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Healthy mitochondrial DNA in balanced mitochondrial dynamics: A potential marker for neuro‑aging prediction (Review)

  • Authors:
    • Made Putra Semadhi
    • Dewi Mulyaty
    • Eli Halimah
    • Jutti Levita
  • View Affiliations / Copyright

    Affiliations: Prodia National Reference Laboratory, Jakarta 10430, Indonesia, Prodia Widyahusada Co., Jakarta 10430, Indonesia, Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang 45363, Indonesia
    Copyright: © Semadhi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 64
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    Published online on: August 7, 2023
       https://doi.org/10.3892/br.2023.1646
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Abstract

The mitochondrial genome or mitochondrial DNA (mtDNA) is released as a response to cellular stress. In mitochondrial biogenesis, active communication between the mitochondria genome and nucleus is associated with the mtDNA profile that affects the mitochondrial quality. The present review aimed to assess the molecular mechanism and potential roles of mitochondria in neuro‑aging, including the importance of evaluating the health status of mtDNA via mitochondrial dynamics. The normal condition of mitochondria, defined as mitochondrial dynamics, includes persistent changes in morphology due to fission and fusion events and autophagy‑mitophagy in the mitochondrial quality control process. The calculated copy number of mtDNA in the mitochondria genome represents cellular health, which can be affected by a long‑term imbalance between the production and accumulation of reactive oxygen species in the neuroendocrine system, which leads to an abnormal function of mitochondria and mtDNA damage. Mitochondria health is a new approach to discovering a potential indicator for the health status of the nervous system and several types of neurodegenerative disorders. Mitochondrial dynamics is a key contributor to predicting neuro‑aging development, which affects the self‑renewal and differentiation of neurons in cell metabolism. Neuro‑aging is associated with uncontrolled mitochondrial dynamics, which generates age‑associated diseases via various mechanisms and signaling routes that lead to the mtDNA damage that has been associated with neurodegeneration. Future studies on the strategic positioning of mtDNA health profile are needed to detect early neurodegenerative disorders.
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1 

Park SS, Jeong H and Andreazza AC: Circulating cell-free mitochondrial DNA in brain health and disease: A systematic review and meta-analysis. World J Biol Psychiatry. 23:87–102. 2022.PubMed/NCBI View Article : Google Scholar

2 

Peng Y, Zheng D, Zhang X, Pan S, Ji T, Zhang J, Shen HY and Wang HH: Cell-free mitochondrial DNA in the CSF: A potential prognostic biomarker of Anti-NMDAR encephalitis. Front Immunol. 10(103)2019.PubMed/NCBI View Article : Google Scholar

3 

Chang CY, Liang MZ and Chen L: Current progress of mitochondrial transplantation that promotes neuronal regeneration. Transl Neurodegener. 8(17)2019.PubMed/NCBI View Article : Google Scholar

4 

Moya GE, Rivera PD and Dittenhafer-Reed KE: Evidence for the role of mitochondrial DNA release in the inflammatory response in neurological disorders. Int J Mol Sci. 22(7030)2021.PubMed/NCBI View Article : Google Scholar

5 

Cai Q and Tammineni P: Alterations in mitochondrial quality control in Alzheimer's disease. Front Cell Neurosci. 10(24)2016.PubMed/NCBI View Article : Google Scholar

6 

Valenti D, Braidy N, De Rasmo D, Signorile A, Rossi L, Atanasov AG, Volpicella M, Henrion-Caude A, Nabavi SM and Vacca RA: Mitochondria as pharmacological targets in Down syndrome. Free Radic Biol Med. 114:69–83. 2018.PubMed/NCBI View Article : Google Scholar

7 

Lindqvist D, Wolkowitz OM, Picard M, Ohlsson L, Bersani FS, Fernström J, Westrin Å, Hough CM, Lin J, Reus VI, et al: Circulating cell-free mitochondrial DNA, but not leukocyte mitochondrial DNA copy number, is elevated in major depressive disorder. Neuropsychopharmacol. 43:1557–1564. 2018.PubMed/NCBI View Article : Google Scholar

8 

Aryaman J, Bowles C, Jones NS and Johnston IG: Supplemental Material for Aryaman et al., 2019. Figshare; 2019 [cited 2022 Sep 11]. p. 1311221 Bytes. Available from: https://gsajournals.figshare.com/articles/Supplemental_Material_for_Aryaman_et_al_2019/8343830.

