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Article

Associations of the MTHFR rs1801133 polymorphism with gastric cancer risk in the Chinese Han population

  • Authors:
    • Zhiqiang Han
    • Huaming Sheng
    • Qiuzhi Gao
    • Yu Fan
    • Xiang Xie
  • View Affiliations / Copyright

    Affiliations: Department of Osteology, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212000, P.R. China, Department of Oncology, Jiangyin Hospital, Wuxi, Jiangsu 214400, P.R. China, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, P.R. China, Cancer Institute, Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu 212002, P.R. China, School of International Relations & Public Affairs, Fudan University, Shanghai 200000, P.R. China
  • Article Number: 14
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    Published online on: November 17, 2020
       https://doi.org/10.3892/br.2020.1390
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Abstract

In recent years, increasing evidence has implicated the importance of mutations in the MTHFR gene in the risk of gastric cancer risk. A single nucleotide polymorphism (SNP) in the MTHFR gene (rs1801133) may serve a critical role in gastric cancer. A hospital‑based case‑controlled study was performed to assess the risk of the rs1801133 polymorphism on gastric cancer. A total of 307 patients with gastric cancer and 560 patients in the control group were recruited. Genomic DNA was extracted from peripheral blood and genotyped for rs1801133 using the ligase detection reaction. The relationship between rs1801133 and gastric cancer risk was evaluated by unconditional logistical regression analysis. The rs1801133‑TT genotype was associated with a borderline significantly decreased risk of gastric cancer [(TT vs. CC, adjusted odds ratio (OR)=0.54, 95% confidence intervals (CI)=0.35‑0.83; P=0.006; CT vs. CC, adjusted OR=0.59, 95% CI=0.44‑0.79, P<0.001; and TT/CT vs. CC, adjusted OR=0.61, 95% CI=0.44‑0.83, P=0.001), and further analysis showed the relationship was evident amongst older patients and patients who never drank alcohol. The C>T mutation at rs1801133 of the MTHFR gene was associated with a decreased risk of gastric cancer in older individuals and those who never drink.
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1 

Sun L, Wang Q, Chen B, Zhao Y, Shen B, Wang H, Xu J, Zhu M, Zhao X, Xu C, et al: Gastric cancer mesenchymal stem cells derived IL-8 induces PD-L1 expression in gastric cancer cells via STAT3/mTOR-c-Myc signal axis. Cell Death Dis. 9(928)2018.PubMed/NCBI View Article : Google Scholar

2 

Potrc S, Ivanecz A, Krebs B, Marolt U, Iljevec B and Jagric T: Outcomes of the surgical treatment for adenocarcinoma of the cardia-single institution experience. Radiol Oncol. 52:65–74. 2018.PubMed/NCBI View Article : Google Scholar

3 

Xin J, Wu Y, Wang X, Li S, Chu H, Wang M, Du M and Zhang Z: A transcriptomic study for identifying cardia- and non-cardia-specific gastric cancer prognostic factors using genetic algorithm-based methods. J Cell Mol Med. 24:9457–9465. 2020.PubMed/NCBI View Article : Google Scholar

4 

Nguyen TH, Mallepally N, Hammad T, Liu Y, Thrift AP, El-Serag HB and Tan MC: Prevalence of Helicobacter pylori positive non-cardia gastric adenocarcinoma is low and decreasing in a US population. Dig Dis Sci. 65:2403–2411. 2020.PubMed/NCBI

5 

Zhang X, Bai Z, Chen B, Feng J, Yan F, Jiang Z, Zhong Y, Wu J, Cheng L, Lu Z, et al: Polymorphism of methylenetetrahydrofolate reductase gene is associated with response to fluorouracil-based chemotherapy in Chinese patients with gastric cancer. Chin Med J (Engl). 127:3562–3567. 2014.PubMed/NCBI

6 

Bray F, Ren JS, Masuyer E and Ferlay J: Global estimates of cancer prevalence for 27 sites in the adult population in 2008. Int J Cancer. 132:1133–1145. 2013.PubMed/NCBI View Article : Google Scholar

