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The diagnostic or prognostic values of FADD in cancers based on pan‑cancer analysis

  • Authors:
    • Chenyu Wang
    • Xianglai Jiang
    • Qiqi Zhao
    • Zhiyuan Xie
    • Hui Cai
  • View Affiliations / Copyright

    Affiliations: Clinical Medical College of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region 750004, P.R. China, Department of General Surgery, General Surgery Clinical Center, Gansu Provincial Hospital, Lanzhou, Gansu 730000, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 77
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    Published online on: September 11, 2023
       https://doi.org/10.3892/br.2023.1659
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Abstract

Previous studies have determined that aberrant expression of the fas‑associated death domain (FADD) contributes to the development of cancer. However, no pan‑cancer analysis has been reported to explore the relationship between FADD and various cancers. Multiple databases were screened to identify cancer datasets for the present study and to validate the expression of FADD in various tumors. The association of FADD alteration with cancer prognosis, clinical features and tumor immunity was also evaluated. Reverse transcription‑quantitative PCR (RT‑qPCR) was utilized to confirm the expression of FADD in breast, colon, liver and gastric cancer cells. Analysis of Gene Expression Omnibus database and The Cancer Genome Atlas database indicated that FADD was highly expressed in breast invasive carcinoma (BRCA), cervical squamous cell carcinoma and endocervical adenocarcinoma, cholangiocarcinoma, colon adenocarcinoma (COAD), esophageal carcinoma (ESCA), kidney renal clear cell carcinoma, kidney renal papillary cell carcinoma, liver hepatocellular carcinoma (LIHC), lung adenocarcinoma (LUAD) and prostate adenocarcinoma, whereas RT‑qPCR results revealed that FADD was highly expressed in breast cancer and colon cancer. Further analyses demonstrated that FADD expression was significantly altered in ESCA, head and neck squamous cell carcinoma (HNSC), lung squamous cell carcinoma and BRCA. FADD expression was observed to be a risk factor of the overall survival in patients with HNSC, LIHC and LUAD as demonstrated by Kaplan‑Meier and Cox regression analyses. The results of the present study demonstrated that FADD is highly expressed in numerous malignancies and can be utilized as a biomarker for the diagnosis of BRCA, COAD, LIHC and stomach adenocarcinoma. Moreover, FADD expression is a predictive risk factor for the development of HNSC, LIHC and LUAD and can potentially be used as a prognostic marker for these cancers.
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1 

Mouasni S and Tourneur L: FADD at the crossroads between cancer and inflammation. Trends Immunol. 39:1036–1053. 2018.PubMed/NCBI View Article : Google Scholar

2 

Wilkerson PM and Reis-Filho JS: The 11q13-q14 amplicon: Clinicopathological correlations and potential drivers. Genes Chromosomes Cancer. 52:333–355. 2013.PubMed/NCBI View Article : Google Scholar

3 

Saggioro FP, Neder L, Stávale JN, Paixão-Becker AN, Malheiros SM, Soares FA, Pittella JE, Matias CC, Colli BO, Carlotti CG Jr and Franco M: Fas, FasL, and cleaved caspases 8 and 3 in glioblastomas: A tissue microarray-based study. Pathol Res Pract. 210:267–273. 2014.PubMed/NCBI View Article : Google Scholar

4 

Marín-Rubio JL, Vela-Martín L, Fernández-Piqueras J and Villa-Morales M: FADD in cancer: Mechanisms of altered expression and function, and clinical implications. Cancers (Basel). 11(1462)2019.PubMed/NCBI View Article : Google Scholar

5 

Tourneur L and Chiocchia G: FADD: A regulator of life and death. Trends Immunol. 31:260–269. 2010.PubMed/NCBI View Article : Google Scholar

6 

Zhuang H, Gan Z, Jiang W, Zhang X and Hua ZC: Functional specific roles of FADD: Comparative proteomic analyses from knockout cell lines. Mol Biosyst. 9:2063–2078. 2013.PubMed/NCBI View Article : Google Scholar

7 

Screaton RA, Kiessling S, Sansom OJ, Millar CB, Maddison K, Bird A, Clarke AR and Frisch SM: Fas-associated death domain protein interacts with methyl-CpG binding domain protein 4: A potential link between genome surveillance and apoptosis. Proc Natl Acad Sci USA. 100:5211–5216. 2003.PubMed/NCBI View Article : Google Scholar

