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pH‑dependent vs. constant release of mesalazine in the treatment of ulcerative colitis: Do drug delivery concepts determine therapeutic efficacy? (Review)

  • Authors:
    • Helmut Deissler
    • Heinrich Krammer
    • Anton Gillessen
  • View Affiliations / Copyright

    Affiliations: HD/U Scientific Consulting, D‑89075 Ulm, Germany, Gastroenterological Practice, Center for Colon and Rectal Diseases, D‑68165 Mannheim, Germany, Department of Internal Medicine (Gastroenterology), Herz‑Jesu Hospital, D‑48165 Muenster, Germany
    Copyright: © Deissler et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 96
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    Published online on: September 22, 2021
       https://doi.org/10.3892/br.2021.1472
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Abstract

Inflammatory bowel diseases (IBD) have developed to become a major global health problem. Ulcerative colitis (UC) is one of two main types of IBD, and >90% of patients suffering from mild or moderate forms of UC are treated with mesalazine, a well‑tolerated and cost‑effective drug. To allow oral administration, the drug has to be protected from resorption before it can reach the affected sites in the colon. The drug is therefore released from most currently used medications either constantly slow (time‑dependent) or triggered by an increased pH during gastrointestinal transition. Both variants are widely used in clinical practice and it is surprising that they have not yet been compared directly in a large clinical study. In this overview, the evidence that may suggest preferential use of one type of mesalazine formulation over the other in general or for defined subgroups of patients is summarized and evaluated. Data from in vitro modelling of drug release and measurements of drug concentrations in colonic mucosa suggest that in many cases, constant release and pH‑dependent formulations are of similar therapeutic efficiency; however, pH‑triggered release may be superior in patients with proctitis‑type UC or sites of inflammation in the proximal colon. Additionally, patients with a long gastric residence time, slow small intestinal transition, disease‑related diarrhea or sensitivity to systemic adverse effects may benefit more from pH‑dependent release formulations. In general, medications based on both concepts show similar efficacies, but the pH‑dependent release formulations seem to be more robust in the treatment of a not further classified group of patients with UC. Future comparative clinical studies are required to clearly define the subgroups of patients that should be treated preferably with constant or pH‑dependent release formulations of mesalazine.
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1 

Ng SC, Shi HY, Hamidi N, Underwood FE, Tang W, Benchimol EI, Panaccione R, Ghosh S, Wu JC, Chan FK, et al: Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: A systematic review of population-based studies. Lancet. 390:2769–2778. 2017.PubMed/NCBI View Article : Google Scholar

2 

Fumery M, Singh S, Dulai PS, Gower-Rousseau C, Peyrin-Biroulet L and Sandborn WJ: Natural history of adult ulcerative colitis in population-based cohorts: A systematic review. Clin Gastroenterol Hepatol. 16:343–356.e3. 2018.PubMed/NCBI View Article : Google Scholar

3 

Harbord M, Eliakim R, Bettenworth D, Karmiris K, Katsanos K, Kopylov U, Kucharzik T, Molnár T, Raine T, Sebastian S, et al: Third European evidence-based consensus on diagnosis and management of ulcerative colitis. Part 2: Current management. J Crohns Colitis. 11:769–784. 2017.PubMed/NCBI View Article : Google Scholar

4 

Ko CW, Singh S, Feuerstein JD, Falck-Ytter C, Falck-Ytter Y and Cross RK: American Gastroenterological Association Institute Clinical Guidelines Committee. AGA clinical practice guidelines on the management of mild-to-moderate ulcerative colitis. Gastroenterology. 156:748–764. 2019.PubMed/NCBI View Article : Google Scholar

5 

Le Berre C, Roda G, Nedeljkovic Protic M, Danese S and Peyrin-Biroulet L: Modern use of 5-aminosalicylic acid compounds for ulcerative colitis. Expert Opin Biol Ther. 20:363–378. 2020.PubMed/NCBI View Article : Google Scholar

6 

Ma C, Battat R, Dulai PS, Parker CE, Sandborn WJ, Feagan BG and Jairath V: Innovations in oral therapies for inflammatory bowel disease. Drugs. 79:1321–1335. 2019.PubMed/NCBI View Article : Google Scholar

7 

Bonovas S, Nikolopoulos GK, Piovani D, González-Lorenzo M, Pantavou K, Lytras T, Peyrin-Biroulet L and Danese S: Comparative assessment of budesonide-MMX and mesalamine in active, mild-to-moderate ulcerative colitis: A systematic review and network meta-analysis. Br J Clin Pharmacol. 85:2244–2254. 2019.PubMed/NCBI View Article : Google Scholar

