Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Biomedical Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9434 Online ISSN: 2049-9442
Journal Cover
July-2022 Volume 17 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2022 Volume 17 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article Open Access

Association of DNA methylation and genetic variations of the APOE gene with the risk of diabetic dyslipidemia

  • Authors:
    • Suheir Ereqat
    • Stéphane Cauchi
    • Khaled Eweidat
    • Muawiyah Elqadi
    • Manal Ghatass
    • Anas Sabarneh
    • Abedelmajeed Nasereddin
  • View Affiliations / Copyright

    Affiliations: Biochemistry and Molecular Biology Department, Faculty of Medicine, Al‑Quds University, Abu Dis P144, Palestine, Centre National de la Recherche Scientfique (CNRS), Unité Mixte de Recherche UMR8204 Lille, France, Faculty of Medicine, Al‑Quds University, East Jerusalem, Abu Dis P144, Palestine, Palestine Medical Complex, Laboratories Division, Ramallah P606, Palestine
    Copyright: © Ereqat et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 61
    |
    Published online on: May 27, 2022
       https://doi.org/10.3892/br.2022.1544
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Apolipoprotein E (APOE) is a key regulator of lipoprotein metabolism, and consequently, affects the plasma and tissue lipid contents. The aim of the present study was to investigate the parallel effects of APOE genetic variants and promoter methylation levels of six CpGs on the risk of diabetic dyslipidemia. A total of 204 Palestinian type 2 diabetes (T2D) patients (mean age ± SD: 62.7±10.2) were enrolled in the present study (n=96 with dyslipidemia and n=108 without dyslipidemia). Next generation sequencing was performed to analyze five single nucleotide polymorphisms: Two variants rs7412 and rs429358 that determine APOE ε alleles, and three variants in the promoter region (rs769446, rs449647, and rs405509). For all subjects, the most common genotype was ε3/ε3 (79.4%). No statistical differences were observed in the APOE ε polymorphisms and the three promoter variants among T2D patients with and without dyslipidemia (P>0.05). A comparison of lipid parameters between ε3/ε3 subjects and ε4 carriers in both groups revealed no significant differences in the mean values of LDL‑C, HDL‑C, TG, and TC levels (P>0.05). Six CpG sites in the APOE promoter on chromosome 19:44905755‑44906078 were identified, and differential DNA methylation in these CpGs were observed between the study groups. Logistic regression analysis revealed a significant association of DNA methylation level at the six CpGs with an increased risk of diabetic dyslipidemia (odds ratio, 1.038; 95% confidence interval, 1.012‑1.064; P=0.004). In conclusion, the present study revealed that DNA methylation levels in six CpGs in the APOE promoter region was associated with the risk of diabetic dyslipidemia independently of the APOE ε4 variant which could be a potential therapeutic target to reverse the methylation of the APOE promoter.
View Figures

Figure 1

Figure 2

View References

1 

Yu CE and Foraker J: Epigenetic considerations of the APOE gene. [corrected]. Biomol Concepts. 6:77–84. 2015.PubMed/NCBI View Article : Google Scholar

2 

Belloy ME, Napolioni V and Greicius MD: A Quarter century of APOE and Alzheimer's disease: Progress to date and the path forward. Neuron. 101:820–838. 2019.PubMed/NCBI View Article : Google Scholar

3 

Ashiq S and Ashiq K: The association of apolipoprotein-E (APOE) gene polymorphisms with coronary artery disease: A systematic review and meta-analysis. Egypt J Med Hum Genet. 22(16)2021.

