Open Access

Currently available molecular analyses for personalized tumor therapy (Review)

  • Authors:
    • Sundaresan Sivapatham
    • Lavanya Selvaraj
  • View Affiliations

  • Published online on: October 14, 2022     https://doi.org/10.3892/br.2022.1578
  • Article Number: 95
  • Copyright: © Sivapatham et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Targeted therapies are becoming more common and genetic tumor profiling is becoming more precise and affordable. The aim of the present review was to demonstrate the importance of molecular analyses in tumors, summarize the current situation, provide an outlook on how to improve diagnosis to facilitate individualized therapy, including the use of specific methodologies for tumor marker analysis to improve patient treatment. Most predicted metabolomic and proteomic biomarkers have not progressed from the laboratory to clinical trials, as most of the trials were stopped at the initial stage of biomarker identification. The use of liquid biopsies as a clinical tool improves cancer screening, diagnosis and prognosis; furthermore, is able to improve the classification of more diverse disease entities, assess therapy response and identify treatment‑resistant clones, allowing for more stringent patient monitoring. Based on specific clinical populations and the unique molecular features of a cancer, the identification of a suitable targeted therapy may be accomplished. The present review provides insight into cancer genomic testing in the clinical setting and the available methods, supporting the prioritization of molecular therapeutic tumor targeting.
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December-2022
Volume 17 Issue 6

Print ISSN: 2049-9434
Online ISSN:2049-9442

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Spandidos Publications style
Sivapatham S and Sivapatham S: Currently available molecular analyses for personalized tumor therapy (Review). Biomed Rep 17: 95, 2022
APA
Sivapatham, S., & Sivapatham, S. (2022). Currently available molecular analyses for personalized tumor therapy (Review). Biomedical Reports, 17, 95. https://doi.org/10.3892/br.2022.1578
MLA
Sivapatham, S., Selvaraj, L."Currently available molecular analyses for personalized tumor therapy (Review)". Biomedical Reports 17.6 (2022): 95.
Chicago
Sivapatham, S., Selvaraj, L."Currently available molecular analyses for personalized tumor therapy (Review)". Biomedical Reports 17, no. 6 (2022): 95. https://doi.org/10.3892/br.2022.1578