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Association between polymorphisms of genes involved in the Renin‑Angiotensin‑Aldosterone System and the adaptive morphological and functional responses to essential hypertension

  • Authors:
    • Oana Mocan
    • Dan Rădulescu
    • Elena Buzdugan
    • Angela Cozma
    • Daniel Corneliu Leucuta
    • Sidonia Alina Bogdan
    • Lucia Maria Procopciuc
  • View Affiliations / Copyright

    Affiliations: Department of Internal Medicine, 5th Medical Clinic, ‘Iuliu Hațieganu’ University of Medicine and Pharmacy, 400012 Cluj‑Napoca, Romania, Department of Internal Medicine, 4th Medical Clinic, ‘Iuliu Hațieganu’ University of Medicine and Pharmacy, 400012 Cluj‑Napoca, Romania, Department of Medical Informatics and Biostatistics, ‘Iuliu Hațieganu’ University of Medicine and Pharmacy, 400349 Cluj‑Napoca, Romania, Department of Surgery, Faculty of Veterinary Medicine, University of Agricultural Science and Veterinary Medicine, 400372 Cluj‑Napoca, Romania, Department of Medical Biochemistry, ‘Iuliu Hațieganu’ University of Medicine and Pharmacy, 400349 Cluj‑Napoca, Romania
    Copyright: © Mocan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 80
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    Published online on: August 4, 2021
       https://doi.org/10.3892/br.2021.1456
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Abstract

Hypertensive cardiac remodeling is illustrated by increased left ventricular (LV) mass index values and/or relative wall thickness (RWT) values >0.42, and functionally by isolated alteration of LV diastole (abnormal relaxation). The aim of the present study was to establish differentiated models of anatomical and functional adaptation to essential hypertension (EHT), in relation to the genetic variants of genes involved in the Renin‑Angiotensin‑Aldosterone System (RAAS). The M235T‑AGT, I/D‑ACE, A1166C‑R1AngII, A3123C‑R2AngII and G83A‑REN genotypes were determined using PCR‑Restriction Fragment Length Polymorphism in 139 hypertensive subjects. The relationship between the studied RAAS gene polymorphisms with morphological and functional cardiac remodeling was assessed by multiple logistic regression analysis. Patients carrying the C/C, A/C genotypes (A3123C‑R2AngII polymorphism) had a 2.72‑fold (P=0.033) increased risk of exhibiting an RWT value <0.42; in the multivariate model the risk was 4.02‑fold higher (P=0.008). Analysis of LV diastolic dysfunction (LVDD) revealed that hypertensive patients carrying the T/T, M/T genotypes (M235T‑AGT polymorphism) had a 2.24‑fold (P=0.037) increased risk of developing LVDD and a 2.42‑fold increased risk (P=0.039) after adjustment for confounders. Similarly, carriers of the G/G, A/G genotypes (G83A‑REN) had a 2.32‑fold (P=0.021) increased risk of developing LVDD, and this remained an independent risk factor based on the multivariate model (P=0.033). The results of the present study showed that no particular gene was associated with increased LV mass, but the A3123C‑R2AngII polymorphism was associated with a non‑concentric type of cardiac response in hypertensive patients. Conversely, the M235T‑AGT and G83A‑REN polymorphisms were found to be statistically significantly associated with LVDD when assessing abnormal relaxation.
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Spandidos Publications style
Mocan O, Rădulescu D, Buzdugan E, Cozma A, Leucuta DC, Bogdan SA and Procopciuc LM: Association between polymorphisms of genes involved in the Renin‑Angiotensin‑Aldosterone System and the adaptive morphological and functional responses to essential hypertension. Biomed Rep 15: 80, 2021.
APA
Mocan, O., Rădulescu, D., Buzdugan, E., Cozma, A., Leucuta, D.C., Bogdan, S.A., & Procopciuc, L.M. (2021). Association between polymorphisms of genes involved in the Renin‑Angiotensin‑Aldosterone System and the adaptive morphological and functional responses to essential hypertension. Biomedical Reports, 15, 80. https://doi.org/10.3892/br.2021.1456
MLA
Mocan, O., Rădulescu, D., Buzdugan, E., Cozma, A., Leucuta, D. C., Bogdan, S. A., Procopciuc, L. M."Association between polymorphisms of genes involved in the Renin‑Angiotensin‑Aldosterone System and the adaptive morphological and functional responses to essential hypertension". Biomedical Reports 15.4 (2021): 80.
Chicago
Mocan, O., Rădulescu, D., Buzdugan, E., Cozma, A., Leucuta, D. C., Bogdan, S. A., Procopciuc, L. M."Association between polymorphisms of genes involved in the Renin‑Angiotensin‑Aldosterone System and the adaptive morphological and functional responses to essential hypertension". Biomedical Reports 15, no. 4 (2021): 80. https://doi.org/10.3892/br.2021.1456
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Spandidos Publications style
Mocan O, Rădulescu D, Buzdugan E, Cozma A, Leucuta DC, Bogdan SA and Procopciuc LM: Association between polymorphisms of genes involved in the Renin‑Angiotensin‑Aldosterone System and the adaptive morphological and functional responses to essential hypertension. Biomed Rep 15: 80, 2021.
APA
Mocan, O., Rădulescu, D., Buzdugan, E., Cozma, A., Leucuta, D.C., Bogdan, S.A., & Procopciuc, L.M. (2021). Association between polymorphisms of genes involved in the Renin‑Angiotensin‑Aldosterone System and the adaptive morphological and functional responses to essential hypertension. Biomedical Reports, 15, 80. https://doi.org/10.3892/br.2021.1456
MLA
Mocan, O., Rădulescu, D., Buzdugan, E., Cozma, A., Leucuta, D. C., Bogdan, S. A., Procopciuc, L. M."Association between polymorphisms of genes involved in the Renin‑Angiotensin‑Aldosterone System and the adaptive morphological and functional responses to essential hypertension". Biomedical Reports 15.4 (2021): 80.
Chicago
Mocan, O., Rădulescu, D., Buzdugan, E., Cozma, A., Leucuta, D. C., Bogdan, S. A., Procopciuc, L. M."Association between polymorphisms of genes involved in the Renin‑Angiotensin‑Aldosterone System and the adaptive morphological and functional responses to essential hypertension". Biomedical Reports 15, no. 4 (2021): 80. https://doi.org/10.3892/br.2021.1456
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