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Article

Association between the ACE‑I/D polymorphism and nicotine dependence amongst patients with lung cancer

  • Authors:
    • Sergej Nadalin
    • Veljko Flego
    • Sanja Dević Pavlić
    • Darian Volarić
    • Anđelka Radojčić Badovinac
    • Miljenko Kapović
    • Smiljana Ristić
  • View Affiliations / Copyright

    Affiliations: Department of Medical Biology and Genetics, Faculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia, Department of Pulmonology, Clinical Hospital Center Rijeka, University of Rijeka, 51000 Rijeka, Croatia
  • Article Number: 58
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    Published online on: October 13, 2020
       https://doi.org/10.3892/br.2020.1365
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Abstract

The biologically active peptide angiotensin II is cleaved from angiotensinogen by the renin and the angiotensin‑converting enzyme (ACE), an enzymatic cascade known as the renin‑angiotensin system (RAS). RAS may be important in the etiology of nicotine dependence by influencing dopaminergic signaling. In the present study, the association between an insertion/deletion (I/D) polymorphism of ACE and nicotine dependence amongst patients with lung cancer was assessed. To date, several studies have shown the relevance of this polymorphic variant in both nicotine dependence and lung cancer. However, the present study is the first to address the potential role of the ACE‑I/D polymorphism in nicotine dependence among patients with lung cancer. Genotyping was performed in 305 patients with lung cancer (males/females, 214/91). Significantly more male smokers had the ACE‑I allele compared with male non‑smokers (44.9 vs. 20.0%; P<0.05). The risk of smoking was ~5‑fold higher for males with the ACE‑I allele (ACE‑II homozygous and ACE‑ID heterozygous) vs. ACE‑DD homozygous (odds ratio, 5.47; 95% confidence interval, 1.4‑21.9; P=0.016). The pack‑year smoking history in a subgroup of females with squamous cell carcinoma carrying the ACE‑I allele was significantly lower compared with ACE‑DD (37.1±14.1 vs. 57.0±29.1; F=4.5; P=0.046). The ACE‑I/D polymorphism accounted for 17.6% of the smoking severity in this patient group (β, ‑0.42; multiple R2 change, 0.176; P=0.046). These results suggest that the ACE‑I/D polymorphism contributes to the risk of nicotine dependence and smoking severity in lung cancer patients in a sex‑specific manner.
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1 

Yokota J, Shiraishi K and Kohno T: Genetic basis for susceptibility to lung cancer: Recent progress and future directions. Adv Cancer Res. 109:51–72. 2010.PubMed/NCBI View Article : Google Scholar

2 

Dela Cruz CS, Tanoue LT and Matthay RA: Lung cancer: Epidemiology, etiology, and prevention. Clin Chest Med. 32:605–644. 2011.PubMed/NCBI View Article : Google Scholar

3 

Pesch B, Kendzia B, Gustavsson P, Jöckel KH, Johnen G, Pohlabeln H, Olsson A, Ahrens W, Gross IM, Brüske I, et al: Cigarette smoking and lung cancer-relative risk estimates for the major histological types from a pooled analysis of case-control studies. Int J Cancer. 131:1210–1219. 2012.PubMed/NCBI View Article : Google Scholar

4 

Carmines EL: Evaluation of the potential effects of ingredients added to cigarettes. Part 1: Cigarette design, testing approach, and review of results. Food Chem Toxicol. 40:77–91. 2002.PubMed/NCBI View Article : Google Scholar

5 

Baker RR, Pereira da Silva JR and Smith G: The effect of tobacco ingredients on smoke chemistry. Part I: Flavourings and additives. Food Chem Toxicol. 42 (Suppl):S3–S37. 2004.PubMed/NCBI View Article : Google Scholar

6 

Greenbaum L and Lerer B: Differential contribution of genetic variation in multiple brain nicotinic cholinergic receptors to nicotine dependence: Recent progress and emerging open questions. Mol Psychiatry. 14:912–945. 2009.PubMed/NCBI View Article : Google Scholar

7 

Lassi G, Taylor AE, Timpson NJ, Kenny PJ, Mather RJ, Eisen T and Munafò MR: The CHRNA5-A3-B4 gene cluster and smoking: From discovery to therapeutics. Trends Neurosci. 39:851–861. 2016.PubMed/NCBI View Article : Google Scholar

