 

Marsell R and Einhorn TA: The biology of fracture healing. Injury. 42:551–555. 2011.PubMed/NCBI View Article : Google Scholar

6 

Ono T and Takayanagi H: Osteoimmunology in bone fracture healing. Curr Osteoporos Rep. 15:367–375. 2017.PubMed/NCBI View Article : Google Scholar

7 

Tsukasaki M and Takayanagi H: Osteoimmunology: Evolving concepts in bone-immune interactions in health and disease. Nat Rev Immunol. 19:626–642. 2019.PubMed/NCBI View Article : Google Scholar

8 

Ono T, Okamoto K, Nakashima T, Nitta T, Hori S, Iwakura Y and Takayanagi H: IL-17-producing γδ T cells enhance bone regeneration. Nat Commun. 7(10928)2016.PubMed/NCBI View Article : Google Scholar

9 

Lorenzo J: Interactions between immune and bone cells: New insights with many remaining questions. J Clin Invest. 106:749–752. 2000.PubMed/NCBI View Article : Google Scholar

10 

Vi L, Baht GS, Whetstone H, Ng A, Wei Q, Poon R, Mylvaganam S, Grynpas M and Alman BA: Macrophages promote osteoblastic differentiation in-vivo: Implications in fracture repair and bone homeostasis. J Bone Min Res. 30:1090–1102. 2015.PubMed/NCBI View Article : Google Scholar

11 

Chang MK, Raggatt LJ, Alexander KA, Kuliwaba JS, Fazzalari NL, Schroder K, Maylin ER, Ripoll VM, Hume DA and Pettit AR: Osteal tissue macrophages are intercalated throughout human and mouse bone lining tissues and regulate osteoblast function in vitro and in vivo. J Immunol. 181:1232–1244. 2008.PubMed/NCBI View Article : Google Scholar

12 

Michalski MN and McCauley LK: Macrophages and skeletal health. Pharmacol Ther. 174:43–54. 2017.PubMed/NCBI View Article : Google Scholar

13 

Epelman S, Lavine KJ and Randolph GJ: Origin and functions of tissue macrophages. Immunity. 41:21–35. 2014.PubMed/NCBI View Article : Google Scholar

14 

Alexander KA, Raggatt LJ, Millard S, Batoon L, Chiu-Ku Wu A, Chang MK, Hume DA and Pettit AR: Resting and injury-induced inflamed periosteum contain multiple macrophage subsets that are located at sites of bone growth and regeneration. Immunol Cell Biol. 95:7–16. 2017.PubMed/NCBI View Article : Google Scholar

15 

Batoon L, Millard SM, Raggatt LJ and Pettit AR: Osteomacs and bone regeneration. Curr Osteoporos Rep. 15:385–395. 2017.PubMed/NCBI View Article : Google Scholar

16 

Batoon L, Millard SM, Wullschleger ME, Preda C, Wu AC, Kaur S, Tseng HW, Hume DA, Levesque JP, Raggatt LJ and Pettit AR: CD169+ macrophages are critical for osteoblast maintenance and promote intramembranous and endochondral ossification during bone repair. Biomaterials. 196:51–66. 2019.PubMed/NCBI View Article : Google Scholar

17 

Alexander KA, Chang MK, Maylin ER, Kohler T, Müller R, Wu AC, Van Rooijen N, Sweet MJ, Hume DA, Raggatt LJ and Pettit AR: Osteal macrophages promote in vivo intramembranous bone healing in a mouse tibial injury model. J Bone Min Res. 26:1517–1532. 2011.PubMed/NCBI View Article : Google Scholar

18 

Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gøtzsche PC, Ioannidis JP, Clarke M, Devereaux PJ, Kleijnen J and Moher D: The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: Explanation and elaboration. J Clin Epidemiol. 62:e1–e34. 2009.PubMed/NCBI View Article : Google Scholar

19 

Hooijmans CR, Rovers MM, De Vries RBM, Leenaars M, Ritskes-Hoitinga M and Langendam MW: SYRCLE's risk of bias tool for animal studies. BMC Med Res Methodol. 14(43)2014.PubMed/NCBI View Article : Google Scholar

20 

Stiuso P, Scognamiglio I, Murolo M, Ferranti P, De Simone C, Rizzo MR, Tuccillo C, Caraglia M, Loguercio C and Federico A: Serum oxidative stress markers and lipidomic profile to detect NASH patients responsive to an antioxidant treatment: A pilot study. Oxid Med Cell Longev. 2014(169216)2014.PubMed/NCBI View Article : Google Scholar

21 

Raggatt LJ, Wullschleger ME, Alexander KA, Wu AC, Millard SM, Kaur S, Maugham ML, Gregory LS, Steck R and Pettit AR: Fracture healing via periosteal callus formation requires macrophages for both initiation and progression of early endochondral ossification. Am J Pathol. 184:3192–3204. 2014.PubMed/NCBI View Article : Google Scholar

