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Review Open Access

A consolidated working classification of gastric cancer for histopathologists (Review)

  • Authors:
    • Simona Costache
    • Maria Sajin
    • Sarah Wedden
    • Corrado D'Arrigo
  • View Affiliations / Copyright

    Affiliations: University of Medicine and Pharmacy ‘Carol Davila’, 020021 Bucharest, Romania, Cancer Diagnostic Quality Assurance Services (CADQAS), Dorchester DT13BJ, UK, Poundbury Cancer Institute, Dorchester DT13BJ, UK
    Copyright: © Costache et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 58
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    Published online on: July 19, 2023
       https://doi.org/10.3892/br.2023.1640
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Abstract

Gastric cancer (GC) remains a disease with poor prognosis despite increasing availability of more effective targeted treatment. This may be in part due to the difficulty in selecting patients for appropriate treatment. Conventional taxonomic classifications of GC are ill‑suited to make full use of recent advances in personalised therapy. In the past decade a number of molecular classifications have been proposed to address this; however, to date, there has been little implementation in the diagnostic routine. The lack of harmonisation between these classifications, the complexity and unavailability of some of the tests required plus the demands on time and resources, all contribute to poor uptake in the diagnostic routine. In the present study, these classifications were reviewed and an inclusive working classification that includes their main points, focuses on prognosis and treatment options and can be delivered using four on‑slide tests (in situ hybridization for Epstein‑Barr encoding region and immunohistochemistry for mismatch repair, E‑cadherin and p53) is proposed. These tests can be performed on paraffin‑embedded tissue and could be available in the majority of histopathology laboratories. The proposed classification also includes reflex testing for specific biomarkers relevant to treatment selection.
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Copy and paste a formatted citation
Spandidos Publications style
Costache S, Sajin M, Wedden S and D'Arrigo C: A consolidated working classification of gastric cancer for histopathologists (Review). Biomed Rep 19: 58, 2023.
APA
Costache, S., Sajin, M., Wedden, S., & D'Arrigo, C. (2023). A consolidated working classification of gastric cancer for histopathologists (Review). Biomedical Reports, 19, 58. https://doi.org/10.3892/br.2023.1640
MLA
Costache, S., Sajin, M., Wedden, S., D'Arrigo, C."A consolidated working classification of gastric cancer for histopathologists (Review)". Biomedical Reports 19.3 (2023): 58.
Chicago
Costache, S., Sajin, M., Wedden, S., D'Arrigo, C."A consolidated working classification of gastric cancer for histopathologists (Review)". Biomedical Reports 19, no. 3 (2023): 58. https://doi.org/10.3892/br.2023.1640
Copy and paste a formatted citation
x
Spandidos Publications style
Costache S, Sajin M, Wedden S and D'Arrigo C: A consolidated working classification of gastric cancer for histopathologists (Review). Biomed Rep 19: 58, 2023.
APA
Costache, S., Sajin, M., Wedden, S., & D'Arrigo, C. (2023). A consolidated working classification of gastric cancer for histopathologists (Review). Biomedical Reports, 19, 58. https://doi.org/10.3892/br.2023.1640
MLA
Costache, S., Sajin, M., Wedden, S., D'Arrigo, C."A consolidated working classification of gastric cancer for histopathologists (Review)". Biomedical Reports 19.3 (2023): 58.
Chicago
Costache, S., Sajin, M., Wedden, S., D'Arrigo, C."A consolidated working classification of gastric cancer for histopathologists (Review)". Biomedical Reports 19, no. 3 (2023): 58. https://doi.org/10.3892/br.2023.1640
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