8 

Dani JA and Harris RA: Nicotine addiction and comorbidity with alcohol abuse and mental illness. Nat Neurosci. 8:1465–1470. 2005.PubMed/NCBI View Article : Google Scholar

9 

Drew AE, Derbez AE and Werling LL: Nicotinic receptor-mediated regulation of dopamine transporter activity in rat prefrontal cortex. Synapse. 38:10–16. 2000.PubMed/NCBI View Article : Google Scholar

10 

Fowler JS, Logan J, Wang GJ and Volkow ND: Monoamine oxidase and cigarette smoking. Neurotoxicology. 24:75–82. 2003.PubMed/NCBI View Article : Google Scholar

11 

Sagud M, Mihaljević-Peles A, Mück-Seler D, Pivac N, Vuksan-Cusa B, Brataljenović T and Jakovljević M: Smoking and schizophrenia. Psychiatr Danub. 21:371–375. 2009.PubMed/NCBI

12 

D'Souza MS and Markou A: Neuronal mechanisms underlying development of nicotine dependence: Implications for novel smoking-cessation treatments. Addict Sci Clin Pract. 6:4–16. 2011.PubMed/NCBI

13 

Hecht SS: Tobacco carcinogens, their biomarkers and tobacco-induced cancer. Nat Rev Cancer. 3:733–744. 2003.PubMed/NCBI View Article : Google Scholar

14 

Bierut LJ, Madden PA, Breslau N, Johnson EO, Hatsukami D, Pomerleau OF, Swan GE, Rutter J, Bertelsen S, Fox L, et al: Novel genes identified in a high-density genome wide association study for nicotine dependence. Hum Mol Genet. 16:24–35. 2007.PubMed/NCBI View Article : Google Scholar

15 

Saccone SF, Hinrichs AL, Saccone NL, Chase GA, Konvicka K, Madden PA, Breslau N, Johnson EO, Hatsukami D, Pomerleau O, et al: Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs. Hum Mol Genet. 16:36–49. 2007.PubMed/NCBI View Article : Google Scholar

16 

Amos CI, Wu X, Broderick P, Gorlov IP, Gu J, Eisen T, Dong Q, Zhang Q, Gu X, Vijayakrishnan J, et al: Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1. Nat Genet. 40:616–622. 2008.PubMed/NCBI View Article : Google Scholar

17 

Wosik K, Cayrol R, Dodelet-Devillers A, Berthelet F, Bernard M, Moumdjian R, Bouthillier A, Reudelhuber TL and Prat A: Angiotensin II controls occludin function and is required for blood brain barrier maintenance: Relevance to multiple sclerosis. J Neurosci. 27:9032–9042. 2007.PubMed/NCBI View Article : Google Scholar

18 

Nawaz SK and Hasnain S: Pleiotropic effects of ACE polymorphism. Biochem Med. 19:36–49. 2008.

19 

van der Knaap R, Siemes C, Coebergh JW, van Duijn CM, Hofman A and Stricker BH: Renin-angiotensin system inhibitors, angiotensin I-converting enzyme gene insertion/deletion polymorphism, and cancer: The rotterdam study. Cancer. 112:748–757. 2008.PubMed/NCBI View Article : Google Scholar

20 

van Haaster MC, McDonough AA and Gurley SB: Blood pressure regulation by the angiotensin type 1 receptor in the proximal tubule. Curr Opin Nephrol Hypertens. 27:1–7. 2018.PubMed/NCBI View Article : Google Scholar

21 

Jenkins TA, Allen AM, Chai SY, MacGregor DP, Paxinos G and Mendelsohn FA: Interactions of angiotensin II with central dopamine. Adv Exp Med Biol. 396:93–103. 1996.PubMed/NCBI View Article : Google Scholar

22 

Jenkins TA, Mendelsohn FA and Chai SY: Angiotensin-converting enzyme modulates dopamine turnover in the striatum. J Neurochem. 68:1304–1311. 1997.PubMed/NCBI View Article : Google Scholar

