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Coffea arabica bean extract inhibits glucose transport and disaccharidase activity in Caco‑2 cells

  • Authors:
    • Atcharaporn Ontawong
    • Acharaporn Duangjai
    • Chutima Srimaroeng
  • View Affiliations / Copyright

    Affiliations: Division of Physiology, School of Medical Sciences, University of Phayao, Muang Phayao, Phayao 56000, Thailand, Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Nong Khai 52000, Thailand
    Copyright: © Ontawong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 73
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    Published online on: July 12, 2021
       https://doi.org/10.3892/br.2021.1449
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Abstract

The major constituents of Coffea arabica (coffee), including caffeine, chlorogenic acid and caffeic acid, exhibit antihyperglycemic properties in in vitro and in vivo models. However, whether Coffea arabica bean extract (CBE) regulates glucose uptake activity and the underlying mechanisms involved remain unclear. The aim of the present study was to examine the effects of CBE on glucose absorption and identify the mechanisms involved using an in vitro model. The uptake of a fluorescent glucose analog into Caco‑2 colorectal adenocarcinoma cells was determined. The expression levels of sodium glucose co‑transporter 1 (SGLT1) and glucose transporter 2 (GLUT2) were evaluated. In addition, glycoside hydrolase enzyme activity was investigated. It was observed that CBE inhibited disaccharidase enzyme activity. Furthermore, CBE exerted an inhibitory effect on intestinal glucose absorption by downregulating SGLT1‑ and GLUT2‑mediated 5' AMP‑activated protein kinase phosphorylation and suppressing hepatocyte nuclear factor 1α expression. These data suggest that CBE may attenuate glucose absorption and may have potentially beneficial antihyperglycemic effects in the body; however, the mechanisms underlying the effects of CBE must be elucidated through further investigation.
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1 

Wright EM, Loo DD and Hirayama BA: Biology of human sodium glucose transporters. Physiol Rev. 91:733–794. 2011.PubMed/NCBI View Article : Google Scholar

2 

Wolffram S, Blöck M and Ader P: Quercetin-3-glucoside is transported by the glucose carrier SGLT1 across the brush border membrane of rat small intestine. J Nutr. 132:630–635. 2002.PubMed/NCBI View Article : Google Scholar

3 

Yoshikawa T, Inoue R, Matsumoto M, Yajima T, Ushida K and Iwanaga T: Comparative expression of hexose transporters (SGLT1, GLUT1, GLUT2 and GLUT5) throughout the mouse gastrointestinal tract. Histochem Cell Biol. 135:183–194. 2011.PubMed/NCBI View Article : Google Scholar

4 

Miyamoto K, Hase K, Taketani Y, Minami H, Oka T, Nakabou Y and Hagihira H: Diabetes and glucose transporter gene expression in rat small intestine. Biochem Biophys Res Commun. 181:1110–1117. 1991.PubMed/NCBI View Article : Google Scholar

5 

Ogata H, Seino Y, Harada N, Iida A, Suzuki K, Izumoto T, Ishikawa K, Uenishi E, Ozaki N, Hayashi Y, et al: KATP channel as well as SGLT1 participates in GIP secretion in the diabetic state. J Endocrinol. 222:191–200. 2014.PubMed/NCBI View Article : Google Scholar

6 

Fujita Y, Kojima H, Hidaka H, Fujimiya M, Kashiwagi A and Kikkawa R: Increased intestinal glucose absorption and postprandial hyperglycaemia at the early step of glucose intolerance in Otsuka Long-Evans Tokushima Fatty rats. Diabetologia. 41:1459–1466. 1998.PubMed/NCBI View Article : Google Scholar

7 

Dyer J, Wood IS, Palejwala A, Ellis A and Shirazi-Beechey SP: Expression of monosaccharide transporters in intestine of diabetic humans. Am J Physiol Gastrointest Liver Physiol. 282:G241–G248. 2002.PubMed/NCBI View Article : Google Scholar

