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Pathophysiology of cervical myelopathy (Review)

  • Authors:
    • George Fotakopoulos
    • Vasiliki Epameinondas Georgakopoulou
    • Ioannis G. Lempesis
    • Petros Papalexis
    • Pagona Sklapani
    • Nikolaos Trakas
    • Demetrios A. Spandidos
    • Konstantinos Faropoulos
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, General University Hospital of Larissa, 41221 Larissa, Greece, Department of Pathophysiology, National and Kapodistrian University of Athens, 11527 Athens, Greece, Unit of Endocrinology, First Department of Internal Medicine, Laiko General Hospital, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece, Department of Biochemistry, Sismanogleio Hospital, 15126 Athens, Greece, Laboratory of Clinical Virology, School of Medicine, University of Crete, 71003 Heraklion, Greece, Department of Neurosurgery, Nicosia General Hospital, 2029 Nicosia, Cyprus
    Copyright: © Fotakopoulos et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 84
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    Published online on: September 25, 2023
       https://doi.org/10.3892/br.2023.1666
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Abstract

Cervical myelopathy is a well‑described medulla spinalis syndrome characterized by sensory disorders, such as pain, numbness, or paresthesia in the limbs, and motor disorders, such as muscle weakness, gait difficulties, spasticity, or hyperreflexia. If left untreated, cervical myelopathy can significantly affect the quality of life of patients, while in severe cases, it can cause disability or even quadriplegia. Cervical myelopathy is the final stage of spinal cord insult and can result from transgene dysplasias of the spinal cord, and acute or chronic injuries. Spondylosis is a common, multifactor cause of cervical myelopathy and affects various elements of the spine. The development of spondylotic changes in the spine is gradual during the patient's life and the symptoms are presented at a late stage, when significant damage has already been inflicted on the spinal cord. Spondylosis is widely considered a condition affecting the middle aged and elderly. Given the fact that the population is gradually becoming older, in the near future, clinicians may have to face an increased number of patients with spondylotic myelopathy.
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1 

Prescher A: Anatomy and pathology of the aging spine. Eur J Radiol. 27:181–195. 1998.PubMed/NCBI View Article : Google Scholar

2 

Nguyen C, Sanchez K, Roren A, Palazzo C, Falcou L, Drapé JL, Rannou F, Poiraudeau S and Lefèvre-Colau MM: Anatomical specificities of the degenerated cervical spine: A narrative review of clinical implications, with special focus on targeted spinal injections. Ann Phys Rehabil Med. 59:276–281. 2016.PubMed/NCBI View Article : Google Scholar

3 

Maiman DJ and Yoganandan N: Biomechanics of cervical spine trauma. In: Clinical neurosurgery. Black P (ed). Vol 97. Williams & Wilkins, Baltimore, MD, pp543-570, 1991.

4 

Neidlinger-Wilke C, Würtz K, Liedert A, Schmidt C, Börm W, Ignatius A, Wilke HJ and Claes L: A three-dimensional collagen matrix as a suitable culture system for the comparison of cyclic strain and hydrostatic pressure effects on intervertebral disc cells. J Neurosurg Spine. 2:457–465. 2005.PubMed/NCBI View Article : Google Scholar

5 

Seipelt H, Griefahn B and Wiersbitzky H: Calcinosis of intervertebral disks-relatively rare, heterogenous and mostly benign. Z Arztl Fortbild (Jena). 81:603–605. 1987.PubMed/NCBI(In German).

6 

Yasuma T, Suzuki F, Koh S and Yamauchi Y: Pathological changes in the cartilaginous plates in relation to intervertebral disc lesions. Acta Pathol Jpn. 38:735–750. 1988.PubMed/NCBI View Article : Google Scholar

7 

White AA and Panjabi MM: Clinical biomechanics of the spine, 2nd edition. J.B. Lippincott, Philadelphia, PA, 1990.

8 

Ratish S, Gao ZX, Prasad HM, Pei Z and Bijendra D: Percutaneous endoscopic lumbar spine surgery for lumbar disc herniation and lumbar spine stenosis: Emphasizing on clinical outcomes of transforaminal technique. Surg Sci. 9:63–84. 2018.

