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Article Open Access

Factors associated with favorable outcomes in acute severe stroke patients: A real‑world, national database study

  • Authors:
    • Narongrit Kasemsap
    • Nisa Vorasoot
    • Kannikar Kongbunkiat
    • Somsak Tiamkao
    • Watchara Boonsawat
    • Kittisak Sawanyawisuth
  • View Affiliations / Copyright

    Affiliations: Department of Medicine and North‑Eastern Stroke Research Group, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
    Copyright: © Kasemsap et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 74
    |
    Published online on: July 22, 2022
       https://doi.org/10.3892/br.2022.1557
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Abstract

Thrombolytic therapy is useful in severe stroke, but it increases the risk of intracerebral hemorrhage. In addition, it may have limited use in resource‑limited due to a lack of trained neurologists and equipment to perform CT scans. There are limited data available from studies of national databases on stroke outcomes and predictors of severe stroke. This study, therefore, aimed to evaluate acute severe ischemic stroke outcomes in a real‑world setting. Additionally, predictors of favorable stroke outcomes were explored using a retrospective cohort. Data were extracted from the National Health Security Office (NHSO) in Thailand. The inclusion criteria were: Aged ≥18 years or older, diagnosis of acute severe ischemic stroke (defined by an admission National Institutes of Health Stroke Scale score of 15‑24), and available data on stroke outcomes. Outcomes were evaluated at discharge using a modified Rankin score at discharge. Factors associated with good outcomes were determined using multivariate logistic regression analysis. During the study period, 268 severe stroke patients met the inclusion criteria. Of those, 38 (14.18%) had good outcomes at discharge. A total of 223 patients received intravenous recombinant tissue plasminogen activator (83.21%). Of those, 38 (17.04%) had favorable outcomes. A predictive model for good outcomes revealed two independent factors: Male sex and atrial fibrillation with adjusted odds ratios (95% confidence interval) of 2.30 (1.10‑4.82) and 0.38 (0.16‑0.91), respectively. Predictors for good stroke outcomes in severe stroke patients included rtPA treatment, atrial fibrillation, and male sex.
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1 

Wu S, Yuan R, Xiong Y, Zhang S, Wu B and Liu M: Clinical features, management and outcomes of severe ischaemic stroke in tertiary hospitals in China: Protocol for a prospective multicentre registry-based observational study. BMJ Open. 8(e024900)2018.PubMed/NCBI View Article : Google Scholar

2 

Bill O, Zufferey P, Faouzi M and Michel P: Severe stroke: Patient profile and predictors of favorable outcome. J Thromb Haemost. 11:92–99. 2013.PubMed/NCBI View Article : Google Scholar

3 

Huttner HB and Schwab S: Malignant middle cerebral artery infarction: Clinical characteristics, treatment strategies, and future perspectives. Lancet Neurol. 8:949–958. 2009.PubMed/NCBI View Article : Google Scholar

4 

Emberson J, Lees KR, Lyden P, Blackwell L, Albers G, Bluhmki E, Brott T, Cohen G, Davis S, Donnan G, et al: Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: A meta-analysis of individual patient data from randomised trials. Lancet. 384:1929–1935. 2014.PubMed/NCBI View Article : Google Scholar

5 

National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. Tissue plasminogen activator for acute ischemic stroke. N Engl J Med. 333:1581–1587. 1995.PubMed/NCBI View Article : Google Scholar

6 

Suwanwela NC, Chutinet A and Kijpaisalratana N: Thrombolytic treatment in Thailand. J Stroke Med. 1:41–44. 2018.

7 

Dharmasaroja PA, Dharmasaroja P and Muengtaweepongsa S: Outcomes of Thai patients with acute ischemic stroke after intravenous thrombolysis. J Neurol Sci. 300:74–77. 2011.PubMed/NCBI View Article : Google Scholar

8 

Banks JL and Marotta CA: Outcomes validity and reliability of the modified Rankin scale: Implications for stroke clinical trials: A literature review and synthesis. Stroke. 38:1091–1096. 2007.PubMed/NCBI View Article : Google Scholar

9 

Quinn TJ, Langhorne P and Stott DJ: Barthel index for stroke trials: Development, properties, and application. Stroke. 42:1146–1151. 2011.PubMed/NCBI View Article : Google Scholar

10 

R Core Team (R Foundation for Statistical Computing): R: A Language and Environment for Statistical Computing. Vienna, 2021.