8 

Gómez-Angelats M and Cidlowski JA: Molecular evidence for the nuclear localization of FADD. Cell Death Differ. 10:791–797. 2003.PubMed/NCBI View Article : Google Scholar

9 

Zhang Y and Zhang Z: The history and advances in cancer immunotherapy: Understanding the characteristics of tumor-infiltrating immune cells and their therapeutic implications. Cell Mol Immunol. 17:807–821. 2020.PubMed/NCBI View Article : Google Scholar

10 

Jiang Y, Chen M, Nie H and Yuan Y: PD-1 and PD-L1 in cancer immunotherapy: Clinical implications and future considerations. Hum Vaccin Immunother. 15:1111–1122. 2019.PubMed/NCBI View Article : Google Scholar

11 

Gajewski TF, Schreiber H and Fu YX: Innate and adaptive immune cells in the tumor microenvironment. Nat Immunol. 14:1014–1022. 2013.PubMed/NCBI View Article : Google Scholar

12 

Balkwill FR, Capasso M and Hagemann T: The tumor microenvironment at a glance. J Cell Sci. 125:5591–5596. 2012.PubMed/NCBI View Article : Google Scholar

13 

Mellman I, Coukos G and Dranoff G: Cancer immunotherapy comes of age. Nature. 480:480–489. 2011.PubMed/NCBI View Article : Google Scholar

14 

Esfahani K, Roudaia L, Buhlaiga N, Del Rincon SV, Papneja N and Miller WH*Jr: A review of cancer immunotherapy: From the past, to the present, to the future. Curr Oncol. 27 (Suppl 2):S87–S97. 2020.PubMed/NCBI View Article : Google Scholar

15 

Ranjan K, Waghela BN, Vaidya FU and Pathak C: Cell-penetrable peptide-conjugated FADD induces apoptosis and regulates inflammatory signaling in cancer cells. Int J Mol Sci. 21(6890)2020.PubMed/NCBI View Article : Google Scholar

16 

Xiang R, Liu Y, Zhu L, Dong W and Qi Y: Adaptor FADD is recruited by RTN3/HAP in ER-bound signaling complexes. Apoptosis. 11:1923–1932. 2006.PubMed/NCBI View Article : Google Scholar

17 

Kim WJ, Kim EJ, Kim SK, Kim YJ, Ha YS, Jeong P, Kim MJ, Yun SJ, Lee KM, Moon SK, et al: Predictive value of progression-related gene classifier in primary non-muscle invasive bladder cancer. Mol Cancer. 9(3)2010.PubMed/NCBI View Article : Google Scholar

18 

Wang J, Zhang X, Beck AH, Collins LC, Collins LC, Chen WY, Tamimi RM, Hazra A, Brown M, Rosner B and Hankinson SE: Alcohol consumption and risk of breast cancer by tumor receptor expression. Horm Cancer. 6:237–246. 2015.PubMed/NCBI View Article : Google Scholar

19 

Scotto L, Narayan G, Nandula SV, Arias-Pulido H, Subramaniyam S, Schneider A, Kaufmann AM, Wright JD, Pothuri B, Mansukhani M and Murty VV: Identification of copy number gain and overexpressed genes on chromosome arm 20q by an integrative genomic approach in cervical cancer: Potential role in progression. Genes Chromosomes Cancer. 47:755–765. 2008.PubMed/NCBI View Article : Google Scholar

20 

Andersen JB, Spee B, Blechacz BR, Avital I, Komuta M, Barbour A, Conner EA, Gillen MC, Roskams T, Roberts LR, et al: Genomic and genetic characterization of cholangiocarcinoma identifies therapeutic targets for tyrosine kinase inhibitors. Gastroenterology. 142:1021–1031.e15. 2012.PubMed/NCBI View Article : Google Scholar

21 

Solé X, Crous-Bou M, Cordero D, Olivares D, Guinó E, Sanz-Pamplona R, Rodriguez-Moranta F, Sanjuan X, de Oca J, Salazar R and Moreno V: Discovery and validation of new potential biomarkers for early detection of colon cancer. PLoS One. 9(e106748)2014.PubMed/NCBI View Article : Google Scholar