9 

An Q, Hu Y, Li Q, Chen X, Huang J, Pellegrini M, Zhou XJ, Rettig M and Fan G: The size of cell-free mitochondrial DNA in blood is inversely correlated with tumor burden in cancer patients. Precision Clinical Medicine. 2:131–139. 2019.PubMed/NCBI View Article : Google Scholar

10 

Wu B, Ni H, Li J, Zhuang X, Zhang J, Qi Z, Chen Q, Wen Z, Shi H, Luo X and Jin B: The impact of circulating mitochondrial DNA on cardiomyocyte apoptosis and myocardial injury after TLR4 activation in experimental autoimmune myocarditis. Cell Physiol Biochem. 42:713–728. 2017.PubMed/NCBI View Article : Google Scholar

11 

Yan C, Duanmu X, Zeng L, Liu B and Song Z: Mitochondrial DNA: Distribution, mutations, and elimination. Cells. 8(379)2019.PubMed/NCBI View Article : Google Scholar

12 

Gambardella S, Limanaqi F, Ferese R, Biagioni F, Campopiano R, Centonze D and Fornai F: ccf-mtDNA as a potential link between the brain and immune system in neuro-immunological disorders. Front Immunol. 10(1064)2019.PubMed/NCBI View Article : Google Scholar

13 

Gao J, Wang L, Liu J, Xie F, Su B and Wang X: Abnormalities of mitochondrial dynamics in neurodegenerative diseases. Antioxidants. 6(25)2017.PubMed/NCBI View Article : Google Scholar

14 

Wang AS and Dreesen O: Biomarkers of cellular senescence and skin aging. Front Genet. 9(247)2018.PubMed/NCBI View Article : Google Scholar

15 

Pugazhenthi S: Metabolic syndrome and the cellular phase of Alzheimer's disease. Prog Mol Biol Transl Sci. 146:243–258. 2017.PubMed/NCBI View Article : Google Scholar

16 

Hood S and Amir S: The aging clock: Circadian rhythms and later life. J Clin Invest. 127:437–446. 2017.PubMed/NCBI View Article : Google Scholar

17 

Malyarchuk B, Derenko M, Grzybowski T, Perkova M, Rogalla U, Vanecek T and Tsybovsky I: The peopling of Europe from the mitochondrial haplogroup U5 perspective. PLoS One. 5(e10285)2010.PubMed/NCBI View Article : Google Scholar

18 

Meiliana A, Dewi NM and Wijaya A: Mitochondria in health and disease. Indones Biomed J. 11:1–15. 2019.PubMed/NCBI View Article : Google Scholar

19 

Richards M, Macaulay V, Hickey E, Vega E, Sykes B, Guida V, Rengo C, Sellitto D, Cruciani F, Kivisild T, et al: Tracing European founder lineages in the Near Eastern mtDNA pool. Am J Hum Genet. 67:1251–1276. 2000.PubMed/NCBI

20 

de Goede P, Wefers J, Brombacher EC, Schrauwen P and Kalsbeek A: Circadian rhythms in mitochondrial respiration. J Mol Endocrinol. 60:R115–R130. 2018.PubMed/NCBI View Article : Google Scholar

21 

Oliver D and Reddy P: Dynamics of dynamin-related protein 1 in Alzheimer's disease and other neurodegenerative diseases. Cells. 8(961)2019.PubMed/NCBI View Article : Google Scholar

22 

Dunham-Snary KJ and Ballinger SW: GENETICS. Mitochondrial-nuclear DNA mismatch matters. Science. 349:1449–1450. 2015.PubMed/NCBI View Article : Google Scholar

23 

Hummel EM, Hessas E, Müller S, Beiter T, Fisch M, Eibl A, Wolf OT, Giebel B, Platen P, Kumsta R and Moser DA: Cell-free DNA release under psychosocial and physical stress conditions. Transl Psychiatry. 8(236)2018.PubMed/NCBI View Article : Google Scholar

24 

Chakravorty A, Jetto CT and Manjithaya R: Dysfunctional mitochondria and mitophagy as drivers of Alzheimer's disease pathogenesis. Front Aging Neurosci. 11(311)2019.PubMed/NCBI View Article : Google Scholar