22 

Van Rooijen N, Sanders A and Van Den Berg TK: Apoptosis of macrophages induced by liposome-mediated intracellular delivery of clodronate and propamidine. J Immunol Methods. 193:93–99. 1996.PubMed/NCBI View Article : Google Scholar

23 

Arai F, Miyamoto T, Ohneda O, Inada T, Sudo T, Brasel K, Miyata T, Anderson DM and Suda T: Commitment and differentiation of osteoclast precursor cells by the sequential expression of c-Fms and receptor activator of nuclear factor κB (RANK) receptors. J Exp Med. 190:1741–1754. 1999.PubMed/NCBI View Article : Google Scholar

24 

Mise-Omata S, Alles N, Fukazawa T, Aoki K, Ohya K, Jimi E, Obata Y and Doi T: NF-κB RELA-deficient bone marrow macrophages fail to support bone formation and to maintain the hematopoietic niche after lethal irradiation and stem cell transplantation. Int Immunol. 26:607–618. 2014.PubMed/NCBI View Article : Google Scholar

25 

Zhang Y, Xu J, Ruan YC, Yu MK, O'Laughlin M, Wise H, Chen D, Tian L, Shi D, Wang J, et al: Implant-derived magnesium induces local neuronal production of CGRP to improve bone-fracture healing in rats. Nat Med. 22:1160–1169. 2016.PubMed/NCBI View Article : Google Scholar

26 

Wintges K, Beil FT, Albers J, Jeschke A, Schweizer M, Claass B, Tiegs G, Amling M and Schinke T: Impaired bone formation and increased osteoclastogenesis in mice lacking chemokine (C-C motif) ligand 5 (Ccl5). J Bone Miner Res. 28:2070–2080. 2013.PubMed/NCBI View Article : Google Scholar

27 

Schlundt C, El Khassawna T, Serra A, Dienelt A, Wendler S, Schell H, van Rooijen N, Radbruch A, Lucius R, Hartmann S, et al: Macrophages in bone fracture healing: Their essential role in endochondral ossification. Bone. 106:78–89. 2018.PubMed/NCBI View Article : Google Scholar

28 

Debnath S, Yallowitz AR, McCormick J, Lalani S, Zhang T, Xu R, Li N, Liu Y, Yang YS, Eiseman M, et al: Discovery of a periosteal stem cell mediating intramembranous bone formation. Nature. 562:133–139. 2018.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Wan Z, Shin L, Wang Y, Huang Z, Dong Y, Lee C, Kumta S and Lee OK: Role of skeletal macrophages in fracture repair: A systematic review. Biomed Rep 13: 53, 2020.
APA
Wan, Z., Shin, L., Wang, Y., Huang, Z., Dong, Y., Lee, C. ... Lee, O.K. (2020). Role of skeletal macrophages in fracture repair: A systematic review. Biomedical Reports, 13, 53. https://doi.org/10.3892/br.2020.1360
MLA
Wan, Z., Shin, L., Wang, Y., Huang, Z., Dong, Y., Lee, C., Kumta, S., Lee, O. K."Role of skeletal macrophages in fracture repair: A systematic review". Biomedical Reports 13.6 (2020): 53.
Chicago
Wan, Z., Shin, L., Wang, Y., Huang, Z., Dong, Y., Lee, C., Kumta, S., Lee, O. K."Role of skeletal macrophages in fracture repair: A systematic review". Biomedical Reports 13, no. 6 (2020): 53. https://doi.org/10.3892/br.2020.1360
Copy and paste a formatted citation
x
Spandidos Publications style
Wan Z, Shin L, Wang Y, Huang Z, Dong Y, Lee C, Kumta S and Lee OK: Role of skeletal macrophages in fracture repair: A systematic review. Biomed Rep 13: 53, 2020.
APA
Wan, Z., Shin, L., Wang, Y., Huang, Z., Dong, Y., Lee, C. ... Lee, O.K. (2020). Role of skeletal macrophages in fracture repair: A systematic review. Biomedical Reports, 13, 53. https://doi.org/10.3892/br.2020.1360
MLA
Wan, Z., Shin, L., Wang, Y., Huang, Z., Dong, Y., Lee, C., Kumta, S., Lee, O. K."Role of skeletal macrophages in fracture repair: A systematic review". Biomedical Reports 13.6 (2020): 53.
Chicago
Wan, Z., Shin, L., Wang, Y., Huang, Z., Dong, Y., Lee, C., Kumta, S., Lee, O. K."Role of skeletal macrophages in fracture repair: A systematic review". Biomedical Reports 13, no. 6 (2020): 53. https://doi.org/10.3892/br.2020.1360
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