Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Biomedical Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9434 Online ISSN: 2049-9442
Journal Cover
March-2022 Volume 16 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March-2022 Volume 16 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Review Open Access

Advances in research on the effects of platelet activation in acute lung injury (Review)

  • Authors:
    • Yuan Xin
    • Jiang Peng
    • Yu Yun Hong
    • Qiao Cong Chao
    • Su Na
    • Sun Pan
    • Lin Fang Zhao
  • View Affiliations / Copyright

    Affiliations: Institute of Blood Transfusion, Chinese Academy of Medical Science and Peking Union Medical College, Chengdu, Sichuan 610052, P.R. China
    Copyright: © Xin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 17
    |
    Published online on: January 19, 2022
       https://doi.org/10.3892/br.2022.1500
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Acute lung injury (ALI) is an acute hypoxic respiratory insufficiency or failure caused by various factors inside and outside the lungs. ALI is associated with high morbidity and a poor prognosis in hospitalized patients. The lungs serve as a reservoir for platelet precursor megakaryocytes and are closely associated with platelets. Platelets not only play a central role in hemostasis, coagulation and wound healing, but can also act as inflammatory cells capable of stimulating non‑hemostatic immune functions under inflammatory conditions, participating in the progression of various inflammatory diseases, and can result in tissue damage. Therefore, it was speculated that platelets may play an important role in the pathogenesis of ALI. In this review, the latest research progress on secretion of bioactive mediators from platelets, platelet activation‑related signaling pathways, and the direct contact reactions between platelets and neutrophils with endothelial cells that result in ALI are described, providing evidence to support the importance of the consideration of platelets in the search for ALI interventional targets.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Bernard GR, Artigas A, Brigham KL, Carlet J, Falke K, Hudson L, Lamy M, Legall JR, Morris A and Spragg R: The American-European consensus conference on ARDS. definitions, mechanisms, relevant outcomes, and clinical trial coordination. Am J Respir Crit Care Med. 149:818–824. 1994.PubMed/NCBI View Article : Google Scholar

2 

Phua J, Badia JR, Adhikari NK, Friedrich JO, Fowler RA, Singh JM, Scales DC, Stather DR, Li A, Jones A, et al: Has mortality from acute respiratory distress syndrome decreased over time?: A systematic review. Am J Respir Crit Care Med. 179:220–227. 2009.PubMed/NCBI View Article : Google Scholar

3 

Jenne CN and Kubes P: Platelets in inflammation and infection. Platelets. 26:286–292. 2015.PubMed/NCBI View Article : Google Scholar

4 

Maouia A, Rebetz J, Kapur R and Semple JW: The immune nature of platelets revisited. Transfus Med Rev. 34:209–220. 2020.PubMed/NCBI View Article : Google Scholar

5 

Smyth SS, McEver RP, Weyrich AS, Morrell CN, Hoffman MR, Arepally GM, French PA, Dauerman HL and Becker RC: 2009 Platelet Colloquium Participants. Platelet functions beyond hemostasis. J Thromb Haemost. 7:1759–1766. 2009.PubMed/NCBI View Article : Google Scholar

6 

Cox D, Kerrigan SW and Watson SP: Platelets and the innate immune system: Mechanisms of bacterial-induced platelet activation. J Thromb Haemost. 9:1097–1107. 2011.PubMed/NCBI View Article : Google Scholar

7 

Pugin J, Verghese G, Widmer MC and Matthay MA: The alveolar space is the site of intense inflammatory and profibrotic reactions in the early phase of acute respiratory distress syndrome. Crit Care Med. 27:304–312. 1999.PubMed/NCBI View Article : Google Scholar

8 

Ware LB and Matthay MA: The acute respiratory distress syndrome. N Engl J Med. 342:1334–1349. 2000.PubMed/NCBI View Article : Google Scholar

9 

Grommes J and Soehnlein O: Contribution of neutrophils to acute lung injury. Mol Med. 17:293–307. 2011.PubMed/NCBI View Article : Google Scholar

