Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Biomedical Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9434 Online ISSN: 2049-9442
Journal Cover
January-2024 Volume 20 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-2024 Volume 20 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Prolonged use of temozolomide leads to increased anxiety and decreased content of aggrecan and chondroitin sulfate in brain tissues of aged rats

  • Authors:
    • Anastasia V. Strokotova
    • Dmitry K. Sokolov
    • Olga P. Molodykh
    • Elena V. Koldysheva
    • Evgenii E. Kliver
    • Victor S. Ushakov
    • Maxim O. Politko
    • Nadezhda V. Mikhnevich
    • Galina M. Kazanskaya
    • Svetlana V. Aidagulova
    • Elvira V. Grigorieva
  • View Affiliations / Copyright

    Affiliations: Institute of Molecular Biology and Biophysics, Federal Research Center for Fundamental and Translational Medicine, Novosibirsk 630117, Russia, Institute of Molecular Pathology and Pathomorphology, Federal Research Center for Fundamental and Translational Medicine, Novosibirsk 630117, Russia, Meshalkin National Medical Research Center, Novosibirsk 630055, Russia
    Copyright: © Strokotova et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 7
    |
    Published online on: November 22, 2023
       https://doi.org/10.3892/br.2023.1695
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Chemotherapy with temozolomide (TMZ) is an essential part of anticancer therapy used for malignant tumors (mainly melanoma and glioblastoma); however, the long‑term effects on patient health and life quality are not fully investigated. Considering that tumors often occur in elderly patients, the present study was conducted on long‑term (4 months) treatment of adult Wistar rats (9 months old, n=40) with TMZ and/or dexamethasone (DXM) to investigate potential behavioral impairments or morphological and molecular changes in their brain tissues. According to the elevated plus maze test, long‑term use of TMZ affected the anxiety of the adult Wistar rats, although no significant deterioration of brain morphology or cellular composition of the brain tissue was revealed. The expression levels of all studied heparan sulfate (HS) proteoglycans (HSPGs) (syndecan‑1, syndecan‑3, glypican‑1 and HSPG2) and the majority of the studied chondroitin sulfate (CS) proteoglycans (CSPGs) (decorin, biglycan, lumican, brevican, neurocan aggrecan, versican, Cspg4/Ng2, Cspg5 and phosphacan) were not affected by TMZ/DXM, except for neurocan and aggrecan. Aggrecan was the most sensitive proteoglycan to TMZ/DXM treatment demonstrating downregulation of its mRNA and protein levels following TMZ (‑10‑fold), DXM (‑45‑fold) and TMZ‑DXM (‑80‑fold) treatment. HS content was not affected by TMZ/DXM treatment, whereas CS content was decreased 1.5‑2.5‑fold in the TMZ‑ and DXM‑treated brain tissues. Taken together, the results demonstrated that treatment of adult Wistar rats with TMZ had long‑term effects on the brain tissues, such as decreased aggrecan core protein levels and CS chain content and increased anxiety of the experimental animals.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Stupp R, Mason WP, van den Bent MJ, Weller M, Fisher B, Taphoorn MJ, Belanger K, Brandes AA, Marosi C, Bogdahn U, et al: Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N\ Engl J Med. 352:987–996. 2005.PubMed/NCBI View Article : Google Scholar

2 

McAleavey PG, Walls GM and Chalmers AJ: Radiotherapy-drug combinations in the treatment of glioblastoma: A brief review. CNS Oncol. 11(CNS86)2022.PubMed/NCBI View Article : Google Scholar

3 

Yuen CA, Barbaro M and Haggiagi A: Newly diagnosed glioblastoma in elderly patients. Curr Oncol Rep. 24:325–334. 2022.PubMed/NCBI View Article : Google Scholar

4 

Wilson MA and Schuchter LM: Chemotherapy for Melanoma. Cancer Treat Res. 167:209–229. 2016.PubMed/NCBI View Article : Google Scholar

