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Article

Autophagy‑related 16‑like 1 is influenced by human herpes virus 1‑encoded microRNAs in biopsy samples from the lower esophageal sphincter muscle during per‑oral endoscopic myotomy for esophageal achalasia

  • Authors:
    • Tsutomu Kanda
    • Akira Yoshida
    • Yuichiro Ikebuchi
    • Haruo Ikeda
    • Takuki Sakaguchi
    • Shigetoshi Urabe
    • Hitomi Minami
    • Kazuhiko Nakao
    • Haruhiro Inoue
    • Hajime Isomoto
  • View Affiliations / Copyright

    Affiliations: Division of Medicine and Clinical Science, Faculty of Medicine, Tottori University, Yonago, Tottori 683‑8504, Japan, Digestive Center, Showa University Koto‑Toyusu Hospital, Tokyo 135‑8577, Japan, Department of Gastroenterology and Hepatology, Nagasaki University Hospital, Nagasaki 852‑8501, Japan
  • Article Number: 7
    |
    Published online on: October 30, 2020
       https://doi.org/10.3892/br.2020.1383
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Abstract

Esophageal achalasia is characterized by abnormal peristalsis of the esophageal body and impaired relaxation of the lower esophageal sphincter (LES); however, its etiology remains unknown. One of the potential causes of esophageal achalasia is herpes simplex virus type 1 (HSV‑1). Following infection with HSV‑1, a complex interaction between the autoimmune and inflammatory responses is initiated. Viral microRNAs (miRNAs/miRs) serve a crucial role in this interaction. In the present study, the expression of E3 ubiquitin‑protein ligase component n‑recognition 1 (UBR1) and autophagy‑related 16‑like 1 (ATG16L1) was assessed in patients with sporadic and classic achalasia as potential targets of the viral miRNAs. We assessed the mRNA levels of target transcripts using reverse transcription‑quantitative PCR. UBR1 expression was slightly decreased, although the difference was not significant. However, ATG16L1 expression was significantly decreased in the LES. In conclusion, ATG16L1 expression was reduced in the LES of achalasia patients; therefore, ATG16L1 might be a target of HSV1‑miR‑H1, and its reduction could be related to the disease mechanism.
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1 

Ikebuchi Y, Kanda T, Ikeda H, Yoshida A, Sakaguchi T, Urabe S, Minami H, Nakao K, Kuwamoto S, Inoue H and Isomoto H: Identification of human herpes virus 1 encoded microRNAs in biopsy samples of lower esophageal sphincter muscle during peroral endoscopic myotomy for esophageal achalasia. Dig Endosc. 32:136–142. 2020.PubMed/NCBI View Article : Google Scholar

2 

Kahrilas PJ and Boeckxstaens G: The spectrum of achalasia: Lessons from studies of pathophysiology and high-resolution manometry. Gastroenterology. 145:954–965. 2013.PubMed/NCBI View Article : Google Scholar

3 

Minami H, Isomoto H, Miuma S, Kobayashi Y, Yamaguchi N, Urabe S, Matsushima K, Akazawa Y, Ohnita K, Takeshima F, et al: New endoscopic indicator of esophageal achalasia: ‘Pinstripe pattern’. PLoS One. 10(e0101833)2015.PubMed/NCBI View Article : Google Scholar

4 

Ghoshal UC, Daschakraborty SB and Singh R: Pathogenesis of achalasia cardia. World J Gastroenterol. 18:3050–3057. 2012.PubMed/NCBI View Article : Google Scholar

5 

Furuzawa-Carballeda J, Torres-Landa S, Valdovinos MÁ, Coss-Adame E, Martín Del Campo LA and Torres-Villalobos G: New insights into the pathophysiology of Achalasia and implications for future treatment. World J Gastroenterol. 22:7892–7907. 2016.PubMed/NCBI View Article : Google Scholar

6 

Inoue H, Shiwaku H, Iwakiri K, Onimaru M, Kobayashi Y, Minami H, Sato H, Kitano S, Iwakiri R, Omura N, et al: Clinical practice guidelines for peroral endoscopic myotomy. Dig Endosc. 30:563–579. 2018.PubMed/NCBI View Article : Google Scholar

7 

Isomoto H and Ikebuchi Y: Japanese guidelines for peroral endoscopic myotomy: 1st edition. Dig Endosc. 31:27–29. 2019.PubMed/NCBI View Article : Google Scholar

8 

Sato H, Inoue H, Ikeda H, Sato C, Santi E, Phalanusitthepha C, Aoyagi Y and Kudo S: In vivo histopathological assessment of the muscularis propria in achalasia by using endocytoscopy (with video). Endosc Int Open. 2:E178–E182. 2014.PubMed/NCBI View Article : Google Scholar