23 

Obata T, Takahashi S, Kashiwagi Y and Kubota S: Protective effect of captopril and enalaprilat, angiotensin-converting enzyme inhibitors, on para-nonylphenol-induced *OH generation and dopamine efflux in rat striatum. Toxicology. 250:96–99. 2008.PubMed/NCBI View Article : Google Scholar

24 

Rigat B, Hubert C, Alhenc-Gelas F, Cambien F, Corvol P and Soubrier F: An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J Clin Invest. 86:1343–1346. 1990.PubMed/NCBI View Article : Google Scholar

25 

Hubacek JA, Pitha J, Skodova Z and Poledne R: Angiotensin converting enzyme gene-a candidate gene for addiction to smoking? Atherosclerosis. 159:237–238. 2001.PubMed/NCBI View Article : Google Scholar

26 

Hubacek JA, Adamkova V, Skodova Z, Lanska V and Poledne R: No relation between angiotensin-converting enzyme gene polymorphism and smoking dependence. Scand J Clin Lab Invest. 64:575–578. 2004.PubMed/NCBI View Article : Google Scholar

27 

Baghai TC, Varallo-Bedarida G, Born C, Häfner S, Schule C, Eser D, von Schacky C, Rupprecht R and Bondy B: A polymorphism in the angiotensin-converting enzyme gene is associated with smoking behavior. J Clin Psychiatry. 69:1983–1985. 2008.PubMed/NCBI View Article : Google Scholar

28 

Nadalin S, Buretić-Tomljanović A, Lavtar P, Starčević Čizmarević N, Hodžić A, Sepčić J, Kapović M, Peterlin B and Ristić S: The lack of association between angiotensin-converting enzyme gene insertion/deletion polymorphism and nicotine dependence in multiple sclerosis. Brain Behav. 7(e00600)2016.PubMed/NCBI View Article : Google Scholar

29 

Nadalin S, Ristić S, Rebić J, Šendula Jengić V, Kapović M and Buretić-Tomljanović A: The insertion/deletion polymorphism in the angiotensin-converting enzyme gene and nicotine dependence in schizophrenia patients. J Neural Transm (Vienna). 124:511–518. 2017.PubMed/NCBI View Article : Google Scholar

30 

Cheon KT, Choi KH, Lee HB, Park SK, Rhee YK and Lee YC: Gene polymorphisms of endothelial nitric oxide synthase and angiotensin-converting enzyme in patients with lung cancer. Lung. 178:351–360. 2000.PubMed/NCBI View Article : Google Scholar

31 

Wang HW, Nie ZS, Duan YZ, Liu DD, Han ZH, Zhang XH and Hua B: Association between polymorphism in ACE gene with lung cancer and COPD patients. Bei Jing Yi Xue. 22:364–365. 2000.(In Chinese).

32 

Zhang Q, Liu X, Zhang Z and Wang L: Analysis of the relationship between polymorphism of angiotensin-converting enzyme gene and lung cancer. Zhongguo Fei Ai Za Zhi. 8:211–214. 2005.PubMed/NCBI View Article : Google Scholar : (In Chinese).

33 

Yaren A, Oztop I, Turgut S, Turgut G, Degirmencioglu S and Demirpence M: Angiotensin-converting enzyme gene polymorphism is associated with anemia in non small-cell lung cancer. Exp Biol Med (Maywood). 233:32–37. 2008.PubMed/NCBI View Article : Google Scholar

34 

Nacak M, Nacak I, Sanli M, Ozkur M, Pektaş M and Aynacioğlu AS: Association of angiotensin converting enzyme gene insertion/deletion polymorphism with lung cancer in Turkey. Cancer Genet Cytogenet. 198:22–26. 2010.PubMed/NCBI View Article : Google Scholar

35 

Dević Pavlić S, Ristić S, Flego V, Kapović M and Radojčić Badovinac A: Angiotensin-converting enzyme insertion/deletion gene polymorphism in lung cancer patients. Genet Test Mol Biomarkers. 16:722–725. 2012.PubMed/NCBI View Article : Google Scholar

36 

Peddireddy V, Badabagni SP, Gundimeda SD and Mundluru HP: Association of eNOS and ACE gene polymorphisms and plasma nitric oxide with risk of non-small cell lung cancer in South India. Clin Respir J. 12:207–217. 2018.PubMed/NCBI View Article : Google Scholar