5 

Harries M, Malvehy J, Lebbe C, Heron L, Amelio J, Szabo Z and Schadendorf D: Treatment patterns of advanced malignant melanoma (stage III-IV)-A review of current standards in Europe. Eur J Cancer. 60:179–189. 2016.PubMed/NCBI View Article : Google Scholar

6 

Khunger A, Buchwald ZS, Lowe M, Khan MK, Delman KA and Tarhini AA: Neoadjuvant therapy of locally/regionally advanced melanoma. Ther Adv Med Oncol. 11(1758835919866959)2019.PubMed/NCBI View Article : Google Scholar

7 

Pietrantonio F, Randon G, Romagnoli D, Di Donato S, Benelli M and de Braud F: Biomarker-guided implementation of the old drug temozolomide as a novel treatment option for patients with metastatic colorectal cancer. Cancer Treat Rev. 82(101935)2020.PubMed/NCBI View Article : Google Scholar

8 

Mollazadegan K, Welin S and Crona J: Systemic treatment of gastroenteropancreatic neuroendocrine carcinoma. Curr Treat Options Oncol. 22(68)2021.PubMed/NCBI View Article : Google Scholar

9 

Scaringi C, De Sanctis V, Minniti G and Enrici RM: Temozolomide-related hematologic toxicity. Onkologie. 36:444–449. 2013.PubMed/NCBI View Article : Google Scholar

10 

Le Rhun E, Oppong FB, Vanlancker M, Stupp R, Nabors B, Chinot O, Wick W, Preusser M, Gorlia T and Weller M: Prognostic significance of therapy-induced myelosuppression in newly diagnosed glioblastoma. Neuro Oncol. 24:1533–1545. 2022.PubMed/NCBI View Article : Google Scholar

11 

Gilbar PJ, Pokharel K and Mangos HM: Temozolomide-induced aplastic anaemia: Case report and review of the literature. J Oncol Pharm Pract. 27:1275–1280. 2021.PubMed/NCBI View Article : Google Scholar

12 

Ahn GS, Hwang K, Kim TM, Park CK, Chang JH, Jung TY, Kim JH, Nam DH, Kim SH, Yoo H, et al: Influence of Concurrent and Adjuvant Temozolomide on Health-Related Quality of Life of Patients with Grade III Gliomas: A Secondary Analysis of a Randomized Clinical Trial (KNOG-1101 Study). Cancer Res Treat. 54:396–405. 2022.PubMed/NCBI View Article : Google Scholar

13 

Hilverda K, Bosma I, Heimans JJ, Postma TJ, Peter Vandertop W, Slotman BJ, Buter J, Reijneveld JC and Klein M: Cognitive functioning in glioblastoma patients during radiotherapy and temozolomide treatment: Initial findings. J Neurooncol. 97:89–94. 2010.PubMed/NCBI View Article : Google Scholar

14 

Lombardi G, Bergo E, Del Bianco P, Bellu L, Pambuku A, Caccese M, Trentin L and Zagonel V: Quality of life perception, cognitive function, and psychological status in a real-world population of glioblastoma patients treated with Radio-therapy and Temozolomide: A single-center prospective study. Am J Clin Oncol. 41:1263–1271. 2018.PubMed/NCBI View Article : Google Scholar

15 

Rooney AG, Brown PD, Reijneveld JC and Grant R: Depression in glioma: A primer for clinicians and researchers. J Neurol Neurosurg Psychiatry. 85:230–235. 2014.PubMed/NCBI View Article : Google Scholar

16 

Wang Q, Qi F, Song X, Di J, Zhang L, Zhou Y, Lu X, Chang J and Yu Y: A prospective longitudinal evaluation of cognition and depression in postoperative patients with high-grade glioma following radiotherapy and chemotherapy. J Cancer Res Ther. 14 (Supplement):S1048–S1051. 2018.PubMed/NCBI View Article : Google Scholar

