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Role of apoptosis inhibitor of macrophages in patients with IgG4‑related disease/autoimmune pancreatitis and the clinical characteristics associated with this condition

  • Authors:
    • Shiroh Tanoue
    • Shuji Kanmura
    • Makoto Hinokuchi
    • Shiho Arima
    • Fumisato Sasaki
    • Shinichi Hashimoto
    • Akio Ido
  • View Affiliations / Copyright

    Affiliations: Department of Digestive and Lifestyle Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890‑8544, Japan
    Copyright: © Tanoue et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 82
    |
    Published online on: August 24, 2022
       https://doi.org/10.3892/br.2022.1565
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Abstract

Type 1 autoimmune pancreatitis (AIP) is a pancreatic manifestation of IgG4‑related disease (IgG4‑RD) and is a unique chronic inflammatory disease characterized by fibrosis. IgG4‑RD is caused by an autoimmune mechanism that mimics malignant tumors and inflammatory disorders. Apoptosis inhibitor of macrophages (AIM) can function as a biomarker of autoimmune or inflammatory diseases with tissue fibrosis, including in inflammatory bowel disease and chronic liver disease. Therefore, the aim of the present study was to clarify the role of serum AIM levels and the clinical characteristics of patients with IgG4‑RD and AIP. For this purpose, serum AIM concentrations were assessed using ELISA and the association between AIM and the laboratory and clinical data from patients with IgG4‑RD/AIP, patients with pancreatic cancer (PC) and healthy controls (HCs), was determined. The results demonstrated that the serum AIM concentrations were not associated with the laboratory data. However, the serum AIM levels were significantly elevated in patients with AIP compared with the HCs and patients with PC. Furthermore, the serum AIM levels significantly decreased following steroid therapy in patients with AIP who were in remission. Overall, the present study demonstrates that serum AIM levels may be a potentially useful biomarker for the differential diagnosis of AIP and for evaluating the therapeutic reactivity of affected patients.
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Copy and paste a formatted citation
Spandidos Publications style
Tanoue S, Kanmura S, Hinokuchi M, Arima S, Sasaki F, Hashimoto S and Ido A: Role of apoptosis inhibitor of macrophages in patients with IgG4‑related disease/autoimmune pancreatitis and the clinical characteristics associated with this condition. Biomed Rep 17: 82, 2022.
APA
Tanoue, S., Kanmura, S., Hinokuchi, M., Arima, S., Sasaki, F., Hashimoto, S., & Ido, A. (2022). Role of apoptosis inhibitor of macrophages in patients with IgG4‑related disease/autoimmune pancreatitis and the clinical characteristics associated with this condition. Biomedical Reports, 17, 82. https://doi.org/10.3892/br.2022.1565
MLA
Tanoue, S., Kanmura, S., Hinokuchi, M., Arima, S., Sasaki, F., Hashimoto, S., Ido, A."Role of apoptosis inhibitor of macrophages in patients with IgG4‑related disease/autoimmune pancreatitis and the clinical characteristics associated with this condition". Biomedical Reports 17.4 (2022): 82.
Chicago
Tanoue, S., Kanmura, S., Hinokuchi, M., Arima, S., Sasaki, F., Hashimoto, S., Ido, A."Role of apoptosis inhibitor of macrophages in patients with IgG4‑related disease/autoimmune pancreatitis and the clinical characteristics associated with this condition". Biomedical Reports 17, no. 4 (2022): 82. https://doi.org/10.3892/br.2022.1565
Copy and paste a formatted citation
x
Spandidos Publications style
Tanoue S, Kanmura S, Hinokuchi M, Arima S, Sasaki F, Hashimoto S and Ido A: Role of apoptosis inhibitor of macrophages in patients with IgG4‑related disease/autoimmune pancreatitis and the clinical characteristics associated with this condition. Biomed Rep 17: 82, 2022.
APA
Tanoue, S., Kanmura, S., Hinokuchi, M., Arima, S., Sasaki, F., Hashimoto, S., & Ido, A. (2022). Role of apoptosis inhibitor of macrophages in patients with IgG4‑related disease/autoimmune pancreatitis and the clinical characteristics associated with this condition. Biomedical Reports, 17, 82. https://doi.org/10.3892/br.2022.1565
MLA
Tanoue, S., Kanmura, S., Hinokuchi, M., Arima, S., Sasaki, F., Hashimoto, S., Ido, A."Role of apoptosis inhibitor of macrophages in patients with IgG4‑related disease/autoimmune pancreatitis and the clinical characteristics associated with this condition". Biomedical Reports 17.4 (2022): 82.
Chicago
Tanoue, S., Kanmura, S., Hinokuchi, M., Arima, S., Sasaki, F., Hashimoto, S., Ido, A."Role of apoptosis inhibitor of macrophages in patients with IgG4‑related disease/autoimmune pancreatitis and the clinical characteristics associated with this condition". Biomedical Reports 17, no. 4 (2022): 82. https://doi.org/10.3892/br.2022.1565
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