9 

Kumaresan S, Yoganandan N and Pintar FA: Posterior complex contribution to the axial compressive and distraction behavior of the cervical spine. J Musculoskeletal Res. 2:257–265. 1998.

10 

Onan OA, Heggeness MH and Hipp JA: A motion analysis of the cervical facet joint. Spine (Phila Pa 1976). 23:430–439. 1998.PubMed/NCBI View Article : Google Scholar

11 

Jonas R, Demmelmaier R and Wilke HJ: Influences of functional structures on the kinematic behavior of the cervical spine. Spine J. 20:2014–2024. 2020.PubMed/NCBI View Article : Google Scholar

12 

Yoganandan N, Kumaresan S and Pintar FA: Biomechanics of the cervical spine Part 2. Cervical spine soft tissue responses and biomechanical modeling. Clin Biomech (Bristol, Avon). 16:1–27. 2001.PubMed/NCBI View Article : Google Scholar

13 

Kumaresan S, Yoganandan N and Pintar FA: Methodology to quantify the uncovertebral joint in the human cervical spine. J Musculoskeletal Res. 1:1–9. 1997.

14 

Sherk HH, Dunn EJ, Eismont FJ, Fielding JW, Long DM, Ono K, Penning L and Raynor R: The cervical spine, 2nd edition. Philadelphia, PA: Lippincott, 1989.

15 

Bland JH: Luschka's Joint. Arch Intern Med. 116(635)1965.

16 

Hayashi K and Yabuki T: Origin of the uncus and of Luschka's joint in the cervical spine. J Bone Joint Surg Am. 67:788–791. 1985.PubMed/NCBI

17 

Hattori S, Oda H and Kawai S: Cervical intradiscal pressure in movements and traction of the cervical spine. Z Orthop. 119:568–569. 1981.

18 

Pospiech J, Stolke D, Wilke HJ and Claes LE: Intradiscal pressure recordings in the cervical spine. Neurosurgery. 44:379–385. 1999.PubMed/NCBI View Article : Google Scholar

19 

Nagamoto Y, Ishii T, Iwasaki M, Sakaura H, Moritomo H, Fujimori T, Kashii M, Murase T, Yoshikawa H and Sugamoto K: Three-dimensional motion of the uncovertebral joint during head rotation. J Neurosurg Spine. 17:327–333. 2012.PubMed/NCBI View Article : Google Scholar

20 

Wolfla CE: Adult and child and neck anatomy. In: Yoganandan N, Pintar FA, Larson SJ and Sances A (eds). Frontiers in head and neck trauma: Clinical and biomechanical. IOS Press, Amsterdam, pp18-33, 1998.

21 

Yoganandan N, Pintar F, Butler J, Reinartz J, Sances A Jr and Larson SJ: Dynamic response of human cervical spine ligaments. Spine (Phila Pa 1976). 14:1102–1110. 1989.PubMed/NCBI View Article : Google Scholar

22 

Yoganandan N, Kumaresan S and Pintar FA: Geometric and mechanical properties of human cervical spine ligaments. J Biomech Eng. 122:623–629. 2000.PubMed/NCBI View Article : Google Scholar

23 

Myklebust JB, Pintar F, Yoganandan N, Cusick JF, Maiman D, Myers TJ and Sances A Jr: Tensile strength of spinal ligaments. Spine (Phila Pa 1976). 13:526–531. 1988.PubMed/NCBI

24 

Ohara Y: Ossification of the ligaments in the cervical spine, including ossification of the anterior longitudinal ligament, ossification of the posterior longitudinal ligament, and ossification of the ligamentum flavum. Neurosurg Clin N Am. 29:63–68. 2018.PubMed/NCBI View Article : Google Scholar

25 

Barros EMKP, Rodrigues CJ, Rodrigues NR, Oliveira RP, Barros TEP and Rodrigues AJ Jr: Aging of the elastic and collagen fibers in the human cervical interspinous ligaments. Spine J. 2:57–62. 2002.PubMed/NCBI View Article : Google Scholar

26 

Yahia LH, Garzon S, Strykowski H and Rivard CH: Ultrastructure of the human interspinous ligament and ligamentum flavum. A preliminary study. Spine (Phila Pa 1976). 15:262–268. 1990.PubMed/NCBI View Article : Google Scholar

27 

Yong-Hing K, Reilly J and Kirkaldy-Willis WH: The ligamentum flavum. Spine. 1:226–234. 1976.

