Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Biomedical Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9434 Online ISSN: 2049-9442
Journal Cover
September-2022 Volume 17 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2022 Volume 17 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Review

β cell regeneration and novel strategies for treatment of diabetes (Review)

  • Authors:
    • Zengyang Ji
    • Min Lu
    • Huanhuan Xie
    • Honggang Yuan
    • Qing Chen
  • View Affiliations / Copyright

    Affiliations: Department of Endocrinology, Changxing County Hospital of Traditional Chinese Medicine, Huzhou, Zhejiang 313199, P.R. China
  • Article Number: 72
    |
    Published online on: June 29, 2022
       https://doi.org/10.3892/br.2022.1555
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The etiology of diabetes is primarily attributed to the lack of functioning β cells, which in‑turn leads to insulin deficiency or insulin resistance, and this ultimately leads to β cell dysfunction. Restoring the number and function of β cells is an effective means of improving or even curing diabetes. β cell regeneration is a potential method for increasing the number of functioning β cells. In addition to self‑duplication of pancreatic β cells, β cells can be regenerated from embryonic stem cells, human induced pluripotent stem cells and pancreatic stem cells. Based on these mechanisms, proliferation and differentiation into functional β cells in vitro is one of the most promising strategies for treatment of diabetes. Although β cell regeneration has significant potential in the treatment of insulin‑deficient diabetes, and significant progress has been made in this regard, there remains challenges which prevent its use in the clinic.
View Figures
View References

1 

Butler AE, Janson J, Bonner-Weir S, Ritzel R, Rizza RA and Butler PC: Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes. 52:102–110. 2003.PubMed/NCBI View Article : Google Scholar

2 

Wang P, Fiaschi-Taesch NM, Vasavada RC, Scott DK, García-Ocaña A and Stewart AF: Diabetes mellitus-advances and challenges in human β-cell proliferation. Nat Rev Endocrinol. 11:201–212. 2015.PubMed/NCBI View Article : Google Scholar

3 

Campbell-Thompson M, Fu A, Kaddis JS, Wasserfall C, Schatz DA, Pugliese A and Atkinson MA: Insulitis and beta-cell mass in the natural history of type 1 diabetes. Diabetes. 65:719–731. 2016.PubMed/NCBI View Article : Google Scholar

4 

Burke GW III, Vendrame F, Virdi SK, Ciancio G, Chen L, Ruiz P, Messinger S, Reijonen HK and Pugliese A: Lessons from pancreas transplantation in type 1 diabetes: Recurrence of islet autoimmunity. Curr Diab Rep. 15(121)2015.PubMed/NCBI View Article : Google Scholar

5 

Afelik S and Rovira M: Pancreatic beta-cell regeneration: Advances in understanding the genes and signaling pathways involved. Genome Med. 9(42)2017.PubMed/NCBI View Article : Google Scholar

6 

Levine F and Itkin-Ansari P: Beta-cell Regeneration: Neogenesis, replication or both? J Mol Med (Berl). 86:247–258. 2008.PubMed/NCBI View Article : Google Scholar

7 

Aguayo-Mazzucato C and Bonner-Weir S: Pancreatic β cell regeneration as a possible therapy for diabetes. Cell Metab. 27:57–67. 2018.PubMed/NCBI View Article : Google Scholar

8 

Benthuysen JR, Carrano AC and Sander M: Advances in beta cell replacement and regeneration strategies for treating diabetes. J Clin Invest. 126:3651–3660. 2016.PubMed/NCBI View Article : Google Scholar

9 

Xu X, D'Hoker J, Stangé G, Bonné S, De Leu N, Xiao X, Van de Casteele M, Mellitzer G, Ling Z, Pipeleers D, et al: Beta cells can be generated from endogenous progenitors in injured adult mouse pancreas. Cell. 132:197–207. 2008.PubMed/NCBI View Article : Google Scholar

