Comparing the pregnancy outcomes of Re‑ICSI and ICSI embryos in fresh ET and FET cycles

Jiang,Yan; Yuan,Jing-Chuan; Song,Ge; Zhang,Xu-Hui; Miao,Sui-Bing; Wu,Xiao-Hua

doi:10.3892/br.2023.1648

October-2023 Volume 19 Issue 4

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

October-2023 Volume 19 Issue 4

Full Size Image

Article Open Access

Comparing the pregnancy outcomes of Re‑ICSI and ICSI embryos in fresh ET and FET cycles

Authors:
- Yan Jiang
- Jing-Chuan Yuan
- Ge Song
- Xu-Hui Zhang
- Sui-Bing Miao
- Xiao-Hua Wu
View Affiliations / Copyright

Affiliations: The Center for Reproductive Medicine and Infertility, The Fourth Hospital of Shijiazhuang, Shijiazhuang Obstetrics and Gynecology Hospital Affiliated to Hebei Medical University, Key Laboratory of Maternal and Fetal Medicine of Hebei, Shijiazhuang, Hebei 050011, P.R. China

Copyright: © Jiang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Article Number: 66
|
Published online on: August 9, 2023

https://doi.org/10.3892/br.2023.1648
Expand metrics +

Abstract

Early rescue intracytoplasmic sperm injection (Re‑ICSI) can prevent total fertilization failure (TFF) during conventional in vitro fertilization (IVF). However, the implantation rate of Re‑ICSI embryos is lower than that of direct ICSI during fresh embryo transfer (ET). The aim of the present study was to investigate the effect of frozen ET (FET) after Re‑ICSI. In the present retrospective study, primary infertility patients that underwent the first Re‑ICSI and ICSI treatment, were studied. The clinical pregnancy rate, implantation rate, ectopic pregnancy, abortion rate and live birth rate were analyzed between the Re‑ICSI and ICSI groups in fresh ET and FET cycles. The average age of patients between Re‑ICSI and ICSI groups in fresh ET and FET cycles was (29.0±3.2 vs. 29.1±3.1, and 29.1±3.3 vs. 28.9±3.0), respectively (P>0.05). Compared with ICSI embryos, the clinical pregnancy, implantation and live birth rates of Re‑ICSI embryos were lower in fresh ET cycles. By contrast, there were no significant differences in the pregnancy, implantation and live birth rates between the Re‑ICSI and ICSI embryos during the FET cycles. Re‑ICSI coupled with FET may overcome the impaired outcomes in fresh ET.

View Figures

View References

1	Paffoni A, Reschini M, Pisaturo V, Guarneri C, Palini S and Viganò P: Should rescue ICSI be re-evaluated considering the deferred transfer of cryopreserved embryos in in-vitro fertilization cycles? A systematic review and meta-analysis. Reprod Biol Endocrinol. 19(121)2021.PubMed/NCBI View Article : Google Scholar
2	Zeng J, Yao Z, Zhang Y, Tian F, Liao T, Wu L and Li Y: Fertilization and neonatal outcomes after early rescue intracytoplasmic sperm injection: A retrospective analysis of 16,769 patients. Arch Gynecol Obstet. 306:249–258. 2022.PubMed/NCBI View Article : Google Scholar
3	He Y, Liu H, Zheng H, Li L, Fu X and Liu J: Effect of early cumulus cells removal and early rescue ICSI on pregnancy outcomes in high-risk patients of fertilization failure. Gynecol Endocrinol. 34:689–693. 2018.PubMed/NCBI View Article : Google Scholar
4	Jiang Y, Cao Q, Zhao X, Li L, Li S and Gao F: Percutaneous epididymal sperm aspiration and short time insemination in the treatment of men with obstructive azoospermia. J Assist Reprod Genet. 30:1175–1179. 2013.PubMed/NCBI View Article : Google Scholar
5	Gardner DK and Schoolcraft WB: Culture and transfer of human blastocysts. Curr Opin Obstet Gynecol. 11:307–311. 1999.PubMed/NCBI View Article : Google Scholar
6	Jiang Y, Song G, Zhang XH, Miao SB and Wu XH: Frozen blastocysts: Assessing the importance of Day 5/Day 6 blastocysts or blastocyst quality. Exp Ther Med. 23(333)2022.PubMed/NCBI View Article : Google Scholar
7	Guo H, Yang J, Zhang C, Li H, Yin B, Gu B, Xie J and He Q: Analysis of clinical data of patients with different outcomes after short-time insemination. Andrologia. 44 (Suppl 1):S667–S671. 2012.PubMed/NCBI View Article : Google Scholar
8	Shiraiwa Y, Enatsu N, Yamagami K, Furuhashi K, Iwasaki T, Otsuki J and Shiotani M: Clinical outcomes of rescue intracytoplasmic sperm injection at different timings following in vitro fertilization. J Reprod Infertil. 22:251–257. 2021.PubMed/NCBI View Article : Google Scholar
9	Liu J, Zhang X, Yang Y, Zhao J, Hao D, Zhang J, Liu Y, Wu W and Wang X: Long-time vs. short-time insemination of sibling eggs. Exp Ther Med. 12:3756–3760. 2016.PubMed/NCBI View Article : Google Scholar
10	Kong P, Yin M, Tang C, Zhu X, Bukulmez O, Chen M and Teng X: Effects of early cumulus cell removal on treatment outcomes in patients undergoing in vitro fertilization: A retrospective cohort study. Front Endocrinol (Lausanne). 12(669507)2021.PubMed/NCBI View Article : Google Scholar
11	Jiang L, Qian Y, Chen X, Ji X, Ou S, Li R, Yang D and Li Y: Effect of early rescue ICSI and split IVF-ICSI in preventing low fertilization rate during the first ART cycle: A real-world retrospective cohort study. Reprod Med Biol. 21(e12420)2021.PubMed/NCBI View Article : Google Scholar
12	Lombardi E, Tiverón M, Inza R, Valcárcel A, Young E and Bisioli C: Live birth and normal 1-year follow-up of a baby born after transfer of cryopreserved embryos from rescue intracytoplasmic sperm injection of 1-Day-old oocytes. Fertil Steril. 80:646–648. 2003.PubMed/NCBI View Article : Google Scholar
13	Sermondade N, Hugues JN, Cedrin-Durnerin I, Poncelet C, Benzacken B, Lévy R and Sifer C: Should all embryos from Day 1 rescue intracytoplasmic sperm injection be transferred during frozen-thawed cycles? Fertil Steril. 94:1157–1158. 2010.PubMed/NCBI View Article : Google Scholar

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Comparing the pregnancy outcomes of Re‑ICSI and ICSI embryos in fresh ET and FET cycles

This article is mentioned in:

Abstract

Figure 1

Related Articles