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Association between the severity of constipation and sarcopenia in elderly adults: A single‑center university hospital‑based, cross‑sectional study

  • Authors:
    • Daisuke Asaoka
    • Tsutomu Takeda
    • Yoshihiro Inami
    • Daiki Abe
    • Yuji Shimada
    • Kenshi Matsumoto
    • Hiroya Ueyama
    • Kohei Matsumoto
    • Hiroyuki Komori
    • Yoichi Akazawa
    • Taro Osada
    • Mariko Hojo
    • Akihito Nagahara
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, Juntendo Tokyo Koto Geriatric Medical Center, Tokyo 136‑0075, Japan, Department of Gastroenterology, University of Juntendo, School of Medicine, Tokyo 113‑8421, Japan
    Copyright: © Asaoka et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 2
    |
    Published online on: October 22, 2020
       https://doi.org/10.3892/br.2020.1378
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Abstract

The aim of the present study was to investigate the association between the severity of constipation and sarcopenia in elderly adults. We conducted a single‑center university hospital‑based, retrospective cross‑sectional study of consecutive outpatients aged ≥65 years from 2017 to 2020. Patients were included in the study if all of the following information were available from medical records: Patient's profile (age, sex, body mass index), laxative/prokinetics use, evaluation of sarcopenia, nutritional status, and questionnaires concerning the severity of constipation [Constipation Scoring System (CSS)], abdominal symptom‑related quality of life (QOL) (Izumo scale) and stool shape [Bristol Stool Form Scale (BSFS)]. Multiple regression analysis of risk factors for high CSS score was performed. The results revealed that of the 310 eligible study subjects, [149 men (48.1%) and 161 women (51.9%); mean age, 75.7±6.1 years; mean body mass index, 23.0±3.6 kg/m2], sarcopenia was noted in 83 cases (26.8%). The CSS score was significantly higher in the sarcopenia group than that noted in the non‑sarcopenia group (4.9±4.9 vs. 3.6±3.6, P=0.009). The CSS score was significantly associated with the albumin level (r=‑0.148), lymphocyte count (r=‑0.118), CONUT score (r=0.130), reflux‑related QOL score (r=0.155), upper abdominal pain‑related QOL score (r=0.171), fullness‑related QOL score (r=0.299), constipation‑related QOL score (r=0.615), diarrhea‑related QOL score (r=0.235) and BSFS score (r=‑0.114). In multiple regression analysis, independent predictors for CSS score were sarcopenia [standardized partial regression coefficient (β)=0.107, P=0.032], constipation‑related QOL score (β=0.537, P<0.001), laxative/prokinetics use (β=0.211, P<0.001) and BSFS score (β=‑0.098, P=0.031) (R2=0.436). In conclusion, sarcopenia, constipation‑related QOL score, laxative/prokinetics use and BSFS score are associated with the severity of constipation in elderly adults.
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Copy and paste a formatted citation
Spandidos Publications style
Asaoka D, Takeda T, Inami Y, Abe D, Shimada Y, Matsumoto K, Ueyama H, Matsumoto K, Komori H, Akazawa Y, Akazawa Y, et al: Association between the severity of constipation and sarcopenia in elderly adults: A single‑center university hospital‑based, cross‑sectional study. Biomed Rep 14: 2, 2021.
APA
Asaoka, D., Takeda, T., Inami, Y., Abe, D., Shimada, Y., Matsumoto, K. ... Nagahara, A. (2021). Association between the severity of constipation and sarcopenia in elderly adults: A single‑center university hospital‑based, cross‑sectional study. Biomedical Reports, 14, 2. https://doi.org/10.3892/br.2020.1378
MLA
Asaoka, D., Takeda, T., Inami, Y., Abe, D., Shimada, Y., Matsumoto, K., Ueyama, H., Matsumoto, K., Komori, H., Akazawa, Y., Osada, T., Hojo, M., Nagahara, A."Association between the severity of constipation and sarcopenia in elderly adults: A single‑center university hospital‑based, cross‑sectional study". Biomedical Reports 14.1 (2021): 2.
Chicago
Asaoka, D., Takeda, T., Inami, Y., Abe, D., Shimada, Y., Matsumoto, K., Ueyama, H., Matsumoto, K., Komori, H., Akazawa, Y., Osada, T., Hojo, M., Nagahara, A."Association between the severity of constipation and sarcopenia in elderly adults: A single‑center university hospital‑based, cross‑sectional study". Biomedical Reports 14, no. 1 (2021): 2. https://doi.org/10.3892/br.2020.1378
Copy and paste a formatted citation
x
Spandidos Publications style
Asaoka D, Takeda T, Inami Y, Abe D, Shimada Y, Matsumoto K, Ueyama H, Matsumoto K, Komori H, Akazawa Y, Akazawa Y, et al: Association between the severity of constipation and sarcopenia in elderly adults: A single‑center university hospital‑based, cross‑sectional study. Biomed Rep 14: 2, 2021.
APA
Asaoka, D., Takeda, T., Inami, Y., Abe, D., Shimada, Y., Matsumoto, K. ... Nagahara, A. (2021). Association between the severity of constipation and sarcopenia in elderly adults: A single‑center university hospital‑based, cross‑sectional study. Biomedical Reports, 14, 2. https://doi.org/10.3892/br.2020.1378
MLA
Asaoka, D., Takeda, T., Inami, Y., Abe, D., Shimada, Y., Matsumoto, K., Ueyama, H., Matsumoto, K., Komori, H., Akazawa, Y., Osada, T., Hojo, M., Nagahara, A."Association between the severity of constipation and sarcopenia in elderly adults: A single‑center university hospital‑based, cross‑sectional study". Biomedical Reports 14.1 (2021): 2.
Chicago
Asaoka, D., Takeda, T., Inami, Y., Abe, D., Shimada, Y., Matsumoto, K., Ueyama, H., Matsumoto, K., Komori, H., Akazawa, Y., Osada, T., Hojo, M., Nagahara, A."Association between the severity of constipation and sarcopenia in elderly adults: A single‑center university hospital‑based, cross‑sectional study". Biomedical Reports 14, no. 1 (2021): 2. https://doi.org/10.3892/br.2020.1378
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