10 

Nagase T, Ishii S, Kume K, Uozumi N, Izumi T, Ouchi Y and Shimizu T: Platelet-activating factor mediates acid-induced lung injury in genetically engineered mice. J Clin Invest. 104:1071–1076. 1999.PubMed/NCBI View Article : Google Scholar

11 

Zemans RL, Colgan SP and Downey GP: Transepithelial migration of neutrophils: Mechanisms and implications for acute lung injury. Am J Respir Cell Mol Biol. 40:519–535. 2009.PubMed/NCBI View Article : Google Scholar

12 

Bhatia M, Zemans RL and Jeyaseelan S: Role of chemokines in the pathogenesis of acute lung injury. Am J Respir Cell Mol Biol. 46:566–572. 2012.PubMed/NCBI View Article : Google Scholar

13 

Saffarzadeh M, Juenemann C, Queisser MA, Lochnit G, Barreto G, Galuska SP, Lohmeyer J and Preissner KT: Neutrophil extracellular traps directly induce epithelial and endothelial cell death: A predominant role of histones. PLoS One. 7(e32366)2012.PubMed/NCBI View Article : Google Scholar

14 

Jeyaseelan S, Chu HW, Young SK, Freeman MW and Worthen GS: Distinct roles of pattern recognition receptors CD14 and Toll-like receptor 4 in acute lung injury. Infect Immun. 73:1754–1763. 2005.PubMed/NCBI View Article : Google Scholar

15 

Huang JJ, Xia J, Huang LL and Li YC: HIF-1α promotes NLRP3 inflammasome activation in bleomycin-induced acute lung injury. Mol Med Rep. 20:3424–3432. 2019.PubMed/NCBI View Article : Google Scholar

16 

Rendu F and Brohard-Bohn B: The platelet release reaction: Granules' constituents, secretion and functions. Platelets. 12:261–273. 2001.PubMed/NCBI View Article : Google Scholar

17 

Meng R, Wang Y, Yao Y, Zhang Z, Harper DC, Heijnen HF, Sitaram A, Li W, Raposo G, Weiss MJ, et al: SLC35D3 delivery from megakaryocyte early endosomes is required for platelet dense granule biogenesis and is differentially defective in Hermansky-Pudlak syndrome models. Blood. 120:404–414. 2012.PubMed/NCBI View Article : Google Scholar

18 

Heijnen H and van der Sluijs P: Platelet secretory behaviour: As diverse as the granules … or not? J Thromb Haemost. 13:2141–2151. 2015.PubMed/NCBI View Article : Google Scholar

19 

Koyama H, Maeno T, Fukumoto S, Shoji T, Yamane T, Yokoyama H, Emoto M, Shoji T, Tahara H, Inaba M, et al: Platelet P-selectin expression is associated with atherosclerotic wall thickness in carotid artery in humans. Circulation. 108:524–529. 2003.PubMed/NCBI View Article : Google Scholar

20 

Wysokinski WE, Cohoon KP, Melduni RM, Mazur M, Ammash N, Munger T, Konik E, McLeod T, Gosk-Bierska I and McBane RD: Association between P-selectin levels and left atrial blood stasis in patients with nonvalvular atrial fibrillation. Thromb Res. 172:4–8. 2018.PubMed/NCBI View Article : Google Scholar

21 

Wang K, Zhou X, Zhou Z, Mal N, Fan L, Zhang M, Lincoff AM, Plow EF, Topol EJ and Penn MS: Platelet, not endothelial, P-selectin is required for neointimal formation after vascular injury. Arterioscler Thromb Vasc Biol. 25:1584–1589. 2005.PubMed/NCBI View Article : Google Scholar

22 

Boilard E, Nigrovic PA, Larabee K, Watts GF, Coblyn JS, Weinblatt ME, Massarotti EM, Remold-O'Donnell E, Farndale RW, Ware J and Lee DM: Platelets amplify inflammation in arthritis via collagen-dependent microparticle production. Science. 327:580–583. 2010.PubMed/NCBI View Article : Google Scholar

23 

Semple JW, Italiano JE Jr and Freedman J: Platelets and the immune continuum. Nat Rev Immunol. 11:264–274. 2011.PubMed/NCBI View Article : Google Scholar