8 

Desreumaux P and Ghosh S: Review article: Mode of action and delivery of 5-aminosalicylic acid-new evidence. Aliment Pharmacol Ther. 24 (Suppl 1):S2–S9. 2006.PubMed/NCBI View Article : Google Scholar

9 

Nakase H: Optimizing the use of current treatments and emerging therapeutic approaches to achieve therapeutic success in patients with inflammatory bowel disease. Gut Liver. 14:7–19. 2020.PubMed/NCBI View Article : Google Scholar

10 

Stolfi C, De Simone V, Pallone F and Monteleone G: Mechanisms of action of non-steroidal anti-inflammatory drugs (NSAIDs) and mesalazine in the chemoprevention of colorectal cancer. Int J Mol Sci. 14:17972–17985. 2013.PubMed/NCBI View Article : Google Scholar

11 

Eaden JA, Abrams KR and Mayberry JF: The risk of colorectal cancer in ulcerative colitis: A meta-analysis. Gut. 48:526–535. 2001.PubMed/NCBI View Article : Google Scholar

12 

Eaden J, Abrams K, Ekbom A, Jackson E and Mayberry J: Colorectal cancer prevention in ulcerative colitis: A case-control study. Aliment Pharmacol Ther. 14:145–153. 2000.PubMed/NCBI View Article : Google Scholar

13 

Zhao LN, Li JY, Yu T, Chen GC, Yuan YH and Chen QK: 5-Aminosalicylates reduce the risk of colorectal neoplasia in patients with ulcerative colitis: An updated meta-analysis. PLoS One. 9(e94208)2014.PubMed/NCBI View Article : Google Scholar

14 

van de Meeberg MM, Schultheiss JP, Oldenburg B, Fidder HH and Huitema AD: Does the 5-aminosalicylate concentration correlate with the efficacy of oral 5-aminosalicylate and predict response in patients with inflammatory bowel disease? A systematic review. Digestion. 101:245–261. 2020.PubMed/NCBI View Article : Google Scholar

15 

Nardelli S, Pisani LF, Tontini GE, Vecchi M and Pastorelli L: MMX® technology and its applications in gastrointestinal diseases. Therap Adv Gastroenterol. 10:545–552. 2017.PubMed/NCBI View Article : Google Scholar

16 

Ogata H, Aoyama N, Mizushima S, Hagino A and Hibi T: Comparison of efficacy of multimatrix mesalazine 4.8 g/day once-daily with other high-dose mesalazine in active ulcerative colitis: A randomized, double-blind study. Intest Res. 15:368–379. 2017.PubMed/NCBI View Article : Google Scholar

17 

Wahlgren M, Axenstrand M, Håkansson Å, Marefati A and Lomstein Pedersen B: In vitro methods to study colon release: State of the Art and an outlook on new strategies for better in-vitro biorelevant release media. Pharmaceutics. 11(95)2019.PubMed/NCBI View Article : Google Scholar

18 

Abuhelwa AY, Foster DJR and Upton RN: A quantitative review and meta-models of the variability and factors affecting oral drug absorption-part I: Gastrointestinal pH. AAPS J. 18:1309–1321. 2016.PubMed/NCBI View Article : Google Scholar

19 

Vertzoni M, Sulaiman S, Goumas K, Kersten E, Anlahr J, Muenster U and Reppas C: Characteristics of contents of lower intestine in the 65-74 years of age range could impact the performance of safe and efficacious modified release products. J Pharm Sci. 110:251–258. 2021.PubMed/NCBI View Article : Google Scholar

20 

Vinarov Z, Abdallah M, Agundez JAG, Allegaert K, Basit AW, Braeckmans M, Ceulemans J, Corsetti M, Griffin BT, Grimm M, et al: Impact of gastrointestinal tract variability on oral drug absorption and pharmacokinetics: An UNGAP review. Eur J Pharm Sci. 162(105812)2021.PubMed/NCBI View Article : Google Scholar

21 

Vertzoni M, Augustijns P, Grimm M, Koziolek M, Lemmens G, Parrott N, Pentafragka C, Reppas C, Rubbens J, Van Den Αbeele J, et al: Impact of regional differences along the gastrointestinal tract of healthy adults on oral drug absorption: An UNGAP review. Eur J Pharm Sci. 134:153–175. 2019.PubMed/NCBI View Article : Google Scholar

22 

Nugent SG, Kumar D, Rampton DS and Evans DF: Intestinal luminal pH in inflammatory bowel disease: Possible determinants and implications for therapy with aminosalicylates and other drugs. Gut. 48:571–577. 2001.PubMed/NCBI View Article : Google Scholar

23 

Vertzoni M, Goumas K, Söderlind E, Abrahamsson B, Dressman JB, Poulou A and Reppas C: Characterization of the ascending colon fluids in ulcerative colitis. Pharm Res. 27:1620–1626. 2010.PubMed/NCBI View Article : Google Scholar

