|
1
|
McDonald PC, Chafe SC, Brown WS, Saberi S,
Swayampakula M, Venkateswaran G, Nemirovsky O, Gillespie JA,
Karasinska JM, Kalloger SE, et al: Regulation of pH by carbonic
anhydrase 9 mediates survival of pancreatic cancer cells with
activated KRAS in response to hypoxia. Gastroenterology.
157:823–837. 2019.PubMed/NCBI View Article : Google Scholar
|
|
2
|
Dalla Pozza E, Dando I, Biondani G, Brandi
J, Costanzo C, Zoratti E, Fassan M, Boschi F, Melisi D, Cecconi D,
et al: Pancreatic ductal adenocarcinoma cell lines display a
plastic ability to bi-directionally convert into cancer stem cells.
Int J Oncol. 46:1099–1108. 2015.PubMed/NCBI View Article : Google Scholar
|
|
3
|
Nakazawa MS, Keith B and Simon MC: Oxygen
availability and metabolic adaptations. Nat Rev Cancer. 16:663–673.
2016.PubMed/NCBI View Article : Google Scholar
|
|
4
|
Keeley TP and Mann GE: Defining
physiological normoxia for improved translation of cell physiology
to animal models and humans. Physiol Rev. 99:161–234.
2019.PubMed/NCBI View Article : Google Scholar
|
|
5
|
Silverman HS, Wei S, Haigney MC, Ocampo CJ
and Stern MD: Myocyte adaptation to chronic hypoxia and development
of tolerance to subsequent acute severe hypoxia. Circ Res.
80:699–707. 1997.PubMed/NCBI View Article : Google Scholar
|
|
6
|
Butturini E, Carcereri de Prati A, Boriero
D and Mariotto S: Tumor Dormancy and interplay with hypoxic tumor
microenvironment. Int J Mol Sci. 20(4305)2019.PubMed/NCBI View Article : Google Scholar
|
|
7
|
Al Tameemi W, Dale TP, Al-Jumaily RMK and
Forsyth NR: Hypoxia-modified cancer cell metabolism. Front Cell Dev
Biol. 7(4)2019.PubMed/NCBI View Article : Google Scholar
|
|
8
|
Vaupel P and Harrison L: Tumor hypoxia:
Causative factors, compensatory mechanisms, and cellular response.
Oncologist. 9 (Suppl 5):S4–S9. 2004.PubMed/NCBI View Article : Google Scholar
|
|
9
|
Schito L and Rey S: Hypoxic pathobiology
of breast cancer metastasis. Biochim Biophys Acta Rev Cancer.
1868:239–245. 2017.PubMed/NCBI View Article : Google Scholar
|
|
10
|
Wolff M, Kosyna FK, Dunst J, Jelkmann W
and Depping R: Impact of hypoxia inducible factors on estrogen
receptor expression in breast cancer cells. Arch Biochem Biophys.
613:23–30. 2017.PubMed/NCBI View Article : Google Scholar
|
|
11
|
Goda N and Kanai M: Hypoxia-inducible
factors and their roles in energy metabolism. Int J Hematol.
95:457–463. 2012.PubMed/NCBI View Article : Google Scholar
|
|
12
|
Hu CJ, Wang LY, Chodosh LA, Keith B and
Simon MC: Differential roles of hypoxia-inducible factor 1alpha
(HIF-1alpha) and HIF-2alpha in hypoxic gene regulation. Mol Cell
Biol. 23:9361–9374. 2003.PubMed/NCBI View Article : Google Scholar
|
|
13
|
Masoud GN and Li W: HIF-1α pathway: Role,
regulation and intervention for cancer therapy. Acta Pharm Sin B.
5:378–389. 2015.PubMed/NCBI View Article : Google Scholar
|
|
14
|
Shao C, Yang F, Miao S, Liu W, Wang C, Shu
Y and Shen H: Role of hypoxia-induced exosomes in tumor biology.
Mol Cancer. 17(120)2018.PubMed/NCBI View Article : Google Scholar
|
|
15
|
Hannafon BN and Ding WQ: Intercellular
communication by exosome-derived microRNAs in cancer. Int J Mol
Sci. 14:14240–14269. 2013.PubMed/NCBI View Article : Google Scholar
|
|
16
|
Milane L, Singh A, Mattheolabakis G,
Suresh M and Amiji MM: Exosome mediated communication within the
tumor microenvironment. J Control Release. 219:278–294.