10 

Li WC, Rukstalis JM, Nishimura W, Tchipashvili V, Habener JF, Sharma A and Bonner-Weir S: Activation of pancreatic-duct-derived progenitor cells during pancreas regeneration in adult rats. J Cell Sci. 123 (Pt 16):2792–2802. 2010.PubMed/NCBI View Article : Google Scholar

11 

Dor Y, Brown J, Martinez OI and Melton DA: Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation. Nature. 429:41–46. 2004.PubMed/NCBI View Article : Google Scholar

12 

Teta M, Rankin MM, Long SY, Stein GM and Kushner JA: Growth and regeneration of adult beta cells does not involve specialized progenitors. Dev Cell. 12:817–826. 2007.PubMed/NCBI View Article : Google Scholar

13 

Thorel F, Népote V, Avril I, Kohno K, Desgraz R, Chera S and Herrera PL: Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell loss. Nature. 464:1149–1154. 2010.PubMed/NCBI View Article : Google Scholar

14 

Chera S, Baronnier D, Ghila L, Cigliola V, Jensen JN, Gu G, Furuyama K, Thorel F, Gribble FM, Reimann F and Herrera PL: Diabetes recovery by age-dependent conversion of pancreatic δ-cells into insulin producers. Nature. 514:503–507. 2014.PubMed/NCBI View Article : Google Scholar

15 

Avrahami D, Li C, Yu M, Jiao Y, Zhang J, Naji A, Ziaie S, Glaser B and Kaestner KH: Targeting the cell cycle inhibitor p57Kip2 promotes adult human β cell replication. J Clin Invest. 124:670–674. 2014.PubMed/NCBI View Article : Google Scholar

16 

Courtney M, Gjernes E, Druelle N, Ravaud C, Vieira A, Ben-Othman N, Pfeifer A, Avolio F, Leuckx G, Lacas-Gervais S, et al: The inactivation of Arx in pancreatic α-cells triggers their neogenesis and conversion into functional β-like cells. PLoS Genet. 9(e1003934)2013.PubMed/NCBI View Article : Google Scholar

17 

Lilly MA, Davis MF, Fabie JE, Terhune EB and Gallicano GI: Current stem cell based therapies in diabetes. Am J Stem Cells. 5:87–98. 2016.PubMed/NCBI

18 

Domínguez-Bendala J, Lanzoni G, Klein D, Álvarez-Cubela S and Pastori RL: The human endocrine pancreas: New insights on replacement and regeneration. Trends Endocrinol Metab. 27:153–162. 2016.PubMed/NCBI View Article : Google Scholar

19 

D'Amour KA, Bang AG, Eliazer S, Kelly OG, Agulnick AD, Smart NG, Moorman MA, Kroon E, Carpenter MK and Baetge EE: Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells. Nat Biotechnol. 24:1392–1401. 2006.PubMed/NCBI View Article : Google Scholar

20 

Kroon E, Martinson LA, Kadoya K, Bang AG, Kelly OG, Eliazer S, Young H, Richardson M, Smart NG, Cunningham J, et al: Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo. Nat Biotechnol. 26:443–452. 2008.PubMed/NCBI View Article : Google Scholar

21 

Rezania A, Bruin JE, Riedel MJ, Mojibian M, Asadi A, Xu J, Gauvin R, Narayan K, Karanu F, O'Neil JJ, et al: Maturation of human embryonic stem cell-derived pancreatic progenitors into functional islets capable of treating pre-existing diabetes in mice. Diabetes. 61:2016–2029. 2012.PubMed/NCBI View Article : Google Scholar

22 

Pagliuca FW, Millman JR, Gürtler M, Segel M, Van Dervort A, Ryu JH, Peterson QP, Greiner D and Melton DA: Generation of functional human pancreatic beta cells in vitro. Cell. 159:428–439. 2014.PubMed/NCBI View Article : Google Scholar

23 

Bruin JE, Rezania A, Xu J, Narayan K, Fox JK, O'Neil JJ and Kieffer TJ: Maturation and function of human embryonic stem cell-derived pancreatic progenitors in macroencapsulation devices following transplant into mice. Diabetologia. 56:1987–1998. 2013.PubMed/NCBI View Article : Google Scholar