28 

Goel VK, Clark CR, McGowan D and Goyal S: An in-vitro study of the kinematics of the normal, injured and stabilized cervical spine. J Biomech. 17:363–376. 1984.PubMed/NCBI View Article : Google Scholar

29 

Zdeblick TA, Abitbol JJ, Kunz DN, McCabe RP and Garfin S: Cervical stability after sequential capsule resection. Spine (Phila Pa 1976). 18:2005–2008. 1993.PubMed/NCBI View Article : Google Scholar

30 

De Geer CM: Intervertebral disk nutrients and transport mechanisms in relation to disk degeneration: A narrative literature review. J Chiropr Med. 17:97–105. 2018.PubMed/NCBI View Article : Google Scholar

31 

Walsh DA: Angiogenesis in osteoarthritis and spondylosis: Successful repair with undesirable outcomes. Curr Opin Rheumatol. 16:609–615. 2004.PubMed/NCBI View Article : Google Scholar

32 

Tracy JA and Bartleson JD: Cervical spondylotic myelopathy. Neurologist. 16:176–187. 2010.PubMed/NCBI View Article : Google Scholar

33 

McCormack BM and Weinstein PR: Cervical spondylosis. An update. West J Med. 165:43–51. 1996.PubMed/NCBI

34 

Ito T, Oyanagi K, Takahashi H, Takahashi HE and Ikuta F: Cervical spondylotic myelopathy. Clinicopathologic study on the progression pattern and thin myelinated fibers of the lesions of seven patients examined during complete autopsy. Spine (Phila Pa 1976). 21:827–833. 1996.PubMed/NCBI View Article : Google Scholar

35 

Adams MA and Dolan P: Spine biomechanics. J Biomech. 38:1972–1983. 2005.PubMed/NCBI View Article : Google Scholar

36 

Benneker LM, Heini PF, Anderson SE, Alini M and Ito K: Correlation of radiographic and MRI parameters to morphological and biochemical assessment of intervertebral disc degeneration. Eur Spine J. 14:27–35. 2005.PubMed/NCBI View Article : Google Scholar

37 

Morishita Y, Naito M, Hymanson H, Miyazaki M, Wu G and Wang JC: The relationship between the cervical spinal canal diameter and the pathological changes in the cervical spine. Eur Spine J. 18:877–883. 2009.PubMed/NCBI View Article : Google Scholar

38 

Gore DR: Roentgenographic findings in the cervical spine in asymptomatic persons: A ten-year follow-up. Spine (Phila Pa 1976). 26:2463–2466. 2001.PubMed/NCBI View Article : Google Scholar

39 

Kuwazawa Y, Pope MH, Bashir W, Takahashi K and Smith FW: The length of the cervical cord: effects of postural changes in healthy volunteers using positional magnetic resonance imaging. Spine (Phila Pa 1976). 31:E579–E583. 2006.PubMed/NCBI View Article : Google Scholar

40 

Boden SD, McCowin PR, Davis DO, Dina TS, Mark AS and Wiesel S: Abnormal magnetic-resonance scans of the cervical spine in asymptomatic subjects. A prospective investigation. J Bone Joint Surg Am. 72:1178–1184. 1990.PubMed/NCBI

41 

Shedid D and Benzel EC: Cervical spondylosis anatomy: Pathophysiology and biomechanics. Neurosurgery. 60 (1 Supp1 1):S7–S13. 2007.PubMed/NCBI View Article : Google Scholar