7 

Wang W, Sun Z, Deng JY, Qi XL, Feng XY, Fang C, Ma XH, Wang ZN, Liang H, Xu HM and Zhou ZW: A novel nomogram individually predicting disease-specific survival after D2 gastrectomy for advanced gastric cancer. Cancer Commun (Lond). 38(23)2018.PubMed/NCBI View Article : Google Scholar

8 

Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J and Jemal A: Global cancer statistics, 2012. CA Cancer J Clin. 65:87–108. 2015.PubMed/NCBI View Article : Google Scholar

9 

Zhang XM, Zhong R, Liu L, Wang Y, Yuan JX, Wang P, Sun C, Zhang Z, Song WG and Miao XP: Smoking and COX-2 functional polymorphisms interact to increase the risk of gastric cardia adenocarcinoma in Chinese population. PLoS One. 6(e21894)2011.PubMed/NCBI View Article : Google Scholar

10 

Selhub J: Homocysteine metabolism. Ann Rev Nutri. 19:217–246. 1999.PubMed/NCBI View Article : Google Scholar

11 

Luo Z, Lu Z, Muhammad I, Chen Y, Chen Q, Zhang J and Song Y: Associations of the MTHFR rs1801133 polymorphism with coronary artery disease and lipid levels: A systematic review and updated meta-analysis. Lipids Health Dis. 17(191)2018.PubMed/NCBI View Article : Google Scholar

12 

Jamshidi M, Mohammadi Pour S and Mahmoudian-Sani MR: Single nucleotide variants associated with colorectal cancer among Iranian patients: A narrative review. Pharmgenomics Pers Med. 13:167–180. 2020.PubMed/NCBI View Article : Google Scholar

13 

Ozen F, Sen M and Ozdemir O: Methylenetetrahydrofolate reductase gene germ-line C677T and A1298C SNPs are associated with colorectal cancer risk in the Turkish population. Asian Pac J Cancer Prev. 15:7731–7735. 2014.PubMed/NCBI View Article : Google Scholar

14 

Zhou X, Shan L, Na J, Li Y and Wang J: The SNP rs4846048 of MTHFR enhances the cervical cancer risk through association with miR-522: A preliminary report. Mol Genet Genomic Med. 8(e1055)2020.PubMed/NCBI View Article : Google Scholar

15 

De Marchi P, Melendez ME, Laus AC, Kuhlmann PA, de Carvalho AC, Arantes LMRB, Evangelista AF, Andrade ES, de Castro G Junior, Reis RM, et al: The role of single-nucleotide polymorphism (SNPs) in toxicity of induction chemotherapy based on cisplatin and paclitaxel in patients with advanced head and neck cancer. Oral Oncol. 98:48–52. 2019.PubMed/NCBI View Article : Google Scholar

16 

Hardi H, Melki R, Boughaleb Z, El Harroudi T, Aissaoui S and Boukhatem N: Significant association between ERCC2 and MTHR polymorphisms and breast cancer susceptibility in Moroccan population: Genotype and haplotype analysis in a case-control study. BMC Cancer. 18(292)2018.PubMed/NCBI View Article : Google Scholar

17 

Xiong Y, Bian C, Lin X, Wang X, Xu K and Zhao X: Methylenetetrahydrofolate reductase gene polymorphisms in the risk of polycystic ovary syndrome and ovarian cancer. Biosci Rep. 40(BSR20200995)2020.PubMed/NCBI View Article : Google Scholar

18 

Floris M, Sanna D, Castiglia P, Putzu C, Sanna V, Pazzola A, De Miglio MR, Sanges F, Pira G, Azara A, et al: MTHFR, XRCC1 and OGG1 genetic polymorphisms in breast cancer: A case-control study in a population from North Sardinia. BMC Cancer. 20(234)2020.PubMed/NCBI View Article : Google Scholar

19 

Le Marchand L, Wilkens LR, Kolonel LN and Henderson BE: The MTHFR C677T polymorphism and colorectal cancer: The multiethnic cohort study. Cancer Epidemiol Biomarkers Prev. 14:1198–1203. 2005.PubMed/NCBI View Article : Google Scholar

20 

Slattery ML, Potter JD, Samowitz W, Schaffer D and Leppert M: Methylenetetrahydrofolate reductase, diet, and risk of colon cancer. Cancer Epidemiol Biomarkers Prev. 8:513–518. 1999.PubMed/NCBI

