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Case Report Open Access

Clinicopathological findings in refractory diabetic macular edema: A case report

  • Authors:
    • Takayuki Tanaka
    • Satoru Kase
    • Michiyuki Saito
    • Ikuyo Hirose
    • Miyuki Murata
    • Emi Takakuwa
    • Susumu Ishida

  • View Affiliations / Copyright

    Affiliations: Department of Ophthalmology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido 060‑8638, Japan, Department of Surgical Pathology, Hokkaido University Hospital, Sapporo, Hokkaido 060‑8648, Japan
    Copyright: © Tanaka et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 13
    |
    Published online on: November 29, 2023
       https://doi.org/10.3892/br.2023.1701
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Abstract

The present study describes the case of a patient with refractory diabetic cystoid macular edema who underwent vitrectomy with en bloc removal of the cystoid lesion component. The current study also performed histopathological and immunohistochemical analyses of the cystoid lesion component to assess fibrin/fibrinogen and advanced glycation end-products (AGEs) immunoreactivity. A 69‑year‑old Japanese man presented with visual loss in the left eye due to residual cystoid macular edema (CME) refractory to anti‑vascular endothelial growth factor therapy. Best‑corrected visual acuity was 1.2 in the right eye (OD) and 0.5 in the left eye (OS). Fundus examination showed dot hemorrhages and hard exudates in the peri‑macular region with pan‑retinal photocoagulation scars in both eye. Swept‑source optical coherence tomography revealed CME with slight hyperreflectivity in the cyst OS. A total of 3 months after the initial visit, pars plana vitrectomy was performed, and the translucent solidified component within the cystoid lesion was isolated. Histopathologically, the excised component was elliptical in shape, measuring 0.7x0.4 mm and exhibited homogeneous eosinophilic material without cellular components. No membranous structure was observed surrounding the component. Immunohistochemistry demonstrated that the tissue was positive for fibrin/fibrinogen and weakly positive for AGEs, but was negative for glial fibrillary acidic protein, type 1 collagen and receptor for AGEs. To the best of our knowledge, the present case report is the first to histopathologically examine the contents of refractory CME, and to immunohistochemically demonstrate that fibrin in diabetic CME may be post‑translationally modified by AGEs. These results suggested that fibrin in CME may escape degradation by plasmin due to post‑translational modifications.
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Copy and paste a formatted citation
Spandidos Publications style
Tanaka T, Kase S, Saito M, Hirose I, Murata M, Takakuwa E and Ishida S: Clinicopathological findings in refractory diabetic macular edema: A case report. Biomed Rep 20: 13, 2024.
APA
Tanaka, T., Kase, S., Saito, M., Hirose, I., Murata, M., Takakuwa, E., & Ishida, S. (2024). Clinicopathological findings in refractory diabetic macular edema: A case report. Biomedical Reports, 20, 13. https://doi.org/10.3892/br.2023.1701
MLA
Tanaka, T., Kase, S., Saito, M., Hirose, I., Murata, M., Takakuwa, E., Ishida, S."Clinicopathological findings in refractory diabetic macular edema: A case report". Biomedical Reports 20.1 (2024): 13.
Chicago
Tanaka, T., Kase, S., Saito, M., Hirose, I., Murata, M., Takakuwa, E., Ishida, S."Clinicopathological findings in refractory diabetic macular edema: A case report". Biomedical Reports 20, no. 1 (2024): 13. https://doi.org/10.3892/br.2023.1701
Copy and paste a formatted citation
x
Spandidos Publications style
Tanaka T, Kase S, Saito M, Hirose I, Murata M, Takakuwa E and Ishida S: Clinicopathological findings in refractory diabetic macular edema: A case report. Biomed Rep 20: 13, 2024.
APA
Tanaka, T., Kase, S., Saito, M., Hirose, I., Murata, M., Takakuwa, E., & Ishida, S. (2024). Clinicopathological findings in refractory diabetic macular edema: A case report. Biomedical Reports, 20, 13. https://doi.org/10.3892/br.2023.1701
MLA
Tanaka, T., Kase, S., Saito, M., Hirose, I., Murata, M., Takakuwa, E., Ishida, S."Clinicopathological findings in refractory diabetic macular edema: A case report". Biomedical Reports 20.1 (2024): 13.
Chicago
Tanaka, T., Kase, S., Saito, M., Hirose, I., Murata, M., Takakuwa, E., Ishida, S."Clinicopathological findings in refractory diabetic macular edema: A case report". Biomedical Reports 20, no. 1 (2024): 13. https://doi.org/10.3892/br.2023.1701
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