42 

Rao R: Neck pain, cervical radiculopathy, and cervical myelopathy: Pathophysiology, natural history, and clinical evaluation. J Bone Joint Surg Am. 84:1872–1881. 2002.PubMed/NCBI View Article : Google Scholar

43 

Tang X, Jing L, Richardson WJ, Isaacs RE, Fitch RD, Brown CR, Erickson MM, Setton LA and Chen J: Identifying molecular phenotype of nucleus pulposus cells in human intervertebral disc with aging and degeneration. J Orthop Res. 34:1316–1326. 2016.PubMed/NCBI View Article : Google Scholar

44 

Baptiste DC and Fehlings MG: Pathophysiology of cervical myelopathy. Spine J. 6 (6 Suppl):190S–197S. 2006.PubMed/NCBI View Article : Google Scholar

45 

Horner HA and Urban JP: 2001 Volvo award winner in basic science studies: Effect of nutrient supply on the viability of cells from the nucleus pulposus of the intervertebral disc. Spine (Phila Pa 1976). 26:2543–2549. 2001.PubMed/NCBI View Article : Google Scholar

46 

Bayliss MT, Hutton S, Hayward J and Maciewicz RA: Distribution of aggrecanase (ADAMts 4/5) cleavage products in normal and osteoarthritic human articular cartilage: The influence of age, topography, and zone of tissue. Osteoarthritis Cartilage. 9:553–560. 2001.PubMed/NCBI View Article : Google Scholar

47 

Duance VC, Crean JK, Sims TJ, Avery N, Smith S, Menage J, Eisenstein SM and Roberts S: Changes in collagen cross-linking in degenerative disc disease and scoliosis. Spine (Phila Pa 1976). 23:2545–2551. 1998.PubMed/NCBI View Article : Google Scholar

48 

Brown MF, Hukkanen MV, McCarthy ID, Redfern DR, Batten JJ, Crock HV, Hughes SP and Polak JM: Sensory and sympathetic innervation of the vertebral endplate in patients with degenerative disc disease. J Bone Joint Surg Br. 79:147–153. 1997.PubMed/NCBI View Article : Google Scholar

49 

Freemont AJ, Watkins A, Le Maitre C, Baird P, Jeziorska M, Knight MT, Ross ER, O'Brien JP and Hoyland JA: Nerve growth factor expression and innervation of the painful intervertebral disc. J Pathol. 197:286–292. 2002.PubMed/NCBI View Article : Google Scholar

50 

Roberts S, Caterson B, Menage J, Evans EH, Jaffray DC and Eisenstein SM: Matrix metalloproteinases and aggrecanase: Their role in disorders of the human intervertebral disc. Spine (Phila Pa 1976). 25:3005–3013. 2000.PubMed/NCBI View Article : Google Scholar

51 

Carette S and Fehlings MG: Clinical practice. Cervical radiculopathy. N Engl J Med. 353:392–399. 2005.PubMed/NCBI View Article : Google Scholar

52 

Llopis E, Belloch E, León JP, Higueras V and Piquer J: The degenerative cervical spine. Radiologia. 58 (Suppl 1):S13–S25. 2016.PubMed/NCBI View Article : Google Scholar : (In English, Spanish).

53 

Pesch HJ, Becker T, Bischoff W and Seibold H: ‘Physiological osteoporosis’ and ‘osteoblast insufficiency’ in old age. Comparative radiological-morphometric and statistical studies on the spongy bone of lumbar and cervical vertebral bodies. Arch Orthop Trauma Surg. 110:1–14. 1990.PubMed/NCBI View Article : Google Scholar

54 

Ferrara LA: The biomechanics of cervical spondylosis. Adv Orthop. 2012(493605)2012.PubMed/NCBI View Article : Google Scholar

55 

Palanca M, Ruspi ML, Cristofolini L, Liebsch C, Villa T, Brayda-Bruno M, Galbusera F, Wilke HJ and La Barbera L: The strain distribution in the lumbar anterior longitudinal ligament is affected by the loading condition and bony features: An in vitro full-field analysis. PLoS One. 15(e0227210)2020.PubMed/NCBI View Article : Google Scholar

56 

Collins DH: The pathology of the articular and spinal diseases. Edward Arnold, London, 1949.

