Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Biomedical Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9434 Online ISSN: 2049-9442
Journal Cover
January-2021 Volume 14 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-2021 Volume 14 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

IL‑17 is a potential biomarker for predicting the severity and outcomes of pulmonary contusion in trauma patients

  • Authors:
    • Shilai Li
    • Quanlin Qin
    • Daqing Luo
    • Wenhui Pan
    • Yuqing Wei
    • Yansong Xu
    • Junxuan Wang
    • Xinping Ye
    • Jijin Zhu
    • Liming Shang
  • View Affiliations / Copyright

    Affiliations: Department of Emergency, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P.R. China, Department of Medical Records, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P.R. China, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 5
    |
    Published online on: October 30, 2020
       https://doi.org/10.3892/br.2020.1381
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Pulmonary contusion (PC) is very common in blunt chest trauma, and always results in negative pulmonary outcomes, such as pneumonia, acute respiratory distress syndrome (ARDS), respiratory failure or even death. However, there are no effective biomarkers which can be used to predict the outcomes in these patients. The present study aimed to determine the value of interleukin (IL)‑17 and IL‑22 in predicting the severity and outcomes of PC in trauma patients. All trauma patients admitted to The First Affiliated Hospital of Guangxi Medical University between January 2015 and December 2017, were studied. Patients aged >14 years old with a diagnosis of PC upon their admission to the emergency department were included. Patients with PC were enrolled as the PC group, patients without PC were enrolled as the non‑PC group, and healthy individuals were selected as the control group. Clinical information, including sociodemographic parameters, clinical data, biological findings and therapeutic interventions were recorded for all patients who were enrolled. Blood samples were collected and stored according to the established protocols. PC volume was measured by computed tomography and plasma cytokine levels were assayed by ELISA. A total of 151 patients with PC (PC group) and 159 patients without PC (non‑PC group) were included in the present study. In addition, 50 healthy individuals were used as the control group. The primary cause of PC was motor vehicle crashes. PC patients had more rib fractures, but similar injury severity scores compared with other patients. More patients received Pleurocan drainage treatment and had pneumonia complications in the PC group compared with the other two groups. PC patients had a high incidence of ARDS and admission to the intensive care unit (ICU). PC patients also experienced longer periods on mechanical ventilation and had longer stays in the ICU and hospital. PC volume was effective in predicting the outcomes of PC patients. IL‑22 levels were similar in the PC group and non‑PC group. However, IL‑17 could be used as a biomarker to predict the severity of PC, and was strongly associated with PC volume. IL‑17 was significantly associated with pro‑inflammatory complications in PC patients and could be used as a biomarker for predicting in‑patient outcomes of patients with PC. In conclusion, IL‑17 is a potential biomarker for predicting the severity and outcomes of PC in trauma patients.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Cohn SM and Dubose JJ: Pulmonary contusion: An update on recent advances in clinical management. World J Surg. 34:1959–1970. 2010.PubMed/NCBI View Article : Google Scholar

2 

Ganie FA, Lone H, Lone GN, Wani ML, Singh S, Dar AM, Wani NU, Wani SN and Nazeer NU: Lung contusion: A clinico-pathological entity with unpredictable clinical course. Bull Emerg Trauma. 1:7–16. 2013.PubMed/NCBI

3 

Rodriguez RM, Friedman B, Langdorf MI, Baumann BM, Nishijima DK, Hendey GW, Medak AJ, Raja AS and Mower WR: Pulmonary contusion in the pan-scan era. Injury. 47:1031–1034. 2016.PubMed/NCBI View Article : Google Scholar

4 

Prunet B, Bourenne J, David JS, Bouzat P, Boutonnet M, Cordier PY, Renaudin P, Meaudre E and Michelet P: Patterns of invasive mechanical ventilation in patients with severe blunt chest trauma and lung contusion: A French multicentric evaluation of practices. J Intensive Care Soc. 20:46–52. 2019.PubMed/NCBI View Article : Google Scholar

5 

Valeri M and Raffatellu M: Cytokines IL-17 and IL-22 in the host response to infection. Pathog Dis. 74(ftw111)2016.PubMed/NCBI View Article : Google Scholar

6 

Becker KL, Snider R and Nylen ES: Procalcitonin assay in systemic inflammation, infection, and sepsis: Clinical utility and limitations. Crit Care Med. 36:941–952. 2008.PubMed/NCBI View Article : Google Scholar

7 

Ahmed Ali M, Mikhael ES, Abdelkader A, Mansour L, El Essawy R, El Sayed R, Eladawy A and Mukhtar A: Interleukin-17 as a predictor of sepsis in polytrauma patients: A prospective cohort study. Eur J Trauma Emerg Surg. 44:621–626. 2018.PubMed/NCBI View Article : Google Scholar

