Open Access

CpG methylation changes in Alu repetitive sequences in normal aging due to diastolic hypertension in human dermal fibroblasts from the facial area

  • Authors:
    • Suvinai Jiraboonsri
    • Panicha Hemvipat
    • Supitcha Kamolratanakul
    • Narumol Bhummaphan
    • Tippawan Siritientong
    • Nakarin Kitkumthorn
    • Apiwat Mutirangura
    • Jiraroch Meevassana
  • View Affiliations

  • Published online on: November 17, 2023     https://doi.org/10.3892/br.2023.1693
  • Article Number: 5
  • Copyright: © Jiraboonsri et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Aging fibroblasts, an important factor contributing to skin aging, are affected by numerous mechanisms, including alterations in DNA methylation and age‑related diseases. The current study aimed to investigate the role of Alu methylation in aging fibroblasts and hypertension. The Alu methylation levels in dermal fibroblasts obtained from patients of different ages and blood pressure status were analyzed using the combined bisulfite restriction analysis technique. An inverse correlation was observed between Alu methylation in dermal fibroblasts and patient age. Dermal fibroblasts from the high‑normal diastolic blood pressure group had higher Alu methylation levels compared with those from the normal group. The findings of the present study suggest that Alu methylation alterations can be observed with chronological aging and hypertension, and are a potential aging marker or therapeutic target.
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January-2024
Volume 20 Issue 1

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Spandidos Publications style
Jiraboonsri S, Hemvipat P, Kamolratanakul S, Bhummaphan N, Siritientong T, Kitkumthorn N, Mutirangura A and Meevassana J: CpG methylation changes in Alu repetitive sequences in normal aging due to diastolic hypertension in human dermal fibroblasts from the facial area. Biomed Rep 20: 5, 2024
APA
Jiraboonsri, S., Hemvipat, P., Kamolratanakul, S., Bhummaphan, N., Siritientong, T., Kitkumthorn, N. ... Meevassana, J. (2024). CpG methylation changes in Alu repetitive sequences in normal aging due to diastolic hypertension in human dermal fibroblasts from the facial area. Biomedical Reports, 20, 5. https://doi.org/10.3892/br.2023.1693
MLA
Jiraboonsri, S., Hemvipat, P., Kamolratanakul, S., Bhummaphan, N., Siritientong, T., Kitkumthorn, N., Mutirangura, A., Meevassana, J."CpG methylation changes in Alu repetitive sequences in normal aging due to diastolic hypertension in human dermal fibroblasts from the facial area". Biomedical Reports 20.1 (2024): 5.
Chicago
Jiraboonsri, S., Hemvipat, P., Kamolratanakul, S., Bhummaphan, N., Siritientong, T., Kitkumthorn, N., Mutirangura, A., Meevassana, J."CpG methylation changes in Alu repetitive sequences in normal aging due to diastolic hypertension in human dermal fibroblasts from the facial area". Biomedical Reports 20, no. 1 (2024): 5. https://doi.org/10.3892/br.2023.1693