57 

Arlet V and Aebi M: Junctional spinal disorders in operated adult spinal deformities: Present understanding and future perspectives. Eur Spine J. 22 (Suppl 2):S276–S295. 2013.PubMed/NCBI View Article : Google Scholar

58 

Braun IF, Pinto RS, De Filipp GJ, Lieberman A, Pasternack P and Zimmerman RD: Brain stem infarction due to chiropractic manipulation of the cervical spine. South Med J. 76:1507–1510. 1983.PubMed/NCBI View Article : Google Scholar

59 

Muthukumar N: Ossification of the ligamentum flavum as a result of fluorosis causing myelopathy: Report of two cases. Neurosurgery. 56(E622)2005.PubMed/NCBI View Article : Google Scholar

60 

Lee MJ, Cassinelli EH and Riew KD: Prevalence of cervical spine stenosis. Anatomic study in cadavers. J Bone Joint Surg Am. 89:376–380. 2007.PubMed/NCBI View Article : Google Scholar

61 

Matsunaga S, Nakamura K, Seichi A, Yokoyama T, Toh S, Ichimura S, Satomi K, Endo K, Yamamoto K, Kato Y, et al: Radiographic predictors for the development of myelopathy in patients with ossification of the posterior longitudinal ligament: A multicenter cohort study. Spine (Phila Pa 1976). 33:2648–2650. 2008.PubMed/NCBI View Article : Google Scholar

62 

Bohlman HH: Cervical spondylosis and myelopathy. Instr Course Lect. 44:81–97. 1995.PubMed/NCBI

63 

Edwards WC and LaRocca H: The developmental segmental sagittal diameter of the cervical spinal canal in patients with cervical spondylosis. Spine (Phila Pa 1976). 8:20–27. 1983.PubMed/NCBI View Article : Google Scholar

64 

Hayashi H, Okada K, Hamada M, Tada K and Ueno R: Etiologic factors of myelopathy. A radiographic evaluation of the aging changes in the cervical spine. Clin Orthop Relat Res. 200–209. 1987.PubMed/NCBI

65 

Schmidt MH, Quinones-Hinojosa A and Rosenberg WS: Cervical myelopathy associated with degenerative spine disease and ossification of the posterior longitudinal ligament. Semin Neurol. 22:143–148. 2002.PubMed/NCBI View Article : Google Scholar

66 

Houten JK and Cooper PR: Laminectomy and posterior cervical plating for multilevel cervical spondylotic myelopathy and ossification of the posterior longitudinal ligament: Effects on cervical alignment, spinal cord compression, and neurological outcome. Neurosurgery. 52:1081–1078. 2003.PubMed/NCBI

67 

Miura J, Doita M, Miyata K, Marui T, Nishida K, Fujii M and Kurosaka M: Dynamic evaluation of the spinal cord in patients with cervical spondylotic myelopathy using a kinematic magnetic resonance imaging technique. J Spinal Disord Tech. 22:8–13. 2009.PubMed/NCBI View Article : Google Scholar

68 

Cooper PR and Epstein F: Radical resection of intramedullary spinal cord tumors in adults. Recent experience in 29 patients. J Neurosurg. 63:492–499. 1985.PubMed/NCBI View Article : Google Scholar

69 

Fehlings MG and Skaf G: A review of the pathophysiology of cervical spondylotic myelopathy with insights for potential novel mechanisms drawn from traumatic spinal cord injury. Spine (Phila Pa 1976). 23:2730–2737. 1998.PubMed/NCBI View Article : Google Scholar

70 

Debois V, Herz R, Berghmans D, Hermans B and Herregodts P: Soft cervical disc herniation. Influence of cervical spinal canal measurements on development of neurologic symptoms. Spine (Phila Pa 1976). 24:1996–2002. 1999.PubMed/NCBI View Article : Google Scholar