17 

Pereira-Caixeta AR, Guarnieri LO, Medeiros DC, Mendes EMAM, Ladeira LCD, Pereira MT, Moraes MFD and Pereira GS: Inhibiting constitutive neurogenesis compromises long-term social recognition memory. Neurobiol Learn Mem. 155:92–103. 2018.PubMed/NCBI View Article : Google Scholar

18 

Dey D, Parihar VK, Szabo GG, Klein PM, Tran J, Moayyad J, Ahmed F, Nguyen QA, Murry A, Merriott D, et al: Neurological impairments in mice subjected to irradiation and chemotherapy. Radiat Res. 193:407–424. 2020.PubMed/NCBI View Article : Google Scholar

19 

Egeland M, Guinaudie C, Du Preez A, Musaelyan K, Zunszain PA, Fernandes C, Pariante CM and Thuret S: Depletion of adult neurogenesis using the chemotherapy drug temozolomide in mice induces behavioural and biological changes relevant to depression. Transl Psychiatry. 7(e1101)2017.PubMed/NCBI View Article : Google Scholar

20 

Gan H, Zhang Q, Zhu B, Wu S and Chai D: Fluoxetine reverses brain radiation and temozolomide-induced anxiety and spatial learning and memory defect in mice. J Neurophysiol. 121:298–305. 2019.PubMed/NCBI View Article : Google Scholar

21 

Nokia MS, Anderson ML and Shors TJ: Chemotherapy disrupts learning, neurogenesis and theta activity in the adult brain. Eur J Neurosci. 36:3521–3530. 2012.PubMed/NCBI View Article : Google Scholar

22 

Pathak N, Cheruku SP, Rao V, Vibhavari RJA, Sumalatha S, Gourishetti K, Rao CM and Kumar N: Dehydrozingerone protects temozolomide-induced cognitive impairment in normal and C6 glioma rats besides enhancing its anticancer potential. 3 Biotech. 10(438)2020.PubMed/NCBI View Article : Google Scholar

23 

Minniti G, Scaringi C, Baldoni A, Lanzetta G, De Sanctis V, Esposito V and Enrici RM: Health-related quality of life in elderly patients with newly diagnosed glioblastoma treated with short-course radiation therapy plus concomitant and adjuvant temozolomide. Int J Radiat Oncol Biol Phys. 86:285–291. 2013.PubMed/NCBI View Article : Google Scholar

24 

Minniti G, Lombardi G and Paolini S: Glioblastoma in elderly patients: Current management and future perspectives. Cancers (Basel). 11(336)2019.PubMed/NCBI View Article : Google Scholar

25 

Suhovskih AV, Molodykh OP, Ushakov VS, Politko MO, Sokolov DK, Koldysheva EV and Grigorieva EV: Long-Term exposure to temozolomide affects locomotor activity and cartilage structure of elderly experimental rats. Biomedicines. 8(541)2020.PubMed/NCBI View Article : Google Scholar

26 

Afshari AR, Sanati M, Aminyavari S, Shakeri F, Bibak B, Keshavarzi Z, Soukhtanloo M, Jalili-Nik M, Sadeghi MM, Mollazadeh H, et al: Advantages and drawbacks of dexamethasone in glioblastoma multiforme. Crit Rev Oncol Hematol. 172(103625)2022.PubMed/NCBI View Article : Google Scholar

27 

Nguyen ET, Streicher J, Berman S, Caldwell JL, Ghisays V, Estrada CM, Wulsin AC and Solomon MB: A mixed glucocorticoid/mineralocorticoid receptor modulator dampens endocrine and hippocampal stress responsivity in male rats. PhysiolBehav. 178:82–92. 2017.PubMed/NCBI View Article : Google Scholar

28 

Nayana J, Shankaranarayana Rao BS and Srikumar BN: Mifepristone's effects on depression- and anxiety-like behavior in rodents. Steroids. 184(109058)2022.PubMed/NCBI View Article : Google Scholar