8 

Corpe CP, Basaleh MM, Affleck J, Gould G, Jess TJ and Kellett GL: The regulation of GLUT5 and GLUT2 activity in the adaptation of intestinal brush-border fructose transport in diabetes. Pflugers Arch. 432:192–201. 1996.PubMed/NCBI View Article : Google Scholar

9 

Kellett GL and Helliwell PA: The diffusive component of intestinal glucose absorption is mediated by the glucose-induced recruitment of GLUT2 to the brush-border membrane. Biochem J. 350:155–162. 2000.PubMed/NCBI

10 

Dharmananda S: Medicine IfT: Coffee in China and the Analysis of Coffee According to Traditional Chinese Medicine. ITM, Portland, OR, 2003.

11 

Nuhu AA: Bioactive micronutrients in coffee: Recent analytical approaches for characterization and quantification. ISRN Nutr. 2014(384230)2014.PubMed/NCBI View Article : Google Scholar

12 

Miran J: Guest Editor's Introduction: Space, Mobility, and Translocal Connections across the Red Sea Area since 1500. Northeast Afr Stud. 12:ix–xxvi. 2012.

13 

Oliveira AL, Cabral FA, Eberlin MN and Cordello HM: Sensory evaluation of black instant coffee beverage with some volatile compounds present in aromatic oil from roasted coffee. Food Sci Technol (Campinas). 29:76–80. 2009.

14 

Salinardi TC, Rubin KH, Black RM and St-Onge MP: Coffee mannooligosaccharides, consumed as part of a free-living, weight-maintaining diet, increase the proportional reduction in body volume in overweight men. J Nutr. 140:1943–1948. 2010.PubMed/NCBI View Article : Google Scholar

15 

International Organization for Standardization: ISO/IEC 17025: General requirements for the competence of testing and calibration laboratories. International Standard ISO/IEC 17025, pp1-39, 2005.

16 

Verhoeckx K, Cotter P, López-Expósito I, Kleiveland C, Lea T, Mackie A, Requena T, Swiatecka D and Wichers H (eds): Caco-2 Cell Line. In: The Impact of Food Bioactives on Health. Springer, Cham, 2015.

17 

Pan GY, Huang ZJ, Wang GJ, Fawcett JP, Liu XD, Zhao XC, Sun JG and Xie YY: The antihyperglycaemic activity of berberine arises from a decrease of glucose absorption. Planta Med. 69:632–636. 2003.PubMed/NCBI View Article : Google Scholar

18 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

19 

Sopjani M, Bhavsar SK, Fraser S, Kemp BE, Föller M and Lang F: Regulation of Na+-coupled glucose carrier SGLT1 by AMP-activated protein kinase. Mol Membr Biol. 27:137–144. 2010.PubMed/NCBI View Article : Google Scholar

20 

Walker J, Jijon HB, Diaz H, Salehi P, Churchill T and Madsen KL: 5-aminoimidazole-4-carboxamide riboside (AICAR) enhances GLUT2-dependent jejunal glucose transport: A possible role for AMPK. Biochem J. 385:485–491. 2005.PubMed/NCBI View Article : Google Scholar

21 

Debnam ES, Ebrahim HY and Swaine DJ: Diabetes mellitus and sugar transport across the brush-border and basolateral membranes of rat jejunal enterocytes. J Physiol. 424:13–25. 1990.PubMed/NCBI View Article : Google Scholar

22 

Fedorak RN, Cheeseman CI, Thomson AB and Porter VM: Altered glucose carrier expression: Mechanism of intestinal adaptation during streptozocin-induced diabetes in rats. Am J Physiol. 261:G585–G591. 1991.PubMed/NCBI View Article : Google Scholar

23 

Miyamoto K, Takagi T, Fujii T, Matsubara T, Hase K, Taketani Y, Oka T, Minami H and Nakabou Y: Role of liver-type glucose transporter (GLUT2) in transport across the basolateral membrane in rat jejunum. FEBS Lett. 314:466–470. 1992.PubMed/NCBI View Article : Google Scholar