25 

Sebastián D, Palacín M and Zorzano A: Mitochondrial dynamics: Coupling mitochondrial fitness with healthy aging. Trends Mol Med. 23:201–215. 2017.PubMed/NCBI View Article : Google Scholar

26 

Bhatia D, Chung KP, Nakahira K, Patino E, Rice MC, Torres LK, Muthukumar T, Choi AM, Akchurin OM and Choi ME: Mitophagy-dependent macrophage reprogramming protects against kidney fibrosis. JCI Insight. 4(e132826)2019.PubMed/NCBI View Article : Google Scholar

27 

Schrepfer E and Scorrano L: Mitofusins, from mitochondria to metabolism. Mol Cell. 61:683–694. 2016.PubMed/NCBI View Article : Google Scholar

28 

Gómez-Serrano M, Camafeita E, Loureiro M and Peral B: Mitoproteomics: Tackling mitochondrial dysfunction in human disease. Oxid Med Cell Longev. 2018(1435934)2018.PubMed/NCBI View Article : Google Scholar

29 

Leung K, Chakraborty K, Saminathan A and Krishnan Y: A DNA nanomachine chemically resolves lysosomes in live cells. Nature Nanotech. 14:176–183. 2019.PubMed/NCBI View Article : Google Scholar

30 

Zhang CW, Hang L, Yao TP and Lim KL: Parkin regulation and neurodegenerative disorders. Front Aging Neurosci. 7(248)2016.PubMed/NCBI View Article : Google Scholar

31 

Nicolas E, Tricarico R, Savage M, Golemis EA and Hall MJ: Disease-associated genetic variation in human mitochondrial protein import. Am J Hum Genet. 104:784–801. 2019.PubMed/NCBI View Article : Google Scholar

32 

Truban D, Hou X, Caulfield TR, Fiesel FC and Springer W: PINK1, Parkin, and mitochondrial quality control: What can we learn about Parkinson's disease pathobiology? J Parkinsons Dis. 7:13–29. 2017.PubMed/NCBI View Article : Google Scholar

33 

Misgeld T and Schwarz TL: Mitostasis in neurons: Maintaining mitochondria in an extended cellular architecture. Neuron. 96:651–666. 2017.PubMed/NCBI View Article : Google Scholar

34 

Clark A and Mach N: The crosstalk between the gut microbiota and mitochondria during exercise. Front Physiol. 8(319)2017.PubMed/NCBI View Article : Google Scholar

35 

Nicholas D, Proctor EA, Raval FM, Ip BC, Habib C, Ritou E, Grammatopoulos TN, Steenkamp D, Dooms H, Apovian CM, et al: Advances in the quantification of mitochondrial function in primary human immune cells through extracellular flux analysis. PLoS One. 12(e0170975)2017.PubMed/NCBI View Article : Google Scholar

36 

Newell C, Hume S, Greenway SC, Podemski L, Shearer J and Khan A: Plasma-derived cell-free mitochondrial DNA: A novel non-invasive methodology to identify mitochondrial DNA haplogroups in humans. Mol Genet Metab. 125:332–337. 2018.PubMed/NCBI View Article : Google Scholar

37 

Martin LJ: Biology of mitochondria in neurodegenerative diseases. Prog Mol Biol Transl Sci. 107:355–415. 2012.PubMed/NCBI View Article : Google Scholar

38 

Castellazzi M, Patergnani S, Donadio M, Giorgi C, Bonora M, Bosi C, Brombo G, Pugliatti M, Seripa D, Zuliani G and Pinton P: Autophagy and mitophagy biomarkers are reduced in sera of patients with Alzheimer's disease and mild cognitive impairment. Sci Rep. 9(20009)2019.PubMed/NCBI View Article : Google Scholar

39 

Kageyama Y, Kasahara T, Kato M, Sakai S, Deguchi Y, Tani M, Kuroda K, Hattori K, Yoshida S, Goto Y, et al: The relationship between circulating mitochondrial DNA and inflammatory cytokines in patients with major depression. J Affect Disord. 233:15–20. 2018.PubMed/NCBI View Article : Google Scholar

40 

Jin SM and Youle RJ: PINK1- and Parkin-mediated mitophagy at a glance. J Cell Sci. 125:795–799. 2012.PubMed/NCBI View Article : Google Scholar

