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Article Open Access

Clinical predictive factors of coronary stenosis in patients with high‑risk valvular heart disease who received diagnostic coronary angiography prior to cardiac valve surgery

  • Authors:
    • Sirorat Wara‑Aswapati
    • Danon Kaewkes
    • Verajit Chotmongkol
    • Kittisak Sawanyawisuth
  • View Affiliations / Copyright

    Affiliations: Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
    Copyright: © Wara‑Aswapati et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 9
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    Published online on: November 23, 2023
       https://doi.org/10.3892/br.2023.1697
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Abstract

Valvular heart disease (VHD) may lead to morbidities and mortality due to heart failure or sudden death. Concomitant coronary artery disease (CAD) is a crucial condition that needs to be explored in patients with VHD prior to cardiac valve surgery as it may increase morbidity and mortality. Patient age >40 years and mitral regurgitation are key risk factors for CAD in patients with VHD. The present study aimed to identify clinical risk factors for coronary stenosis in patients with high‑risk VHD. The retrospective cohort study recruited patients aged >40 years who received cardiac valve surgery and coronary angiogram prior to cardiac valve surgery. Clinical factors predictive of coronary stenosis were computed by logistic regression analysis. There were 533 patients; 114 patients (21.38%) had coronary stenosis. Four factors were positively associated with coronary stenosis including age, male sex, mitral regurgitation and hypertension, while two factors were negatively associated with coronary stenosis, namely estimated glomerular filtration rate and rheumatic heart disease. Hypertension had the highest adjusted odds ratio at 2.596, while rheumatic heart disease had the lowest adjusted odds ratio at 0.428. Patient age >55 years showed a sensitivity and specificity of coronary stenosis of 80.70 and 37.47%, respectively. Clinical factors predictive of coronary stenosis in patients with high‑risk VHD were age >55 years, male sex, mitral regurgitation and hypertension, while a high estimated glomerular filtration rate and presence of rheumatic heart disease were protective factors.
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Copy and paste a formatted citation
Spandidos Publications style
Wara‑Aswapati S, Kaewkes D, Chotmongkol V and Sawanyawisuth K: Clinical predictive factors of coronary stenosis in patients with high‑risk valvular heart disease who received diagnostic coronary angiography prior to cardiac valve surgery. Biomed Rep 20: 9, 2024.
APA
Wara‑Aswapati, S., Kaewkes, D., Chotmongkol, V., & Sawanyawisuth, K. (2024). Clinical predictive factors of coronary stenosis in patients with high‑risk valvular heart disease who received diagnostic coronary angiography prior to cardiac valve surgery. Biomedical Reports, 20, 9. https://doi.org/10.3892/br.2023.1697
MLA
Wara‑Aswapati, S., Kaewkes, D., Chotmongkol, V., Sawanyawisuth, K."Clinical predictive factors of coronary stenosis in patients with high‑risk valvular heart disease who received diagnostic coronary angiography prior to cardiac valve surgery". Biomedical Reports 20.1 (2024): 9.
Chicago
Wara‑Aswapati, S., Kaewkes, D., Chotmongkol, V., Sawanyawisuth, K."Clinical predictive factors of coronary stenosis in patients with high‑risk valvular heart disease who received diagnostic coronary angiography prior to cardiac valve surgery". Biomedical Reports 20, no. 1 (2024): 9. https://doi.org/10.3892/br.2023.1697
Copy and paste a formatted citation
x
Spandidos Publications style
Wara‑Aswapati S, Kaewkes D, Chotmongkol V and Sawanyawisuth K: Clinical predictive factors of coronary stenosis in patients with high‑risk valvular heart disease who received diagnostic coronary angiography prior to cardiac valve surgery. Biomed Rep 20: 9, 2024.
APA
Wara‑Aswapati, S., Kaewkes, D., Chotmongkol, V., & Sawanyawisuth, K. (2024). Clinical predictive factors of coronary stenosis in patients with high‑risk valvular heart disease who received diagnostic coronary angiography prior to cardiac valve surgery. Biomedical Reports, 20, 9. https://doi.org/10.3892/br.2023.1697
MLA
Wara‑Aswapati, S., Kaewkes, D., Chotmongkol, V., Sawanyawisuth, K."Clinical predictive factors of coronary stenosis in patients with high‑risk valvular heart disease who received diagnostic coronary angiography prior to cardiac valve surgery". Biomedical Reports 20.1 (2024): 9.
Chicago
Wara‑Aswapati, S., Kaewkes, D., Chotmongkol, V., Sawanyawisuth, K."Clinical predictive factors of coronary stenosis in patients with high‑risk valvular heart disease who received diagnostic coronary angiography prior to cardiac valve surgery". Biomedical Reports 20, no. 1 (2024): 9. https://doi.org/10.3892/br.2023.1697
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