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Impact of preoperative type 2 diabetes mellitus on the outcomes of patients with gastric cancer following gastrectomy: Analysis of 834 patients using propensity score matching

  • Authors:
    • Dong Peng
    • Ying-Chun Xiang
    • Kai-Lin Tang
    • Yan-Yu Qiu
  • View Affiliations / Copyright

    Affiliations: Department of Gastrointestinal Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, P.R. China
    Copyright: © Peng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 97
    |
    Published online on: October 19, 2023
       https://doi.org/10.3892/br.2023.1679
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Abstract

The purpose of the current study was to compare the outcomes of patients with gastric cancer (GC) between the type 2 diabetes mellitus (T2DM) group and the non‑T2DM group. The PubMed, Embase and Cochrane Library databases were searched from inception to March 8, 2022, to identify propensity score matching (PSM) studies that analyzed the effect of T2DM on the outcomes of patients with GC. Total complications, overall survival (OS), disease‑free survival (DFS) and cancer‑specific survival (CSS) were compared between the T2DM group and the non‑T2DM group. A total of four PSM studies with 834 patients were included in the current study. There were 311 and 523 patients in the T2DM group and the non‑T2DM group, respectively. Baseline characteristics of the two groups were adjusted with PSM in all the four studies, however, no significant difference was found in baseline characteristics (P>0.05). DFS was significantly worse in the T2DM group compared with that in the non‑T2DM group [hazard ratio (HR), 1.45; 95% confidence interval (CI), 1.10‑1.90; P=0.007)]. However, after pooling up the data, there was no significant difference between the T2DM group and the non‑T2DM group in terms of OS (HR, 1.41; 95% CI, 0.92‑2.16; P=0.11), CSS (HR, 1.29; 95% CI, 0.92‑1.81; P=0.14) and total complications (odds ratio, 1.01; 95% CI, 0.64‑1.60; P=0.95). Patients with GC and T2DM are associated with poor DFS. However, there were no significant differences between the T2DM group and the non‑T2DM group in terms of OS, CSS and total complications.
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Copy and paste a formatted citation
Spandidos Publications style
Peng D, Xiang Y, Tang K and Qiu Y: Impact of preoperative type 2 diabetes mellitus on the outcomes of patients with gastric cancer following gastrectomy: Analysis of 834 patients using propensity score matching. Biomed Rep 19: 97, 2023.
APA
Peng, D., Xiang, Y., Tang, K., & Qiu, Y. (2023). Impact of preoperative type 2 diabetes mellitus on the outcomes of patients with gastric cancer following gastrectomy: Analysis of 834 patients using propensity score matching. Biomedical Reports, 19, 97. https://doi.org/10.3892/br.2023.1679
MLA
Peng, D., Xiang, Y., Tang, K., Qiu, Y."Impact of preoperative type 2 diabetes mellitus on the outcomes of patients with gastric cancer following gastrectomy: Analysis of 834 patients using propensity score matching". Biomedical Reports 19.6 (2023): 97.
Chicago
Peng, D., Xiang, Y., Tang, K., Qiu, Y."Impact of preoperative type 2 diabetes mellitus on the outcomes of patients with gastric cancer following gastrectomy: Analysis of 834 patients using propensity score matching". Biomedical Reports 19, no. 6 (2023): 97. https://doi.org/10.3892/br.2023.1679
Copy and paste a formatted citation
x
Spandidos Publications style
Peng D, Xiang Y, Tang K and Qiu Y: Impact of preoperative type 2 diabetes mellitus on the outcomes of patients with gastric cancer following gastrectomy: Analysis of 834 patients using propensity score matching. Biomed Rep 19: 97, 2023.
APA
Peng, D., Xiang, Y., Tang, K., & Qiu, Y. (2023). Impact of preoperative type 2 diabetes mellitus on the outcomes of patients with gastric cancer following gastrectomy: Analysis of 834 patients using propensity score matching. Biomedical Reports, 19, 97. https://doi.org/10.3892/br.2023.1679
MLA
Peng, D., Xiang, Y., Tang, K., Qiu, Y."Impact of preoperative type 2 diabetes mellitus on the outcomes of patients with gastric cancer following gastrectomy: Analysis of 834 patients using propensity score matching". Biomedical Reports 19.6 (2023): 97.
Chicago
Peng, D., Xiang, Y., Tang, K., Qiu, Y."Impact of preoperative type 2 diabetes mellitus on the outcomes of patients with gastric cancer following gastrectomy: Analysis of 834 patients using propensity score matching". Biomedical Reports 19, no. 6 (2023): 97. https://doi.org/10.3892/br.2023.1679
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