2015.PubMed/NCBI View Article : Google Scholar
|
|
17
|
Valadi H, Ekström K, Bossios A, Sjöstrand
M, Lee JJ and Lötvall JO: Exosome-mediated transfer of mRNAs and
microRNAs is a novel mechanism of genetic exchange between cells.
Nat Cell Biol. 9:654–659. 2007.PubMed/NCBI View Article : Google Scholar
|
|
18
|
Umezu T, Tadokoro H, Azuma K, Yoshizawa S,
Ohyashiki K and Ohyashiki JH: Exosomal miR-135b shed from hypoxic
multiple myeloma cells enhances angiogenesis by targeting
factor-inhibiting HIF-1. Blood. 124:3748–3757. 2014.PubMed/NCBI View Article : Google Scholar
|
|
19
|
Denko NC: Hypoxia, HIF1 and glucose
metabolism in the solid tumour. Nat Rev Cancer. 8:705–713.
2008.PubMed/NCBI View Article : Google Scholar
|
|
20
|
Li B, Qiu B, Lee DS, Walton ZE, Ochocki
JD, Mathew LK, Mancuso A, Gade TP, Keith B, Nissim I and Simon MC:
Fructose-1, 6-bisphosphatase opposes renal carcinoma progression.
Nature. 513:251–255. 2014.PubMed/NCBI View Article : Google Scholar
|
|
21
|
Xie C, Yagai T, Luo Y, Liang X, Chen T,
Wang Q, Sun D, Zhao J, Ramakrishnan SK, Sun L, et al: Activation of
intestinal hypoxia-inducible factor 2α during obesity contributes
to hepatic steatosis. Nat Med. 23:1298–1308. 2017.PubMed/NCBI View Article : Google Scholar
|
|
22
|
Jia D, Lu M, Jung KH, Park JH, Yu L,
Onuchic JN, Kaipparettu BA and Levine H: Elucidating cancer
metabolic plasticity by coupling gene regulation with metabolic
pathways. Proc Natl Acad Sci USA. 116:3909–3918. 2019.PubMed/NCBI View Article : Google Scholar
|
|
23
|
Saxena K and Jolly MK: Acute vs chronic vs
cyclic hypoxia: Their differential dynamics, molecular mechanisms,
and effects on tumor progression. Biomolecules.
9(339)2019.PubMed/NCBI View Article : Google Scholar
|
|
24
|
Rofstad EK, Galappathi K, Mathiesen B and
Ruud EB: Fluctuating and diffusion-limited hypoxia in
hypoxia-induced metastasis. Clin Cancer Res. 13:1971–1978.
2007.PubMed/NCBI View Article : Google Scholar
|
|
25
|
Hu J and Verkman AS: Increased migration
and metastatic potential of tumor cells expressing aquaporin water
channels. FASEB J. 20:1892–1894. 2006.PubMed/NCBI View Article : Google Scholar
|
|
26
|
Song J, Miermont A, Lim CT and Kamm RD: A
3D microvascular network model to study the impact of hypoxia on
the extravasation potential of breast cell lines. Sci Rep.
8(17949)2018.PubMed/NCBI View Article : Google Scholar
|
|
27
|
Minassian LM, Cotechini T, Huitema E and
Graham CH: Hypoxia-induced resistance to chemotherapy in cancer.
Adv Exp Med Biol. 1136:123–139. 2019.PubMed/NCBI View Article : Google Scholar
|
|
28
|
He X, Wang J, Wei W, Shi M, Xin B, Zhang T
and Shen X: Hypoxia regulates ABCG2 activity through the
activivation of ERK1/2/HIF-1α and contributes to chemoresistance in
pancreatic cancer cells. Cancer Biol Ther. 17:188–198.