71 

Albert TJ and Vacarro A: Postlaminectomy kyphosis. Spine (Phila Pa 1976). 23:2738–2745. 1998.PubMed/NCBI View Article : Google Scholar

72 

Henderson FC, Geddes JF, Vaccaro AR, Woodard E, Berry KJ and Benzel EC: Stretch-associated injury in cervical spondylotic myelopathy: New concept and review. Neurosurgery. 56:1101–1113. 2005.PubMed/NCBI

73 

Matz PG, Pritchard PR and Hadley MN: Anterior cervical approach for the treatment of cervical myelopathy. Neurosurgery. 60 (1 Supp1 1):S64–S70. 2007.PubMed/NCBI View Article : Google Scholar

74 

Ferguson RJ and Caplan LR: Cervical spondylitic myelopathy. Neurol Clin. 3:373–382. 1985.PubMed/NCBI

75 

Muhle C, Metzner J, Weinert D, Schön R, Rautenberg E, Falliner A, Brinkmann G, Mehdorn HM, Heller M and Resnick D: Kinematic MR imaging in surgical management of cervical disc disease, spondylosis and spondylotic myelopathy. Acta Radiol. 40:146–153. 1999.PubMed/NCBI View Article : Google Scholar

76 

Kimura M, Ito K, Onizuka J, Hirayama M and Kuriyama M: Cervical spinal cord infarction in a patient with unilateral internal carotid artery occlusion and cervical spondylosis. Rinsho Shinkeigaku. 37:927–929. 1997.(In Japanese).

77 

Otani K, Sato K, Yabuki S, Iwabuchi M and Kikuchi S: A segmental partial laminectomy for cervical spondylotic myelopathy: Anatomical basis and clinical outcome in comparison with expansive open-door laminoplasty. Spine (Phila Pa 1976). 34:268–273. 2009.PubMed/NCBI View Article : Google Scholar

78 

Polak-Kraśna K, Robak-Nawrocka S, Szotek S, Czyż M, Gheek D and Pezowicz C: The denticulate ligament-tensile characterisation and finite element micro-scale model of the structure stabilising spinal cord. J Mech Behav Biomed Mater. 91:10–17. 2019.PubMed/NCBI View Article : Google Scholar

79 

Ichihara K, Taguchi T, Sakuramoto I, Kawano S and Kawai S: Mechanism of the spinal cord injury and the cervical spondylotic myelopathy: New approach based on the mechanical features of the spinal cord white and gray matter. J Neurosurg. 99 (3 Suppl):278–285. 2003.PubMed/NCBI View Article : Google Scholar

80 

Zeng C, Xiong J, Wang JC, Inoue H, Tan Y, Tian H and Aghdasi B: The evaluation and observation of ‘Hidden’ hypertrophy of cervical ligamentum flavum, cervical canal, and related factors using kinetic magnetic resonance imaging. Global Spine J. 6:155–163. 2016.PubMed/NCBI View Article : Google Scholar

81 

Chen CJ, Hsu HL, Niu CC, Chen TY, Chen MC, Tseng YC, Wong YC and Wang LJ: Cervical degenerative disease at flexion-extension MR imaging: Prediction criteria. Radiology. 227:136–142. 2003.PubMed/NCBI View Article : Google Scholar

82 

Maurer PK, Ellenbogen RG, Ecklund J, Simonds GR, van Dam B and Ondra SL: Cervical spondylotic myelopathy: Treatment with posterior decompression and Luque rectangle bone fusion. Neurosurgery. 28:680–684. 1991.PubMed/NCBI

83 

Lau D, Winkler EA, Than KD, Chou D and Mummaneni PV: Laminoplasty versus laminectomy with posterior spinal fusion for multilevel cervical spondylotic myelopathy: Influence of cervical alignment on outcomes. J Neurosurg Spine. 27:508–517. 2017.PubMed/NCBI View Article : Google Scholar