21 

Tang C, Yu S, Jiang H, Li W, Xu X, Cheng X, Peng K, Chen E, Cui Y and Liu T: A meta-analysis: Methylenetetrahydrofolate reductase C677T polymorphism in gastric cancer patients treated with 5-Fu based chemotherapy predicts serious hematologic toxicity but not prognosis. J Cancer. 9:1057–1066. 2018.PubMed/NCBI View Article : Google Scholar

22 

Zhang S, Lin J, Jiang J, Chen Y, Tang W and Liu L: Association between methylenetetrahydrofolate reductase tagging polymorphisms and susceptibility of hepatocellular carcinoma: A case-control study. Biosci Rep. 39(BSR20192517)2019.PubMed/NCBI View Article : Google Scholar

23 

World Medical Association (WMA): WMA Declaration of Helsinki - Ethical Principles for Medical Research Involving Human Subjects. WMA, Ferney-Voltaire, 2018. urihttp://https://www.wma.net/policies-post/wma-declaration-of-helsinki-ethical-principles-for-medical-research-involving-human-subjects/simplehttps://www.wma.net/policies-post/wma-declaration-of-helsinki-ethical-principles-for-medical-research-involving-human-subjects/. Accessed July 9, 2018.

24 

Rohlfs RV and Weir BS: Distributions of Hardy-Weinberg equilibrium test statistics. Genetics. 180:1609–1616. 2008.PubMed/NCBI View Article : Google Scholar

25 

Hou G, Jin Y, Liu M, Wang C and Song G: UCP2-866G/A polymorphism is associated with prediabetes and type 2 diabetes. Arch Med Res. 51:556–563. 2020.PubMed/NCBI View Article : Google Scholar

26 

Sohn KJ, Croxford R, Yates Z, Lucock M and Kim YI: Effect of the methylenetetrahydrofolate reductase C677T polymorphism on chemosensitivity of colon and breast cancer cells to 5-fluorouracil and methotrexate. J Natl Cancer Inst. 96:134–144. 2004.PubMed/NCBI View Article : Google Scholar

27 

Tang W, Zhang S, Qiu H, Wang L, Sun B, Yin J and Gu H: Genetic variations in MTHFR and esophageal squamous cell carcinoma susceptibility in Chinese Han population. Med Oncol. 31(915)2014.PubMed/NCBI View Article : Google Scholar

28 

Lin J, Zeng RM, Li RN and Cao WH: Aberrant DNA methylation of the P16, MGMT, and hMLH1 genes in combination with the methylenetetrahydrofolate reductase C677T genetic polymorphism and folate intake in gastric cancer. Genet Mol Res. 13:2060–2068. 2014.PubMed/NCBI View Article : Google Scholar

29 

Chen J, Yuan L, Duan YQ, Jiang JQ, Zhang R, Huang ZJ and Xiao XR: Impact of methylenetetrahydrofolate reductase polymorphisms and folate intake on the risk of gastric cancer and their association with Helicobacter pylori infection and tumor site. Genet Mol Res. 13:9718–9726. 2014.PubMed/NCBI View Article : Google Scholar

30 

Li S, Ji M, He N and Lu Z: Application of microarray-based method for methylenetetrahydrofolate reductase (MTHFR) polymorphisms in the risk of gastric carcinoma in east China population. J Nanosci Nanotechnol. 7:3245–3249. 2007.PubMed/NCBI View Article : Google Scholar

31 

Galván-Portillo MV, Oñate-Ocaña LF, Pérez-Pérez GI, Chen J, Herrera-Goepfert R, Chihu-Amparan L, Flores-Luna L, Mohar-Betancourt A and López-Carrillo L: Dietary folate and vitamin B12 intake before diagnosis decreases gastric cancer mortality risk among susceptible MTHFR 677TT carriers. Nutrition. 26:201–208. 2010.PubMed/NCBI View Article : Google Scholar

32 

Lu JW, Gao CM, Wu JZ, Sun XF, Wang L and Feng JF: Relationship of methylenetetrahydrofolate reductase C677T polymorphism and chemosensitivity to 5-fluorouracil in gastric carcinoma. Ai Zheng. 23:958–962. 2004.PubMed/NCBI(In Chinese).