9 

Nakajima N, Sato H, Takahashi K, Hasegawa G, Mizuno K, Hashimoto S, Sato Y and Terai S: Muscle layer histopathology and manometry pattern of primary esophageal motility disorders including achalasia. Neurogastroenterol Motil. 29(e12968)2017.PubMed/NCBI View Article : Google Scholar

10 

Pressman A and Behar J: Etiology and pathogenesis of idiopathic achalasia. J Clin Gastroenterol. 51:195–202. 2017.PubMed/NCBI View Article : Google Scholar

11 

Furuzawa-Carballeda J, Aguilar-León D, Gamboa-Domínguez A, Valdovinos MA, Nuñez-Álvarez C, Martín-del-Campo LA, Enríquez AB, Coss-Adame E, Svarch AE, Flores-Nájera A, et al: Achalasia-An autoimmune inflammatory disease: A cross-sectional study. J Immunol Res. 2015(729217)2015.PubMed/NCBI View Article : Google Scholar

12 

Piedade D and Azevedo-Pereira JM: The role of microRNAs in the pathogenesis of herpesvirus infection. Viruses. 8(156)2016.PubMed/NCBI View Article : Google Scholar

13 

Brdovčak MC, Zubković A and Jurak I: Herpes simplex virus 1 deregulation of host microRNAs. Noncoding RNA. 4(36)2018.PubMed/NCBI View Article : Google Scholar

14 

Zheng K, Liu Q, Wang S, Ren Z, Kitazato K, Yang D and Wang Y: HSV-1-encoded microRNA miR-H1 targets Ubr1 to promote accumulation of neurodegeneration-associated protein. Virus Genes. 54:343–350. 2018.PubMed/NCBI View Article : Google Scholar

15 

Bernier A and Sagan SM: The diverse roles of microRNAs at the host-virus interface. Viruses. 10(440)2018.PubMed/NCBI View Article : Google Scholar

16 

Lussignol M and Esclatine A: Herpesvirus and autophagy: ‘All right, everybody be cool, this is a robbery!’. Viruses. 9(372)2017.PubMed/NCBI View Article : Google Scholar

17 

Cavignac Y and Esclatine A: Herpesviruses and autophagy: Catch me if you can! Viruses. 2:314–333. 2010.PubMed/NCBI View Article : Google Scholar

18 

Dong X and Levine B: Autophagy and viruses: Adversaries or allies? J Innate Immun. 5:480–493. 2013.PubMed/NCBI View Article : Google Scholar

19 

Harris J, Hartman M, Roche C, Zeng SG, O'Shea A, Sharp FA, Lambe EM, Creagh EM, Golenbock DT, Tschopp J, et al: Autophagy controls IL-1β secretion by targeting Pro-IL-1β for degradation. J Biol Chem. 286:9587–9597. 2011.PubMed/NCBI View Article : Google Scholar

20 

Japan Esophageal Society: Descriptive rules for achalasia of the esophagus, June 2012: 4th edition. Esophagus 14: 275-289, 2017.

21 

McFarlane S, Aitken J, Sutherland JS, Nicholl MJ, Preston VG and Preston CM: Early induction of autophagy in human fibroblasts after infection with human cytomegalovirus or herpes simplex virus 1. J Virol. 85:4212–4221. 2011.PubMed/NCBI View Article : Google Scholar

22 

O'Connell D and Liang C: Autophagy interaction with herpes simplex virus type-1 infection. Autophagy. 12:451–459. 2016.PubMed/NCBI View Article : Google Scholar

23 

Zhang H, Zheng L, McGovern DP, Hamill AM, Ichikawa R, Kanazawa Y, Luu J, Kumagai K, Cilluffo M, Fukata M, et al: Myeloid ATG16L1 facilitates host-bacteria interactions in maintaining intestinal homeostasis. J Immunol. 198:2133–2146. 2017.PubMed/NCBI View Article : Google Scholar

24 

Yakoub AM and Shukla D: Autophagy stimulation abrogates herpes simplex virus-1 infection. Sci Rep. 5(9730)2015.PubMed/NCBI View Article : Google Scholar

25 

Saitoh T, Fujita N, Jang MH, Uematsu S, Yang BG, Satoh T, Omori H, Noda T, Yamamoto N, Komatsu M, et al: Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production. Nature. 456:264–268. 2008.PubMed/NCBI View Article : Google Scholar

26 

Lassen KG, Kuballa P, Conway KL, Patel KK, Becker CE, Peloquin JM, Villablanca EJ, Norman JM, Liu TC, Heath RJ, et al: Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense. Proc Natl Acad Sci USA. 111:7741–7746. 2014.PubMed/NCBI View Article : Google Scholar