29 

Lenze EJ, Hershey T, Newcomer JW, Karp JF, Blumberger D, Anger J, Doré P and Dixon D: Antiglucocorticoid therapy for older adults with anxiety and co-occurring cognitive dysfunction: Results from a pilot study with mifepristone. Int J Geriatr Psychiatry. 29:962–969. 2014.PubMed/NCBI View Article : Google Scholar

30 

Mantilla EC Jr, Abramowitz J, Dan TU and Pan E: Prolonged steroid dependence in adult patients with glioma. Anticancer Res. 40:2059–2064. 2020.PubMed/NCBI View Article : Google Scholar

31 

Skupio U, Tertil M, Sikora M, Golda S, Wawrzczak-Bargiela A and Przewlocki R: Behavioral and molecular alterations in mice resulting from chronic treatment with dexamethasone: Relevance to depression. Neuroscience. 286:141–150. 2015.PubMed/NCBI View Article : Google Scholar

32 

Vafaei AA, Rashidy-Pour A and Taherian AA: Peripheral injection of dexamethasone modulates anxiety related behaviors in mice: An interaction with opioidergic neurons. Pak J Pharm Sci. 21:285–289. 2008.PubMed/NCBI

33 

Gómez-Oliva R, Domínguez-García S, Carrascal L, Abalos-Martínez J, Pardillo-Díaz R, Verástegui C, Castro C, Nunez-Abades P and Geribaldi-Doldán N: Evolution of experimental models in the study of glioblastoma: Toward finding efficient treatments. Front Oncol. 10(614295)2021.PubMed/NCBI View Article : Google Scholar

34 

Martin S, Janouskova H and Dontenwill M: Integrins and p53 pathways in glioblastoma resistance to temozolomide. Front Oncol. 2(157)2012.PubMed/NCBI View Article : Google Scholar

35 

Dong F, Eibach M, Bartsch JW, Dolga AM, Schlomann U, Conrad C, Schieber S, Schilling O, Biniossek ML, Culmsee C, et al: The metalloprotease-disintegrin ADAM8 contributes to temozolomide chemoresistance and enhanced invasiveness of human glioblastoma cells. Neuro Oncol. 17:1474–1485. 2015.PubMed/NCBI View Article : Google Scholar

36 

Farace C, Oliver JA, Melguizo C, Alvarez P, Bandiera P, Rama AR, Malaguarnera G, Ortiz R, Madeddu R and Prados J: Microenvironmental modulation of decorin and lumican in temozolomide-resistant glioblastoma and neuroblastoma cancer stem-like cells. PLoS One. 10(e0134111)2015.PubMed/NCBI View Article : Google Scholar

37 

Sayegh ET, Kaur G, Bloch O and Parsa AT: Systematic review of protein biomarkers of invasive behavior in glioblastoma. Mol Neurobiol. 49:1212–1244. 2014.PubMed/NCBI View Article : Google Scholar

38 

Pibuel MA, Poodts D, Díaz M, Hajos SE and Lompardía SL: The scrambled story between hyaluronan and glioblastoma. J Biol Chem. 296(100549)2021.PubMed/NCBI View Article : Google Scholar

39 

Tsidulko AY, Bezier C, de La Bourdonnaye G, Suhovskih AV, Pankova TM, Kazanskaya GM, Aidagulova SV and Grigorieva EV: Conventional Anti-glioblastoma chemotherapy affects proteoglycan composition of brain extracellular matrix in rat experimental model in vivo. Front Pharmacol. 9(1104)2018.PubMed/NCBI View Article : Google Scholar

40 

Tsidulko AY, Shevelev OB, Khotskina AS, Kolpakova MA, Suhovskih AV, Kazanskaya GM, Volkov AM, Aidagulova SV, Zavyalov EL and Grigorieva EV: Chemotherapy-Induced degradation of glycosylated components of the brain extracellular matrix promotes glioblastoma relapse development in an animal model. Front Oncol. 11(713139)2021.PubMed/NCBI View Article : Google Scholar

41 

Walf AA and Frye CA: The use of the elevated plus maze as an assay of anxiety-related behavior in rodents. Nat Protoc. 2:322–328. 2007.PubMed/NCBI View Article : Google Scholar

42 

Pádua Carobrez A, Kincheski GC and Bertoglio LJ: Elevated Plus. Maze. In: Encyclopedia of Psychopharmacology. Stolerman I.P. (ed). Springer, Berlin, Heidelberg, 2010.