4 

Smelt AH and de Beer F: Apolipoprotein E and familial dysbetalipoproteinemia: Clinical, biochemical, and genetic aspects. Semin Vasc Med. 4:249–257. 2004.PubMed/NCBI View Article : Google Scholar

5 

Sun Y, Wei R, Yan D, Xu F, Zhang X, Zhang B, Yimiti D, Li H, Sun H, Hu C, et al: Association between APOE polymorphism and metabolic syndrome in Uyghur ethnic men. BMJ Open. 6(e010049)2016.PubMed/NCBI View Article : Google Scholar

6 

Villeneuve S, Brisson D, Marchant NL and Gaudet D: The potential applications of apolipoprotein E in personalized medicine. Front Aging Neurosci. 6(154)2014.PubMed/NCBI View Article : Google Scholar

7 

Maitland-van der Zee AH, Stricker BH, Klungel OH, Mantel-Teeuwisse AK, Kastelein JJ, Hofman A, Leufkens HG, van Duijn CM and de Boer A: Adherence to and dosing of beta-hydroxy-beta-methylglutaryl coenzyme A reductase inhibitors in the general population differs according to apolipoprotein E-genotypes. Pharmacogenetics. 13:219–223. 2003.PubMed/NCBI View Article : Google Scholar

8 

Cai C, Wen Z and Li L: The relationship between ApoE gene polymorphism and the efficacy of statins controlling hyperlipidemia. Am J Transl Res. 13:6772–6777. 2021.PubMed/NCBI

9 

Zhang L, He S, Li Z, Gan X, Li S, Cheng X, Yang N and Zheng F: Apolipoprotein E polymorphisms contribute to statin response in Chinese ASCVD patients with dyslipidemia. Lipids Health Dis. 18(129)2019.PubMed/NCBI View Article : Google Scholar

10 

Bizzarro A, Seripa D, Acciarri A, Matera MG, Pilotto A, Tiziano FD, Brahe C and Masullo C: The complex interaction between APOE promoter and AD: An Italian case-control study. Eur J Hum Genet. 17:938–945. 2009.PubMed/NCBI View Article : Google Scholar

11 

Bekris LM, Lutz F and Yu CE: Functional analysis of APOE locus genetic variation implicates regional enhancers in the regulation of both TOMM40 and APOE. J Hum Genet. 57:18–25. 2012.PubMed/NCBI View Article : Google Scholar

12 

Ciceri F, Rotllant D and Maes T: Understanding epigenetic alterations in Alzheimer's and Parkinson's disease: Towards targeted biomarkers and therapies. Curr Pharm Des. 23:839–857. 2017.PubMed/NCBI View Article : Google Scholar

13 

Bae MG, Kim JY and Choi JK: Frequent hypermethylation of orphan CpG islands with enhancer activity in cancer. BMC Med Genomics. 9 (Suppl 1)(S38)2016.PubMed/NCBI View Article : Google Scholar

14 

Kumar R, Nandhini LP, Kamalanathan S, Sahoo J and Vivekanadan M: Evidence for current diagnostic criteria of diabetes mellitus. World J Diabetes. 7:396–405. 2016.PubMed/NCBI View Article : Google Scholar

15 

Jellinger PS, Dickey RA, Ganda OP, Mehta AE, Nguyen TT, Rodbard HW, Seibel JA, Shepherd MD and Smith DA: AACE Lipid Guidelines Committee. The American Association of Clinical Endocrinologists. AACE medical guidelines for clinical practice for the diagnosis and treatment of dyslipidemia and prevention of atherogenesis. Endocr Pract. 6:162–213. 2000.PubMed/NCBI

16 

Goodyear MD, Krleza-Jeric K and Lemmens T: The declaration of Helsinki. BMJ. 335:624–625. 2007.PubMed/NCBI View Article : Google Scholar

17 

Krishnaveni P and Gowda VM: Assessing the validity of friedewald's formula and anandraja's formula for serum LDL-cholesterol calculation. J Clin Diagn Res. 9:BC01–BC04. 2015.PubMed/NCBI View Article : Google Scholar

18 

Ereqat S, Cauchi S, Eweidat K, Elqadi M and Nasereddin A: Estrogen receptor 1 gene polymorphisms (PvuII and XbaI) are associated with type 2 diabetes in Palestinian women. PeerJ. 7(e7164)2019.PubMed/NCBI View Article : Google Scholar

