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Association between clinicopathological features of breast cancer with adipocytokine levels and oxidative stress markers before and after chemotherapy

  • Authors:
    • Joanna Grupińska
    • Magdalena Budzyń
    • Jacek J. Brzeziński
    • Bogna Gryszczyńska
    • Magdalena P. Kasprzak
    • Witold Kycler
    • Ewa Leporowska
    • Maria Iskra
  • View Affiliations / Copyright

    Affiliations: Chair and Department of Medical Chemistry and Laboratory Medicine, Poznan University of Medical Sciences, 60‑806 Poznań, Poland, Gastrointestinal Surgical Oncology Department, Greater Poland Cancer Centre, 61‑866 Poznań, Poland, Department of Laboratory Diagnostics, Greater Poland Cancer Centre, 61‑866 Poznań, Poland
    Copyright: © Grupińska et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 30
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    Published online on: January 28, 2021
       https://doi.org/10.3892/br.2021.1406
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Abstract

Adipocytokines and markers of oxidative stress have been shown to exhibit potential for detection of advanced stage, HER2/neu status and lymph node metastases in patients with breast cancer, as well as in determining the efficiency of anti‑cancer treatments. In the present study, blood concentrations of apelin (APLN), retinol‑binding protein 4 (RBP4), 8‑hydroxydeoxyguanosine (8‑oxo‑dG) and total antioxidant capacity (TAC) in women with breast cancer with different clinicopathological features were measured prior to and following adjuvant chemotherapy. The study included 60 women with breast cancer stratified according to tumor grade and size, HER‑2/neu expression, and lymph node and hormone receptor status. Blood samples were taken before and after two cycles of adjuvant chemotherapy. None of the clinicopathological features were associated with the baseline concentrations of RBP4, 8‑oxo‑dG or TAC. An increased baseline concentration of APLN was observed in HER‑2/neu positive patients. Moreover, through multivariate logistical regression analysis, APLN was shown to be independently associated with a positive HER/neu status. Chemotherapy treatment did not affect the levels of RBP4 or APLN, or TAC values when assessing all the patients, and when assessing the stratified groups of patients. Only 8‑oxo‑dG was found to be significantly decreased following drug administration (P=0.0009). This preliminary study demonstrated that APLN is a significant and independent predictor of HER‑2/neu positive breast cancer. A significant reduction in 8‑oxo‑dG levels following chemotherapy may indicate its potential clinical utility in monitoring the effects of chemotherapy in breast cancer patients.
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Copy and paste a formatted citation
Spandidos Publications style
Grupińska J, Budzyń M, Brzeziński JJ, Gryszczyńska B, Kasprzak MP, Kycler W, Leporowska E and Iskra M: Association between clinicopathological features of breast cancer with adipocytokine levels and oxidative stress markers before and after chemotherapy. Biomed Rep 14: 30, 2021.
APA
Grupińska, J., Budzyń, M., Brzeziński, J.J., Gryszczyńska, B., Kasprzak, M.P., Kycler, W. ... Iskra, M. (2021). Association between clinicopathological features of breast cancer with adipocytokine levels and oxidative stress markers before and after chemotherapy. Biomedical Reports, 14, 30. https://doi.org/10.3892/br.2021.1406
MLA
Grupińska, J., Budzyń, M., Brzeziński, J. J., Gryszczyńska, B., Kasprzak, M. P., Kycler, W., Leporowska, E., Iskra, M."Association between clinicopathological features of breast cancer with adipocytokine levels and oxidative stress markers before and after chemotherapy". Biomedical Reports 14.3 (2021): 30.
Chicago
Grupińska, J., Budzyń, M., Brzeziński, J. J., Gryszczyńska, B., Kasprzak, M. P., Kycler, W., Leporowska, E., Iskra, M."Association between clinicopathological features of breast cancer with adipocytokine levels and oxidative stress markers before and after chemotherapy". Biomedical Reports 14, no. 3 (2021): 30. https://doi.org/10.3892/br.2021.1406
Copy and paste a formatted citation
x
Spandidos Publications style
Grupińska J, Budzyń M, Brzeziński JJ, Gryszczyńska B, Kasprzak MP, Kycler W, Leporowska E and Iskra M: Association between clinicopathological features of breast cancer with adipocytokine levels and oxidative stress markers before and after chemotherapy. Biomed Rep 14: 30, 2021.
APA
Grupińska, J., Budzyń, M., Brzeziński, J.J., Gryszczyńska, B., Kasprzak, M.P., Kycler, W. ... Iskra, M. (2021). Association between clinicopathological features of breast cancer with adipocytokine levels and oxidative stress markers before and after chemotherapy. Biomedical Reports, 14, 30. https://doi.org/10.3892/br.2021.1406
MLA
Grupińska, J., Budzyń, M., Brzeziński, J. J., Gryszczyńska, B., Kasprzak, M. P., Kycler, W., Leporowska, E., Iskra, M."Association between clinicopathological features of breast cancer with adipocytokine levels and oxidative stress markers before and after chemotherapy". Biomedical Reports 14.3 (2021): 30.
Chicago
Grupińska, J., Budzyń, M., Brzeziński, J. J., Gryszczyńska, B., Kasprzak, M. P., Kycler, W., Leporowska, E., Iskra, M."Association between clinicopathological features of breast cancer with adipocytokine levels and oxidative stress markers before and after chemotherapy". Biomedical Reports 14, no. 3 (2021): 30. https://doi.org/10.3892/br.2021.1406
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