Open Access

MicroRNAs as a therapeutic target in IgA nephropathy in Indian population

  • Authors:
    • Anindita Tripathy
    • Poornachandra Yedla
    • Ravikanth V Vishnubhotla
    • Anuradha Sekaran
    • Sai Ram Keithi Reddy
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  • Published online on: April 4, 2023     https://doi.org/10.3892/br.2023.1617
  • Article Number: 35
  • Copyright: © Tripathy et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Immunoglobulin A nephropathy (IgAN) is the most frequent glomerular disease with rapid development to end stage renal disease, requiring renal replacement therapy. Genome‑wide studies suggest geographical variations in genetic susceptibility to IgAN and disease progression. Specific ‘candidate genes’ were indicated to correlate with different functions that are involved in the pathogenesis of renal conditions. MicroRNAs (miRNAs/miRs) have a major role in mRNA degradation or translation repression, thereby regulating the expression of their target proteins. Previously, a small number of miRNAs were reported to have direct associations with IgAN. In the present study, new miRNAs linked to IgAN were identified in the Indian population. The miRNA was isolated from kidney biopsies of patients with IgAN (n=6) and healthy control tissue from patients with renal cell carcinoma (n=6). The sequencing results indicated that the miRNA percentage acquired from controls and patients with IgAN was 5.61 and 4.35%, respectively. From the results, 10 upregulated and 15 downregulated miRNAs were identified. Of the 25 differentially expressed miRNAs (DEMs), miR‑181a‑5p, miR‑28‑3p, let‑7g‑5p, miR‑92a‑3p and miR‑30c‑5p were not reported previously. Furthermore, Kyoto Encyclopedia of Genes and Genomes and Gene Ontology analyses suggested that the target genes of the DEMs were mainly enriched in pathways such as cancer, ErbB signalling, proteoglycans in cancer, Hippo signalling and MAPK pathways. The newly identified miRNAs may impact the behaviour of tissues or IgA deposition by regulating signalling pathways, which forms a basis for future studies aimed at improving the diagnosis and care of patients with IgAN in the Indian community.
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May-2023
Volume 18 Issue 5

Print ISSN: 2049-9434
Online ISSN:2049-9442

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Spandidos Publications style
Tripathy A, Yedla P, Vishnubhotla RV, Sekaran A and Keithi Reddy SR: MicroRNAs as a therapeutic target in IgA nephropathy in Indian population. Biomed Rep 18: 35, 2023
APA
Tripathy, A., Yedla, P., Vishnubhotla, R.V., Sekaran, A., & Keithi Reddy, S.R. (2023). MicroRNAs as a therapeutic target in IgA nephropathy in Indian population. Biomedical Reports, 18, 35. https://doi.org/10.3892/br.2023.1617
MLA
Tripathy, A., Yedla, P., Vishnubhotla, R. V., Sekaran, A., Keithi Reddy, S. R."MicroRNAs as a therapeutic target in IgA nephropathy in Indian population". Biomedical Reports 18.5 (2023): 35.
Chicago
Tripathy, A., Yedla, P., Vishnubhotla, R. V., Sekaran, A., Keithi Reddy, S. R."MicroRNAs as a therapeutic target in IgA nephropathy in Indian population". Biomedical Reports 18, no. 5 (2023): 35. https://doi.org/10.3892/br.2023.1617