19 

Shao Y, Shaw M, Todd K, Khrestian M, D'Aleo G, Barnard PJ, Zahratka J, Pillai J, Yu CE, Keene CD, et al: DNA methylation of TOMM40-APOE-APOC2 in Alzheimer's disease. J Hum Genet. 63:459–471. 2018.PubMed/NCBI View Article : Google Scholar

20 

Shatwan IM, Winther KH, Ellahi B, Elwood P, Ben-Shlomo Y, Givens I, Rayman MP, Lovegrove JA and Vimaleswaran KS: Association of apolipoprotein E gene polymorphisms with blood lipids and their interaction with dietary factors. Lipids Health Dis. 17(98)2018.PubMed/NCBI View Article : Google Scholar

21 

Satizabal CL, Samieri C, Davis-Plourde KL, Voetsch B, Aparicio HJ, Pase MP, Romero JR, Helmer C, Vasan RS, Kase CS, et al: APOE and the association of fatty acids with the risk of stroke, coronary heart disease, and mortality. Stroke. 49:2822–2829. 2018.PubMed/NCBI View Article : Google Scholar

22 

Duman BS, Oztürk M, Yilmazer S and Hatemi H: Apolipoprotein E polymorphism in Turkish subjects with Type 2 diabetes mellitus: Allele frequency and relation to serum lipid concentrations. Diabetes Nutr Metab. 17:267–274. 2004.PubMed/NCBI

23 

Galal AA, Abd Elmajeed AA, Elbaz RA, Wafa AM and Elshazli RM: Association of apolipoprotein E gene polymorphism with the risk of T2DM and obesity among Egyptian subjects. Gene. 769(145223)2021.PubMed/NCBI View Article : Google Scholar

24 

Alharbi KK, Khan IA and Syed R: Association of apolipoprotein E polymorphism with type 2 diabetes mellitus in a Saudi population. DNA Cell Biol. 33:637–641. 2014.PubMed/NCBI View Article : Google Scholar

25 

Ali I, Kharma A, Samara M, Odeh S, Jaradat N, Zaid AN and Ahmad MA: Prevalence of dyslipidemia in undiagnosed palestinian men: A cross-sectional study. J Lipids. 2019(3473042)2019.PubMed/NCBI View Article : Google Scholar

26 

Bayram F, Kocer D, Gundogan K, Kaya A, Demir O, Coskun R, Sabuncu T, Karaman A, Cesur M, Rizzo M, et al: Prevalence of dyslipidemia and associated risk factors in Turkish adults. J Clin Lipidol. 8:206–216. 2014.PubMed/NCBI View Article : Google Scholar

27 

Alzahrani GS, Aljehani SM and Al-Johani JJ: Risk factors of dyslipidemia among Saudi population, 2017. Egypt J Hosp Med. 71:2262–2265. 2018.

28 

Reda A, Ragy H, Saeed K and Alhussaini MA: A semi-systematic review on hypertension and dyslipidemia care in Egypt-highlighting evidence gaps and recommendations for better patient outcomes. J Egypt Public Health Assoc. 96(32)2021.PubMed/NCBI View Article : Google Scholar

29 

Damiri B, Aghbar A, Alkhdour S and Arafat Y: Characterization and prevalence of metabolic syndrome among overweight and obese young Palestinian students at An-Najah National University. Diabetes Metab Syndr. 12:343–348. 2018.PubMed/NCBI View Article : Google Scholar

30 

Mahley RW: Central nervous system lipoproteins: ApoE and regulation of cholesterol metabolism. Arterioscler Thromb Vasc Biol. 36:1305–1315. 2016.PubMed/NCBI View Article : Google Scholar

31 

Al-Shammari S, Fatania H, Al-Radwan R and Akanji AO: Apolipoprotein E polymorphism and lipoprotein levels in a Gulf Arab population in Kuwait: A pilot study. Ann Saudi Med. 24:361–364. 2004.PubMed/NCBI View Article : Google Scholar

