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Telomere length as a predictive biomarker in osteoporosis (Review)

  • Authors:
    • Fotios Kakridonis
    • Spyros G. Pneumatikos
    • Elena Vakonaki
    • Aikaterini Berdiaki
    • Manolis N. Tzatzarakis
    • Persefoni Fragkiadaki
    • Demetrios A. Spandidos
    • Stella Baliou
    • Petros Ioannou
    • Eleftheria Hatzidaki
    • Dragana Nikitovic
    • Aristidis Tsatsakis
    • Elias Vasiliadis
  • View Affiliations / Copyright

    Affiliations: 5th Department of Orthopaedics, KAT Attica General Hospital, 14561 Athens, Greece, 3rd Department of Orthopaedics, KAT Attica General Hospital, 14561 Athens, Greece, Laboratory of Toxicology, Medical School, University of Crete, 71003 Heraklion, Greece, Laboratory of Anatomy‑Histology‑Embryology, Medical School, University of Crete, 71003 Heraklion, Greece, Laboratory of Clinical Virology, Medical School, University of Crete, 71003 Heraklion, Greece, Laboratory of Internal Medicine, Medical School, University of Crete, 71003 Heraklion, Greece, Department of Neonatology and NICU, University Hospital of Heraklion, 71500 Heraklion, Greece
    Copyright: © Kakridonis et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 87
    |
    Published online on: October 3, 2023
       https://doi.org/10.3892/br.2023.1669
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Abstract

Telomeres are the ends of chromosomes that protect them from DNA damage. There is evidence to suggest that telomere shortening appears with advanced age. Since aging is a significant risk factor for developing age‑related complications, it is plausible that telomere shortening may be involved in the development of osteoporosis. The present review summarizes the potential of telomere shortening as a biomarker for detecting the onset of osteoporosis. For the purposes of the present review, the following scientific databases were searched for relevant articles: PubMed/NCBI, Cochrane Library of Systematic Reviews, Scopus, Embase and Google Scholar. The present review includes randomized and non‑randomized controlled studies and case series involving humans, irrespective of the time of their publication. In six out of the 11 included studies providing data on humans, there was at least a weak association between telomere length and osteoporosis, with the remaining studies exhibiting no such association. As a result, telomere shortening may be used as a biomarker or as part of a panel of biomarkers for tracking the onset and progression of osteoporosis.
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Copy and paste a formatted citation
Spandidos Publications style
Kakridonis F, Pneumatikos SG, Vakonaki E, Berdiaki A, Tzatzarakis MN, Fragkiadaki P, Spandidos DA, Baliou S, Ioannou P, Hatzidaki E, Hatzidaki E, et al: Telomere length as a predictive biomarker in osteoporosis (Review). Biomed Rep 19: 87, 2023.
APA
Kakridonis, F., Pneumatikos, S.G., Vakonaki, E., Berdiaki, A., Tzatzarakis, M.N., Fragkiadaki, P. ... Vasiliadis, E. (2023). Telomere length as a predictive biomarker in osteoporosis (Review). Biomedical Reports, 19, 87. https://doi.org/10.3892/br.2023.1669
MLA
Kakridonis, F., Pneumatikos, S. G., Vakonaki, E., Berdiaki, A., Tzatzarakis, M. N., Fragkiadaki, P., Spandidos, D. A., Baliou, S., Ioannou, P., Hatzidaki, E., Nikitovic, D., Tsatsakis, A., Vasiliadis, E."Telomere length as a predictive biomarker in osteoporosis (Review)". Biomedical Reports 19.5 (2023): 87.
Chicago
Kakridonis, F., Pneumatikos, S. G., Vakonaki, E., Berdiaki, A., Tzatzarakis, M. N., Fragkiadaki, P., Spandidos, D. A., Baliou, S., Ioannou, P., Hatzidaki, E., Nikitovic, D., Tsatsakis, A., Vasiliadis, E."Telomere length as a predictive biomarker in osteoporosis (Review)". Biomedical Reports 19, no. 5 (2023): 87. https://doi.org/10.3892/br.2023.1669
Copy and paste a formatted citation
x
Spandidos Publications style
Kakridonis F, Pneumatikos SG, Vakonaki E, Berdiaki A, Tzatzarakis MN, Fragkiadaki P, Spandidos DA, Baliou S, Ioannou P, Hatzidaki E, Hatzidaki E, et al: Telomere length as a predictive biomarker in osteoporosis (Review). Biomed Rep 19: 87, 2023.
APA
Kakridonis, F., Pneumatikos, S.G., Vakonaki, E., Berdiaki, A., Tzatzarakis, M.N., Fragkiadaki, P. ... Vasiliadis, E. (2023). Telomere length as a predictive biomarker in osteoporosis (Review). Biomedical Reports, 19, 87. https://doi.org/10.3892/br.2023.1669
MLA
Kakridonis, F., Pneumatikos, S. G., Vakonaki, E., Berdiaki, A., Tzatzarakis, M. N., Fragkiadaki, P., Spandidos, D. A., Baliou, S., Ioannou, P., Hatzidaki, E., Nikitovic, D., Tsatsakis, A., Vasiliadis, E."Telomere length as a predictive biomarker in osteoporosis (Review)". Biomedical Reports 19.5 (2023): 87.
Chicago
Kakridonis, F., Pneumatikos, S. G., Vakonaki, E., Berdiaki, A., Tzatzarakis, M. N., Fragkiadaki, P., Spandidos, D. A., Baliou, S., Ioannou, P., Hatzidaki, E., Nikitovic, D., Tsatsakis, A., Vasiliadis, E."Telomere length as a predictive biomarker in osteoporosis (Review)". Biomedical Reports 19, no. 5 (2023): 87. https://doi.org/10.3892/br.2023.1669
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