2016.PubMed/NCBI View Article : Google Scholar
|
|
29
|
Shukla SK, Purohit V, Mehla K, Gunda V,
Chaika NV, Vernucci E, King RJ, Abrego J, Goode GD, Dasgupta A, et
al: MUC1 and HIF-1alpha signaling crosstalk induces anabolic
glucose metabolism to impart gemcitabine resistance to pancreatic
cancer. Cancer Cell. 32:71–87.e7. 2017.PubMed/NCBI View Article : Google Scholar
|
|
30
|
Kim JY and Lee JY: Targeting tumor
adaption to chronic hypoxia: Implications for drug resistance, and
how it can be overcome. Int J Mol Sci. 18(1854)2017.PubMed/NCBI View Article : Google Scholar
|
|
31
|
Qian J and Rankin EB: Hypoxia-induced
phenotypes that mediate tumor heterogeneity. In: Gilkes D (ed).
Hypoxia and Cancer Metastasis. Advances in Experimental Medicine
and Biology. Vol. 1136. Springer, Cham, pp43-55, 2019.
|
|
32
|
Kizaka-Kondoh S, Itasaka S, Zeng L, Tanaka
S, Zhao T, Takahashi Y, Shibuya K, Hirota K, Semenza GL and Hiraoka
M: Selective killing of hypoxia-inducible factor-1-active cells
improves survival in a mouse model of invasive and metastatic
pancreatic cancer. Clin Cancer Res. 15:3433–3441. 2019.PubMed/NCBI View Article : Google Scholar
|
|
33
|
Joseph JV, Conroy S, Pavlov K, Sontakke P,
Tomar T, Eggens-Meijer E, Balasubramaniyan V, Wagemakers M, den
Dunnen WF and Kruyt FA: Hypoxia enhances migration and invasion in
glioblastoma by promoting a mesenchymal shift mediated by the
HIF1α-ZEB1 axis. Cancer Lett. 359:107–116. 2015.PubMed/NCBI View Article : Google Scholar
|
|
34
|
Li W, Cao L, Chen X, Lei J and Ma Q:
Resveratrol inhibits hypoxia-driven ROS-induced invasive and
migratory ability of pancreatic cancer cells via suppression of the
Hedgehog signaling pathway. Oncol Rep. 35:1718–1726.
2016.PubMed/NCBI View Article : Google Scholar
|
|
35
|
Huang W, Ding X, Ye H, Wang J, Shao J and
Huang T: Hypoxia enhances the migration and invasion of human
glioblastoma U87 cells through PI3K/Akt/mTOR/HIF-1α pathway.
Neuroreport. 29:1578–1585. 2018.PubMed/NCBI View Article : Google Scholar
|
|
36
|
Wang Y, Liu T, Yang N, Xu S, Li X and Wang
D: Hypoxia and macrophages promote glioblastoma invasion by the
CCL4-CCR5 axis. Oncol Rep. 36:3522–3528. 2016.PubMed/NCBI View Article : Google Scholar
|
|
37
|
Chiou SH, Risca VI, Wang GX, Yang D,
Grüner BM, Kathiria AS, Ma RK, Vaka D, Chu P, Kozak M, et al:
BLIMP1 induces transient metastatic heterogeneity in pancreatic
cancer. Cancer Discov. 7:1184–1199. 2017.PubMed/NCBI View Article : Google Scholar
|
|
38
|
Velásquez C, Mansouri S, Gutiérrez O,
Mamatjan Y, Mollinedo P, Karimi S, Singh O, Terán N, Martino J,
Zadeh G and Fernández-Luna JL: Hypoxia can induce migration of
glioblastoma cells through a methylation-dependent control of ODZ1
gene expression. Front Oncol. 9(1036)2019.PubMed/NCBI View Article : Google Scholar
|
|
39
|
Yu S, Zhou R, Yang T, Liu S, Cui Z, Qiao Q
and Zhang J: Hypoxia promotes colorectal cancer cell migration and
invasion in a SIRT1-dependent manner. Cancer Cell Int.
19(116)2019.PubMed/NCBI View Article : Google Scholar
|
|
40
|
Semenza GL: HIF-1 mediates metabolic
responses to intratumoral hypoxia and oncogenic mutations. J Clin
Invest. 123:3664–3671. 2013.PubMed/NCBI View Article : Google Scholar
|
|
41
|
Zhao F, Mancuso A, Bui TV, Tong X, Gruber
JJ, Swider CR, Sanchez PV, Lum JJ, Sayed N, Melo JV, et al:
Imatinib resistance associated with BCR-ABL upregulation is
dependent on HIF-1alpha-induced metabolic reprograming. Oncogene.
