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Anti‑inflammatory effect of red ginseng marc, Artemisia scoparia, Paeonia japonica and Angelica gigas extract mixture in LPS‑stimulated RAW 264.7 cells

  • Authors:
    • Jae Young Shin
    • Eun Seo Kang
    • Ji Hyeon Park
    • Byoung Ok Cho
    • Seon Il Jang
  • View Affiliations / Copyright

    Affiliations: Institute of Health and Science, Jeonju University, Jeonju‑si, Jeollabuk‑do 55069, Republic of Korea
    Copyright: © Shin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 63
    |
    Published online on: June 2, 2022
       https://doi.org/10.3892/br.2022.1546
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Abstract

A normal inflammatory response is essential in protecting the body from foreign substances. However, excessive inflammation contributes to diseases such as oxidative stress, heart disease, and cancer. In this study, we evaluated the anti‑inflammatory effects of RAPA (red ginseng marc, Artemisia scoparia Waldst.et Kit, Paeonia japonica Miyabe & Takeda, and Angelica gigas Nakai extract mixture) in LPS‑stimulated RAW 264.7 cells (macrophages). RAPA suppressed the expression of inflammatory factors such as iNOS and COX‑2 and decreased the production of nitric oxide. In addition, RAPA decreased the expression of the inflammatory cytokines TNF‑α and IL‑6. Furthermore, RAPA inhibited the phosphorylation of MAPKs such as JNK and ERK as well as IκB and NF‑κB. In conclusion, RAPA inhibited production of inflammatory mediators via downregulation of the MAPK and NF‑κB signaling pathways in LPS‑stimulated RAW 264.7 cells. The results of this study demonstrated that RAPA regulates excessive inflammatory responses at the cellular level. Therefore, it is necessary to investigate whether the same effect is observed in vivo through further research.
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Copy and paste a formatted citation
Spandidos Publications style
Shin JY, Kang ES, Park JH, Cho BO and Jang SI: Anti‑inflammatory effect of red ginseng marc, Artemisia scoparia, Paeonia japonica and Angelica gigas extract mixture in LPS‑stimulated RAW 264.7 cells. Biomed Rep 17: 63, 2022.
APA
Shin, J.Y., Kang, E.S., Park, J.H., Cho, B.O., & Jang, S.I. (2022). Anti‑inflammatory effect of red ginseng marc, Artemisia scoparia, Paeonia japonica and Angelica gigas extract mixture in LPS‑stimulated RAW 264.7 cells. Biomedical Reports, 17, 63. https://doi.org/10.3892/br.2022.1546
MLA
Shin, J. Y., Kang, E. S., Park, J. H., Cho, B. O., Jang, S. I."Anti‑inflammatory effect of red ginseng marc, Artemisia scoparia, Paeonia japonica and Angelica gigas extract mixture in LPS‑stimulated RAW 264.7 cells". Biomedical Reports 17.1 (2022): 63.
Chicago
Shin, J. Y., Kang, E. S., Park, J. H., Cho, B. O., Jang, S. I."Anti‑inflammatory effect of red ginseng marc, Artemisia scoparia, Paeonia japonica and Angelica gigas extract mixture in LPS‑stimulated RAW 264.7 cells". Biomedical Reports 17, no. 1 (2022): 63. https://doi.org/10.3892/br.2022.1546
Copy and paste a formatted citation
x
Spandidos Publications style
Shin JY, Kang ES, Park JH, Cho BO and Jang SI: Anti‑inflammatory effect of red ginseng marc, Artemisia scoparia, Paeonia japonica and Angelica gigas extract mixture in LPS‑stimulated RAW 264.7 cells. Biomed Rep 17: 63, 2022.
APA
Shin, J.Y., Kang, E.S., Park, J.H., Cho, B.O., & Jang, S.I. (2022). Anti‑inflammatory effect of red ginseng marc, Artemisia scoparia, Paeonia japonica and Angelica gigas extract mixture in LPS‑stimulated RAW 264.7 cells. Biomedical Reports, 17, 63. https://doi.org/10.3892/br.2022.1546
MLA
Shin, J. Y., Kang, E. S., Park, J. H., Cho, B. O., Jang, S. I."Anti‑inflammatory effect of red ginseng marc, Artemisia scoparia, Paeonia japonica and Angelica gigas extract mixture in LPS‑stimulated RAW 264.7 cells". Biomedical Reports 17.1 (2022): 63.
Chicago
Shin, J. Y., Kang, E. S., Park, J. H., Cho, B. O., Jang, S. I."Anti‑inflammatory effect of red ginseng marc, Artemisia scoparia, Paeonia japonica and Angelica gigas extract mixture in LPS‑stimulated RAW 264.7 cells". Biomedical Reports 17, no. 1 (2022): 63. https://doi.org/10.3892/br.2022.1546
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