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Rational use of tigecycline and tigecycline blood concentration monitoring in patients with severe infection

  • Authors:
    • Meiling Yu
    • Sheng Wu
    • Benquan Qi
    • Xiaofei Wu
    • Ximing Deng
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacy, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, P.R. China, Department of Emergency Internal Medicine, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, P.R. China, Department of Critical Care Medicine, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, P.R. China
    Copyright: © Yu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 51
    |
    Published online on: June 13, 2023
       https://doi.org/10.3892/br.2023.1634
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Abstract

Tigecycline, a tetracycline antibiotic, is widely used against antimicrobial resistance; therefore, medical staff should use tigecycline rationally to improve clinical efficacy and reduce resistance to this drug. The present study aimed to enhance the rate of rational tigecycline usage. The patients were divided into a low‑dose (50 mg tigecycline twice daily, every 12 h) and a high‑dose group (100 mg twice daily, every 12 h). The blood concentrations of tigecycline were examined and the area under the curve (AUC)0‑12 h values of the two groups were calculated. Prescriptions of tigecycline for 40 intensive care unit (ICU) cases were reviewed to evaluate the rationality of tigecycline usage. The peak plasma concentrations (the 7th administration after 1 h) of tigecycline were significantly higher in the high‑dose group (2.46±0.43 µg/ml) compared with those in the low‑dose group (1.25±0.16 µg/ml). The AUC0‑12 h was 16.35±3.09 h µg/ml in the high‑dose group and 9.83±1.23 h µg/ml in the low‑dose group (P<0.001). There were 29 irrational prescriptions identified, involving: i) Lack of consultation records (n=20); ii) inappropriate usage or dosage (n=17); iii) inappropriate drug selection (n=2); or iv) lack of dynamic laboratory tests to evaluate the efficacy (n=4). The irrational use of tigecycline in ICU patients is common. The rate of rational tigecycline usage can be improved by strengthening the management, training and participation of clinical pharmacists.
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Copy and paste a formatted citation
Spandidos Publications style
Yu M, Wu S, Qi B, Wu X and Deng X: Rational use of tigecycline and tigecycline blood concentration monitoring in patients with severe infection. Biomed Rep 19: 51, 2023.
APA
Yu, M., Wu, S., Qi, B., Wu, X., & Deng, X. (2023). Rational use of tigecycline and tigecycline blood concentration monitoring in patients with severe infection. Biomedical Reports, 19, 51. https://doi.org/10.3892/br.2023.1634
MLA
Yu, M., Wu, S., Qi, B., Wu, X., Deng, X."Rational use of tigecycline and tigecycline blood concentration monitoring in patients with severe infection". Biomedical Reports 19.2 (2023): 51.
Chicago
Yu, M., Wu, S., Qi, B., Wu, X., Deng, X."Rational use of tigecycline and tigecycline blood concentration monitoring in patients with severe infection". Biomedical Reports 19, no. 2 (2023): 51. https://doi.org/10.3892/br.2023.1634
Copy and paste a formatted citation
x
Spandidos Publications style
Yu M, Wu S, Qi B, Wu X and Deng X: Rational use of tigecycline and tigecycline blood concentration monitoring in patients with severe infection. Biomed Rep 19: 51, 2023.
APA
Yu, M., Wu, S., Qi, B., Wu, X., & Deng, X. (2023). Rational use of tigecycline and tigecycline blood concentration monitoring in patients with severe infection. Biomedical Reports, 19, 51. https://doi.org/10.3892/br.2023.1634
MLA
Yu, M., Wu, S., Qi, B., Wu, X., Deng, X."Rational use of tigecycline and tigecycline blood concentration monitoring in patients with severe infection". Biomedical Reports 19.2 (2023): 51.
Chicago
Yu, M., Wu, S., Qi, B., Wu, X., Deng, X."Rational use of tigecycline and tigecycline blood concentration monitoring in patients with severe infection". Biomedical Reports 19, no. 2 (2023): 51. https://doi.org/10.3892/br.2023.1634
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