43 

Livak KJ and Schmittgen TD: . Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

44 

Freireich EJ, Gehan EA, Rall DP, Schmidt LH and Skipper HE: Quantitative comparison of toxicity of anticancer agents in mouse, rat, hamster, dog, monkey and man. Cancer Chemother Rep. 50:219–244. 1966.PubMed/NCBI

45 

Reyderman L, Statkevich P, Thonoor CM, Patrick J, Batra VK and Wirth M: Disposition and pharmacokinetics of temozolomide in rat. Xenobiotica. 34:487–500. 2004.PubMed/NCBI View Article : Google Scholar

46 

Kostaras X, Cusano F, Kline GA, Roa W and Easaw J: Use of dexamethasone in patients with high-grade glioma: A clinical practice guideline. Curr Oncol. 21:e493–e503. 2014.PubMed/NCBI View Article : Google Scholar

47 

Chen X, Lin YP, Wang D and Zhang JN: Dexamethasone exacerbates spatial acquisition deficits after traumatic brain injury in rats. Neurol Res. 32:1097–1102. 2010.PubMed/NCBI View Article : Google Scholar

48 

From the American Association of Neurological Surgeons (AANS), American Society of Neuroradiology (ASNR), Cardiovascular and Interventional Radiology Society of Europe (CIRSE), Canadian Interventional Radiology Association (CIRA), Congress of Neurological Surgeons (CNS), European Society of Minimally Invasive Neurological Therapy (ESMINT), European Society of Neuroradiology (ESNR), European Stroke Organization (ESO), Society for Cardiovascular Angiography and Interventions (SCAI), Society of Interventional Radiology (SIR) et al. Multisociety Consensus Quality Improvement Revised Consensus Statement for Endovascular Therapy of Acute Ischemic Stroke. Int J Stroke. 13:612–632. 2018.PubMed/NCBI View Article : Google Scholar

49 

Yao YY, Liu DM, Xu DF and Li WP: Memory and learning impairment induced by dexamethasone in senescent but not young mice. Eur J Pharmacol. 574:20–28. 2007.PubMed/NCBI View Article : Google Scholar

50 

Narang VS, Fraga C, Kumar N, Shen J, Throm S, Stewart CF and Waters CM: Dexamethasone increases expression and activity of multidrug resistance transporters at the rat blood-brain barrier. Am J Physiol Cell Physiol. 295:C440–C450. 2008.PubMed/NCBI View Article : Google Scholar

51 

Drakulić D, Veličković N, Stanojlović M, Grković I, Mitrović N, Lavrnja I and Horvat A: Low-dose dexamethasone treatment promotes the pro-survival signalling pathway in the adult rat prefrontal cortex. J Neuroendocrinol. 25:605–616. 2013.PubMed/NCBI View Article : Google Scholar

52 

Drakulić D, Stanojlović M, Nedeljković N, Grković I, Veličković N, Guševac I, Mitrović N, Buzadžić I and Horvat A: Upregulation of nucleoside triphosphate diphosphohydrolase-1 and ecto-5'-nucleotidase in rat hippocampus after re-peated low-dose dexamethasone administration. J Mol Neurosci. 55:959–967. 2015.PubMed/NCBI View Article : Google Scholar

53 

Huang B, Yu Z and Liang R: Effect of long-term adjuvant temozolomide chemotherapy on primary glioblastoma patient survival. BMC Neurol. 21(424)2021.PubMed/NCBI View Article : Google Scholar