84 

Park Y, Maeda T, Cho W and Riew KD: Comparison of anterior cervical fusion after two-level discectomy or single-level corpectomy: Sagittal alignment, cervical lordosis, graft collapse, and adjacent-level ossification. Spine J. 10:193–199. 2010.PubMed/NCBI View Article : Google Scholar

85 

Kim PK and Alexander JT: Indications for circumferential surgery for cervical spondylotic myelopathy. Spine J. 6 (Suppl 6):299S–307S. 2006.PubMed/NCBI View Article : Google Scholar

86 

Panjabi M and White A III: Biomechanics of nonacute cervical spinal cord trauma. Spine (Phila Pa 1976). 13:838–842. 1988.PubMed/NCBI View Article : Google Scholar

87 

Smart KM, Blake C, Staines A, Thacker M and Doody C: Mechanisms-based classifications of musculoskeletal pain: Part 2 of 3: Symptoms and signs of peripheral neuropathic pain in patients with low back (± leg) pain. Man Ther. 17:345–351. 2012.PubMed/NCBI View Article : Google Scholar

88 

Tu J, Vargas Castillo J, Das A and Diwan AD: Degenerative cervical myelopathy: Insights into its pathobiology and molecular mechanisms. J Clin Med. 10(1214)2021.PubMed/NCBI View Article : Google Scholar

89 

Dohle E, Beardall S, Chang A, Mena KPC, Jovanović L, Nath U, Lee KS, Smith AH, Thirunavukarasu AJ, Touzet AY, et al: Human spinal cord tissue is an underutilised resource in degenerative cervical myelopathy: Findings from a systematic review of human autopsies. Acta Neurochir (Wien). 165:1121–1131. 2023.PubMed/NCBI View Article : Google Scholar

90 

Lestini WF and Wiesel SW: The pathogenesis of cervical spondylosis. Clin Orthop Relat Res. 69–93. 1989.PubMed/NCBI

91 

Lee WH, Lee SU and Jung SH: Ischemic cervical myelopathy caused by vertebral artery dissection: The clinical utility of a motor-evoked potential study. Neurologist. 21:8–10. 2016.PubMed/NCBI View Article : Google Scholar

92 

Strek P, Reroń E, Maga P, Modrzejewski M and Szybist N: A possible correlation between vertebral artery insufficiency and degenerative changes in the cervical spine. Eur Arch Otorhinolaryngol. 255:437–440. 1998.PubMed/NCBI View Article : Google Scholar

93 

Hashizume Y, Iijima S, Kishimoto H and Yanagi T: Pathology of spinal cord lesions caused by ossification of the posterior longitudinal ligament. Acta Neuropathol. 63:123–130. 1984.PubMed/NCBI View Article : Google Scholar

94 

Gooding MR, Wilson CB and Hoff JT: Experimental cervical myelopathy. Effects of ischemia and compression of the canine cervical spinal cord. J Neurosurg. 43:9–17. 1975.PubMed/NCBI View Article : Google Scholar

95 

Wilson CB, Bertan V, Norrell HA Jr and Hukuda S: Experimental cervical myelopathy. II. Acute ischemic myelopathy. Arch Neurol. 21:571–589. 1969.PubMed/NCBI View Article : Google Scholar

96 

Hukuda S and Wilson CB: Experimental cervical myelopathy: Effects of compression and ischemia on the canine cervical cord. J Neurosurg. 37:631–652. 1972.PubMed/NCBI View Article : Google Scholar

97 

Gooding MR, Wilson CB and Hoff JT: Experimental cervical myelopathy: Autoradiographic studies of spinal cord blood flow patterns. Surg Neurol. 5:233–239. 1976.PubMed/NCBI

98 

Pavlov PW: Anterior decompression for cervical spondylotic myelopathy. Eur Spine J. 12 (Suppl 2):S188–S194. 2003.PubMed/NCBI View Article : Google Scholar

99 

Pranteda G, Magri F, Moliterni E, Pranteda G and Quaglino P: Sannino-barduagni-bottoni syndrome. G Ital Dermatol Venereol. 154:732–734. 2019.PubMed/NCBI View Article : Google Scholar

100 

al-Mefty O, Harkey HL, Marawi I, Haines DE, Peeler DF, Wilner HI, Smith RR, Holaday HR, Haining JL, Russell WF, et al: Experimental chronic compressive cervical myelopathy. J Neurosurg. 79:550–561. 1993.PubMed/NCBI View Article : Google Scholar

101 

Hoff JNM, Pitts L, Vilnis V, Tuerk K and Lagger R: The role of ischemia in the pathogenesis of cervical spondylotic myelopathy: A review and new microangiopathic evidence. Spine (Phila Pa 1976). 2:100–108. 1977.

