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Review Open Access

Periodontitis, female fertility and conception (Review)

  • Authors:
    • Elena Ricci
    • Simone Ciccarelli
    • Paola Agnese Mauri
    • Sandro Gerli
    • Alessandro Favilli
    • Sonia Cipriani
    • Francesco Fedele
    • Elena Roncella
    • Giovanna Esposito
    • Fabio Parazzini
    • Michele Vignali
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Sciences and Community Health, School of Medicine and Surgery, University of Milan, I‑20122 Milan, Italy, Department of Obstetrics and Gynecology, University of Perugia, S.M. Della Misericordia Hospital, I‑06156 Perugia, Italy, Department of Woman, Newborn and Child, Gynaecology Unit, ‘Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Ca' Granda Ospedale Maggiore Policlinico’, I‑20122 Milan, Italy, Department of Biomedical Sciences for Health, University of Milan, I‑20133 Milan, Italy
    Copyright: © Ricci et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 86
    |
    Published online on: September 13, 2022
       https://doi.org/10.3892/br.2022.1569
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Abstract

Periodontal disease (PD) has been shown to increase the risk of preterm birth, preeclampsia and low birth weight. These observations have suggested that PD may also affect the early phase of pregnancy, including conception. The present study aimed to evaluate whether an association exists between oral health status and the chance of clinical pregnancy, according to the currently published literature, by performing a systematic review. The PubMed and EMBASE databases were searched from their start dates to October 2021 using the following keywords: ‘Infertility’ OR ‘conception’ OR ‘pre‑pregnancy’ OR ‘time‑to‑pregnancy’ AND ‘periodontitis’ OR ‘periodontal disease’ OR ‘dental infection’ OR ‘gingivitis’ OR ‘odontogenic infection’ (limits: Full article, English, Human). A total of 6 papers reporting observational information on PD and spontaneous (4 studies) or medically induced conception (2 studies) were retrieved. As such, there were limited studies with different designs (randomized controlled trials and observational studies) and different settings. Moreover, in the selected studies, the ethnicity of the women was heterogeneous. According to the limited published literature, oral health might affect fertility in women. However, only results from prospective randomized trials, comparing PD treatment vs. no treatment in women seeking pregnancy, may clarify the real effectiveness of treatment in improving the conception rate.
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Copy and paste a formatted citation
Spandidos Publications style
Ricci E, Ciccarelli S, Mauri PA, Gerli S, Favilli A, Cipriani S, Fedele F, Roncella E, Esposito G, Parazzini F, Parazzini F, et al: Periodontitis, female fertility and conception (Review). Biomed Rep 17: 86, 2022.
APA
Ricci, E., Ciccarelli, S., Mauri, P.A., Gerli, S., Favilli, A., Cipriani, S. ... Vignali, M. (2022). Periodontitis, female fertility and conception (Review). Biomedical Reports, 17, 86. https://doi.org/10.3892/br.2022.1569
MLA
Ricci, E., Ciccarelli, S., Mauri, P. A., Gerli, S., Favilli, A., Cipriani, S., Fedele, F., Roncella, E., Esposito, G., Parazzini, F., Vignali, M."Periodontitis, female fertility and conception (Review)". Biomedical Reports 17.5 (2022): 86.
Chicago
Ricci, E., Ciccarelli, S., Mauri, P. A., Gerli, S., Favilli, A., Cipriani, S., Fedele, F., Roncella, E., Esposito, G., Parazzini, F., Vignali, M."Periodontitis, female fertility and conception (Review)". Biomedical Reports 17, no. 5 (2022): 86. https://doi.org/10.3892/br.2022.1569
Copy and paste a formatted citation
x
Spandidos Publications style
Ricci E, Ciccarelli S, Mauri PA, Gerli S, Favilli A, Cipriani S, Fedele F, Roncella E, Esposito G, Parazzini F, Parazzini F, et al: Periodontitis, female fertility and conception (Review). Biomed Rep 17: 86, 2022.
APA
Ricci, E., Ciccarelli, S., Mauri, P.A., Gerli, S., Favilli, A., Cipriani, S. ... Vignali, M. (2022). Periodontitis, female fertility and conception (Review). Biomedical Reports, 17, 86. https://doi.org/10.3892/br.2022.1569
MLA
Ricci, E., Ciccarelli, S., Mauri, P. A., Gerli, S., Favilli, A., Cipriani, S., Fedele, F., Roncella, E., Esposito, G., Parazzini, F., Vignali, M."Periodontitis, female fertility and conception (Review)". Biomedical Reports 17.5 (2022): 86.
Chicago
Ricci, E., Ciccarelli, S., Mauri, P. A., Gerli, S., Favilli, A., Cipriani, S., Fedele, F., Roncella, E., Esposito, G., Parazzini, F., Vignali, M."Periodontitis, female fertility and conception (Review)". Biomedical Reports 17, no. 5 (2022): 86. https://doi.org/10.3892/br.2022.1569
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