32 

Maratni NP, Saraswati MR, Dewi NN, Yasa I, Eka Widyadharma IP, Putra IB and Suastika K: Association of apolipoprotein E gene polymorphism with lipid profile and ischemic stroke risk in type 2 diabetes mellitus patients. J Nutr Metab. 2021(5527736)2021.PubMed/NCBI View Article : Google Scholar

33 

Srirojnopkun C, Kietrungwilaikul K, Boonsong K, Thongpoonkaew J and Jeenduang N: Association of APOE and CETP TaqIB polymorphisms with type 2 diabetes mellitus. Arch Med Res. 49:479–485. 2018.PubMed/NCBI View Article : Google Scholar

34 

Seo JY, Youn BJ, Cheong HS and Shin HD: Association of APOE genotype with lipid profiles and type 2 diabetes mellitus in a Korean population. Genes Genomics. 43:725–735. 2021.PubMed/NCBI View Article : Google Scholar

35 

Zhou T, Li H, Zhong H, Zhong Z and Lin S: Association of apoE gene polymorphisms with lipid metabolism in renal diseases. Afr Health Sci. 20:1368–1381. 2020.PubMed/NCBI View Article : Google Scholar

36 

Radwan ZH, Wang X, Waqar F, Pirim D, Niemsiri V, Hokanson JE, Hamman RF, Bunker CH, Barmada MM, Demirci FY and Kamboh MI: Comprehensive evaluation of the association of APOE genetic variation with plasma lipoprotein traits in U.S. whites and African blacks. PLoS One. 9(e114618)2014.PubMed/NCBI View Article : Google Scholar

37 

Lee EG, Tulloch J, Chen S, Leong L, Saxton AD, Kraemer B, Darvas M, Keene CD, Shutes-David A, Todd K, et al: Redefining transcriptional regulation of the APOE gene and its association with Alzheimer's disease. PLoS One. 15(e0227667)2020.PubMed/NCBI View Article : Google Scholar

38 

Rasmussen KL, Tybjaerg-Hansen A, Nordestgaard BG and Frikke-Schmidt R: APOE and dementia-resequencing and genotyping in 105,597 individuals. Alzheimers Dement. 16:1624–1637. 2020.PubMed/NCBI View Article : Google Scholar

39 

Khalil YA, Rabès JP, Boileau C and Varret M: APOE gene variants in primary dyslipidemia. Atherosclerosis. 328:11–22. 2021.PubMed/NCBI View Article : Google Scholar

40 

Karlsson IK, Ploner A, Wang Y, Gatz M, Pedersen NL and Hägg S: Apolipoprotein E DNA methylation and late-life disease. Int J Epidemiol. 47:899–907. 2018.PubMed/NCBI View Article : Google Scholar

41 

Zhang H, Zhao X, Wang C, Du R, Wang X, Fu J and Sun Q: A preliminary study of the association between apolipoprotein E promoter methylation and atherosclerotic cerebral infarction. J Stroke Cerebrovasc Dis. 28:1056–1061. 2019.PubMed/NCBI View Article : Google Scholar

42 

Mur J, McCartney DL, Walker RM, Campbell A, Bermingham ML, Morris SW, Porteous DJ, McIntosh AM, Deary IJ, Evans KL and Marioni RE: DNA methylation in APOE: The relationship with Alzheimer's and with cardiovascular health. Alzheimers Dement (NY). 6(e12026)2020.PubMed/NCBI View Article : Google Scholar

43 

Mitchell C, Schneper LM and Notterman DA: DNA methylation, early life environment, and health outcomes. Pediatr Res. 79:212–219. 2016.PubMed/NCBI View Article : Google Scholar

44 

Cacabelos R and Torrellas C: Epigenetics of aging and Alzheimer's disease: Implications for pharmacogenomics and drug response. Int J Mol Sci. 16:30483–30543. 2015.PubMed/NCBI View Article : Google Scholar

45 

Chaudhary R, Likidlilid A, Peerapatdit T, Tresukosol D, Srisuma S, Ratanamaneechat S and Sriratanasathavorn C: Apolipoprotein E gene polymorphism: Effects on plasma lipids and risk of type 2 diabetes and coronary artery disease. Cardiovasc Diabetol. 11(36)2012.PubMed/NCBI View Article : Google Scholar