37 

Gao M, Wang Y, Shi Y, Liu D, Liang Y, Yu Y, Zhaobin J, Zhu L and Jin S: The relationship between three well-characterized polymorphisms of the angiotensin converting enzyme gene and lung cancer risk: A case-control study and a meta-analysis. J Renin Angiotensin Aldosterone Syst. 13:455–460. 2012.PubMed/NCBI View Article : Google Scholar

38 

Cheng Z, Ma R, Tan W, Zhang L and Tan Q: Lack of association between ACE insertion/deletion polymorphism and lung cancer: A meta-analysis. J Renin Angiotensin Aldosterone Syst. 16:453–458. 2015.PubMed/NCBI View Article : Google Scholar

39 

Wang N, Yang D, Ji B and Li J: Angiotensin-converting enzyme insertion/deletion gene polymorphism and lung cancer risk: A meta-analysis. J Renin Angiotensin Aldosterone Syst. 16:189–194. 2015.PubMed/NCBI View Article : Google Scholar

40 

Satoh H, Yamashita YT, Ishikawa H, Kamma H, Ohtsuka M and Sekizawa K: Smoking and smoking-related lung cancer in female patients. Anticancer Res. 19:5627–5630. 1999.PubMed/NCBI

41 

Travis WD, Brambilla E, Nicholson AG, Yatabe Y, Austin JHM, Beasley MB, Chirieac LR, Dacic S, Duhig E, Flieder DB, et al: The 2015 world health organization classification of lung tumors: Impact of genetic, clinical and radiologic advances since the 2004 classification. J Thorac Oncol. 10:1243–1260. 2015.PubMed/NCBI View Article : Google Scholar

42 

Detterbeck FC, Boffa DJ, Kim AW and Tanoue LT: The eighth edition lung cancer stage classification. Chest. 151:193–203. 2017.PubMed/NCBI View Article : Google Scholar

43 

de Leon J and Diaz FJ: A meta-analysis of worldwide studies demonstrates an association between schizophrenia and tobacco smoking behaviors. Schizophr Res. 76:135–157. 2005.PubMed/NCBI View Article : Google Scholar

44 

Guo S, Chen DF, Zhou DF, Sun HQ, Wu GY, Haile CN, Kosten TA, Kosten TR and Zhang XY: Association of functional catechol O-methyl transferase (COMT) Val108Met polymorphism with smoking severity and age of smoking initiation in Chinese male smokers. Psychopharmacology (Berl). 190:449–456. 2007.PubMed/NCBI View Article : Google Scholar

45 

Carlson RV, Boyd KM and Webb DJ: The revision of the declaration of Helsinki: Past, present and future. Br J Clin Pharmacol. 57:695–713. 2004.PubMed/NCBI View Article : Google Scholar

46 

Qiagen: FlexiGene DNA Handbook. urihttps://www.qiagen.com/us/resources/resourcedetail?id=6b147421-7846-411e-9993-bb01563b807e&lang=ensimplehttps://www.qiagen.com/us/resources/resourcedetail?id=6b147421-7846-411e-9993-bb01563b807e&lang=en. Accessed March 6, 2020.

47 

Shanmugam V, Sell KW and Saha BK: Mistyping ACE heterozygotes. PCR Methods Appl. 3:120–121. 1993.PubMed/NCBI View Article : Google Scholar

48 

Lovrecić L, Ristić S, Starcević-Cizmarević N, Jazbec SS, Sepcić J, Kapović M and Peterlin B: Angiotensin-converting enzyme I/D gene polymorphism and risk of multiple sclerosis. Acta Neurol Scand. 114:374–377. 2006.PubMed/NCBI View Article : Google Scholar

49 

Sipahi T, Budak M, Şen S, Ay A and Şener S: Association between ACE gene insertion (I)/deletion (D) polymorphism and primary hypertension in Turkish patients of Trakya region. Biotechnol Biotechnol Equip. 20:104–108. 2006.

