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Variant Philadelphia t(X;9;22)(q22?;q34;q11.2) can be successfully treated with second generation tyrosine kinase inhibitors: A case report and literature review

  • Authors:
    • Ana Iglesias
    • Raluca Oancea
    • Carmen Cotarelo
    • Eduardo Anguita
  • View Affiliations / Copyright

    Affiliations: Clinical Genetics Unit, Clinical Analysis Department, Instituto de Medicina de Laboratorio, IdISSC, Hospital Clínico San Carlos, Madrid 28040, Spain, Hematology Department, Instituto de Medicina de Laboratorio, IdISSC, Hospital Clínico San Carlo, Madrid 28040, Spain
    Copyright: © Iglesias et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 83
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    Published online on: August 9, 2021
       https://doi.org/10.3892/br.2021.1459
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Abstract

Chronic myeloid leukemia (CML) is characterized by the reciprocal translocation between chromosomes 9 and 22: t(9;22)(q34;q11). However, 5‑10% of patients with CML have complex variant translocations involving at least a third chromosome; only a few cases affect the X chromosome. Therefore, the data available regarding their features and the response to treatment is limited. In the present report, a case of a variant Philadelphia translocation t(X;9;22)(q22?;q34;q11.2) identified in a 51‑year‑old female with a newly diagnosed CML is described. The patient was treated with nilotinib. A major molecular response was observed after 12 months of starting treatment. Deep molecular response was obtained 20 months later and maintained after the 110‑month follow‑up. Additionally, a literature review was performed, with the aim of comprehending the complex clinical and biological characteristics of CML cytogenetic variants involving the X chromosome.
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Spandidos Publications style
Iglesias A, Oancea R, Cotarelo C and Anguita E: Variant Philadelphia t(X;9;22)(q22?;q34;q11.2) can be successfully treated with second generation tyrosine kinase inhibitors: A case report and literature review. Biomed Rep 15: 83, 2021.
APA
Iglesias, A., Oancea, R., Cotarelo, C., & Anguita, E. (2021). Variant Philadelphia t(X;9;22)(q22?;q34;q11.2) can be successfully treated with second generation tyrosine kinase inhibitors: A case report and literature review. Biomedical Reports, 15, 83. https://doi.org/10.3892/br.2021.1459
MLA
Iglesias, A., Oancea, R., Cotarelo, C., Anguita, E."Variant Philadelphia t(X;9;22)(q22?;q34;q11.2) can be successfully treated with second generation tyrosine kinase inhibitors: A case report and literature review". Biomedical Reports 15.4 (2021): 83.
Chicago
Iglesias, A., Oancea, R., Cotarelo, C., Anguita, E."Variant Philadelphia t(X;9;22)(q22?;q34;q11.2) can be successfully treated with second generation tyrosine kinase inhibitors: A case report and literature review". Biomedical Reports 15, no. 4 (2021): 83. https://doi.org/10.3892/br.2021.1459
Copy and paste a formatted citation
x
Spandidos Publications style
Iglesias A, Oancea R, Cotarelo C and Anguita E: Variant Philadelphia t(X;9;22)(q22?;q34;q11.2) can be successfully treated with second generation tyrosine kinase inhibitors: A case report and literature review. Biomed Rep 15: 83, 2021.
APA
Iglesias, A., Oancea, R., Cotarelo, C., & Anguita, E. (2021). Variant Philadelphia t(X;9;22)(q22?;q34;q11.2) can be successfully treated with second generation tyrosine kinase inhibitors: A case report and literature review. Biomedical Reports, 15, 83. https://doi.org/10.3892/br.2021.1459
MLA
Iglesias, A., Oancea, R., Cotarelo, C., Anguita, E."Variant Philadelphia t(X;9;22)(q22?;q34;q11.2) can be successfully treated with second generation tyrosine kinase inhibitors: A case report and literature review". Biomedical Reports 15.4 (2021): 83.
Chicago
Iglesias, A., Oancea, R., Cotarelo, C., Anguita, E."Variant Philadelphia t(X;9;22)(q22?;q34;q11.2) can be successfully treated with second generation tyrosine kinase inhibitors: A case report and literature review". Biomedical Reports 15, no. 4 (2021): 83. https://doi.org/10.3892/br.2021.1459
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