24 

Hasegawa S, Tashiro N, Matsubara T, Furukawa S and Ra C: A comparison of FcepsilonRI-mediated RANTES release from human platelets between allergic patients and healthy individuals. Int Arch Allergy Immunol. 125 (Suppl 1):S42–S47. 2001.PubMed/NCBI View Article : Google Scholar

25 

Lapchak PH, Ioannou A, Kannan L, Rani P, Dalle Lucca JJ and Tsokos GC: Platelet-associated CD40/CD154 mediates remote tissue damage after mesenteric ischemia/reperfusion injury. PLoS One. 7(e32260)2012.PubMed/NCBI View Article : Google Scholar

26 

Ghoshal K and Bhattacharyya M: Overview of platelet physiology: Its hemostatic and nonhemostatic role in disease pathogenesis. ScientificWorldJournal. 2014(781857)2014.PubMed/NCBI View Article : Google Scholar

27 

Yeaman MR: Platelets: At the nexus of antimicrobial defence. Nat Rev Microbiol. 12:426–437. 2014.PubMed/NCBI View Article : Google Scholar

28 

Danese S, de la Motte C, Sturm A, Vogel JD, West GA, Strong SA, Katz JA and Fiocchi C: Platelets trigger a CD40-dependent inflammatory response in the microvasculature of inflammatory bowel disease patients. Gastroenterology. 124:1249–1264. 2003.PubMed/NCBI View Article : Google Scholar

29 

Kasperska-Zajac A, Brzoza Z and Rogala B: Seasonal changes in platelet activity in pollen-induced seasonal allergic rhinitis and asthma. J Asthma. 45:485–487. 2008.PubMed/NCBI View Article : Google Scholar

30 

O'Sullivan BP and Michelson AD: The inflammatory role of platelets in cystic fibrosis. Am J Respir Crit Care Med. 173:483–490. 2006.PubMed/NCBI View Article : Google Scholar

31 

Weyrich AS and Zimmerman GA: Platelets in lung biology. Annu Rev Physiol. 75:569–591. 2013.PubMed/NCBI View Article : Google Scholar

32 

Lefrançais E and Looney MR: Platelet biogenesis in the lung circulation. Physiology (Bethesda). 34:392–401. 2019.PubMed/NCBI View Article : Google Scholar

33 

Tabuchi A and Kuebler WM: Endothelium-platelet interactions in inflammatory lung disease. Vascul Pharmacol. 49:141–150. 2008.PubMed/NCBI View Article : Google Scholar

34 

Ho-Tin-Noé B, Demers M and Wagner DD: How platelets safeguard vascular integrity. J Thromb Haemost. 9 (Suppl 1):S56–S65. 2011.PubMed/NCBI View Article : Google Scholar

35 

Middleton EA, Weyrich AS and Zimmerman GA: Platelets in pulmonary immune responses and inflammatory lung diseases. Physiol Rev. 96:1211–1259. 2016.PubMed/NCBI View Article : Google Scholar

36 

Lê VB, Schneider JG, Boergeling Y, Berri F, Ducatez M, Guerin JL, Adrian I, Errazuriz-Cerda E, Frasquilho S, Antunes L, et al: Platelet activation and aggregation promote lung inflammation and influenza virus pathogenesis. Am J Respir Crit Care Med. 191:804–819. 2015.PubMed/NCBI View Article : Google Scholar

37 

Looney MR, Nguyen JX, Hu Y, Van Ziffle JA, Lowell CA and Matthay MA: Platelet depletion and aspirin treatment protect mice in a two-event model of transfusion-related acute lung injury. J Clin Invest. 119:3450–3461. 2009.PubMed/NCBI View Article : Google Scholar

38 

Yasui H, Donahue DL, Walsh M, Castellino FJ and Ploplis VA: Early coagulation events induce acute lung injury in a rat model of blunt traumatic brain injury. Am J Physiol Lung Cell Mol Physiol. 311:L74–L86. 2016.PubMed/NCBI View Article : Google Scholar

39 

Clark SR, Ma AC, Tavener SA, McDonald B, Goodarzi Z, Kelly MM, Patel KD, Chakrabarti S, McAvoy E, Sinclair GD, et al: Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood. Nat Med. 13:463–469. 2007.PubMed/NCBI View Article : Google Scholar