22 

Su H, Hu N, Yang HH, Wang C, Takikita M, Wang QH, Giffen C, Clifford R, Hewitt SM, Shou JZ, et al: Global gene expression profiling and validation in esophageal squamous cell carcinoma and its association with clinical phenotypes. Clin Cancer Res. 17:2955–2966. 2011.PubMed/NCBI View Article : Google Scholar

23 

Chen C, Méndez E, Houck J, Fan W, Lohavanichbutr P, Doody D, Yueh B, Futran ND, Upton M, Farwell DG, et al: Gene expression profiling identifies genes predictive of oral squamous cell carcinoma. Cancer Epidemiol Biomarkers Prev. 17:2152–2162. 2008.PubMed/NCBI View Article : Google Scholar

24 

Laskar RS, Li P, Ecsedi S, Abedi-Ardekani B, Durand G, Robinot N, Hubert JN, Janout V, Zaridze D, Mukeria A, et al: Sexual dimorphism in cancer: Insights from transcriptional signatures in kidney tissue and renal cell carcinoma. Hum Mol Genet. 30:343–355. 2021.PubMed/NCBI View Article : Google Scholar

25 

Jones J, Otu H, Spentzos D, Kolia S, Inan M, Beecken WD, Fellbaum C, Gu X, Joseph M, Pantuck AJ, et al: Gene signatures of progression and metastasis in renal cell cancer. Clin Cancer Res. 11:5730–5739. 2005.PubMed/NCBI View Article : Google Scholar

26 

Ivanovska I, Zhang C, Liu AM, Wong KF, Lee NP, Lewis P, Philippar U, Bansal D, Buser C, Scott M, et al: Gene signatures derived from a c-MET-driven liver cancer mouse model predict survival of patients with hepatocellular carcinoma. PLoS One. 6(e24582)2011.PubMed/NCBI View Article : Google Scholar

27 

Zhang Y, Foreman O, Wigle DA, Kosari F, Vasmatzis G, Salisbury JL, van Deursen J and Galardy PJ: USP44 regulates centrosome positioning to prevent aneuploidy and suppress tumorigenesis. J Clin Invest. 122:4362–4374. 2012.PubMed/NCBI View Article : Google Scholar

28 

Hou J, Aerts J, den Hamer B, van Ijcken W, den Bakker M, Riegman P, van der Leest C, van der Spek P, Foekens JA, Hoogsteden HC, et al: Gene expression-based classification of non-small cell lung carcinomas and survival prediction. PLoS One. 5(e10312)2010.PubMed/NCBI View Article : Google Scholar

29 

Suraokar MB, Nunez MI, Diao L, Chow CW, Kim D, Behrens C, Lin H, Lee S, Raso G, Moran C, et al: Expression profiling stratifies mesothelioma tumors and signifies deregulation of spindle checkpoint pathway and microtubule network with therapeutic implications. Ann Oncol. 25:1184–1192. 2014.PubMed/NCBI View Article : Google Scholar

30 

Vathipadiekal V, Wang V, Wei W, Waldron L, Drapkin R, Gillette M, Skates S and Birrer M: Creation of a human secretome: A novel composite library of human secreted proteins: Validation using ovarian cancer gene expression data and a virtual secretome array. Clin Cancer Res. 21:4960–4969. 2015.PubMed/NCBI View Article : Google Scholar

31 

Moffitt RA, Marayati R, Flate EL, Volmar KE, Loeza SG, Hoadley KA, Rashid NU, Williams LA, Eaton SC, Chung AH, et al: Virtual microdissection identifies distinct tumor- and stroma-specific subtypes of pancreatic ductal adenocarcinoma. Nat Genet. 47:1168–1178. 2015.PubMed/NCBI View Article : Google Scholar

32 

Giordano TJ, Kuick R, Else T, Gauger PG, Vinco M, Bauersfeld J, Sanders D, Thomas DG, Doherty G and Hammer G: Molecular classification and prognostication of adrenocortical tumors by transcriptome profiling. Clin Cancer Res. 15:668–676. 2009.PubMed/NCBI View Article : Google Scholar

33 

Whitington T, Gao P, Song W, Ross-Adams H, Lamb AD, Yang Y, Svezia I, Klevebring D, Mills IG, Karlsson R, et al: Gene regulatory mechanisms underpinning prostate cancer susceptibility. Nat Genet. 48:387–397. 2016.PubMed/NCBI View Article : Google Scholar