11 

Mazya MV, Lees KR, Collas D, Rand VM, Mikulik R, Toni D, Wahlgren N and Ahmed N: IV thrombolysis in very severe and severe ischemic stroke: Results from the SITS-ISTR Registry. Neurology. 85:2098–2106. 2015.PubMed/NCBI View Article : Google Scholar

12 

Sharma S, Mazya MV, Wahlgren N and Ahmed N: IV thrombolysis in very severe and severe ischemic stroke: Results from the SITS-ISTR Registry. Neurology. 86(2115)2016.PubMed/NCBI View Article : Google Scholar

13 

Kongbunkiat K, Kasemsap N, Thepsuthammarat K, Tiamkao S and Sawanyawisuth K: National data on stroke outcomes in Thailand. J Clin Neurosci. 22:493–497. 2015.PubMed/NCBI View Article : Google Scholar

14 

Appelros P, Nydevik I, Seiger A and Terént A: Predictors of severe stroke: Influence of preexisting dementia and cardiac disorders. Stroke. 33:2357–2362. 2002.PubMed/NCBI View Article : Google Scholar

15 

Jørgensen HS, Nakayama H, Reith J, Raaschou HO and Olsen TS: Acute stroke with atrial fibrillation. The Copenhagen stroke study. Stroke. 27:1765–1769. 1996.PubMed/NCBI View Article : Google Scholar

16 

Yoo J, Song D, Baek JH, Kim YD, Nam HS, Hong GR, Kim J, Lee HS and Heo JH: Poor outcome of stroke patients with atrial fibrillation in the presence of coexisting spontaneous echo contrast. Stroke. 47:1920–1922. 2016.PubMed/NCBI View Article : Google Scholar

17 

Junejo RT, Braz ID, Lucas SJ, van Lieshout JJ, Phillips AA, Lip GY and Fisher JP: Neurovascular coupling and cerebral autoregulation in atrial fibrillation. J Cereb Blood Flow Metab. 40:1647–1657. 2020.PubMed/NCBI View Article : Google Scholar

18 

Liebeskind DS: Collateral circulation. Stroke. 34:2279–2284. 2003.PubMed/NCBI View Article : Google Scholar

19 

Guglielmi V, LeCouffe NE, Zinkstok SM, Compagne KC, Eker R, Treurniet KM, Tolhuisen ML, van der Worp HB, Jansen IG, van Oostenbrugge RJ, et al: Collateral circulation and outcome in atherosclerotic versus cardioembolic cerebral large vessel occlusion. Stroke. 50:3360–3368. 2019.PubMed/NCBI View Article : Google Scholar

20 

Kimura K, Iguchi Y, Yamashita S, Shibazaki K, Kobayashi K and Inoue T: Atrial fibrillation as an independent predictor for no early recanalization after IV-t-PA in acute ischemic stroke. J Neurol Sci. 267:57–61. 2008.PubMed/NCBI View Article : Google Scholar

21 

Vinding NE, Kristensen SL, Rørth R, Butt JH, Østergaard L, Olesen JB, Torp-Pedersen C, Gislason GH, Køber L, Kruuse C, et al: Ischemic stroke severity and mortality in patients with and without atrial fibrillation. J Am Heart Assoc. 11(e022638)2022.PubMed/NCBI View Article : Google Scholar

22 

Girijala RL, Sohrabji F and Bush RL: Sex differences in stroke: Review of current knowledge and evidence. Vasc Med. 22:135–145. 2017.PubMed/NCBI View Article : Google Scholar

23 

Gall SL, Donnan G, Dewey HM, Macdonel R, Sturm J, Gilligan A, Srikanth V and Thrift AG: Sex differences in presentation, severity, and management of stroke in a population-based study. Neurology. 74:975–981. 2010.PubMed/NCBI View Article : Google Scholar

24 

Andrade JG, Deyell MW, Lee AY and Macle L: Sex differences in atrial fibrillation. Can J Cardiol. 34:429–436. 2018.PubMed/NCBI View Article : Google Scholar

25 

Sawunyavisuth B: What are predictors for a continuous positive airway pressure machine purchasing in obstructive sleep apnea patients? Asia Pac J Sci Technol. 23(APST-23-03-10)2018.

26 

Jeerasuwannakul B, Sawunyavisuth B, Khamsai S and Sawanyawisuth K: Prevalence and risk factors of proteinuria in patients with type 2 diabetes mellitus. Asia Pac J Sci Technol. 26(APST-26-04-02)2021.