40 

Zarbock A, Polanowska-Grabowska RK and Ley K: Platelet-neutrophil-interactions: Linking hemostasis and inflammation. Blood Rev. 21:99–111. 2007.PubMed/NCBI View Article : Google Scholar

41 

Nurden AT: Platelets, inflammation and tissue regeneration. Thromb Haemost. 105 (Suppl 1):S13–S33. 2011.PubMed/NCBI View Article : Google Scholar

42 

Xie RF, Hu P, Wang ZC, Yang J, Yang YM, Gao L, Fan HH and Zhu YM: Platelet-derived microparticles induce polymorphonuclear leukocyte-mediated damage of human pulmonary microvascular endothelial cells. Transfusion. 55:1051–1057. 2015.PubMed/NCBI View Article : Google Scholar

43 

Barry OP, Pratico D, Lawson JA and FitzGerald GA: Transcellular activation of platelets and endothelial cells by bioactive lipids in platelet microparticles. J Clin Invest. 99:2118–2127. 1997.PubMed/NCBI View Article : Google Scholar

44 

Bulut D, Becker V and Mügge A: Acetylsalicylate reduces endothelial and platelet-derived microparticles in patients with coronary artery disease. Can J Physiol Pharmacol. 89:239–244. 2011.PubMed/NCBI View Article : Google Scholar

45 

Zhou Q, Lian Y, Zhang Y, Li L, Li H, Shen D, Zhou Y, Zhang M, Lu Y, Liu J, et al: Platelet-derived microparticles from recurrent miscarriage associated with antiphospholipid antibody syndrome influence behaviours of trophoblast and endothelial cells. Mol Hum Reprod. 25:483–494. 2019.PubMed/NCBI View Article : Google Scholar

46 

Bhattacharya J and Matthay MA: Regulation and repair of the alveolar-capillary barrier in acute lung injury. Annu Rev Physiol. 75:593–615. 2013.PubMed/NCBI View Article : Google Scholar

47 

Zarbock A, Singbartl K and Ley K: Complete reversal of acid-induced acute lung injury by blocking of platelet-neutrophil aggregation. J Clin Invest. 116:3211–3219. 2006.PubMed/NCBI View Article : Google Scholar

48 

Bdeir K, Gollomp K, Stasiak M, Mei J, Papiewska-Pajak I, Zhao G, Worthen GS, Cines DB, Poncz M and Kowalska MA: Platelet-specific chemokines contribute to the pathogenesis of acute lung injury. Am J Respir Cell Mol Biol. 56:261–270. 2017.PubMed/NCBI View Article : Google Scholar

49 

Medford AR and Millar AB: Vascular endothelial growth factor (VEGF) in acute lung injury (ALI) and acute respiratory distress syndrome (ARDS): Paradox or paradigm? Thorax. 61:621–626. 2006.PubMed/NCBI View Article : Google Scholar

50 

Barratt S, Medford AR and Millar AB: Vascular endothelial growth factor in acute lung injury and acute respiratory distress syndrome. Respiration. 87:329–342. 2014.PubMed/NCBI View Article : Google Scholar

51 

André P, Nannizzi-Alaimo L, Prasad SK and Phillips DR: Platelet-derived CD40L: The switch-hitting player of cardiovascular disease. Circulation. 106:896–899. 2002.PubMed/NCBI View Article : Google Scholar

52 

Henn V, Slupsky JR, Gräfe M, Anagnostopoulos I, Förster R, Müller-Berghaus G and Kroczek RA: CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells. Nature. 391:591–594. 1998.PubMed/NCBI View Article : Google Scholar

53 

Rahman M, Zhang S, Chew M, Ersson A, Jeppsson B and Thorlacius H: Platelet-derived CD40L (CD154) mediates neutrophil upregulation of Mac-1 and recruitment in septic lung injury. Ann Surg. 250:783–790. 2009.PubMed/NCBI View Article : Google Scholar

54 

Coxon CH, Geer MJ and Senis YA: ITIM receptors: More than just inhibitors of platelet activation. Blood. 129:3407–3418. 2017.PubMed/NCBI View Article : Google Scholar