34 

Oh SC, Sohn BH, Cheong JH, Kim SB, Lee JE, Park KC, Lee SH, Park JL, Park YY, Lee HS, et al: Clinical and genomic landscape of gastric cancer with a mesenchymal phenotype. Nat Commun. 9(1777)2018.PubMed/NCBI View Article : Google Scholar

35 

Dom G, Tarabichi M, Unger K, Thomas G, Oczko-Wojciechowska M, Bogdanova T, Jarzab B, Dumont JE, Detours V and Maenhaut C: A gene expression signature distinguishes normal tissues of sporadic and radiation-induced papillary thyroid carcinomas. Br J Cancer. 107:994–1000. 2012.PubMed/NCBI View Article : Google Scholar

36 

Pappa KI, Polyzos A, Jacob-Hirsch J, Amariglio N, Vlachos GD, Loutradis D and Anagnou NP: Profiling of discrete gynecological cancers reveals novel transcriptional modules and common features shared by other cancer types and embryonic stem cells. PLoS One. 10(e0142229)2015.PubMed/NCBI View Article : Google Scholar

37 

Cerami E, Gao J, Dogrusoz U, Gross BE, Sumer SO, Aksoy BA, Jacobsen A, Byrne CJ, Heuer ML, Larsson E, et al: The cBio cancer genomics portal: An open platform for exploring multidimensional cancer genomics data. Cancer Discov. 2:401–404. 2012.PubMed/NCBI View Article : Google Scholar

38 

Zhang Y, Chen F, Chandrashekar DS, Varambally S and Creighton CJ: Proteogenomic characterization of 2002 human cancers reveals pan-cancer molecular subtypes and associated pathways. Nat Commun. 13(2669)2022.PubMed/NCBI View Article : Google Scholar

39 

Lánczky A and Győrffy B: Web-based survival analysis tool tailored for medical research (KMplot): Development and implementation. J Med Internet Res. 23(e27633)2021.PubMed/NCBI View Article : Google Scholar

40 

Whiteside TJ: The tumor microenvironment and its role in promoting tumor growth. Oncogene. 27:5904–5912. 2008.PubMed/NCBI View Article : Google Scholar

41 

Arneth B: Tumor microenvironment. Medicina (Kaunas). 56(15)2019.PubMed/NCBI View Article : Google Scholar

42 

Fridman WH, Galon J, Dieu-Nosjean MC, Cremer I, Fisson S, Damotte D, Pagès F, Tartour E and Sautès-Fridman C: Immune infiltration in human cancer: Prognostic significance and disease control. Curr Top Microbiol Immunol. 344:1–24. 2011.PubMed/NCBI View Article : Google Scholar

43 

Pagès F, Galon J, Dieu-Nosjean MC, Tartour E, Sautès-Fridman C and Fridman WH: Immune infiltration in human tumors: A prognostic factor that should not be ignored. Oncogene. 29:1093–1102. 2010.PubMed/NCBI View Article : Google Scholar

44 

Shen W, Song Z, Zhong X, Huang M, Shen D, Gao P, Qian X, Wang M, He X, Wang T, et al: Sangerbox: A comprehensive, interaction-friendly clinical bioinformatics analysis platform. iMeta. 1(e36)2022.

45 

Li T, Fu J, Zeng Z, Cohen D, Li J, Chen Q, Li B and Liu XS: TIMER2.0 for analysis of tumor-infiltrating immune cells. Nucleic Acids Res. 48 (W1):W509–W514. 2020.PubMed/NCBI View Article : Google Scholar

46 

Niu B, Ye K, Zhang Q, Lu C, Xie M, McLellan MD, Wendl MC and Ding L: MSIsensor: Microsatellite instability detection using paired tumor-normal sequence data. Bioinformatics. 30:1015–1016. 2014.PubMed/NCBI View Article : Google Scholar

47 

Goodman AM, Kato S, Bazhenova L, Patel SP, Frampton GM, Miller V, Stephens PJ, Daniels GA and Kurzrock R: Tumor mutational burden as an independent predictor of response to immunotherapy in diverse cancers. Mol Cancer Ther. 16:2598–2608. 2017.PubMed/NCBI View Article : Google Scholar