27 

Lee J, Kim HR, Quinley C, Kim J, Gonzalez-Navajas J, Xavier R and Raz E: Autophagy suppresses interleukin-1β (IL-1β) signaling by activation of p62 degradation via lysosomal and proteasomal pathways. J Biol Chem. 287:4033–4040. 2012.PubMed/NCBI View Article : Google Scholar

28 

Saitoh T and Akira S: Regulation of inflammasomes by autophagy. J Allergy Clin Immunol. 138:28–36. 2016.PubMed/NCBI View Article : Google Scholar

29 

Choe JY, Jung HY, Park KY and Kim SK: Enhanced p62 expression through impaired proteasomal degradation is involved in caspase-1 activation in monosodium urate crystal-induced interleukin-1β expression. Rheumatology (Oxford). 53:1043–1053. 2014.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Kanda T, Yoshida A, Ikebuchi Y, Ikeda H, Sakaguchi T, Urabe S, Minami H, Nakao K, Inoue H, Isomoto H, Isomoto H, et al: Autophagy‑related 16‑like 1 is influenced by human herpes virus 1‑encoded microRNAs in biopsy samples from the lower esophageal sphincter muscle during per‑oral endoscopic myotomy for esophageal achalasia. Biomed Rep 14: 7, 2021.
APA
Kanda, T., Yoshida, A., Ikebuchi, Y., Ikeda, H., Sakaguchi, T., Urabe, S. ... Isomoto, H. (2021). Autophagy‑related 16‑like 1 is influenced by human herpes virus 1‑encoded microRNAs in biopsy samples from the lower esophageal sphincter muscle during per‑oral endoscopic myotomy for esophageal achalasia. Biomedical Reports, 14, 7. https://doi.org/10.3892/br.2020.1383
MLA
Kanda, T., Yoshida, A., Ikebuchi, Y., Ikeda, H., Sakaguchi, T., Urabe, S., Minami, H., Nakao, K., Inoue, H., Isomoto, H."Autophagy‑related 16‑like 1 is influenced by human herpes virus 1‑encoded microRNAs in biopsy samples from the lower esophageal sphincter muscle during per‑oral endoscopic myotomy for esophageal achalasia". Biomedical Reports 14.1 (2021): 7.
Chicago
Kanda, T., Yoshida, A., Ikebuchi, Y., Ikeda, H., Sakaguchi, T., Urabe, S., Minami, H., Nakao, K., Inoue, H., Isomoto, H."Autophagy‑related 16‑like 1 is influenced by human herpes virus 1‑encoded microRNAs in biopsy samples from the lower esophageal sphincter muscle during per‑oral endoscopic myotomy for esophageal achalasia". Biomedical Reports 14, no. 1 (2021): 7. https://doi.org/10.3892/br.2020.1383
Copy and paste a formatted citation
x
Spandidos Publications style
Kanda T, Yoshida A, Ikebuchi Y, Ikeda H, Sakaguchi T, Urabe S, Minami H, Nakao K, Inoue H, Isomoto H, Isomoto H, et al: Autophagy‑related 16‑like 1 is influenced by human herpes virus 1‑encoded microRNAs in biopsy samples from the lower esophageal sphincter muscle during per‑oral endoscopic myotomy for esophageal achalasia. Biomed Rep 14: 7, 2021.
APA
Kanda, T., Yoshida, A., Ikebuchi, Y., Ikeda, H., Sakaguchi, T., Urabe, S. ... Isomoto, H. (2021). Autophagy‑related 16‑like 1 is influenced by human herpes virus 1‑encoded microRNAs in biopsy samples from the lower esophageal sphincter muscle during per‑oral endoscopic myotomy for esophageal achalasia. Biomedical Reports, 14, 7. https://doi.org/10.3892/br.2020.1383
MLA
Kanda, T., Yoshida, A., Ikebuchi, Y., Ikeda, H., Sakaguchi, T., Urabe, S., Minami, H., Nakao, K., Inoue, H., Isomoto, H."Autophagy‑related 16‑like 1 is influenced by human herpes virus 1‑encoded microRNAs in biopsy samples from the lower esophageal sphincter muscle during per‑oral endoscopic myotomy for esophageal achalasia". Biomedical Reports 14.1 (2021): 7.
Chicago
Kanda, T., Yoshida, A., Ikebuchi, Y., Ikeda, H., Sakaguchi, T., Urabe, S., Minami, H., Nakao, K., Inoue, H., Isomoto, H."Autophagy‑related 16‑like 1 is influenced by human herpes virus 1‑encoded microRNAs in biopsy samples from the lower esophageal sphincter muscle during per‑oral endoscopic myotomy for esophageal achalasia". Biomedical Reports 14, no. 1 (2021): 7. https://doi.org/10.3892/br.2020.1383
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