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Article

IgG from patients with mild or severe COVID‑19 reduces the frequency and modulates the function of peripheral mucosal-associated invariant T cells in PBMCs from healthy individuals

  • Authors:
    • Nicolle Rakanidis Machado
    • Beatriz Oliveira Fagundes
    • Iara Grigoletto Fernandes
    • Daniela Terra De Apoena Reche
    • Maria Notomi Sato
    • Jefferson Russo Victor
  • View Affiliations / Copyright

    Affiliations: Laboratory of Medical Investigation LIM-56, Division of Dermatology, Medical School, University of São Paulo, São Paulo 05403-000, Brazil, Post Graduation Program in Health Sciences, Santo Amaro University (UNISA), São Paulo 04829-300, Brazil
  • Article Number: 95
    |
    Published online on: October 16, 2023
       https://doi.org/10.3892/br.2023.1677
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Abstract

Lower levels of peripheral mucosal‑associated invariant T (MAIT) cells have been observed in the peripheral blood of patients with severe coronavirus disease 2019 (COVID‑19). Following on from previous research into the effect of the IgG repertoire on human lymphocytes, the present study aimed to evaluate if immunoglobulin G (IgG) antibodies obtained from patients with mild or severe COVID‑19 contribute to these effects on MAIT cells. Culture experiments were performed using healthy human peripheral blood mononuclear cells (PBMCs) and different repertoires of IgG obtained from patients with COVID‑19 as a mild or severe disease and compared with mock, healthy control or therapeutic IgG conditions. The results indicate that the IgG repertoire induced during the development of mild and severe COVID‑19 has, per se, the in vitro potential to reduce the frequency of MAIT cells and the production of IFN‑γ by the MAIT cell population in PBMCs from healthy individuals. In conclusion, the results of the present study indicate that IgG in patients with severe COVID‑19 may participate in the reduction of peripheral MAIT cell frequency and hinder the antiviral activity of these cells.
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Copy and paste a formatted citation
Spandidos Publications style
Rakanidis Machado N, Fagundes BO, Fernandes IG, Terra De Apoena Reche D, Sato MN and Victor JR: IgG from patients with mild or severe COVID‑19 reduces the frequency and modulates the function of peripheral mucosal-associated invariant T cells in PBMCs from healthy individuals. Biomed Rep 19: 95, 2023.
APA
Rakanidis Machado, N., Fagundes, B.O., Fernandes, I.G., Terra De Apoena Reche, D., Sato, M.N., & Victor, J.R. (2023). IgG from patients with mild or severe COVID‑19 reduces the frequency and modulates the function of peripheral mucosal-associated invariant T cells in PBMCs from healthy individuals. Biomedical Reports, 19, 95. https://doi.org/10.3892/br.2023.1677
MLA
Rakanidis Machado, N., Fagundes, B. O., Fernandes, I. G., Terra De Apoena Reche, D., Sato, M. N., Victor, J. R."IgG from patients with mild or severe COVID‑19 reduces the frequency and modulates the function of peripheral mucosal-associated invariant T cells in PBMCs from healthy individuals". Biomedical Reports 19.6 (2023): 95.
Chicago
Rakanidis Machado, N., Fagundes, B. O., Fernandes, I. G., Terra De Apoena Reche, D., Sato, M. N., Victor, J. R."IgG from patients with mild or severe COVID‑19 reduces the frequency and modulates the function of peripheral mucosal-associated invariant T cells in PBMCs from healthy individuals". Biomedical Reports 19, no. 6 (2023): 95. https://doi.org/10.3892/br.2023.1677
Copy and paste a formatted citation
x
Spandidos Publications style
Rakanidis Machado N, Fagundes BO, Fernandes IG, Terra De Apoena Reche D, Sato MN and Victor JR: IgG from patients with mild or severe COVID‑19 reduces the frequency and modulates the function of peripheral mucosal-associated invariant T cells in PBMCs from healthy individuals. Biomed Rep 19: 95, 2023.
APA
Rakanidis Machado, N., Fagundes, B.O., Fernandes, I.G., Terra De Apoena Reche, D., Sato, M.N., & Victor, J.R. (2023). IgG from patients with mild or severe COVID‑19 reduces the frequency and modulates the function of peripheral mucosal-associated invariant T cells in PBMCs from healthy individuals. Biomedical Reports, 19, 95. https://doi.org/10.3892/br.2023.1677
MLA
Rakanidis Machado, N., Fagundes, B. O., Fernandes, I. G., Terra De Apoena Reche, D., Sato, M. N., Victor, J. R."IgG from patients with mild or severe COVID‑19 reduces the frequency and modulates the function of peripheral mucosal-associated invariant T cells in PBMCs from healthy individuals". Biomedical Reports 19.6 (2023): 95.
Chicago
Rakanidis Machado, N., Fagundes, B. O., Fernandes, I. G., Terra De Apoena Reche, D., Sato, M. N., Victor, J. R."IgG from patients with mild or severe COVID‑19 reduces the frequency and modulates the function of peripheral mucosal-associated invariant T cells in PBMCs from healthy individuals". Biomedical Reports 19, no. 6 (2023): 95. https://doi.org/10.3892/br.2023.1677
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