48 

Chalmers ZR, Connelly CF, Fabrizio D, Gay L, Ali SM, Ennis R, Schrock A, Campbell B, Shlien A, Chmielecki J, et al: Analysis of 100,000 human cancer genomes reveals the landscape of tumor mutational burden. Genome Med. 9(34)2017.PubMed/NCBI View Article : Google Scholar

49 

Mootha VK, Lindgren CM, Eriksson KF, Subramanian A, Sihag S, Lehar J, Puigserver P, Carlsson E, Ridderstråle M, Laurila E, et al: PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet. 34:267–273. 2003.PubMed/NCBI View Article : Google Scholar

50 

Kanehisa M and Goto S: KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 28:27–30. 2000.PubMed/NCBI View Article : Google Scholar

51 

Harris MA, Clark J, Ireland A, Lomax J, Ashburner M, Foulger R, Eilbeck K, Lewis S, Marshall B, Mungall C, et al: The gene ontology (GO) database and informatics resource. Nucleic Acids Res. 32 (Database Issue):D258–D261. 2004.PubMed/NCBI View Article : Google Scholar

52 

Sharma VK, Singh TG, Singh S, Garg N and Dhiman S: Apoptotic pathways and Alzheimer's disease: Probing therapeutic potential. Neurochem Res. 46:3103–3122. 2021.PubMed/NCBI View Article : Google Scholar

53 

Zhou W, Lai Y, Zhu J, Xu X, Yu W, Du Z, Wu L, Zhang X and Hua Z: The classical apoptotic adaptor FADD regulates glycolytic capacity in acute lymphoblastic leukemia. Int J Biol Sci. 18:3137–3155. 2022.PubMed/NCBI View Article : Google Scholar

54 

Lee EW, Seo J, Jeong M, Lee S and Song J: The roles of FADD in extrinsic apoptosis and necroptosis. BMB Rep. 45:496–508. 2012.PubMed/NCBI View Article : Google Scholar

55 

Singh N, Baby D, Rajguru JP, Patil PB, Thakkannavar SS and Pujari VB: Inflammation and cancer. Ann Afr Med. 18:121–126. 2019.PubMed/NCBI View Article : Google Scholar

56 

Murata M: Inflammation and cancer. Environ Health Prev Med. 23(50)2018.PubMed/NCBI View Article : Google Scholar

57 

Prapinjumrune C, Morita K, Kuribayashi Y, Hanabata Y, Shi Q, Nakajima Y, Inazawa J and Omura K: DNA amplification and expression of FADD in oral squamous cell carcinoma. J Oral Pathol Med. 39:525–532. 2010.PubMed/NCBI View Article : Google Scholar

58 

Saberi E, Kordi-Tamandani DM, Jamali S and Rigi-Ladiz MA: Analysis of methylation and mRNA expression status of FADD and FAS genes in patients with oral squamous cell carcinoma. Med Oral Patol Oral Cir Bucal. 19:e562–e568. 2014.PubMed/NCBI View Article : Google Scholar

59 

Liu Z, Zhang K, Zhao Z, Qin Z and Tang H: Prognosis-related autophagy genes in female lung adenocarcinoma. Medicine (Baltimore). 101(e28500)2022.PubMed/NCBI View Article : Google Scholar

60 

Jiang Y, Li Y, Ge H, Wu Y, Zhang Y, Guo S, Zhang P, Cheng J and Wang Y: Identification of an autophagy-related prognostic signature in head and neck squamous cell carcinoma. J Oral Pathol Med. 50:1040–1049. 2021.PubMed/NCBI View Article : Google Scholar

61 

Fan S, Müller S, Chen ZG, Pan L, Tighiouart M, Shin DM, Khuri FR and Sun SY: Prognostic impact of Fas-associated death domain, a key component in death receptor signaling, is dependent on the presence of lymph node metastasis in head and neck squamous cell carcinoma. Cancer Biol Ther. 14:365–369. 2013.PubMed/NCBI View Article : Google Scholar

62 

González-Moles MÁ, Ayén Á, González-Ruiz I, de Porras-Carrique T, González-Ruiz L, Ruiz-Ávila I and Ramos-García P: Prognostic and clinicopathological significance of FADD upregulation in head and neck squamous cell carcinoma: A systematic review and meta-analysis. Cancers (Basel). 12(2393)2020.PubMed/NCBI View Article : Google Scholar