55 

Watson SP, Herbert JM and Pollitt AY: GPVI and CLEC-2 in hemostasis and vascular integrity. J Thromb Haemost. 8:1456–1467. 2010.PubMed/NCBI View Article : Google Scholar

56 

Kerrigan AM, Dennehy KM, Mourão-Sá D, Faro-Trindade I, Willment JA, Taylor PR, Eble JA, Reis e Sousa C and Brown GD: CLEC-2 is a phagocytic activation receptor expressed on murine peripheral blood neutrophils. J Immunol. 182:4150–4157. 2009.PubMed/NCBI View Article : Google Scholar

57 

Badolia R, Kostyak JC, Dangelmaier C and Kunapuli SP: Syk activity is dispensable for platelet GP1b-IX-V signaling. Int J Mol Sci. 18(1238)2017.PubMed/NCBI View Article : Google Scholar

58 

Suzuki-Inoue K: Roles of the CLEC-2-podoplanin interaction in tumor progression. Platelets: Jun 4, 2018 (Epub ahead of print). doi: 10.1080/09537104.2018.1478401.

59 

Quintanilla M, Montero-Montero L, Renart J and Martín-Villar E: Podoplanin in inflammation and cancer. Int J Mol Sci. 20(707)2019.PubMed/NCBI View Article : Google Scholar

60 

Mammadova-Bach E, Gil-Pulido J, Sarukhanyan E, Burkard P, Shityakov S, Schonhart C, Stegner D, Remer K, Nurden P, Nurden AT, et al: Platelet glycoprotein VI promotes metastasis through interaction with cancer cell-derived galectin-3. Blood. 135:1146–1160. 2020.PubMed/NCBI View Article : Google Scholar

61 

Huang JS, Ramamurthy SK, Lin X and Le Breton GC: Cell signalling through thromboxane A2 receptors. Cell Signal. 16:521–533. 2004.PubMed/NCBI View Article : Google Scholar

62 

Goff CD, Corbin RS, Theiss SD, Frierson HF Jr, Cephas GA, Tribble CG, Kron IL and Young JS: Postinjury thromboxane receptor blockade ameliorates acute lung injury. Ann Thorac Surg. 64:826–829. 1997.PubMed/NCBI View Article : Google Scholar

63 

Zhang S, Yuan J, Yu M, Fan H, Guo ZQ, Yang R, Guo HP, Liao YH and Wang M: IL-17A facilitates platelet function through the ERK2 signaling pathway in patients with acute coronary syndrome. PLoS One. 7(e40641)2012.PubMed/NCBI View Article : Google Scholar

64 

Caudrillier A, Kessenbrock K, Gilliss BM, Nguyen JX, Marques MB, Monestier M, Toy P, Werb Z and Looney MR: Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury. J Clin Invest. 122:2661–2671. 2012.PubMed/NCBI View Article : Google Scholar

65 

Holm S, Kared H, Michelsen AE, Kong XY, Dahl TB, Schultz NH, Nyman TA, Fladeby C, Seljeflot I, Ueland T, et al: Immune complexes, innate immunity, and NETosis in ChAdOx1 vaccine-induced thrombocytopenia. Eur Heart J. 42:4064–4072. 2021.PubMed/NCBI View Article : Google Scholar

66 

Brinkmann V, Reichard U, Goosmann C, Fauler B, Uhlemann Y, Weiss DS, Weinrauch Y and Zychlinsky A: Neutrophil extracellular traps kill bacteria. Science. 303:1532–1535. 2004.PubMed/NCBI View Article : Google Scholar

67 

Fuchs TA, Brill A, Duerschmied D, Schatzberg D, Monestier M, Myers DD Jr, Wrobleski SK, Wakefield TW, Hartwig JH and Wagner DD: Extracellular DNA traps promote thrombosis. Proc Natl Acad Sci USA. 107:15880–15885. 2010.PubMed/NCBI View Article : Google Scholar