33 

Rozen R: Molecular genetics of methylenetetrahydrofolate reductase deficiency. J Inherit Metab Dis. 19:589–594. 1996.PubMed/NCBI View Article : Google Scholar

34 

Custodio A, Moreno-Rubio J, Aparicio J, Gallego-Plazas J, Yaya R, Maurel J, Rodríguez-Salas N, Burgos E, Ramos D, Calatrava A, et al: Pharmacogenetic predictors of outcome in patients with stage II and III colon cancer treated with oxaliplatin and fluoropyrimidine-based adjuvant chemotherapy. Mol Cancer Ther. 13:2226–2237. 2014.PubMed/NCBI View Article : Google Scholar

35 

Cecchin E, Perrone G, Nobili S, Polesel J, De Mattia E, Zanusso C, Petreni P, Lonardi S, Pella N, D'Andrea M, et al: MTHFR-1298 A>C (rs1801131) is a predictor of survival in two cohorts of stage II/III colorectal cancer patients treated with adjuvant fluoropyrimidine chemotherapy with or without oxaliplatin. Pharmacogenomics J. 15:219–225. 2015.PubMed/NCBI View Article : Google Scholar

36 

De Mattia E and Toffoli G: C677T and A1298C MTHFR polymorphisms, a challenge for antifolate and fluoropyrimidine-based therapy personalisation. Eur J Cancer. 45:1333–1351. 2009.PubMed/NCBI View Article : Google Scholar

37 

Ramos-Esquivel A, Chinchilla R and Valle M: Association of C677T and A1298C MTHFR polymorphisms and fluoropyrimidine-induced toxicity in mestizo patients with metastatic colorectal cancer. Anticancer Res. 40:4263–4270. 2020.PubMed/NCBI View Article : Google Scholar

38 

Chen L, Lu N, Zhang BH, Weng LI and Lu J: Association between the MTHFR C677T polymorphism and gastric cancer susceptibility: A meta-analysis of 5,757 cases and 8,501 controls. Oncol Lett. 10:1159–1165. 2015.PubMed/NCBI View Article : Google Scholar

39 

Zintzaras E: Association of methylenetetrahydrofolate reductase (MTHFR) polymorphisms with genetic susceptibility to gastric cancer: A meta-analysis. J Hum Genet. 51:618–624. 2006.PubMed/NCBI View Article : Google Scholar

40 

Liew SC and Gupta ED: Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism: Epidemiology, metabolism and the associated diseases. Eur J Med Genet. 58:1–10. 2015.PubMed/NCBI View Article : Google Scholar

41 

Beckett EL, Martin C, Choi JH, King K, Niblett S, Boyd L, Duesing K, Yates Z, Veysey M and Lucock M: Folate status, folate-related genes and serum miR-21 expression: Implications for miR-21 as a biomarker. BBA Clin. 4:45–51. 2015.PubMed/NCBI View Article : Google Scholar

42 

He WA, Calore F, Londhe P, Canella A, Guttridge DC and Croce CM: Microvesicles containing miRNAs promote muscle cell death in cancer cachexia via TLR7. Proc Natl Acad Sci USA. 111:4525–4529. 2014.PubMed/NCBI View Article : Google Scholar

43 

Vidmar Golja M, Smid A, Karas Kuzelicki N, Trontelj J, Gersak K and Mlinaric-Rascan I: Folate insufficiency due to MTHFR deficiency is bypassed by 5-methyltetrahydrofolate. J Clin Med. 9:2020.PubMed/NCBI View Article : Google Scholar

44 

Kim YI: Methylenetetrahydrofolate reductase polymorphisms, folate, and cancer risk: A paradigm of gene-nutrient interactions in carcinogenesis. Nutr Rev. 58:205–209. 2000.PubMed/NCBI View Article : Google Scholar

45 

Tan W, Miao X, Wang L, Yu C, Xiong P, Liang G, Sun T, Zhou Y, Zhang X, Li H and Lin D: Significant increase in risk of gastroesophageal cancer is associated with interaction between promoter polymorphisms in thymidylate synthase and serum folate status. Carcinogenesis. 26:1430–1435. 2005.PubMed/NCBI View Article : Google Scholar