50 

Nadalin S, Buretić-Tomljanović A, Rubeša G, Jonovska S, Tomljanović D and Ristić S: Angiotensin-converting enzyme gene insertion/deletion polymorphism is not associated with schizophrenia in a Croatian population. Psychiatr Genet. 22:267–268. 2012.PubMed/NCBI View Article : Google Scholar

51 

Avila-Vanzzini N, Posadas-Romero C, Gonzalez-Salazar Mdel C, Maass-Iturbide C, Melendez-Ramirez G, Perez-Mendez O, Del Valle-Mondragon L, Masso-Rojas F, Varela Lopez E, Herrera-Bello H, et al: The ACE I/D polymorphism is associated with nitric oxide metabolite and blood pressure levels in healthy Mexican men. Arch Cardiol Mex. 85:105–110. 2015.PubMed/NCBI View Article : Google Scholar

52 

Nadalin S, Buretić-Tomljanović A, Ristić S, Jonovska S and Tomljanović D: The impact of ACE gene I/D polymorphism on plasma glucose and lipid concentrations in schizophrenia patients. Psychiatry Res. 227:71–72. 2015.PubMed/NCBI View Article : Google Scholar

53 

Röcken C, Neumann K, Carl-McGrath S, Lage H, Ebert MP, Dierkes J, Jacobi CA, Kalmuk S, Neuhaus P and Neumann U: The gene polymorphism of the angiotensin I-converting enzyme correlates with tumor size and patient survival in colorectal cancer patients. Neoplasia. 9:716–722. 2007.PubMed/NCBI View Article : Google Scholar

54 

Turek S, Rudan I, Smolej-Narancić N, Szirovicza L, Cubrilo-Turek M, Zerjavić-Hrabak V, Rak-Kaić A, Vrhovski-Hebrang D, Prebeg Z, Ljubicić M, et al: A large cross-sectional study of health attitudes, knowledge, behaviour and risks in the post-war Croatian population (the first Croatian health project). Coll Antropol. 25:77–96. 2001.PubMed/NCBI

55 

National Center for Biotechnology Information, U.S. National Library of Medicine: rs1799752 [Homo sapiens]. urihttps://www.ncbi.nlm.nih.gov/snp/?term=rs1799752simplehttps://www.ncbi.nlm.nih.gov/snp/?term=rs1799752. Accessed March 6, 2020.

56 

Li MD: Identifying susceptibility loci for nicotine dependence: 2008 update based on recent genome-wide linkage analyses. Hum Genet. 123:119–131. 2008.PubMed/NCBI View Article : Google Scholar

57 

Bierut LJ: Convergence of genetic findings for nicotine dependence and smoking related diseases with chromosome 15q24-25. Trends Pharmacol Sci. 31:46–51. 2010.PubMed/NCBI View Article : Google Scholar

58 

Gallagher PE, Li P, Lenhart JR, Chappell MC and Brosnihan KB: Estrogen regulation of angiotensin-converting enzyme mRNA. Hypertension. 33:323–328. 1999.PubMed/NCBI View Article : Google Scholar

59 

Sanada M, Higashi Y, Nakagawa K, Sasaki S, Kodama I, Tsuda M, Nagai N and Ohama K: Relationship between the angiotensin-converting enzyme genotype and the forearm vasodilator response to estrogen replacement therapy in postmenopausal women. J Am Coll Cardiol. 37:1529–1535. 2001.PubMed/NCBI View Article : Google Scholar

60 

Sumino H, Ichikawa S, Ohyama Y, Nakamura T, Kanda T, Sakamoto H, Sakamaki T, Mizunuma H and Kurabayashi M: Effects of hormone replacement therapy on serum angiotensin-converting enzyme activity and plasma bradykinin in postmenopausal women according to angiotensin-converting enzyme-genotype. Hypertens Res. 26:53–58. 2003.PubMed/NCBI View Article : Google Scholar

61 

Chavez C, Hollaus M, Scarr E, Pavey G, Gogos A and van den Buuse M: The effect of estrogen on dopamine and serotonin receptor and transporter levels in the brain: An autoradiography study. Brain Res. 1321:51–59. 2010.PubMed/NCBI View Article : Google Scholar