68 

Worth RG, Chien CD, Chien P, Reilly MP, McKenzie SE and Schreiber AD: Platelet FcgammaRIIA binds and internalizes IgG-containing complexes. Exp Hematol. 34:1490–1495. 2006.PubMed/NCBI View Article : Google Scholar

69 

Antczak AJ, Vieth JA, Singh N and Worth RG: Internalization of IgG-coated targets results in activation and secretion of soluble CD40 ligand and RANTES by human platelets. Clin Vaccine Immunol. 18:210–216. 2011.PubMed/NCBI View Article : Google Scholar

70 

Semple JW, Rebetz J, Maouia A and Kapur R: An update on the pathophysiology of immune thrombocytopenia. Curr Opin Hematol. 27:423–429. 2020.PubMed/NCBI View Article : Google Scholar

71 

Sowa JM, Crist SA, Ratliff TL and Elzey BD: Platelet influence on T- and B-cell responses. Arch Immunol Ther Exp (Warsz). 57:235–241. 2009.PubMed/NCBI View Article : Google Scholar

72 

Romo GM, Dong JF, Schade AJ, Gardiner EE, Kansas GS, Li CQ, McIntire LV, Berndt MC and López JA: The glycoprotein Ib-IX-V complex is a platelet counterreceptor for P-selectin. J Exp Med. 190:803–814. 1999.PubMed/NCBI View Article : Google Scholar

73 

Srivastava K, Cockburn IA, Swaim A, Thompson LE, Tripathi A, Fletcher CA, Shirk EM, Sun H, Kowalska MA, Fox-Talbot K, et al: Platelet factor 4 mediates inflammation in experimental cerebral malaria. Cell Host Microbe. 4:179–187. 2008.PubMed/NCBI View Article : Google Scholar

74 

Hagiwara S, Iwasaka H, Hasegawa A, Oyama M, Imatomi R, Uchida T and Noguchi T: Adenosine diphosphate receptor antagonist clopidogrel sulfate attenuates LPS-induced systemic inflammation in a rat model. Shock. 35:289–292. 2011.PubMed/NCBI View Article : Google Scholar

75 

Asaduzzaman M, Lavasani S, Rahman M, Zhang S, Braun OO, Jeppsson B and Thorlacius H: Platelets support pulmonary recruitment of neutrophils in abdominal sepsis. Crit Care Med. 37:1389–1396. 2009.PubMed/NCBI View Article : Google Scholar

76 

Cognasse F, Tariket S, Hamzeh-Cognasse H, Arthaud CA, Eyraud MA, Bourlet T, Berthelot P, Laradi S, Fauteux-Daniel S and Garraud O: Platelet depletion limits the severity but does not prevent the occurrence of experimental transfusion-related acute lung injury. Transfusion. 60:713–723. 2020.PubMed/NCBI View Article : Google Scholar

77 

Zhou J, Lee S, Guo CL, Chang C, Liu T, Leung KSK, Wai AKC, Cheung BMY, Tse G and Zhang Q: Anticoagulant or antiplatelet use and severe COVID-19 disease: A propensity score-matched territory-wide study. Pharmacol Res. 165(105473)2021.PubMed/NCBI View Article : Google Scholar

78 

Zhu Y, Wang J, Meng X, Xie H, Tan J, Guo X, Han P and Wang R: A positive feedback loop promotes HIF-1α stability through miR-210-mediated suppression of RUNX3 in paraquat-induced EMT. J Cell Mol Med. 21:3529–3539. 2017.PubMed/NCBI View Article : Google Scholar

79 

Zhou N, Liu Q, Qi X, Zhang X, Ru Z, Ma Y, Yu T, Zhang M, Li Y, Zhang Y and Cao Z: Paraquat exposure impairs porcine oocyte meiotic maturation. Theriogenology. 179:60–68. 2021.PubMed/NCBI View Article : Google Scholar

80 

Zu Y, Ban J, Xia Z, Wang J, Cai Y, Ping W and Sun W: Genetic variation in a miR-335 binding site in BIRC5 alters susceptibility to lung cancer in Chinese Han populations. Biochem Biophys Res Commun. 430:529–534. 2013.PubMed/NCBI View Article : Google Scholar

