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Profile of vitamin D receptor gene polymorphism TaqI in patients with periodontitis

  • Authors:
    • Nurlindah Hamrun
    • Muhammad Ruslin
    • Erni Marlina
    • Sri Oktawati
    • Takashi Saito
    • Andi Sitti Hajrah Yusuf
    • Keng-Liang Ou
  • View Affiliations / Copyright

    Affiliations: Department of Oral Biology, Faculty of Dentistry, Hasanuddin University, Makassar, South Sulawesi 90425, Indonesia, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Hasanuddin University, Makassar, South Sulawesi 90425, Indonesia, Department of Oral Medicine, Faculty of Dentistry, Hasanuddin University, Makassar, South Sulawesi 90425, Indonesia, Department of Periodontology, Faculty of Dentistry, Hasanuddin University, Makassar, South Sulawesi 90425, Indonesia, Division of Clinical Cariology and Endodontology, Department of Oral Rehabilitation, School of Dentistry, Health Sciences University of Hokkaido, Hokkaido 060‑8586, Japan, Department of Dentistry, Taipei Medical University‑Shuang Ho Hospital, New Taipei City 235, Taiwan, R.O.C.
    Copyright: © Hamrun et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 35
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    Published online on: March 1, 2022
       https://doi.org/10.3892/br.2022.1518
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Abstract

The present study aimed to assess the incidence of the vitamin D receptor (VDR) gene polymorphism TaqI in patients with periodontitis, and the potential association of this polymorphism with the severity of the disease. This was a case‑controlled study, which included 162 adults divided into two groups as follows: Case group (81 patients diagnosed with periodontitis) and control group (81 patients without periodontitis). Venous blood was obtained from each sample from which DNA was extracted. The gene polymorphism was determined using restricted fragment length polymorphism‑PCR and DNA sequencing to identify endonuclease restrictions in exon 9 (TaqI). The data were analyzed using an independent samples t‑test. VDR gene polymorphisms were detected in periodontitis cases with TT (86.4%), Tt (12.4%) and tt (1.2%) genotypes. DNA sequencing confirmed a change in the sequence of the VDR gene nucleotides in patients with periodontitis. The data indicated that the severity of periodontal tissue damage may be influenced by changes in the nucleotide sequence.
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Copy and paste a formatted citation
Spandidos Publications style
Hamrun N, Ruslin M, Marlina E, Oktawati S, Saito T, Yusuf AH and Ou K: Profile of vitamin D receptor gene polymorphism TaqI in patients with periodontitis. Biomed Rep 16: 35, 2022.
APA
Hamrun, N., Ruslin, M., Marlina, E., Oktawati, S., Saito, T., Yusuf, A.H., & Ou, K. (2022). Profile of vitamin D receptor gene polymorphism TaqI in patients with periodontitis. Biomedical Reports, 16, 35. https://doi.org/10.3892/br.2022.1518
MLA
Hamrun, N., Ruslin, M., Marlina, E., Oktawati, S., Saito, T., Yusuf, A. H., Ou, K."Profile of vitamin D receptor gene polymorphism TaqI in patients with periodontitis". Biomedical Reports 16.5 (2022): 35.
Chicago
Hamrun, N., Ruslin, M., Marlina, E., Oktawati, S., Saito, T., Yusuf, A. H., Ou, K."Profile of vitamin D receptor gene polymorphism TaqI in patients with periodontitis". Biomedical Reports 16, no. 5 (2022): 35. https://doi.org/10.3892/br.2022.1518
Copy and paste a formatted citation
x
Spandidos Publications style
Hamrun N, Ruslin M, Marlina E, Oktawati S, Saito T, Yusuf AH and Ou K: Profile of vitamin D receptor gene polymorphism TaqI in patients with periodontitis. Biomed Rep 16: 35, 2022.
APA
Hamrun, N., Ruslin, M., Marlina, E., Oktawati, S., Saito, T., Yusuf, A.H., & Ou, K. (2022). Profile of vitamin D receptor gene polymorphism TaqI in patients with periodontitis. Biomedical Reports, 16, 35. https://doi.org/10.3892/br.2022.1518
MLA
Hamrun, N., Ruslin, M., Marlina, E., Oktawati, S., Saito, T., Yusuf, A. H., Ou, K."Profile of vitamin D receptor gene polymorphism TaqI in patients with periodontitis". Biomedical Reports 16.5 (2022): 35.
Chicago
Hamrun, N., Ruslin, M., Marlina, E., Oktawati, S., Saito, T., Yusuf, A. H., Ou, K."Profile of vitamin D receptor gene polymorphism TaqI in patients with periodontitis". Biomedical Reports 16, no. 5 (2022): 35. https://doi.org/10.3892/br.2022.1518
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