46 

Chai W, Zhang Z, Ni M, Geng P, Lian Z, Zhang G, Shi LL and Chen J: Genetic association between methylenetetrahydrofolate reductase gene polymorphism and risk of osteonecrosis of the femoral head. Biomed Res Int. 2015(196495)2015.PubMed/NCBI View Article : Google Scholar

47 

Jain M, Pandey P, Tiwary NK and Jain S: MTHFR C677T polymorphism is associated with hyperlipidemia in women with polycystic ovary syndrome. J Hum Reprod Sci. 5:52–56. 2012.PubMed/NCBI View Article : Google Scholar

48 

Födinger M, Wagner OF, Hörl WH and Sunder-Plassmann G: Recent insights into the molecular genetics of the homocysteine metabolism. Kidney Int Suppl. 78:S238–S242. 2001.PubMed/NCBI View Article : Google Scholar

49 

Kim YI: Role of the MTHFR polymorphisms in cancer risk modification and treatment. Future Oncol. 5:523–542. 2009.PubMed/NCBI View Article : Google Scholar

50 

Bezerra JF, Oliveira GH, Soares CD, Cardoso ML, Ururahy MA, Neto FP, Lima-Neto LG, Luchessi AD, Silbiger VN, Fajardo CM, et al: Genetic and non-genetic factors that increase the risk of non-syndromic cleft lip and/or palate development. Oral Dis. 21:393–399. 2015.PubMed/NCBI View Article : Google Scholar

51 

Ericson UC, Ivarsson MI, Sonestedt E, Gullberg B, Carlson J, Olsson H and Wirfält E: Increased breast cancer risk at high plasma folate concentrations among women with the MTHFR 677T allele. Am J Clin Nutr. 90:1380–1389. 2009.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Han Z, Sheng H, Gao Q, Fan Y and Xie X: Associations of the <em>MTHFR</em> rs1801133 polymorphism with gastric cancer risk in the Chinese Han population. Biomed Rep 14: 14, 2021.
APA
Han, Z., Sheng, H., Gao, Q., Fan, Y., & Xie, X. (2021). Associations of the <em>MTHFR</em> rs1801133 polymorphism with gastric cancer risk in the Chinese Han population. Biomedical Reports, 14, 14. https://doi.org/10.3892/br.2020.1390
MLA
Han, Z., Sheng, H., Gao, Q., Fan, Y., Xie, X."Associations of the <em>MTHFR</em> rs1801133 polymorphism with gastric cancer risk in the Chinese Han population". Biomedical Reports 14.1 (2021): 14.
Chicago
Han, Z., Sheng, H., Gao, Q., Fan, Y., Xie, X."Associations of the <em>MTHFR</em> rs1801133 polymorphism with gastric cancer risk in the Chinese Han population". Biomedical Reports 14, no. 1 (2021): 14. https://doi.org/10.3892/br.2020.1390
Copy and paste a formatted citation
x
Spandidos Publications style
Han Z, Sheng H, Gao Q, Fan Y and Xie X: Associations of the <em>MTHFR</em> rs1801133 polymorphism with gastric cancer risk in the Chinese Han population. Biomed Rep 14: 14, 2021.
APA
Han, Z., Sheng, H., Gao, Q., Fan, Y., & Xie, X. (2021). Associations of the <em>MTHFR</em> rs1801133 polymorphism with gastric cancer risk in the Chinese Han population. Biomedical Reports, 14, 14. https://doi.org/10.3892/br.2020.1390
MLA
Han, Z., Sheng, H., Gao, Q., Fan, Y., Xie, X."Associations of the <em>MTHFR</em> rs1801133 polymorphism with gastric cancer risk in the Chinese Han population". Biomedical Reports 14.1 (2021): 14.
Chicago
Han, Z., Sheng, H., Gao, Q., Fan, Y., Xie, X."Associations of the <em>MTHFR</em> rs1801133 polymorphism with gastric cancer risk in the Chinese Han population". Biomedical Reports 14, no. 1 (2021): 14. https://doi.org/10.3892/br.2020.1390
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