24 

Fallingborg J, Christensen LA, Jacobsen BA and Rasmussen SN: Very low intraluminal colonic pH in patients with active ulcerative colitis. Dig Dis Sci. 38:1989–1993. 1993.PubMed/NCBI View Article : Google Scholar

25 

Abuhelwa AY, Foster DJR and Upton RN: A quantitative review and meta-models of the variability and factors affecting oral drug absorption-part II: Gastrointestinal transit time. AAPS J. 18:1322–1333. 2016.PubMed/NCBI View Article : Google Scholar

26 

Andreas CJ, Chen YC, Markopoulos C, Reppas C and Dressman J: In vitro biorelevant models for evaluating modified release mesalamine products to forecast the effect of formulation and meal intake on drug release. Eur J Pharm Biopharm. 97:39–50. 2015.PubMed/NCBI View Article : Google Scholar

27 

Goyanes A, Hatton GB, Merchant HA and Basit AW: Gastrointestinal release behaviour of modified-release drug products: Dynamic dissolution testing of mesalazine formulations. Int J Pharm. 484:103–108. 2015.PubMed/NCBI View Article : Google Scholar

28 

Karkossa F and Klein S: A biopredictive in vitro comparison of oral locally acting mesalazine formulations by a novel dissolution model for assessing intraluminal drug release in individual subjects. J Pharm Sci. 107:1680–1689. 2018.PubMed/NCBI View Article : Google Scholar

29 

Leifeld L, Pfützer R, Morgenstern J, Gibson PR, Marakhouski Y, Greinwald R, Mueller R and Kruis W: Mesalazine granules are superior to Eudragit-L-coated mesalazine tablets for induction of remission in distal ulcerative colitis-a pooled analysis. Aliment Pharmacol Ther. 34:1115–1122. 2011.PubMed/NCBI View Article : Google Scholar

30 

Christensen LA, Slot O, Sanchez G, Boserup J, Rasmussen SN, Bondesen S, Hansen SH and Hvidberg EF: Release of 5-aminosalicylic acid from Pentasa during normal and accelerated intestinal transit time. Br J Clin Pharmacol. 23:365–369. 1987.PubMed/NCBI View Article : Google Scholar

31 

Koziolek M, Grimm M, Becker D, Iordanov V, Zou H, Shimizu J, Wanke C, Garbacz G and Weitschies W: Investigation of pH and temperature profiles in the GI tract of fasted human subjects using the intellicap(®) system. J Pharm Sci. 104:2855–2863. 2015.PubMed/NCBI View Article : Google Scholar

32 

Ito H, Iida M, Matsumoto T, Suzuki Y, Sasaki H, Yoshida T, Takano Y and Hibi T: Direct comparison of two different mesalamine formulations for the induction of remission in patients with ulcerative colitis: A double-blind, randomized study. Inflamm Bowel Dis. 16:1567–1574. 2010.PubMed/NCBI View Article : Google Scholar

33 

Frieri G, Giacomelli R, Pimpo M, Palumbo G, Passacantando A, Pantaleoni G and Caprilli R: Mucosal 5-aminosalicylic acid concentration inversely correlates with severity of colonic inflammation in patients with ulcerative colitis. Gut. 47:410–414. 2000.PubMed/NCBI View Article : Google Scholar

34 

Hirayama M, Toda R, Ozaki T, Hasegawa J, Nakamura T, Naraki Y, Haraguchi Y, Hori Y, Tanaka T, Takei M, et al: Concentration dependence of 5-aminosalicylic acid pharmacological actions in intestinal mucosa after oral administration of a pH-dependent formulation. Mol Pharm. 8:1083–1089. 2011.PubMed/NCBI View Article : Google Scholar

35 

D'Incà R, Paccagnella M, Cardin R, Pathak S, Baldo V, Giron MC and Sturniolo GC: 5-ASA colonic mucosal concentrations resulting from different pharmaceutical formulations in ulcerative colitis. World J Gastroenterol. 19:5665–5670. 2013.PubMed/NCBI View Article : Google Scholar

36 

Yamamoto Y, Masuda S, Nakase H, Matsuura M, Maruyama S, Hisamatsu T, Suzuki Y and Matsubara K: Influence of pharmaceutical formulation on the mucosal concentration of 5-aminosalicylic acid and N-acetylmesalamine in Japanese patients with ulcerative colitis. Biol Pharm Bull. 42:81–86. 2019.PubMed/NCBI View Article : Google Scholar