41 

Fernström J, Ohlsson L, Asp M, Lavant E, Holck A, Grudet C, Westrin Å and Lindqvist D: Plasma circulating cell-free mitochondrial DNA in depressive disorders. PLoS One. 16(e0259591)2021.PubMed/NCBI View Article : Google Scholar

42 

Cai Q and Jeong YY: Mitophagy in Alzheimer's disease and other age-related neurodegenerative diseases. Cells. 9(150)2020.PubMed/NCBI View Article : Google Scholar

43 

Wang W, Zhao F, Ma X, Perry G and Zhu X: Mitochondria dysfunction in the pathogenesis of Alzheimer's disease: Recent advances. Mol Neurodegeneration. 15(30)2020.PubMed/NCBI View Article : Google Scholar

44 

Iwata R and Vanderhaeghen P: Regulatory roles of mitochondria and metabolism in neurogenesis. Curr Opin Neurobiol. 69:231–240. 2021.PubMed/NCBI View Article : Google Scholar

45 

Blagov AV, Grechko AV, Nikiforov NG, Borisov EE, Sadykhov NK and Orekhov AN: Role of impaired mitochondrial dynamics processes in the pathogenesis of Alzheimer's disease. Int J Mol Sci. 23(6954)2022.PubMed/NCBI View Article : Google Scholar

46 

Apaijai N, Sriwichaiin S, Phrommintikul A, Jaiwongkam T, Kerdphoo S, Chansirikarnjana S, Thongmung N, Mahantassanapong U, Vathesatogkit P, Kitiyakara C, et al: Cognitive impairment is associated with mitochondrial dysfunction in peripheral blood mononuclear cells of elderly population. Sci Rep. 10(21400)2020.PubMed/NCBI View Article : Google Scholar

47 

Starkov AA: An update on the role of mitochondrial α-ketoglutarate dehydrogenase in oxidative stress. Mol Cell Neurosci. 55:13–16. 2013.PubMed/NCBI View Article : Google Scholar

48 

Shamsi TN, Athar T, Parveen R and Fatima S: A review on protein misfolding, aggregation and strategies to prevent related ailments. Int J Biol Macromol. 105:993–1000. 2017.PubMed/NCBI View Article : Google Scholar

49 

Stephan BCM, Hunter S, Harris D, Llewellyn DJ, Siervo M, Matthews FE and Brayne C: The neuropathological profile of mild cognitive impairment (MCI): A systematic review. Mol Psychiatry. 17:1056–1076. 2012.PubMed/NCBI View Article : Google Scholar

50 

Ding WX and Yin XM: Mitophagy: Mechanisms, pathophysiological roles, and analysis. Biol Chem. 393:547–564. 2012.PubMed/NCBI View Article : Google Scholar

51 

Sas K, Szabó E and Vécsei L: Mitochondria, oxidative stress and the kynurenine system, with a focus on ageing and neuroprotection. Molecules. 23(191)2018.PubMed/NCBI View Article : Google Scholar

52 

Jagannathan R, Thapa D, Nichols CE, Shepherd DL, Stricker JC, Croston TL, Baseler WA, Lewis SE, Martinez I and Hollander JM: Translational regulation of the mitochondrial genome following redistribution of mitochondrial MicroRNA in the diabetic heart. Circ Cardiovasc Genet. 8:785–802. 2015.PubMed/NCBI View Article : Google Scholar

53 

Kaliszewska A, Allison J, Martini M and Arias N: Improving Age-related cognitive decline through dietary interventions targeting mitochondrial dysfunction. Int J Mol Sci. 22(3574)2021.PubMed/NCBI View Article : Google Scholar

54 

Moehle EA, Shen K and Dillin A: Mitochondrial proteostasis in the context of cellular and organismal health and aging. J Biol Chem. 294:5396–5407. 2019.PubMed/NCBI View Article : Google Scholar

55 

Xu ZP, Yang SL, Zhao S, Zheng CH, Li HH, Zhang Y, Huang RX, Li MZ, Gao Y, Zhang SJ, et al: Biomarkers for early diagnostic of mild cognitive impairment in type-2 diabetes patients: A multicentre, retrospective, nested Case-control study. EBioMedicine. 5:105–113. 2016.PubMed/NCBI View Article : Google Scholar

56 

Trumpff C, Anna LM, Carla BA, James LM, Judith EC, Gabriel S, Amy EV, Eugene VM, Zhenglong G, Brett AK and Martin P: Acute psychological stress increases serum circulating cell-free mitochondrial DNA. Psychoneuroendocrinology. 106:268–276. 2019.PubMed/NCBI View Article : Google Scholar