24 

Kirk K, Hao E, Lahmy R and Itkin-Ansari P: Human embryonic stem cell derived islet progenitors mature inside an encapsulation device without evidence of increased biomass or cell escape. Stem Cell Res. 12:807–814. 2014.PubMed/NCBI View Article : Google Scholar

25 

Vegas AJ, Veiseh O, Gürtler M, Millman JR, Pagliuca FW, Bader AR, Doloff JC, Li J, Chen M, Olejnik K, et al: Long-term glycemic control using polymer-encapsulated human stem cell-derived beta cells in immune-competent mice. Nat Med. 22:306–311. 2016.PubMed/NCBI View Article : Google Scholar

26 

Xie R, Everett LJ, Lim HW, Patel NA, Schug J, Kroon E, Kelly OG, Wang A, D'Amour KA, Robins AJ, et al: Dynamic chromatin remodeling mediated by polycomb proteins orchestrates pancreatic differentiation of human embryonic stem cells. Cell Stem Cell. 12:224–237. 2013.PubMed/NCBI View Article : Google Scholar

27 

Rezania A, Bruin JE, Arora P, Rubin A, Batushansky I, Asadi A, O'Dwyer S, Quiskamp N, Mojibian M, Albrecht T, et al: Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells. Nat Biotechnol. 32:1121–1133. 2014.PubMed/NCBI View Article : Google Scholar

28 

Millman JR, Xie C, Van Dervort A, Gürtler M, Pagliuca FW and Melton DA: Generation of stem cell-derived beta-cells from patients with type 1 diabetes. Nat Commun. 7(11463)2016.PubMed/NCBI View Article : Google Scholar

29 

Navarro-Tableros V, Gomez Y, Brizzi MF and Camussi G: Generation of human stem cell-derived pancreatic organoids (POs) for regenerative medicine. Adv Exp Med Biol. 1212:179–220. 2020.PubMed/NCBI View Article : Google Scholar

30 

Van de Casteele M, Leuckx G, Baeyens L, Cai Y, Yuchi Y, Coppens V, De Groef S, Eriksson M, Svensson C, Ahlgren U, et al: Neurogenin 3+ cells contribute to β-cell neogenesis and proliferation in injured adult mouse pancreas. Cell Death Dis. 4(e523)2013.PubMed/NCBI View Article : Google Scholar

31 

Lee SH, Hao E and Levine F: β-Cell replication and islet neogenesis following partial pancreatectomy. Islets. 3:188–195. 2011.PubMed/NCBI View Article : Google Scholar

32 

Gao R, Ustinov J, Korsgren O and Otonkoski T: In vitro neogenesis of human islets reflects the plasticity of differentiated human pancreatic cells. Diabetologia. 48:2296–2304. 2005.PubMed/NCBI View Article : Google Scholar

33 

Lechner A, Nolan AL, Blacken RA and Habener JF: Redifferentiation of insulin-secreting cells after in vitro expansion of adult human pancreatic islet tissue. Biochem Biophys Res Commun. 327:581–588. 2005.PubMed/NCBI View Article : Google Scholar

34 

Gershengorn MC, Hardikar AA, Wei C, Geras-Raaka E, Marcus-Samuels B and Raaka BM: Epithelial-to-mesenchymal transition generates proliferative human islet precursor cells. Science. 306:2261–2264. 2004.PubMed/NCBI View Article : Google Scholar

35 

Seaberg RM, Smukler SR, Kieffer TJ, Enikolopov G, Asghar Z, Wheeler MB, Korbutt G and van der Kooy D: Clonal identification of multipotent precursors from adult mouse pancreas that generate neural and pancreatic lineages. Nat Biotechnol. 22:1115–1124. 2004.PubMed/NCBI View Article : Google Scholar

36 

Bonner-Weir S, Toschi E, Inada A, Reitz P, Fonseca SY, Aye T and Sharma A: The pancreatic ductal epithelium serves as a potential pool of progenitor cells. Pediatr Diabetes. 5 (Suppl 2):S16–S22. 2004.PubMed/NCBI View Article : Google Scholar