24 

Williamson G: Possible effects of dietary polyphenols on sugar absorption and digestion. Mol Nutr Food Res. 57:48–57. 2013.PubMed/NCBI View Article : Google Scholar

25 

Röder PV, Geillinger KE, Zietek TS, Thorens B, Koepsell H and Daniel H: The role of SGLT1 and GLUT2 in intestinal glucose transport and sensing. PLoS One. 9(e89977)2014.PubMed/NCBI View Article : Google Scholar

26 

Alzaid F, Cheung HM, Preedy VR and Sharp PA: Regulation of glucose transporter expression in human intestinal Caco-2 cells following exposure to an anthocyanin-rich berry extract. PLoS One. 8(e78932)2013.PubMed/NCBI View Article : Google Scholar

27 

Farrell TL, Ellam SL, Forrelli T and Williamson G: Attenuation of glucose transport across Caco-2 cell monolayers by a polyphenol-rich herbal extract: Interactions with SGLT1 and GLUT2 transporters. Biofactors. 39:448–456. 2013.PubMed/NCBI View Article : Google Scholar

28 

Kwon O, Eck P, Chen S, Corpe CP, Lee JH, Kruhlak M and Levine M: Inhibition of the intestinal glucose transporter GLUT2 by flavonoids. FASEB J. 21:366–377. 2007.PubMed/NCBI View Article : Google Scholar

29 

Carling D: The role of the AMP-activated protein kinase in the regulation of energy homeostasis. Novartis Found Symp. 286:72–85, 162-163, 196-203. 2007.PubMed/NCBI View Article : Google Scholar

30 

Horie T, Ono K, Nagao K, Nishi H, Kinoshita M, Kawamura T, Wada H, Shimatsu A, Kita T and Hasegawa K: Oxidative stress induces GLUT4 translocation by activation of PI3-K/Akt and dual AMPK kinase in cardiac myocytes. J Cell Physiol. 215:733–742. 2008.PubMed/NCBI View Article : Google Scholar

31 

Jensen TE, Rose AJ, Hellsten Y, Wojtaszewski JF and Richter EA: Caffeine-induced Ca(2+) release increases AMPK-dependent glucose uptake in rodent soleus muscle. Am J Physiol Endocrinol Metab. 293:E286–E292. 2007.PubMed/NCBI View Article : Google Scholar

32 

Winder WW and Thomson DM: Cellular energy sensing and signaling by AMP-activated protein kinase. Cell Biochem Biophys. 47:332–347. 2007.PubMed/NCBI View Article : Google Scholar

33 

Gabler NK, Radcliffe JS, Spencer JD, Webel DM and Spurlock ME: Feeding long-chain n-3 polyunsaturated fatty acids during gestation increases intestinal glucose absorption potentially via the acute activation of AMPK. J Nutr Biochem. 20:17–25. 2009.PubMed/NCBI View Article : Google Scholar

34 

Tsuda S, Egawa T, Ma X, Oshima R, Kurogi E and Hayashi T: Coffee polyphenol caffeic acid but not chlorogenic acid increases 5'AMP-activated protein kinase and insulin-independent glucose transport in rat skeletal muscle. J Nutr Biochem. 23:1403–1409. 2012.PubMed/NCBI View Article : Google Scholar

35 

Tyszka-Czochara M, Bukowska-Strakova K, Kocemba-Pilarczyk KA and Majka M: Caffeic acid targets AMPK signaling and regulates tricarboxylic acid cycle anaplerosis while metformin downregulates HIF-1α-induced glycolytic enzymes in human cervical squamous cell carcinoma lines. Nutrients. 10(841)2018.PubMed/NCBI View Article : Google Scholar

36 

Balakrishnan A, Stearns AT, Rhoads DB, Ashley SW and Tavakkolizadeh A: Defining the transcriptional regulation of the intestinal sodium-glucose cotransporter using RNA-interference mediated gene silencing. Surgery. 144:168–173. 2008.PubMed/NCBI View Article : Google Scholar