29:2962–2972. 2010.PubMed/NCBI View Article : Google Scholar
|
|
42
|
Liberti MV and Locasale JW: The Warburg
effect: How does it benefit cancer cells? Trends Biochem Sci.
41:211–218. 2016.PubMed/NCBI View Article : Google Scholar
|
|
43
|
Natsuizaka M, Ozasa M, Darmanin S,
Miyamoto M, Kondo S, Kamada S, Shindoh M, Higashino F, Suhara W,
Koide H, et al: Synergistic up-regulation of Hexokinase-2, glucose
transporters and angiogenic factors in pancreatic cancer cells by
glucose deprivation and hypoxia. Exp Cell Res. 313:3337–3348.
2007.PubMed/NCBI View Article : Google Scholar
|
|
44
|
von Forstner C, Egberts JH, Ammerpohl O,
Niedzielska D, Buchert R, Mikecz P, Schumacher U, Peldschus K, Adam
G, Pilarsky C, et al: Gene expression patterns and tumor uptake of
18F-FDG, 18F-FLT, and 18F-FEC in PET/MRI of an orthotopic mouse
xenotransplantation model of pancreatic cancer. J Nucl Med.
49:1362–1370. 2008.PubMed/NCBI View Article : Google Scholar
|
|
45
|
Anderson M, Marayati R, Moffitt R and Yeh
JJ: Hexokinase 2 promotes tumor growth and metastasis by regulating
lactate production in pancreatic cancer. Oncotarget. 8:56081–56094.
2016.PubMed/NCBI View Article : Google Scholar
|
|
46
|
Das MR, Bag AK, Saha S, Ghosh A, Dey SK,
Das P, Mandal C, Ray S, Chakrabarti S, Ray M, et al: Molecular
association of glucose-6-phosphate isomerase and pyruvate kinase M2
with glyceraldehyde-3-phosphate dehydrogenase in cancer cells. BMC
Cancer. 16(152)2016.PubMed/NCBI View Article : Google Scholar
|
|
47
|
Chan AK, Bruce JI and Siriwardena AK:
Glucose metabolic phenotype of pancreatic cancer. World J
Gastroenterol. 22:3471–3485. 2016.PubMed/NCBI View Article : Google Scholar
|
|
48
|
Lucarelli G, Rutigliano M, Sanguedolce F,
Galleggiante V, Giglio A, Cagiano S, Bufo P, Maiorano E, Ribatti D,
Ranieri E, et al: Increased expression of the autocrine motility
factor is associated with poor prognosis in patients with clear
cell-renal cell carcinoma. Medicine (Baltimore).
94(e2117)2015.PubMed/NCBI View Article : Google Scholar
|
|
49
|
Kho DH, Nangia-Makker P, Balan V, Hogan V,
Tait L, Wang Y and Raz A: Autocrine motility factor promotes HER2
cleavage and signaling in breast cancer cells. Cancer Res.
73:1411–1419. 2013.PubMed/NCBI View Article : Google Scholar
|
|
50
|
de Padua MC, Delodi G, Vučetić M,
Durivault J, Vial V, Bayer P, Noleto GR, Mazure NM, Ždralević M and
Pouysségur J: Disrupting glucose-6-phosphate isomerase fully
suppresses the ‘Warburg effect’ and activates OXPHOS with minimal
impact on tumor growth except in hypoxia. Oncotarget.
8:87623–87637. 2017.PubMed/NCBI View Article : Google Scholar
|
|
51
|
Golias T, Papandreou I, Sun R, Kumar B,
Brown NV, Swanson BJ, Pai R, Jaitin D, Le QT, Teknos TN and Denko
NC: Hypoxic repression of pyruvate dehydrogenase activity is
necessary for metabolic reprogramming and growth of model tumours.
Sci Rep. 6(31146)2016.PubMed/NCBI View Article : Google Scholar
|
|
52
|
Prigione A, Rohwer N, Hoffmann S, Mlody B,
Drews K, Bukowiecki R, Blümlein K, Wanker EE, Ralser M, Cramer T
and Adjaye J: HIF1α modulates cell fate reprogramming through early
glycolytic shift and upregulation of PDK1-3 and PKM2. Stem Cells.