63 

Verboom L, Martens A, Priem D, Hoste E, Sze M, Vikkula H, Van Hove L, Voet S, Roels J, Maelfait J, et al: OTULIN prevents liver inflammation and hepatocellular carcinoma by inhibiting FADD- and RIPK1 kinase-mediated hepatocyte apoptosis. Cell Rep. 30:2237–2247.e6. 2020.PubMed/NCBI View Article : Google Scholar

64 

Harari-Steinfeld R, Gefen M, Simerzin A, Zorde-Khvalevsky E, Rivkin M, Ella E, Friehmann T, Gerlic M, Zucman-Rossi J, Caruso S, et al: The lncRNA H19-derived MicroRNA-675 promotes liver necroptosis by targeting FADD. Cancers (Basel). 13(411)2021.PubMed/NCBI View Article : Google Scholar

65 

Liu W, Jing ZT, Xue CR, Wu SX, Chen WN, Lin XJ and Lin X: PI3K/AKT inhibitors aggravate death receptor-mediated hepatocyte apoptosis and liver injury. Toxicol Appl Pharmacol. 381(114729)2019.PubMed/NCBI View Article : Google Scholar

66 

Euler M and Hoffmann MH: The double-edged role of neutrophil extracellular traps in inflammation. Biochem Soc Trans. 47:1921–1930. 2019.PubMed/NCBI View Article : Google Scholar

67 

Liew PX and Kubes P: The neutrophil's role during health and disease. Physiol Rev. 99:1223–1248. 2019.PubMed/NCBI View Article : Google Scholar

68 

Murphy TL and Murphy KM: Dendritic cells in cancer immunology. Cell Mol Immunol. 19:3–13. 2022.PubMed/NCBI View Article : Google Scholar

69 

Bowman BM, Sebolt KA, Hoff BA, Boes JL, Daniels DL, Heist KA, Galbán CJ, Patel RM, Zhang J, Beer DG, et al: Phosphorylation of FADD by the kinase CK1α promotes KRASG12D-induced lung cancer. Sci Signal. 8(ra9)2015.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Wang C, Jiang X, Zhao Q, Xie Z and Cai H: The diagnostic or prognostic values of FADD in cancers based on pan‑cancer analysis. Biomed Rep 19: 77, 2023.
APA
Wang, C., Jiang, X., Zhao, Q., Xie, Z., & Cai, H. (2023). The diagnostic or prognostic values of FADD in cancers based on pan‑cancer analysis. Biomedical Reports, 19, 77. https://doi.org/10.3892/br.2023.1659
MLA
Wang, C., Jiang, X., Zhao, Q., Xie, Z., Cai, H."The diagnostic or prognostic values of FADD in cancers based on pan‑cancer analysis". Biomedical Reports 19.5 (2023): 77.
Chicago
Wang, C., Jiang, X., Zhao, Q., Xie, Z., Cai, H."The diagnostic or prognostic values of FADD in cancers based on pan‑cancer analysis". Biomedical Reports 19, no. 5 (2023): 77. https://doi.org/10.3892/br.2023.1659
Copy and paste a formatted citation
x
Spandidos Publications style
Wang C, Jiang X, Zhao Q, Xie Z and Cai H: The diagnostic or prognostic values of FADD in cancers based on pan‑cancer analysis. Biomed Rep 19: 77, 2023.
APA
Wang, C., Jiang, X., Zhao, Q., Xie, Z., & Cai, H. (2023). The diagnostic or prognostic values of FADD in cancers based on pan‑cancer analysis. Biomedical Reports, 19, 77. https://doi.org/10.3892/br.2023.1659
MLA
Wang, C., Jiang, X., Zhao, Q., Xie, Z., Cai, H."The diagnostic or prognostic values of FADD in cancers based on pan‑cancer analysis". Biomedical Reports 19.5 (2023): 77.
Chicago
Wang, C., Jiang, X., Zhao, Q., Xie, Z., Cai, H."The diagnostic or prognostic values of FADD in cancers based on pan‑cancer analysis". Biomedical Reports 19, no. 5 (2023): 77. https://doi.org/10.3892/br.2023.1659
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