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Differences in the reaction of hyperlipidemia on different endothelial progenitor cells based on sex

  • Authors:
    • Xiaoqing Zhuo
    • Haoran Bu
    • Ke Hu
    • Zhihua Si
    • Liming Chen
    • Yong Chen
    • Le Yang
    • Yufan Jiang
    • Yixin Xu
    • Peng Zhao
    • Xiaochun Ma
    • Shufei Tao
    • Qingyi Zhu
    • Lianqun Cui
    • Haihui Sun
    • Yuqi Cui
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250021, P.R. China, Department of Emergency, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250021, P.R. China, Department of Emergency, Qianfoshan Hospital, Shandong First Medical University, Jinan, Shandong 250014, P.R. China, Department of Neurology, Qianfoshan Hospital, Shandong First Medical University, Jinan, Shandong 250014, P.R. China, Department of Cardiovascular Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250021, P.R. China, Ross University School of Medicine, Barbados 60515, Barbados, Department of Cardiovascular Medicine, Second Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China
    Copyright: © Zhuo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 64
    |
    Published online on: June 7, 2021
       https://doi.org/10.3892/br.2021.1440
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Abstract

The sex of a patient can affect the outcomes of several cardiovascular diseases, and men generally tend to experience earlier episodes of cardiovascular diseases compared with women. The progression of atherosclerosis during hyperlipidemia can be induced by reactive oxygen species (ROS) and oxidized‑low‑density lipoprotein (ox‑LDL). By contrast, bone marrow (BM)‑derived endothelial progenitor cells (EPCs) have been reported to serve a protective role against atherosclerosis. The aim of the present was to compare the effects of sex under conditions of hyperlipidemia on different populations of EPCs, and to identify the potential underlying mechanisms. EPC numbers and ROS levels in the blood and BM were measured using fluorescence activated cell sorting in male and female LDL receptor knock‑out C57BL/6 mice maintained on a high‑fat diet for 6 months, and in male and female wild type C57BL/6 mice following ox‑LDL injection for 3 days. Female hyperlipidemic mice exhibited lower levels of plasma lipids, atherosclerotic plaque formation, intracellular EPC ROS formation and inflammatory cytokine levels. Furthermore, BM CD34+/ fetal liver kinase‑1 (Flk‑1+), CD34+/CD133+ and stem cell antigen‑1+/Flk‑1+, as well as all circulating EPCs, were maintained at higher levels in female hyperlipidemic mice. In addition, similar changes with regards to BM CD34+/Flk‑1+, CD34+/CD133+, c‑Kit+/CD31+ and circulating CD34+/Flk1+ and CD34+/CD133+ EPCs were observed in female mice following ox‑LDL treatment. These sustained higher levels of BM and circulating EPCs in female mice with hyperlipidemia may be associated with reduced levels of ox‑LDL as a result of reduced intracellular ROS formation in EPCs and decreased inflammatory cytokine production.
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Spandidos Publications style
Zhuo X, Bu H, Hu K, Si Z, Chen L, Chen Y, Yang L, Jiang Y, Xu Y, Zhao P, Zhao P, et al: Differences in the reaction of hyperlipidemia on different endothelial progenitor cells based on sex. Biomed Rep 15: 64, 2021.
APA
Zhuo, X., Bu, H., Hu, K., Si, Z., Chen, L., Chen, Y. ... Cui, Y. (2021). Differences in the reaction of hyperlipidemia on different endothelial progenitor cells based on sex. Biomedical Reports, 15, 64. https://doi.org/10.3892/br.2021.1440
MLA
Zhuo, X., Bu, H., Hu, K., Si, Z., Chen, L., Chen, Y., Yang, L., Jiang, Y., Xu, Y., Zhao, P., Ma, X., Tao, S., Zhu, Q., Cui, L., Sun, H., Cui, Y."Differences in the reaction of hyperlipidemia on different endothelial progenitor cells based on sex". Biomedical Reports 15.2 (2021): 64.
Chicago
Zhuo, X., Bu, H., Hu, K., Si, Z., Chen, L., Chen, Y., Yang, L., Jiang, Y., Xu, Y., Zhao, P., Ma, X., Tao, S., Zhu, Q., Cui, L., Sun, H., Cui, Y."Differences in the reaction of hyperlipidemia on different endothelial progenitor cells based on sex". Biomedical Reports 15, no. 2 (2021): 64. https://doi.org/10.3892/br.2021.1440
Copy and paste a formatted citation
x
Spandidos Publications style
Zhuo X, Bu H, Hu K, Si Z, Chen L, Chen Y, Yang L, Jiang Y, Xu Y, Zhao P, Zhao P, et al: Differences in the reaction of hyperlipidemia on different endothelial progenitor cells based on sex. Biomed Rep 15: 64, 2021.
APA
Zhuo, X., Bu, H., Hu, K., Si, Z., Chen, L., Chen, Y. ... Cui, Y. (2021). Differences in the reaction of hyperlipidemia on different endothelial progenitor cells based on sex. Biomedical Reports, 15, 64. https://doi.org/10.3892/br.2021.1440
MLA
Zhuo, X., Bu, H., Hu, K., Si, Z., Chen, L., Chen, Y., Yang, L., Jiang, Y., Xu, Y., Zhao, P., Ma, X., Tao, S., Zhu, Q., Cui, L., Sun, H., Cui, Y."Differences in the reaction of hyperlipidemia on different endothelial progenitor cells based on sex". Biomedical Reports 15.2 (2021): 64.
Chicago
Zhuo, X., Bu, H., Hu, K., Si, Z., Chen, L., Chen, Y., Yang, L., Jiang, Y., Xu, Y., Zhao, P., Ma, X., Tao, S., Zhu, Q., Cui, L., Sun, H., Cui, Y."Differences in the reaction of hyperlipidemia on different endothelial progenitor cells based on sex". Biomedical Reports 15, no. 2 (2021): 64. https://doi.org/10.3892/br.2021.1440
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