37 

Otonkoski T, Gao R and Lundin K: Stem cells in the treatment of diabetes. Ann Med. 37:513–520. 2005.PubMed/NCBI View Article : Google Scholar

38 

Corritore E, Lee YS, Sokal EM and Lysy PA: β-cell replacement sources for type 1 diabetes: A focus on pancreatic ductal cells. Ther Adv Endocrinol Metab. 7:182–199. 2016.PubMed/NCBI View Article : Google Scholar

39 

Ramiya VK, Maraist M, Arfors KE, Schatz DA, Peck AB and Cornelius JG: Reversal of insulin-dependent diabetes using islets generated in vitro from pancreatic stem cells. Nat Med. 6:278–282. 2000.PubMed/NCBI View Article : Google Scholar

40 

Bonner-Weir S, Taneja M, Weir GC, Tatarkiewicz K, Song KH, Sharma A and O'Neil JJ: In vitro cultivation of human islets from expanded ductal tissue. Proc Natl Acad Sci USA. 97:7999–8004. 2000.PubMed/NCBI View Article : Google Scholar

41 

Gmyr V, Belaich S, Muharram G, Lukowiak B, Vandewalle B, Pattou F and Kerr-Conte J: Rapid purification of human ductal cells from human pancreatic fractions with surface antibody CA19-9. Biochem Biophys Res Commun. 320:27–33. 2004.PubMed/NCBI View Article : Google Scholar

42 

Lee J, Sugiyama T, Liu Y, Wang J, Gu X, Lei J, Markmann JF, Miyazaki S, Miyazaki J, Szot GL, et al: Expansion and conversion of human pancreatic ductal cells into insulin-secreting endocrine cells. Elife. 2(e00940)2013.PubMed/NCBI View Article : Google Scholar

43 

Yatoh S, Dodge R, Akashi T, Omer A, Sharma A, Weir GC and Bonner-Weir S: Differentiation of affinity-purified human pancreatic duct cells to beta-cells. Diabetes. 56:1802–1809. 2007.PubMed/NCBI View Article : Google Scholar

44 

Rescan C, Le Bras S, Lefebvre VH, Frandsen U, Klein T, Foschi M, Pipeleers DG, Scharfmann R, Madsen OD and Heimberg H: EGF-induced proliferation of adult human pancreatic duct cells is mediated by the MEK/ERK cascade. Lab Invest. 85:65–74. 2005.PubMed/NCBI View Article : Google Scholar

45 

Hoesli CA, Johnson JD and Piret JM: Purified human pancreatic duct cell culture conditions defined by serum-free high-content growth factor screening. PLoS One. 7(e33999)2012.PubMed/NCBI View Article : Google Scholar

46 

Abdel Aziz MT, El-Asmar MF, Rezq AM, Mahfouz SM, Wassef MA, Fouad HH, Ahmed HH and Taha FM: The effect of a novel curcumin derivative on pancreatic islet regeneration in experimental type-1 diabetes in rats (long term study). Diabetol Metab Syndr. 5(75)2013.PubMed/NCBI View Article : Google Scholar

47 

Stolovich-Rain M, Hija A, Grimsby J, Glaser B and Dor Y: Pancreatic beta cells in very old mice retain capacity for compensatory proliferation. J Biol Chem. 287:27407–27414. 2012.PubMed/NCBI View Article : Google Scholar

48 

Al-Hasani K, Pfeifer A, Courtney M, Ben-Othman N, Gjernes E, Vieira A, Druelle N, Avolio F, Ravassard P, Leuckx G, et al: Adult duct-lining cells can reprogram into β-like cells able to counter repeated cycles of toxin-induced diabetes. Dev Cell. 26:86–100. 2013.PubMed/NCBI View Article : Google Scholar

49 

Collombat P, Xu X, Ravassard P, Sosa-Pineda B, Dussaud S, Billestrup N, Madsen OD, Serup P, Heimberg H and Mansouri A: The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells. Cell. 138:449–462. 2009.PubMed/NCBI View Article : Google Scholar