46 

Liu Y, Shen Y, Guo T, Parnell LD, Westerman KE, Smith CE, Ordovas JM and Lai CQ: Statin use associates with risk of type 2 diabetes via epigenetic patterns at ABCG1. Front Genet. 11(622)2020.PubMed/NCBI View Article : Google Scholar

47 

Iqbal MS, Rahman S, Haque MA, Bhuyan MJ, Faruque ASG and Ahmed T: Lower intakes of protein, carbohydrate, and energy are associated with increased global DNA methylation in 2- to 3-year-old urban slum children in Bangladesh. Matern Child Nutr. 15(e12815)2019.PubMed/NCBI View Article : Google Scholar

48 

Hervouet E, Peixoto P, Delage-Mourroux R, Boyer-Guittaut M and Cartron PF: Specific or not specific recruitment of DNMTs for DNA methylation, an epigenetic dilemma. Clin Epigenetics. 10(17)2018.PubMed/NCBI View Article : Google Scholar

49 

Mahmoud AM and Ali MM: Methyl donor micronutrients that modify DNA methylation and cancer outcome. Nutrients. 11(608)2019.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Ereqat S, Cauchi S, Eweidat K, Elqadi M, Ghatass M, Sabarneh A and Nasereddin A: Association of DNA methylation and genetic variations of the <em>APOE</em> gene with the risk of diabetic dyslipidemia. Biomed Rep 17: 61, 2022.
APA
Ereqat, S., Cauchi, S., Eweidat, K., Elqadi, M., Ghatass, M., Sabarneh, A., & Nasereddin, A. (2022). Association of DNA methylation and genetic variations of the <em>APOE</em> gene with the risk of diabetic dyslipidemia. Biomedical Reports, 17, 61. https://doi.org/10.3892/br.2022.1544
MLA
Ereqat, S., Cauchi, S., Eweidat, K., Elqadi, M., Ghatass, M., Sabarneh, A., Nasereddin, A."Association of DNA methylation and genetic variations of the <em>APOE</em> gene with the risk of diabetic dyslipidemia". Biomedical Reports 17.1 (2022): 61.
Chicago
Ereqat, S., Cauchi, S., Eweidat, K., Elqadi, M., Ghatass, M., Sabarneh, A., Nasereddin, A."Association of DNA methylation and genetic variations of the <em>APOE</em> gene with the risk of diabetic dyslipidemia". Biomedical Reports 17, no. 1 (2022): 61. https://doi.org/10.3892/br.2022.1544
Copy and paste a formatted citation
x
Spandidos Publications style
Ereqat S, Cauchi S, Eweidat K, Elqadi M, Ghatass M, Sabarneh A and Nasereddin A: Association of DNA methylation and genetic variations of the <em>APOE</em> gene with the risk of diabetic dyslipidemia. Biomed Rep 17: 61, 2022.
APA
Ereqat, S., Cauchi, S., Eweidat, K., Elqadi, M., Ghatass, M., Sabarneh, A., & Nasereddin, A. (2022). Association of DNA methylation and genetic variations of the <em>APOE</em> gene with the risk of diabetic dyslipidemia. Biomedical Reports, 17, 61. https://doi.org/10.3892/br.2022.1544
MLA
Ereqat, S., Cauchi, S., Eweidat, K., Elqadi, M., Ghatass, M., Sabarneh, A., Nasereddin, A."Association of DNA methylation and genetic variations of the <em>APOE</em> gene with the risk of diabetic dyslipidemia". Biomedical Reports 17.1 (2022): 61.
Chicago
Ereqat, S., Cauchi, S., Eweidat, K., Elqadi, M., Ghatass, M., Sabarneh, A., Nasereddin, A."Association of DNA methylation and genetic variations of the <em>APOE</em> gene with the risk of diabetic dyslipidemia". Biomedical Reports 17, no. 1 (2022): 61. https://doi.org/10.3892/br.2022.1544
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team