8 

Dai H, Xu L, Tang Y, Liu Z and Sun T: Treatment with a neutralising anti-rat interleukin-17 antibody after multiple-trauma reduces lung inflammation. Injury. 46:1465–1470. 2015.PubMed/NCBI View Article : Google Scholar

9 

Mizoguchi A, Yano A, Himuro H, Ezaki Y, Sadanaga T and Mizoguchi E: Clinical importance of IL-22 cascade in IBD. J Gastroenterol. 53:465–474. 2018.PubMed/NCBI View Article : Google Scholar

10 

Mühl H, Scheiermann P, Bachmann M, Härdle L, Heinrichs A and Pfeilschifter J: IL-22 in tissue-protective therapy. Br J Pharmacol. 169:761–771. 2013.PubMed/NCBI View Article : Google Scholar

11 

Alcorn JF: IL-22 plays a critical role in maintaining epithelial integrity during pulmonary infection. Front Immunol. 11(1160)2020.PubMed/NCBI View Article : Google Scholar

12 

Hoegl S, Bachmann M, Scheiermann P, Goren I, Hofstetter C, Pfeilschifter J, Zwissler B and Muhl H: Protective properties of inhaled IL-22 in a model of ventilator-induced lung injury. Am J Respir Cell Mol Biol. 44:369–376. 2011.PubMed/NCBI View Article : Google Scholar

13 

McAleer JP and Kolls JK: Directing traffic: IL-17 and IL-22 coordinate pulmonary immune defense. Immunol Rev. 260:129–144. 2014.PubMed/NCBI View Article : Google Scholar

14 

Rendon JL and Choudhry MA: Th17 cells: Critical mediators of host responses to burn injury and sepsis. J Leukoc Biol. 92:529–538. 2012.PubMed/NCBI View Article : Google Scholar

15 

Li G, Zhang L, Han N, Zhang K and Li H: Increased Th17 and Th22 cell percentages predict acute lung injury in patients with sepsis. Lung. 198:687–693. 2020.PubMed/NCBI View Article : Google Scholar

16 

Baker SP, O'Neill B, Haddon W Jr and Long WB: The injury severity score: A method for describing patients with multiple injuries and evaluating emergency care. J Trauma. 14:187–196. 1974.PubMed/NCBI

17 

Mahmood I, El-Menyar A, Younis B, Ahmed K, Nabir S, Ahmed MN, Al-Yahri O, Mahmood S, Consunji R and Al-Thani H: Clinical significance and prognostic implications of quantifying pulmonary contusion volume in patients with blunt chest trauma. Med Sci Monit. 23:3641–3648. 2017.PubMed/NCBI View Article : Google Scholar

18 

Tufman A, Huber RM, Völk S, Aigner F, Edelmann M, Gamarra F, Kiefl R, Kahnert K, Tian F, Boulesteix AL, et al: Interleukin-22 is elevated in lavage from patients with lung cancer and other pulmonary diseases. BMC Cancer. 16(409)2016.PubMed/NCBI View Article : Google Scholar

19 

Abboud A, Namas RA, Ramadan M, Mi Q, Almahmoud K, Abdul-Malak O, Azhar N, Zaaqoq A, Namas R, Barclay DA, et al: Computational analysis supports an early, type 17 cell-associated divergence of blunt trauma survival and mortality. Crit Care Med. 44:e1074–e1081. 2016.PubMed/NCBI View Article : Google Scholar

20 

Pehlivanlar Küçük M, Küçük AO, Aksoy İ, Aydın D and Ülger F: Prognostic evaluation of cases with thoracic trauma admitted to the intensive care unit: 10-year clinical outcomes. Ulus Travma Acil Cerrahi Derg. 25:46–54. 2019.PubMed/NCBI View Article : Google Scholar

21 

Požgain Z, Kristek D, Lovrić I, Kondža G, Jelavić M, Kocur J and Danilović M: Pulmonary contusions after blunt chest trauma: Clinical significance and evaluation of patient management. Eur J Trauma Emerg Surg. 44:773–777. 2018.PubMed/NCBI View Article : Google Scholar

22 

Miller C, Stolarski A, Ata A, Pfaff A, Nadendla P, Owens K, Evans L, Bonville D, Rosati C, Stain SC and Tafen M: Impact of blunt pulmonary contusion in polytrauma patients with rib fractures. Am J Surg. 218:51–55. 2019.PubMed/NCBI View Article : Google Scholar

23 

Flores-Funes D, Lluna-Llorens AD, Jiménez-Ballester MÁ, Valero-Navarro G, Carrillo-Alcaráz A, Campillo-Soto Á and Aguayo-Albasini JL: Is the number of rib fractures a risk factor for delayed complications? A case-control study. Eur J Trauma Emerg Surg. 46:435–440. 2020.PubMed/NCBI View Article : Google Scholar