62 

Cosgrove KP, Wang S, Kim SJ, McGovern E, Nabulsi N, Gao H, Labaree D, Tagare HD, Sullivan JM and Morris ED: Sex differences in the brain's dopamine signature of cigarette smoking. J Neurosci. 34:16851–16855. 2014.PubMed/NCBI View Article : Google Scholar

63 

Alifano M, Souazé F, Dupouy S, Camilleri-Broët S, Younes M, Ahmed-Zaïd SM, Takahashi T, Cancellieri A, Damiani S, Boaron M, et al: Neurotensin receptor 1 determines the outcome of non-small cell lung cancer. Clin Cancer Res. 16:4401–4410. 2010.PubMed/NCBI View Article : Google Scholar

64 

Muñoz M, González-Ortega A, Rosso M, Robles-Frias MJ, Carranza A, Salinas-Martín MV and Coveñas R: The substance P/neurokinin-1 receptor system in lung cancer: Focus on the antitumor action of neurokinin-1 receptor antagonists. Peptides. 38:318–325. 2012.PubMed/NCBI View Article : Google Scholar

65 

Ljungberg L, Alehagen U, Länne T, Björck H, De Basso R, Dahlström U and Persson K: The association between circulating angiotensin-converting enzyme and cardiovascular risk in the elderly: A cross-sectional study. J Renin Angiotensin Aldosterone Syst. 12:281–289. 2011.PubMed/NCBI View Article : Google Scholar

66 

Laustiola KE, Lassila R and Nurmi AK: Enhanced activation of the renin-angiotensin-aldosterone system in chronic cigarette smokers: A study of monozygotic twin pairs discordant for smoking. Clin Pharmacol Ther. 44:426–430. 1988.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Nadalin S, Flego V, Pavlić SD, Volarić D, Radojčić Badovinac A, Kapović M and Ristić S: Association between the ACE‑I/D polymorphism and nicotine dependence amongst patients with lung cancer. Biomed Rep 13: 58, 2020.
APA
Nadalin, S., Flego, V., Pavlić, S.D., Volarić, D., Radojčić Badovinac, A., Kapović, M., & Ristić, S. (2020). Association between the ACE‑I/D polymorphism and nicotine dependence amongst patients with lung cancer. Biomedical Reports, 13, 58. https://doi.org/10.3892/br.2020.1365
MLA
Nadalin, S., Flego, V., Pavlić, S. D., Volarić, D., Radojčić Badovinac, A., Kapović, M., Ristić, S."Association between the ACE‑I/D polymorphism and nicotine dependence amongst patients with lung cancer". Biomedical Reports 13.6 (2020): 58.
Chicago
Nadalin, S., Flego, V., Pavlić, S. D., Volarić, D., Radojčić Badovinac, A., Kapović, M., Ristić, S."Association between the ACE‑I/D polymorphism and nicotine dependence amongst patients with lung cancer". Biomedical Reports 13, no. 6 (2020): 58. https://doi.org/10.3892/br.2020.1365
Copy and paste a formatted citation
x
Spandidos Publications style
Nadalin S, Flego V, Pavlić SD, Volarić D, Radojčić Badovinac A, Kapović M and Ristić S: Association between the ACE‑I/D polymorphism and nicotine dependence amongst patients with lung cancer. Biomed Rep 13: 58, 2020.
APA
Nadalin, S., Flego, V., Pavlić, S.D., Volarić, D., Radojčić Badovinac, A., Kapović, M., & Ristić, S. (2020). Association between the ACE‑I/D polymorphism and nicotine dependence amongst patients with lung cancer. Biomedical Reports, 13, 58. https://doi.org/10.3892/br.2020.1365
MLA
Nadalin, S., Flego, V., Pavlić, S. D., Volarić, D., Radojčić Badovinac, A., Kapović, M., Ristić, S."Association between the ACE‑I/D polymorphism and nicotine dependence amongst patients with lung cancer". Biomedical Reports 13.6 (2020): 58.
Chicago
Nadalin, S., Flego, V., Pavlić, S. D., Volarić, D., Radojčić Badovinac, A., Kapović, M., Ristić, S."Association between the ACE‑I/D polymorphism and nicotine dependence amongst patients with lung cancer". Biomedical Reports 13, no. 6 (2020): 58. https://doi.org/10.3892/br.2020.1365
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