32:364–376. 2014.PubMed/NCBI View Article : Google Scholar
|
|
53
|
Lu CW, Lin SC, Chen KF, Lai YY and Tsai
SJ: Induction of pyruvate dehydrogenase kinase-3 by
hypoxia-inducible factor-1 promotes metabolic switch and drug
resistance. J Biol Chem. 283:28106–28114. 2008.PubMed/NCBI View Article : Google Scholar
|
|
54
|
Kluza J, Corazao-Rozas P, Touil Y,
Jendoubi M, Maire C, Guerreschi P, Jonneaux A, Ballot C, Balayssac
S, Valable S, et al: Inactivation of the HIF-1α/PDK3 signaling axis
drives melanoma toward mitochondrial oxidative metabolism and
potentiates the therapeutic activity of pro-oxidants. Cancer Res.
72:5035–5047. 2012.PubMed/NCBI View Article : Google Scholar
|
|
55
|
Jin L and Zhou Y: Crucial role of the
pentose phosphate pathway in malignant tumors. Oncol Lett.
17:4213–4221. 2019.PubMed/NCBI View Article : Google Scholar
|
|
56
|
Chaika NV, Yu F, Purohit V, Mehla K,
Lazenby AJ, DiMaio D, Anderson JM, Yeh JJ, Johnson KR,
Hollingsworth MA and Singh PK: Differential expression of metabolic
genes in tumor and stromal components of primary and metastatic
loci in pancreatic adenocarcinoma. PLoS One.
7(e32996)2012.PubMed/NCBI View Article : Google Scholar
|
|
57
|
Je DW, O YM, Ji YG, Cho Y and Lee DH: The
inhibition of SRC family kinase suppresses pancreatic cancer cell
proliferation, migration, and invasion. Pancreas. 43:768–776.
2014.PubMed/NCBI View Article : Google Scholar
|
|
58
|
Payen VL, Porporato PE, Baselet B and
Sonveaux P: Metabolic changes associated with tumor metastasis,
part 1: Tumor pH, glycolysis and the pentose phosphate pathway.
Cell Mol Life Sci. 73:1333–1348. 2016.PubMed/NCBI View Article : Google Scholar
|
|
59
|
Camelo F and Le A: The intricate
metabolism of pancreatic cancers. In: Le A (ed): The Heterogeneity
of Cancer Metabolism. Advances in Experimental Medicine and
Biology. Vol. 1063. Springer, Cham, pp73-81, 2018.
|
|
60
|
Best SA, De Souza DP, Kersbergen A,
Policheni AN, Dayalan S, Tull D, Rathi V, Gray DH, Ritchie ME,
McConville MJ and Sutherland KD: Synergy between the KEAP1/NRF2 and
PI3K pathways drives non-small-cell lung cancer with an altered
immune microenvironment. Cell Metab. 27:935–943.e4. 2018.PubMed/NCBI View Article : Google Scholar
|
|
61
|
Stewart L, Glenn GM, Stratton P, Goldstein
AM, Merino MJ, Tucker MA, Linehan WM and Toro JR: Association of
germline mutations in the fumarate hydratase gene and uterine
fibroids in women with hereditary leiomyomatosis and renal cell
cancer. Arch Dermatol. 144:1584–1592. 2008.PubMed/NCBI View Article : Google Scholar
|
|
62
|
Zhao Q and Jiang Y: Fumarase mediates
transcriptional response to nutrient stress. Cell Stress. 1:68–69.
2017.PubMed/NCBI View Article : Google Scholar
|
|
63
|
Wang Z, Wang C, Wu Z, Xue J, Shen B, Zuo
W, Wang Z and Wang SL: Artesunate suppresses the growth of
prostatic cancer cells through inhibiting androgen receptor. Biol
Pharm Bull. 40:479–485. 2017.PubMed/NCBI View Article : Google Scholar
|
|
64
|
Zois CE and Harris AL: Glycogen metabolism
has a key role in the cancer microenvironment and provides new
targets for cancer therapy. J Mol Med (Berl). 94:137–154.
2016.PubMed/NCBI View Article : Google Scholar
|
|
65
|
Zhang B, Tornmalm J, Widengren J,
Vakifahmetoglu-Norberg H and Norberg E: Characterization of the
role of the malate dehydrogenases to lung tumor cell survival. J
Cancer. 8:2088–2096. 2017.PubMed/NCBI View Article : Google Scholar
|