81 

Zuo X, Xu W, Xu M, Tian R, Moussalli MJ, Mao F, Zheng X, Wang J, Morris JS, Gagea M, et al: Metastasis regulation by PPARD expression in cancer cells. JCI Insight. 2(e91419)2017.PubMed/NCBI View Article : Google Scholar

82 

Zu L, Xue Y and Wang J, Fu Y, Wang X, Xiao G, Hao M, Sun X, Wang Y, Fu G and Wang J: The feedback loop between miR-124 and TGF-β pathway plays a significant role in non-small cell lung cancer metastasis. Carcinogenesis. 37:333–343. 2016.PubMed/NCBI View Article : Google Scholar

83 

Zou W, Chen L, Mao W, Hu S, Liu Y and Hu C: Identification of inflammatory response-related gene signature associated with immune status and prognosis of lung adenocarcinoma. Front Bioeng Biotechnol. 9(772206)2021.PubMed/NCBI View Article : Google Scholar

84 

Zou M, Xia S, Zhuang L, Han N, Chu Q, Chao T, Peng P, Chen Y, Gui Q and Yu S: Knockdown of the Bcl-2 gene increases sensitivity to EGFR tyrosine kinase inhibitors in the H1975 lung cancer cell line harboring T790M mutation. Int J Oncol. 42:2094–2102. 2013.PubMed/NCBI View Article : Google Scholar

85 

Zou K, Tong E, Xu Y, Deng X and Zou L: Down regulation of mammalian target of rapamycin decreases HIF-1α and survivin expression in anoxic lung adenocarcinoma A549 cell to elemene and/or irradiation. Tumour Biol. 35:9735–9741. 2014.PubMed/NCBI View Article : Google Scholar

86 

Zong L, Sun Q, Zhang H, Chen Z, Deng Y, Li D and Zhang L: Increased expression of circRNA_102231 in lung cancer and its clinical significance. Biomed Pharmacother. 102:639–644. 2018.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Xin Y, Peng J, Hong YY, Chao QC, Na S, Pan S and Zhao LF: Advances in research on the effects of platelet activation in acute lung injury (Review). Biomed Rep 16: 17, 2022.
APA
Xin, Y., Peng, J., Hong, Y.Y., Chao, Q.C., Na, S., Pan, S., & Zhao, L.F. (2022). Advances in research on the effects of platelet activation in acute lung injury (Review). Biomedical Reports, 16, 17. https://doi.org/10.3892/br.2022.1500
MLA
Xin, Y., Peng, J., Hong, Y. Y., Chao, Q. C., Na, S., Pan, S., Zhao, L. F."Advances in research on the effects of platelet activation in acute lung injury (Review)". Biomedical Reports 16.3 (2022): 17.
Chicago
Xin, Y., Peng, J., Hong, Y. Y., Chao, Q. C., Na, S., Pan, S., Zhao, L. F."Advances in research on the effects of platelet activation in acute lung injury (Review)". Biomedical Reports 16, no. 3 (2022): 17. https://doi.org/10.3892/br.2022.1500
Copy and paste a formatted citation
x
Spandidos Publications style
Xin Y, Peng J, Hong YY, Chao QC, Na S, Pan S and Zhao LF: Advances in research on the effects of platelet activation in acute lung injury (Review). Biomed Rep 16: 17, 2022.
APA
Xin, Y., Peng, J., Hong, Y.Y., Chao, Q.C., Na, S., Pan, S., & Zhao, L.F. (2022). Advances in research on the effects of platelet activation in acute lung injury (Review). Biomedical Reports, 16, 17. https://doi.org/10.3892/br.2022.1500
MLA
Xin, Y., Peng, J., Hong, Y. Y., Chao, Q. C., Na, S., Pan, S., Zhao, L. F."Advances in research on the effects of platelet activation in acute lung injury (Review)". Biomedical Reports 16.3 (2022): 17.
Chicago
Xin, Y., Peng, J., Hong, Y. Y., Chao, Q. C., Na, S., Pan, S., Zhao, L. F."Advances in research on the effects of platelet activation in acute lung injury (Review)". Biomedical Reports 16, no. 3 (2022): 17. https://doi.org/10.3892/br.2022.1500
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team