37 

Fukuda T, Naganuma M, Takabayashi K, Hagihara Y, Tanemoto S, Nomura E, Yoshimatsu Y, Sugimoto S, Nanki K, Mizuno S, et al: Mucosal concentrations of N-acetyl-5-aminosalicylic acid related to endoscopic activity in ulcerative colitis patients with mesalamine. J Gastroenterol Hepatol. 35:1878–1885. 2020.PubMed/NCBI View Article : Google Scholar

38 

Kawashima K, Ishihara S, Yuki T, Onishi K, Kushiyama Y, Fujishiro H, Miyaoka Y, Yuki M, Komazawa Y, Tanimura T, et al: Therapeutic efficacy of pH-dependent release formulation of mesalazine on active ulcerative colitis resistant to time-dependent release formulation: Analysis of fecal calprotectin concentration. Biomed Res Int. 2014(342751)2014.PubMed/NCBI View Article : Google Scholar

39 

Yasutomi E, Hiraoka S, Yamamoto S, Oka S, Hirai M, Yamasaki Y, Inokuchi T, Kinugasa H, Takahara M, Harada K, et al: Switching between three types of mesalazine formulation and sulfasalazine in patients with active ulcerative colitis who have already received high-dose treatment with these agents. J Clin Med. 8(2019)2019.PubMed/NCBI View Article : Google Scholar

40 

Nagahori M, Kochi S, Hanai H, Yamamoto T, Nakamura S, Omuro S, Watanabe M and Hibi T: OPTIMUM Study Group. Real life results in using 5-ASA for maintaining mild to moderate UC patients in Japan, a multi-center study, OPTIMUM Study. BMC Gastroenterol. 17(47)2017.PubMed/NCBI View Article : Google Scholar

41 

Ito H, Iida M, Matsumoto T, Suzuki Y, Aida Y, Yoshida T, Takano Y and Hibi T: Direct comparison of two different mesalamine formulations for the maintenance of remission in patients with ulcerative colitis: A double-blind, randomized study. Inflamm Bowel Dis. 16:1575–1582. 2010.PubMed/NCBI View Article : Google Scholar

42 

Gibson PR, Fixa B, Pekárková B, Bátovský M, Radford-Smith G, Tibitanzl J, Gabalec L, Florin TH and Greinwald R: Comparison of the efficacy and safety of Eudragit-L-coated mesalazine tablets with ethylcellulose-coated mesalazine tablets in patients with mild to moderately active ulcerative colitis. Aliment Pharmacol Ther. 23:1017–1026. 2006.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Deissler H, Krammer H and Gillessen A: pH‑dependent vs. constant release of mesalazine in the treatment of ulcerative colitis: Do drug delivery concepts determine therapeutic efficacy? (Review). Biomed Rep 15: 96, 2021.
APA
Deissler, H., Krammer, H., & Gillessen, A. (2021). pH‑dependent vs. constant release of mesalazine in the treatment of ulcerative colitis: Do drug delivery concepts determine therapeutic efficacy? (Review). Biomedical Reports, 15, 96. https://doi.org/10.3892/br.2021.1472
MLA
Deissler, H., Krammer, H., Gillessen, A."pH‑dependent vs. constant release of mesalazine in the treatment of ulcerative colitis: Do drug delivery concepts determine therapeutic efficacy? (Review)". Biomedical Reports 15.5 (2021): 96.
Chicago
Deissler, H., Krammer, H., Gillessen, A."pH‑dependent vs. constant release of mesalazine in the treatment of ulcerative colitis: Do drug delivery concepts determine therapeutic efficacy? (Review)". Biomedical Reports 15, no. 5 (2021): 96. https://doi.org/10.3892/br.2021.1472
Copy and paste a formatted citation
x
Spandidos Publications style
Deissler H, Krammer H and Gillessen A: pH‑dependent vs. constant release of mesalazine in the treatment of ulcerative colitis: Do drug delivery concepts determine therapeutic efficacy? (Review). Biomed Rep 15: 96, 2021.
APA
Deissler, H., Krammer, H., & Gillessen, A. (2021). pH‑dependent vs. constant release of mesalazine in the treatment of ulcerative colitis: Do drug delivery concepts determine therapeutic efficacy? (Review). Biomedical Reports, 15, 96. https://doi.org/10.3892/br.2021.1472
MLA
Deissler, H., Krammer, H., Gillessen, A."pH‑dependent vs. constant release of mesalazine in the treatment of ulcerative colitis: Do drug delivery concepts determine therapeutic efficacy? (Review)". Biomedical Reports 15.5 (2021): 96.
Chicago
Deissler, H., Krammer, H., Gillessen, A."pH‑dependent vs. constant release of mesalazine in the treatment of ulcerative colitis: Do drug delivery concepts determine therapeutic efficacy? (Review)". Biomedical Reports 15, no. 5 (2021): 96. https://doi.org/10.3892/br.2021.1472
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