β cell regeneration and novel strategies for treatment of diabetes (Review)

  • Authors:
    • Zengyang Ji
    • Min Lu
    • Huanhuan Xie
    • Honggang Yuan
    • Qing Chen
  • View Affiliations

  • Published online on: June 29, 2022     https://doi.org/10.3892/br.2022.1555
  • Article Number: 72
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Abstract

The etiology of diabetes is primarily attributed to the lack of functioning β cells, which in‑turn leads to insulin deficiency or insulin resistance, and this ultimately leads to β cell dysfunction. Restoring the number and function of β cells is an effective means of improving or even curing diabetes. β cell regeneration is a potential method for increasing the number of functioning β cells. In addition to self‑duplication of pancreatic β cells, β cells can be regenerated from embryonic stem cells, human induced pluripotent stem cells and pancreatic stem cells. Based on these mechanisms, proliferation and differentiation into functional β cells in vitro is one of the most promising strategies for treatment of diabetes. Although β cell regeneration has significant potential in the treatment of insulin‑deficient diabetes, and significant progress has been made in this regard, there remains challenges which prevent its use in the clinic.
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September-2022
Volume 17 Issue 3

Print ISSN: 2049-9434
Online ISSN:2049-9442

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Copy and paste a formatted citation
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Spandidos Publications style
Ji Z, Lu M, Xie H, Yuan H and Chen Q: β cell regeneration and novel strategies for treatment of diabetes (Review). Biomed Rep 17: 72, 2022
APA
Ji, Z., Lu, M., Xie, H., Yuan, H., & Chen, Q. (2022). β cell regeneration and novel strategies for treatment of diabetes (Review). Biomedical Reports, 17, 72. https://doi.org/10.3892/br.2022.1555
MLA
Ji, Z., Lu, M., Xie, H., Yuan, H., Chen, Q."β cell regeneration and novel strategies for treatment of diabetes (Review)". Biomedical Reports 17.3 (2022): 72.
Chicago
Ji, Z., Lu, M., Xie, H., Yuan, H., Chen, Q."β cell regeneration and novel strategies for treatment of diabetes (Review)". Biomedical Reports 17, no. 3 (2022): 72. https://doi.org/10.3892/br.2022.1555