102 

Ono K, Ota H, Tada K and Yamamoto T: Cervical myelopathy secondary to multiple spondylotic protrusions; a clinicopathologic study. Spine. 2:109–125. 1977.

103 

Ogino H, Tada K, Okada K, Yonenobu K, Yamamoto T, Ono K and Namiki H: Canal diameter, anteroposterior compression ratio, and spondylotic myelopathy of the cervical spine. Spine (Phila Pa 1976). 8:1–15. 1983.PubMed/NCBI View Article : Google Scholar

104 

Carlson GD, Warden KE, Barbeau JM, Bahniuk E, Kutina-Nelson KL, Biro CL, Bohlman HH and LaManna JC: Viscoelastic relaxation and regional blood flow response to spinal cord compression and decompression. Spine (Phila Pa 1976). 22:1285–1291. 1997.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Fotakopoulos G, Georgakopoulou VE, Lempesis IG, Papalexis P, Sklapani P, Trakas N, Spandidos DA and Faropoulos K: Pathophysiology of cervical myelopathy (Review). Biomed Rep 19: 84, 2023.
APA
Fotakopoulos, G., Georgakopoulou, V.E., Lempesis, I.G., Papalexis, P., Sklapani, P., Trakas, N. ... Faropoulos, K. (2023). Pathophysiology of cervical myelopathy (Review). Biomedical Reports, 19, 84. https://doi.org/10.3892/br.2023.1666
MLA
Fotakopoulos, G., Georgakopoulou, V. E., Lempesis, I. G., Papalexis, P., Sklapani, P., Trakas, N., Spandidos, D. A., Faropoulos, K."Pathophysiology of cervical myelopathy (Review)". Biomedical Reports 19.5 (2023): 84.
Chicago
Fotakopoulos, G., Georgakopoulou, V. E., Lempesis, I. G., Papalexis, P., Sklapani, P., Trakas, N., Spandidos, D. A., Faropoulos, K."Pathophysiology of cervical myelopathy (Review)". Biomedical Reports 19, no. 5 (2023): 84. https://doi.org/10.3892/br.2023.1666
Copy and paste a formatted citation
x
Spandidos Publications style
Fotakopoulos G, Georgakopoulou VE, Lempesis IG, Papalexis P, Sklapani P, Trakas N, Spandidos DA and Faropoulos K: Pathophysiology of cervical myelopathy (Review). Biomed Rep 19: 84, 2023.
APA
Fotakopoulos, G., Georgakopoulou, V.E., Lempesis, I.G., Papalexis, P., Sklapani, P., Trakas, N. ... Faropoulos, K. (2023). Pathophysiology of cervical myelopathy (Review). Biomedical Reports, 19, 84. https://doi.org/10.3892/br.2023.1666
MLA
Fotakopoulos, G., Georgakopoulou, V. E., Lempesis, I. G., Papalexis, P., Sklapani, P., Trakas, N., Spandidos, D. A., Faropoulos, K."Pathophysiology of cervical myelopathy (Review)". Biomedical Reports 19.5 (2023): 84.
Chicago
Fotakopoulos, G., Georgakopoulou, V. E., Lempesis, I. G., Papalexis, P., Sklapani, P., Trakas, N., Spandidos, D. A., Faropoulos, K."Pathophysiology of cervical myelopathy (Review)". Biomedical Reports 19, no. 5 (2023): 84. https://doi.org/10.3892/br.2023.1666
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