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Comparison of calculated body muscle mass and SARC‑F as methods of screening for sarcopenia in patients with chronic liver disease

  • Authors:
    • Tatsuki Ichikawa
    • Hisamitsu Miyaaki
    • Satoshi Miuma
    • Yasuhide Motoyoshi
    • Mio Yamashima
    • Shinobu Yamamichi
    • Makiko Koike
    • Yusuke Nakano
    • Tetsurou Honda
    • Hiroyuki Yajima
    • Ryouhei Uehara
    • Osamu Miyazaki
    • Yasutaka Kuribayashi
    • Keiji Kira
    • Naota Taura
    • Kazuhiko Nakao
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, Nagasaki Harbor Medical Center, Nagasaki 850‑8555, Japan, Department of Gastroenterology and Hepatology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852‑8501, Japan, Innovation and Translational Research Center, Nagasaki Harbor Medical Center, Nagasaki 850‑8555, Japan
    Copyright: © Ichikawa et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 34
    |
    Published online on: February 11, 2021
       https://doi.org/10.3892/br.2021.1410
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Abstract

A simple method is required to screen for sarcopenia in patients with chronic liver disease. In the present study, the value of the existing SARC‑F questionnaire as well as calculated body muscle mass (CBMM) approaches were assessed for screening of sarcopenia. A total of 482 patients with chronic liver disease underwent CBMM, grip strength (GS) and SARC‑F score assessments. Cross‑sectional computed tomography images of the third lumbar vertebrae were analyzed to determine the skeletal muscle (SM) mass in 303 patients. Cutoff CBMM values for sarcopenia were <27.903 in females and <39.731 in males. The cutoff SARC‑F score for sarcopenia was ≥4 points. Sarcopenia was diagnosed using the criteria described in the Japan Society of Hepatology. GS was moderately correlated with SARC‑F score (females, R=‑0.578; males, ‑0.453) and CBMM (females, R=0.497; males, 0.548). The SM index was moderately correlated with CBMM for both sexes (females, R=0.546; males, 0.612), but not with SARC‑F score in females (females, R=‑0.132; males, ‑0.246). The area under the curve (AUC) for CBMM against sarcopenia (0.85964) was significantly larger than that for SARC‑F score (0.72013) amongst males (P=0.03577) but not females. The AUCs for a modified SARC‑F questionnaire (encompassing the SARC‑F questionnaire, CBMM, sex and age; mSARC‑F) against sarcopenia were 0.864 in males and 0.78185 in females. As a screening method, SARC‑F is less useful than CBMM. However, the AUC for mSARC‑F is greater than SARC‑F and CBMM.
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Copy and paste a formatted citation
Spandidos Publications style
Ichikawa T, Miyaaki H, Miuma S, Motoyoshi Y, Yamashima M, Yamamichi S, Koike M, Nakano Y, Honda T, Yajima H, Yajima H, et al: Comparison of calculated body muscle mass and SARC‑F as methods of screening for sarcopenia in patients with chronic liver disease. Biomed Rep 14: 34, 2021.
APA
Ichikawa, T., Miyaaki, H., Miuma, S., Motoyoshi, Y., Yamashima, M., Yamamichi, S. ... Nakao, K. (2021). Comparison of calculated body muscle mass and SARC‑F as methods of screening for sarcopenia in patients with chronic liver disease. Biomedical Reports, 14, 34. https://doi.org/10.3892/br.2021.1410
MLA
Ichikawa, T., Miyaaki, H., Miuma, S., Motoyoshi, Y., Yamashima, M., Yamamichi, S., Koike, M., Nakano, Y., Honda, T., Yajima, H., Uehara, R., Miyazaki, O., Kuribayashi, Y., Kira, K., Taura, N., Nakao, K."Comparison of calculated body muscle mass and SARC‑F as methods of screening for sarcopenia in patients with chronic liver disease". Biomedical Reports 14.4 (2021): 34.
Chicago
Ichikawa, T., Miyaaki, H., Miuma, S., Motoyoshi, Y., Yamashima, M., Yamamichi, S., Koike, M., Nakano, Y., Honda, T., Yajima, H., Uehara, R., Miyazaki, O., Kuribayashi, Y., Kira, K., Taura, N., Nakao, K."Comparison of calculated body muscle mass and SARC‑F as methods of screening for sarcopenia in patients with chronic liver disease". Biomedical Reports 14, no. 4 (2021): 34. https://doi.org/10.3892/br.2021.1410
Copy and paste a formatted citation
x
Spandidos Publications style
Ichikawa T, Miyaaki H, Miuma S, Motoyoshi Y, Yamashima M, Yamamichi S, Koike M, Nakano Y, Honda T, Yajima H, Yajima H, et al: Comparison of calculated body muscle mass and SARC‑F as methods of screening for sarcopenia in patients with chronic liver disease. Biomed Rep 14: 34, 2021.
APA
Ichikawa, T., Miyaaki, H., Miuma, S., Motoyoshi, Y., Yamashima, M., Yamamichi, S. ... Nakao, K. (2021). Comparison of calculated body muscle mass and SARC‑F as methods of screening for sarcopenia in patients with chronic liver disease. Biomedical Reports, 14, 34. https://doi.org/10.3892/br.2021.1410
MLA
Ichikawa, T., Miyaaki, H., Miuma, S., Motoyoshi, Y., Yamashima, M., Yamamichi, S., Koike, M., Nakano, Y., Honda, T., Yajima, H., Uehara, R., Miyazaki, O., Kuribayashi, Y., Kira, K., Taura, N., Nakao, K."Comparison of calculated body muscle mass and SARC‑F as methods of screening for sarcopenia in patients with chronic liver disease". Biomedical Reports 14.4 (2021): 34.
Chicago
Ichikawa, T., Miyaaki, H., Miuma, S., Motoyoshi, Y., Yamashima, M., Yamamichi, S., Koike, M., Nakano, Y., Honda, T., Yajima, H., Uehara, R., Miyazaki, O., Kuribayashi, Y., Kira, K., Taura, N., Nakao, K."Comparison of calculated body muscle mass and SARC‑F as methods of screening for sarcopenia in patients with chronic liver disease". Biomedical Reports 14, no. 4 (2021): 34. https://doi.org/10.3892/br.2021.1410
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