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Article Open Access

CpG methylation changes in Alu repetitive sequences in normal aging due to diastolic hypertension in human dermal fibroblasts from the facial area

  • Authors:
    • Suvinai Jiraboonsri
    • Panicha Hemvipat
    • Supitcha Kamolratanakul
    • Narumol Bhummaphan
    • Tippawan Siritientong
    • Nakarin Kitkumthorn
    • Apiwat Mutirangura
    • Jiraroch Meevassana
  • View Affiliations / Copyright

    Affiliations: Center of Excellence in Burn and Wound Care, Chulalongkorn University, Bangkok 10330, Thailand, Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand, College of Public Health Sciences, Chulalongkorn University, Bangkok 10330, Thailand, Department of Oral Biology, Faculty of Dentistry, Mahidol University, Bangkok 10400, Thailand, Department of Anatomy, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand
    Copyright: © Jiraboonsri et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 5
    |
    Published online on: November 17, 2023
       https://doi.org/10.3892/br.2023.1693
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Abstract

Aging fibroblasts, an important factor contributing to skin aging, are affected by numerous mechanisms, including alterations in DNA methylation and age‑related diseases. The current study aimed to investigate the role of Alu methylation in aging fibroblasts and hypertension. The Alu methylation levels in dermal fibroblasts obtained from patients of different ages and blood pressure status were analyzed using the combined bisulfite restriction analysis technique. An inverse correlation was observed between Alu methylation in dermal fibroblasts and patient age. Dermal fibroblasts from the high‑normal diastolic blood pressure group had higher Alu methylation levels compared with those from the normal group. The findings of the present study suggest that Alu methylation alterations can be observed with chronological aging and hypertension, and are a potential aging marker or therapeutic target.
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Copy and paste a formatted citation
Spandidos Publications style
Jiraboonsri S, Hemvipat P, Kamolratanakul S, Bhummaphan N, Siritientong T, Kitkumthorn N, Mutirangura A and Meevassana J: CpG methylation changes in Alu repetitive sequences in normal aging due to diastolic hypertension in human dermal fibroblasts from the facial area. Biomed Rep 20: 5, 2024.
APA
Jiraboonsri, S., Hemvipat, P., Kamolratanakul, S., Bhummaphan, N., Siritientong, T., Kitkumthorn, N. ... Meevassana, J. (2024). CpG methylation changes in Alu repetitive sequences in normal aging due to diastolic hypertension in human dermal fibroblasts from the facial area. Biomedical Reports, 20, 5. https://doi.org/10.3892/br.2023.1693
MLA
Jiraboonsri, S., Hemvipat, P., Kamolratanakul, S., Bhummaphan, N., Siritientong, T., Kitkumthorn, N., Mutirangura, A., Meevassana, J."CpG methylation changes in Alu repetitive sequences in normal aging due to diastolic hypertension in human dermal fibroblasts from the facial area". Biomedical Reports 20.1 (2024): 5.
Chicago
Jiraboonsri, S., Hemvipat, P., Kamolratanakul, S., Bhummaphan, N., Siritientong, T., Kitkumthorn, N., Mutirangura, A., Meevassana, J."CpG methylation changes in Alu repetitive sequences in normal aging due to diastolic hypertension in human dermal fibroblasts from the facial area". Biomedical Reports 20, no. 1 (2024): 5. https://doi.org/10.3892/br.2023.1693
Copy and paste a formatted citation
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Spandidos Publications style
Jiraboonsri S, Hemvipat P, Kamolratanakul S, Bhummaphan N, Siritientong T, Kitkumthorn N, Mutirangura A and Meevassana J: CpG methylation changes in Alu repetitive sequences in normal aging due to diastolic hypertension in human dermal fibroblasts from the facial area. Biomed Rep 20: 5, 2024.
APA
Jiraboonsri, S., Hemvipat, P., Kamolratanakul, S., Bhummaphan, N., Siritientong, T., Kitkumthorn, N. ... Meevassana, J. (2024). CpG methylation changes in Alu repetitive sequences in normal aging due to diastolic hypertension in human dermal fibroblasts from the facial area. Biomedical Reports, 20, 5. https://doi.org/10.3892/br.2023.1693
MLA
Jiraboonsri, S., Hemvipat, P., Kamolratanakul, S., Bhummaphan, N., Siritientong, T., Kitkumthorn, N., Mutirangura, A., Meevassana, J."CpG methylation changes in Alu repetitive sequences in normal aging due to diastolic hypertension in human dermal fibroblasts from the facial area". Biomedical Reports 20.1 (2024): 5.
Chicago
Jiraboonsri, S., Hemvipat, P., Kamolratanakul, S., Bhummaphan, N., Siritientong, T., Kitkumthorn, N., Mutirangura, A., Meevassana, J."CpG methylation changes in Alu repetitive sequences in normal aging due to diastolic hypertension in human dermal fibroblasts from the facial area". Biomedical Reports 20, no. 1 (2024): 5. https://doi.org/10.3892/br.2023.1693
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