50 

Pfeifer A, Courtney M, Ben-Othman N, Al-Hasani K, Gjernes E, Vieira A, Druelle N, Avolio F, Faurite B, Mansouri A and Collombat P: Induction of multiple cycles of pancreatic β-cell replacement. Cell Cycle. 12:3243–3244. 2013.PubMed/NCBI View Article : Google Scholar

51 

Gu D and Sarvetnick N: Epithelial cell proliferation and islet neogenesis in IFN-g transgenic mice. Development. 118:33–46. 1993.PubMed/NCBI View Article : Google Scholar

52 

Wang TC, Bonner-Weir S, Oates PS, Chulak M, Simon B, Merlino GT, Schmidt EV and Brand SJ: Pancreatic gastrin stimulates islet differentiation of transforming growth factor alpha-induced ductular precursor cells. J Clin Invest. 92:1349–1356. 1993.PubMed/NCBI View Article : Google Scholar

53 

Sancho R, Gruber R, Gu G and Behrens A: Loss of Fbw7 reprograms adult pancreatic ductal cells into α, δ, and β cells. Cell Stem Cell. 15:139–153. 2014.PubMed/NCBI View Article : Google Scholar

54 

Baeyens L, De Breuck S, Lardon J, Mfopou JK, Rooman I and Bouwens L: In vitro generation of insulin-producing beta cells from adult exocrine pancreatic cells. Diabetologia. 48:49–57. 2005.PubMed/NCBI View Article : Google Scholar

55 

Baeyens L, Lemper M, Leuckx G, De Groef S, Bonfanti P, Stangé G, Shemer R, Nord C, Scheel DW, Pan FC, et al: Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice. Nat Biotechnol. 32:76–83. 2014.PubMed/NCBI View Article : Google Scholar

56 

Rong Z, Wang M, Hu Z, Stradner M, Zhu S, Kong H, Yi H, Goldrath A, Yang YG, Xu Y and Fu X: An effective approach to prevent immune rejection of human ESC-derived allografts. Cell Stem Cell. 14:121–130. 2014.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Ji Z, Lu M, Xie H, Yuan H and Chen Q: β cell regeneration and novel strategies for treatment of diabetes (Review). Biomed Rep 17: 72, 2022.
APA
Ji, Z., Lu, M., Xie, H., Yuan, H., & Chen, Q. (2022). β cell regeneration and novel strategies for treatment of diabetes (Review). Biomedical Reports, 17, 72. https://doi.org/10.3892/br.2022.1555
MLA
Ji, Z., Lu, M., Xie, H., Yuan, H., Chen, Q."β cell regeneration and novel strategies for treatment of diabetes (Review)". Biomedical Reports 17.3 (2022): 72.
Chicago
Ji, Z., Lu, M., Xie, H., Yuan, H., Chen, Q."β cell regeneration and novel strategies for treatment of diabetes (Review)". Biomedical Reports 17, no. 3 (2022): 72. https://doi.org/10.3892/br.2022.1555
Copy and paste a formatted citation
x
Spandidos Publications style
Ji Z, Lu M, Xie H, Yuan H and Chen Q: β cell regeneration and novel strategies for treatment of diabetes (Review). Biomed Rep 17: 72, 2022.
APA
Ji, Z., Lu, M., Xie, H., Yuan, H., & Chen, Q. (2022). β cell regeneration and novel strategies for treatment of diabetes (Review). Biomedical Reports, 17, 72. https://doi.org/10.3892/br.2022.1555
MLA
Ji, Z., Lu, M., Xie, H., Yuan, H., Chen, Q."β cell regeneration and novel strategies for treatment of diabetes (Review)". Biomedical Reports 17.3 (2022): 72.
Chicago
Ji, Z., Lu, M., Xie, H., Yuan, H., Chen, Q."β cell regeneration and novel strategies for treatment of diabetes (Review)". Biomedical Reports 17, no. 3 (2022): 72. https://doi.org/10.3892/br.2022.1555
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team