27 

Khamsai S, Chootrakool A, Limpawattana P, Chindaprasirt J, Sukeepaisarnjaroen W, Chotmongkol V, Silaruks S, Senthong V, Sittichanbuncha Y, Sawunyavisuth B and Sawanyawisuth K: Hypertensive crisis in patients with obstructive sleep apnea-induced hypertension. BMC Cardiovasc Disord. 21(310)2021.PubMed/NCBI View Article : Google Scholar

28 

Khamsai S, Mahawarakorn P, Limpawattana P, Chindaprasirt J, Sukeepaisarnjaroen W, Silaruks S, Senthong V, Sawunyavisuth B and Sawanyawisuth K: Prevalence and factors correlated with hypertension secondary from obstructive sleep apnea. Multidiscip Respir Med. 16(777)2021.PubMed/NCBI View Article : Google Scholar

29 

Soontornrungsun B, Khamsai S, Sawunyavisuth B, Limpawattana P, Chindaprasirt J, Senthong V, Chotmongkol V and Sawanyawisuth K: Obstructive sleep apnea in patients with diabetes less than 40 years of age. Diabetes Metab Syndr. 14:1859–1863. 2020.PubMed/NCBI View Article : Google Scholar

30 

Yaranov DM, Smyrlis A, Usatii N, Butler A, Petrini JR, Mendez J and Warshofsky MK: Effect of obstructive sleep apnea on frequency of stroke in patients with atrial fibrillation. Am J Cardiol. 115:461–465. 2015.PubMed/NCBI View Article : Google Scholar

31 

Kaewkes C, Sawanyawisuth K and Sawunyavisuth B: Are symptoms of obstructive sleep apnoea related to good continuous positive airway pressure compliance? ERJ Open Res. 6:00169–02019. 2020.PubMed/NCBI View Article : Google Scholar

32 

Manasirisuk P, Chainirun N, Tiamkao S, Lertsinudom S, Phunikhom K, Sawunyavisuth B and Sawanyawisuth K: Efficacy of generic atorvastatin in a real-world setting. Clin Pharmacol. 13:45–51. 2021.PubMed/NCBI View Article : Google Scholar

33 

Sawunyavisuth B, Ngamjarus C and Sawanyawisuth K: Any effective intervention to improve CPAP adherence in children with obstructive sleep apnea: A systematic review. Glob Pediatr Health:. 8(2333794X211019884)2021.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Kasemsap N, Vorasoot N, Kongbunkiat K, Tiamkao S, Boonsawat W and Sawanyawisuth K: Factors associated with favorable outcomes in acute severe stroke patients: A real‑world, national database study. Biomed Rep 17: 74, 2022.
APA
Kasemsap, N., Vorasoot, N., Kongbunkiat, K., Tiamkao, S., Boonsawat, W., & Sawanyawisuth, K. (2022). Factors associated with favorable outcomes in acute severe stroke patients: A real‑world, national database study. Biomedical Reports, 17, 74. https://doi.org/10.3892/br.2022.1557
MLA
Kasemsap, N., Vorasoot, N., Kongbunkiat, K., Tiamkao, S., Boonsawat, W., Sawanyawisuth, K."Factors associated with favorable outcomes in acute severe stroke patients: A real‑world, national database study". Biomedical Reports 17.3 (2022): 74.
Chicago
Kasemsap, N., Vorasoot, N., Kongbunkiat, K., Tiamkao, S., Boonsawat, W., Sawanyawisuth, K."Factors associated with favorable outcomes in acute severe stroke patients: A real‑world, national database study". Biomedical Reports 17, no. 3 (2022): 74. https://doi.org/10.3892/br.2022.1557
Copy and paste a formatted citation
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Spandidos Publications style
Kasemsap N, Vorasoot N, Kongbunkiat K, Tiamkao S, Boonsawat W and Sawanyawisuth K: Factors associated with favorable outcomes in acute severe stroke patients: A real‑world, national database study. Biomed Rep 17: 74, 2022.
APA
Kasemsap, N., Vorasoot, N., Kongbunkiat, K., Tiamkao, S., Boonsawat, W., & Sawanyawisuth, K. (2022). Factors associated with favorable outcomes in acute severe stroke patients: A real‑world, national database study. Biomedical Reports, 17, 74. https://doi.org/10.3892/br.2022.1557
MLA
Kasemsap, N., Vorasoot, N., Kongbunkiat, K., Tiamkao, S., Boonsawat, W., Sawanyawisuth, K."Factors associated with favorable outcomes in acute severe stroke patients: A real‑world, national database study". Biomedical Reports 17.3 (2022): 74.
Chicago
Kasemsap, N., Vorasoot, N., Kongbunkiat, K., Tiamkao, S., Boonsawat, W., Sawanyawisuth, K."Factors associated with favorable outcomes in acute severe stroke patients: A real‑world, national database study". Biomedical Reports 17, no. 3 (2022): 74. https://doi.org/10.3892/br.2022.1557
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