37 

Ban N, Yamada Y, Someya Y, Miyawaki K, Ihara Y, Hosokawa M, Toyokuni S, Tsuda K and Seino Y: Hepatocyte nuclear factor-1alpha recruits the transcriptional co-activator p300 on the GLUT2 gene promoter. Diabetes. 51:1409–1418. 2002.PubMed/NCBI View Article : Google Scholar

38 

Párrizas M, Maestro MA, Boj SF, Paniagua A, Casamitjana R, Gomis R, Rivera F and Ferrer J: Hepatic nuclear factor 1-alpha directs nucleosomal hyperacetylation to its tissue-specific transcriptional targets. Mol Cell Biol. 21:3234–3243. 2001.PubMed/NCBI View Article : Google Scholar

39 

Shih DQ, Screenan S, Munoz KN, Philipson L, Pontoglio M, Yaniv M, Polonsky KS and Stoffel M: Loss of HNF-1alpha function in mice leads to abnormal expression of genes involved in pancreatic islet development and metabolism. Diabetes. 50:2472–2480. 2001.PubMed/NCBI View Article : Google Scholar

40 

Li Q, Wang C, Liu F, Hu T, Shen W, Li E, Liao S and Zou Y: Mulberry leaf polyphenols attenuated postprandial glucose absorption via inhibition of disaccharidases activity and glucose transport in Caco-2 cells. Food Funct. 11:1835–1844. 2020.PubMed/NCBI View Article : Google Scholar

41 

Malunga LN, Eck P and Beta T: Inhibition of intestinal α-glucosidase and glucose absorption by feruloylated arabinoxylan mono- and oligosaccharides from corn bran and wheat aleurone. J Nutr Metab. 2016(1932532)2016.PubMed/NCBI View Article : Google Scholar

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Spandidos Publications style
Ontawong A, Duangjai A and Srimaroeng C: <em>Coffea arabica</em> bean extract inhibits glucose transport and disaccharidase activity in Caco‑2 cells. Biomed Rep 15: 73, 2021.
APA
Ontawong, A., Duangjai, A., & Srimaroeng, C. (2021). <em>Coffea arabica</em> bean extract inhibits glucose transport and disaccharidase activity in Caco‑2 cells. Biomedical Reports, 15, 73. https://doi.org/10.3892/br.2021.1449
MLA
Ontawong, A., Duangjai, A., Srimaroeng, C."<em>Coffea arabica</em> bean extract inhibits glucose transport and disaccharidase activity in Caco‑2 cells". Biomedical Reports 15.3 (2021): 73.
Chicago
Ontawong, A., Duangjai, A., Srimaroeng, C."<em>Coffea arabica</em> bean extract inhibits glucose transport and disaccharidase activity in Caco‑2 cells". Biomedical Reports 15, no. 3 (2021): 73. https://doi.org/10.3892/br.2021.1449
Copy and paste a formatted citation
x
Spandidos Publications style
Ontawong A, Duangjai A and Srimaroeng C: <em>Coffea arabica</em> bean extract inhibits glucose transport and disaccharidase activity in Caco‑2 cells. Biomed Rep 15: 73, 2021.
APA
Ontawong, A., Duangjai, A., & Srimaroeng, C. (2021). <em>Coffea arabica</em> bean extract inhibits glucose transport and disaccharidase activity in Caco‑2 cells. Biomedical Reports, 15, 73. https://doi.org/10.3892/br.2021.1449
MLA
Ontawong, A., Duangjai, A., Srimaroeng, C."<em>Coffea arabica</em> bean extract inhibits glucose transport and disaccharidase activity in Caco‑2 cells". Biomedical Reports 15.3 (2021): 73.
Chicago
Ontawong, A., Duangjai, A., Srimaroeng, C."<em>Coffea arabica</em> bean extract inhibits glucose transport and disaccharidase activity in Caco‑2 cells". Biomedical Reports 15, no. 3 (2021): 73. https://doi.org/10.3892/br.2021.1449
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