Spirometric values associated with clinical form and risk of death and stroke in chagasic patients

De Morais,Nickson Melo; De Andrade,Micássio Fernandes; De Almeida,Valéria Duarte; De Morais Leonez,Lara Candice Costa; De Andrade,Cléber Mesquita; Bezerra,Christiane Medeiros; Cosme Do Nascimento,Ellany Gurgel; Fernandes,José Veríssimo; Araújo De Medeiros Fernandes,Thales Allyrio

doi:10.3892/br.2022.1571

Spirometric values associated with clinical form and risk of death and stroke in chagasic patients

Authors:
- Nickson Melo De Morais
- Micássio Fernandes De Andrade
- Valéria Duarte De Almeida
- Lara Candice Costa De Morais Leonez
- Cléber Mesquita De Andrade
- Christiane Medeiros Bezerra
- Ellany Gurgel Cosme Do Nascimento
- José Veríssimo Fernandes
- Thales Allyrio Araújo De Medeiros Fernandes
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Affiliations: Multicentric Postgraduate Program in Physiological Sciences, University of Rio Grande do Norte State, Mossoró, Rio Grande do Norte 59607‑360, Brazil, Postgraduate Program in Health and Society, University of Rio Grande do Norte State, Mossoró, Rio Grande do Norte 59607‑360, Brazil, Department of Biomedical Sciences, University of Rio Grande do Norte State, Mossoró, Rio Grande do Norte 59607‑360, Brazil, Department of Microbiology and Parasitology, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte 59072‑970, Brazil
Published online on: September 15, 2022 https://doi.org/10.3892/br.2022.1571
Article Number: 88

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Abstract

The aim of the present study was to compare pulmonary function among patients with different clinical forms and scores for risk of death and stroke. Patients were recruited from the Chagas Disease Ambulatory Service at the University of Rio Grande do Norte State (Mossoró, Brazil). The evaluation of pulmonary function was performed through spirometry techniques using a digital spirometer, and information about the clinical forms (cardiac, cardiodigestive, digestive and undetermined) and scores for risk of death (Rassi's risk‑of‑death score) and stroke was subsequently collected. Upon completion of the evaluation, comparisons of the values obtained between the groups for different clinical forms, risk stratification of stroke and Rassi's risk‑of‑death were made. The study cohort consisted of 72 patients. Individuals with a low risk of death had significantly higher values in the Tiffeneau index and individuals with a low risk of stroke presented with higher percentage values for forced vital capacity and forced expiratory volume in 1 sec. In addition, individuals with heart disease had worse percentage values for FVC and FEV₁. In conclusion, the results showed that spirometry was an effective analytical technique and was associated with clinical forms, and death and stroke risk scores, in patients with Chagas disease, adding an important prognostic tool to those currently available.

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