24 

Dominguez-Villar M and Hafler DA: Immunology. An innate role for IL-17. Science. 332:47–48. 2011.PubMed/NCBI View Article : Google Scholar

25 

Schwarzenberger P, Huang W, Ye P, Oliver P, Manuel M, Zhang Z, Bagby G, Nelson S and Kolls JK: Requirement of endogenous stem cell factor and granulocyte-colony-stimulating factor for IL-17-mediated granulopoiesis. J Immunol. 164:4783–4789. 2000.PubMed/NCBI View Article : Google Scholar

26 

Frangen TM, Bogdanski D, Schinkel C, Roetman B, Kälicke T, Muhr G and Köller M: Systemic IL-17 after severe injuries. Shock. 29:462–467. 2008.PubMed/NCBI View Article : Google Scholar

27 

Dai H, Sun T, Liu Z, Zhang J and Zhou M: The imbalance between regulatory and IL-17-secreting CD4+ T cells in multiple-trauma rat. Injury. 44:1521–1527. 2013.PubMed/NCBI View Article : Google Scholar

28 

Eyerich K, Dimartino V and Cavani A: IL-17 and IL-22 in immunity: Driving protection and pathology. Eur J Immunol. 47:607–614. 2017.PubMed/NCBI View Article : Google Scholar

29 

Alabbas SY, Begun J, Florin TH and Oancea I: The role of IL-22 in the resolution of sterile and nonsterile inflammation. Clin Transl Immunology. 7(e1017)2018.PubMed/NCBI View Article : Google Scholar

30 

Brockmann L, Giannou AD, Gagliani N and Huber S: Regulation of TH17 cells and associated cytokines in wound healing, tissue regeneration, and carcinogenesis. Int J Mol Sci. 18(1033)2017.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Li S, Qin Q, Luo D, Pan W, Wei Y, Xu Y, Wang J, Ye X, Zhu J, Shang L, Shang L, et al: IL‑17 is a potential biomarker for predicting the severity and outcomes of pulmonary contusion in trauma patients. Biomed Rep 14: 5, 2021.
APA
Li, S., Qin, Q., Luo, D., Pan, W., Wei, Y., Xu, Y. ... Shang, L. (2021). IL‑17 is a potential biomarker for predicting the severity and outcomes of pulmonary contusion in trauma patients. Biomedical Reports, 14, 5. https://doi.org/10.3892/br.2020.1381
MLA
Li, S., Qin, Q., Luo, D., Pan, W., Wei, Y., Xu, Y., Wang, J., Ye, X., Zhu, J., Shang, L."IL‑17 is a potential biomarker for predicting the severity and outcomes of pulmonary contusion in trauma patients". Biomedical Reports 14.1 (2021): 5.
Chicago
Li, S., Qin, Q., Luo, D., Pan, W., Wei, Y., Xu, Y., Wang, J., Ye, X., Zhu, J., Shang, L."IL‑17 is a potential biomarker for predicting the severity and outcomes of pulmonary contusion in trauma patients". Biomedical Reports 14, no. 1 (2021): 5. https://doi.org/10.3892/br.2020.1381
Copy and paste a formatted citation
x
Spandidos Publications style
Li S, Qin Q, Luo D, Pan W, Wei Y, Xu Y, Wang J, Ye X, Zhu J, Shang L, Shang L, et al: IL‑17 is a potential biomarker for predicting the severity and outcomes of pulmonary contusion in trauma patients. Biomed Rep 14: 5, 2021.
APA
Li, S., Qin, Q., Luo, D., Pan, W., Wei, Y., Xu, Y. ... Shang, L. (2021). IL‑17 is a potential biomarker for predicting the severity and outcomes of pulmonary contusion in trauma patients. Biomedical Reports, 14, 5. https://doi.org/10.3892/br.2020.1381
MLA
Li, S., Qin, Q., Luo, D., Pan, W., Wei, Y., Xu, Y., Wang, J., Ye, X., Zhu, J., Shang, L."IL‑17 is a potential biomarker for predicting the severity and outcomes of pulmonary contusion in trauma patients". Biomedical Reports 14.1 (2021): 5.
Chicago
Li, S., Qin, Q., Luo, D., Pan, W., Wei, Y., Xu, Y., Wang, J., Ye, X., Zhu, J., Shang, L."IL‑17 is a potential biomarker for predicting the severity and outcomes of pulmonary contusion in trauma patients". Biomedical Reports 14, no. 1 (2021): 5. https://doi.org/10.3892/br.2020.1381
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team