Open Access

Strategies for in situ tissue engineering of vascularized bone regeneration (Review)

  • Authors:
    • Yijun He
    • Lin Liang
    • Cheng Luo
    • Zhi-Yong Zhang
    • Jiongfeng Huang
  • View Affiliations

  • Published online on: May 22, 2023     https://doi.org/10.3892/br.2023.1625
  • Article Number: 42
  • Copyright: © He et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Numerous physiological processes occur following bone fracture, including inflammatory cell recruitment, vascularization, and callus formation and remodeling. In particular circumstances, such as critical bone defects or osteonecrosis, the regenerative microenvironment is compromised, rendering endogenous stem/progenitor cells incapable of fully manifesting their reparative potential. Consequently, external interventions, such as grafting or augmentation, are frequently necessary. In situ bone tissue engineering (iBTE) employs cell‑free scaffolds that possess microenvironmental cues, which, upon implantation, redirect the behavior of endogenous stem/progenitor cells towards a pro‑regenerative inflammatory response and reestablish angiogenesis‑osteogenesis coupling. This process ultimately results in vascularized bone regeneration (VBR). In this context, a comprehensive review of the current techniques and modalities in VBR‑targeted iBTE technology is provided.
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June-2023
Volume 18 Issue 6

Print ISSN: 2049-9434
Online ISSN:2049-9442

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Copy and paste a formatted citation
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Spandidos Publications style
He Y, Liang L, Luo C, Zhang Z and Huang J: Strategies for <em>in situ</em> tissue engineering of vascularized bone regeneration (Review). Biomed Rep 18: 42, 2023
APA
He, Y., Liang, L., Luo, C., Zhang, Z., & Huang, J. (2023). Strategies for <em>in situ</em> tissue engineering of vascularized bone regeneration (Review). Biomedical Reports, 18, 42. https://doi.org/10.3892/br.2023.1625
MLA
He, Y., Liang, L., Luo, C., Zhang, Z., Huang, J."Strategies for <em>in situ</em> tissue engineering of vascularized bone regeneration (Review)". Biomedical Reports 18.6 (2023): 42.
Chicago
He, Y., Liang, L., Luo, C., Zhang, Z., Huang, J."Strategies for <em>in situ</em> tissue engineering of vascularized bone regeneration (Review)". Biomedical Reports 18, no. 6 (2023): 42. https://doi.org/10.3892/br.2023.1625