Open Access

A comprehensive review of the influence of Epigallocatechin gallate on Sjögren's syndrome associated molecular regulators of exocytosis (Review)

  • Authors:
    • Abdelmounaim Errachid
    • Michal Nohawica
    • Marzena Wyganowska‑Swiatkowska
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  • Published online on: September 21, 2021     https://doi.org/10.3892/br.2021.1471
  • Article Number: 95
  • Copyright: © Errachid et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Sjögren's syndrome (SS) is an autoimmune disorder that affects the salivary glands, leading to reduced secretory functions and oral and ocular dryness. The salivary glands are composed of acinar cells that are responsible for the secretion and production of secretory granules, which contain salivary components, such as amylase, mucins and immunoglobulins. This secretion process involves secretory vesicle trafficking, docking, priming and membrane fusion. A failure during any of the steps in exocytosis in the salivary glands results in the altered secretion of saliva. Soluble N‑ethylmaleimide‑sensitive‑factor attachment protein receptors, actin, tight junctions and aquaporin 5 all serve an important role in the trafficking regulation of secretory vesicles in the secretion of saliva via exocytosis. Alterations in the expression and distribution of these selected proteins leads to salivary gland dysfunction, including SS. Several studies have demonstrated that green tea polyphenols, most notably Epigallocatechin gallate (EGCG), possess both anti‑inflammatory and anti‑apoptotic properties in normal human cells. Molecular, cellular and animal studies have indicated that EGCG can provide protective effects against autoimmune and inflammatory reactions in salivary glands in diseases such as SS. The aim of the present article is to provide a comprehensive and up‑to‑date review on the possible therapeutic interactions between EGCG and the selected molecular mechanisms associated with SS.
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November-2021
Volume 15 Issue 5

Print ISSN: 2049-9434
Online ISSN:2049-9442

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Spandidos Publications style
Errachid A, Nohawica M and Wyganowska‑Swiatkowska M: A comprehensive review of the influence of Epigallocatechin gallate on Sjögren's syndrome associated molecular regulators of exocytosis (Review). Biomed Rep 15: 95, 2021
APA
Errachid, A., Nohawica, M., & Wyganowska‑Swiatkowska, M. (2021). A comprehensive review of the influence of Epigallocatechin gallate on Sjögren's syndrome associated molecular regulators of exocytosis (Review). Biomedical Reports, 15, 95. https://doi.org/10.3892/br.2021.1471
MLA
Errachid, A., Nohawica, M., Wyganowska‑Swiatkowska, M."A comprehensive review of the influence of Epigallocatechin gallate on Sjögren's syndrome associated molecular regulators of exocytosis (Review)". Biomedical Reports 15.5 (2021): 95.
Chicago
Errachid, A., Nohawica, M., Wyganowska‑Swiatkowska, M."A comprehensive review of the influence of Epigallocatechin gallate on Sjögren's syndrome associated molecular regulators of exocytosis (Review)". Biomedical Reports 15, no. 5 (2021): 95. https://doi.org/10.3892/br.2021.1471