Open Access

Advances in research on the effects of platelet activation in acute lung injury (Review)

  • Authors:
    • Yuan Xin
    • Jiang Peng
    • Yu Yun Hong
    • Qiao Cong Chao
    • Su Na
    • Sun Pan
    • Lin Fang Zhao
  • View Affiliations

  • Published online on: January 19, 2022     https://doi.org/10.3892/br.2022.1500
  • Article Number: 17
  • Copyright: © Xin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Acute lung injury (ALI) is an acute hypoxic respiratory insufficiency or failure caused by various factors inside and outside the lungs. ALI is associated with high morbidity and a poor prognosis in hospitalized patients. The lungs serve as a reservoir for platelet precursor megakaryocytes and are closely associated with platelets. Platelets not only play a central role in hemostasis, coagulation and wound healing, but can also act as inflammatory cells capable of stimulating non‑hemostatic immune functions under inflammatory conditions, participating in the progression of various inflammatory diseases, and can result in tissue damage. Therefore, it was speculated that platelets may play an important role in the pathogenesis of ALI. In this review, the latest research progress on secretion of bioactive mediators from platelets, platelet activation‑related signaling pathways, and the direct contact reactions between platelets and neutrophils with endothelial cells that result in ALI are described, providing evidence to support the importance of the consideration of platelets in the search for ALI interventional targets.
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March-2022
Volume 16 Issue 3

Print ISSN: 2049-9434
Online ISSN:2049-9442

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Copy and paste a formatted citation
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Spandidos Publications style
Xin Y, Peng J, Hong YY, Chao QC, Na S, Pan S and Zhao LF: Advances in research on the effects of platelet activation in acute lung injury (Review). Biomed Rep 16: 17, 2022
APA
Xin, Y., Peng, J., Hong, Y.Y., Chao, Q.C., Na, S., Pan, S., & Zhao, L.F. (2022). Advances in research on the effects of platelet activation in acute lung injury (Review). Biomedical Reports, 16, 17. https://doi.org/10.3892/br.2022.1500
MLA
Xin, Y., Peng, J., Hong, Y. Y., Chao, Q. C., Na, S., Pan, S., Zhao, L. F."Advances in research on the effects of platelet activation in acute lung injury (Review)". Biomedical Reports 16.3 (2022): 17.
Chicago
Xin, Y., Peng, J., Hong, Y. Y., Chao, Q. C., Na, S., Pan, S., Zhao, L. F."Advances in research on the effects of platelet activation in acute lung injury (Review)". Biomedical Reports 16, no. 3 (2022): 17. https://doi.org/10.3892/br.2022.1500