57 

Labbadia J, Brielmann RM, Neto MF, Lin YF, Haynes CM and Morimoto RI: Mitochondrial stress restores the heat shock response and prevents proteostasis collapse during aging. Cell Rep. 21:1481–1494. 2017.PubMed/NCBI View Article : Google Scholar

58 

Silzer T, Robert B, Jie S, Gita P, Leigh J, Sid O'B and Nicole P: Circulating Mitochondrial DNA: New indices of type 2 diabetes-related cognitive impairment in Mexican Americans. PLoS One. 14(e0213527)2019.PubMed/NCBI View Article : Google Scholar

59 

Horejs CM: Lysosomes uncovered. Nat Rev Mater. 4(2)2019.

60 

Holstege H, van der Lee SJ, Hulsman M, Wong TH, van Rooij JG, Weiss M, Louwersheimer E, Wolters FJ, Amin N, Uitterlinden AG, et al: Characterization of pathogenic SORL1 genetic variants for association with Alzheimer's disease: A clinical interpretation strategy. Eur J Hum Genet. 25:973–981. 2017.PubMed/NCBI View Article : Google Scholar

61 

Forlenza OV, Diniz BS, Teixeira AL, Stella F and Gattaz W: Mild cognitive impairment (part 2): Biological markers for diagnosis and prediction of dementia in Alzheimer's disease. Rev Bras Psiquiatr. 35:284–294. 2013.PubMed/NCBI View Article : Google Scholar

62 

Klaips CL, Jayaraj GG and Hartl FU: Pathways of cellular proteostasis in aging and disease. J Cell Biol. 217:51–63. 2018.PubMed/NCBI View Article : Google Scholar

63 

Giau VV, Bagyinszky E and An SSA: Potential fluid biomarkers for the diagnosis of mild cognitive impairment. Int J Mol Sci. 20(4149)2019.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Semadhi MP, Mulyaty D, Halimah E and Levita J: Healthy mitochondrial DNA in balanced mitochondrial dynamics: A potential marker for neuro‑aging prediction (Review). Biomed Rep 19: 64, 2023.
APA
Semadhi, M.P., Mulyaty, D., Halimah, E., & Levita, J. (2023). Healthy mitochondrial DNA in balanced mitochondrial dynamics: A potential marker for neuro‑aging prediction (Review). Biomedical Reports, 19, 64. https://doi.org/10.3892/br.2023.1646
MLA
Semadhi, M. P., Mulyaty, D., Halimah, E., Levita, J."Healthy mitochondrial DNA in balanced mitochondrial dynamics: A potential marker for neuro‑aging prediction (Review)". Biomedical Reports 19.3 (2023): 64.
Chicago
Semadhi, M. P., Mulyaty, D., Halimah, E., Levita, J."Healthy mitochondrial DNA in balanced mitochondrial dynamics: A potential marker for neuro‑aging prediction (Review)". Biomedical Reports 19, no. 3 (2023): 64. https://doi.org/10.3892/br.2023.1646
Copy and paste a formatted citation
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Spandidos Publications style
Semadhi MP, Mulyaty D, Halimah E and Levita J: Healthy mitochondrial DNA in balanced mitochondrial dynamics: A potential marker for neuro‑aging prediction (Review). Biomed Rep 19: 64, 2023.
APA
Semadhi, M.P., Mulyaty, D., Halimah, E., & Levita, J. (2023). Healthy mitochondrial DNA in balanced mitochondrial dynamics: A potential marker for neuro‑aging prediction (Review). Biomedical Reports, 19, 64. https://doi.org/10.3892/br.2023.1646
MLA
Semadhi, M. P., Mulyaty, D., Halimah, E., Levita, J."Healthy mitochondrial DNA in balanced mitochondrial dynamics: A potential marker for neuro‑aging prediction (Review)". Biomedical Reports 19.3 (2023): 64.
Chicago
Semadhi, M. P., Mulyaty, D., Halimah, E., Levita, J."Healthy mitochondrial DNA in balanced mitochondrial dynamics: A potential marker for neuro‑aging prediction (Review)". Biomedical Reports 19, no. 3 (2023): 64. https://doi.org/10.3892/br.2023.1646
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