54 

Rowlands D, Lensjø KK, Dinh T, Yang S, Andrews MR, Hafting T, Fyhn M, Fawcett JW and Dick G: Aggrecan directs extracellular matrix-mediated neuronal plasticity. J Neurosci. 38:10102–10113. 2018.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Strokotova AV, Sokolov DK, Molodykh OP, Koldysheva EV, Kliver EE, Ushakov VS, Politko MO, Mikhnevich NV, Kazanskaya GM, Aidagulova SV, Aidagulova SV, et al: Prolonged use of temozolomide leads to increased anxiety and decreased content of aggrecan and chondroitin sulfate in brain tissues of aged rats. Biomed Rep 20: 7, 2024.
APA
Strokotova, A.V., Sokolov, D.K., Molodykh, O.P., Koldysheva, E.V., Kliver, E.E., Ushakov, V.S. ... Grigorieva, E.V. (2024). Prolonged use of temozolomide leads to increased anxiety and decreased content of aggrecan and chondroitin sulfate in brain tissues of aged rats. Biomedical Reports, 20, 7. https://doi.org/10.3892/br.2023.1695
MLA
Strokotova, A. V., Sokolov, D. K., Molodykh, O. P., Koldysheva, E. V., Kliver, E. E., Ushakov, V. S., Politko, M. O., Mikhnevich, N. V., Kazanskaya, G. M., Aidagulova, S. V., Grigorieva, E. V."Prolonged use of temozolomide leads to increased anxiety and decreased content of aggrecan and chondroitin sulfate in brain tissues of aged rats". Biomedical Reports 20.1 (2024): 7.
Chicago
Strokotova, A. V., Sokolov, D. K., Molodykh, O. P., Koldysheva, E. V., Kliver, E. E., Ushakov, V. S., Politko, M. O., Mikhnevich, N. V., Kazanskaya, G. M., Aidagulova, S. V., Grigorieva, E. V."Prolonged use of temozolomide leads to increased anxiety and decreased content of aggrecan and chondroitin sulfate in brain tissues of aged rats". Biomedical Reports 20, no. 1 (2024): 7. https://doi.org/10.3892/br.2023.1695
Copy and paste a formatted citation
x
Spandidos Publications style
Strokotova AV, Sokolov DK, Molodykh OP, Koldysheva EV, Kliver EE, Ushakov VS, Politko MO, Mikhnevich NV, Kazanskaya GM, Aidagulova SV, Aidagulova SV, et al: Prolonged use of temozolomide leads to increased anxiety and decreased content of aggrecan and chondroitin sulfate in brain tissues of aged rats. Biomed Rep 20: 7, 2024.
APA
Strokotova, A.V., Sokolov, D.K., Molodykh, O.P., Koldysheva, E.V., Kliver, E.E., Ushakov, V.S. ... Grigorieva, E.V. (2024). Prolonged use of temozolomide leads to increased anxiety and decreased content of aggrecan and chondroitin sulfate in brain tissues of aged rats. Biomedical Reports, 20, 7. https://doi.org/10.3892/br.2023.1695
MLA
Strokotova, A. V., Sokolov, D. K., Molodykh, O. P., Koldysheva, E. V., Kliver, E. E., Ushakov, V. S., Politko, M. O., Mikhnevich, N. V., Kazanskaya, G. M., Aidagulova, S. V., Grigorieva, E. V."Prolonged use of temozolomide leads to increased anxiety and decreased content of aggrecan and chondroitin sulfate in brain tissues of aged rats". Biomedical Reports 20.1 (2024): 7.
Chicago
Strokotova, A. V., Sokolov, D. K., Molodykh, O. P., Koldysheva, E. V., Kliver, E. E., Ushakov, V. S., Politko, M. O., Mikhnevich, N. V., Kazanskaya, G. M., Aidagulova, S. V., Grigorieva, E. V."Prolonged use of temozolomide leads to increased anxiety and decreased content of aggrecan and chondroitin sulfate in brain tissues of aged rats". Biomedical Reports 20, no. 1 (2024): 7. https://doi.org/10.3892/br.2023.1695
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team