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Article Open Access

Protein expression analysis for predicting recurrent laryngeal squamous cell carcinoma

  • Authors:
    • Siwaporn Thanasan
    • Komkrit Ruangritchankul
    • Nakarin Kitkumthorn
    • Somboon Keelawat
    • Patnarin Mahattanasakul
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand, Special Task Force for Activating Research, Department of Pathology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand, Department of Oral Biology, Faculty of Dentistry, Mahidol University, Bangkok 10400, Thailand, Department of Otolaryngology, Head and Neck Surgery, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand
    Copyright: © Thanasan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 15
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    Published online on: December 1, 2023
       https://doi.org/10.3892/br.2023.1702
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Abstract

The expression of a number of proteins plays a major role in predicting recurrent laryngeal squamous cell carcinoma (LSCC). Thus, the aim of the present study was to investigate the expression of 16 selected proteins as prognostic indicators for recurrent and non‑recurrent LSCC. Samples from a total of 41 patients with LSCC were investigated by immunohistochemistry. Digital image analysis was performed, and various associated factors were calculated. Histoscore (H‑score) and receiver operating characteristic curves were used to divide protein expression in high and low for predicting disease recurrence. Disease‑free survival (DFS) curves, crude hazard ratios (HRs) and adjusted HRs were analyzed and compared. Significantly different H‑scores were found between the recurrent and non‑recurrent groups in terms of pRb and c‑Met expression. pRb was expressed at high levels in recurrent LSCC, while c‑Met was expressed at low levels. Patients with low pRb expression had a longer DFS than those with high pRb expression (log‑rank χ2, 5.161; P=0.023). Patients with high c‑Met expression had a longer DFS than those with low c‑Met expression (log‑rank χ2, 6.441; P=0.011). Moreover, patients with high pRb expression and low c‑Met expression had the shortest DFS (log‑rank χ2, 11.827; P=0.008). Differentiated histological factors had an impact on the risk of recurrence (Cox regression test; crude HR, 9.53; 95% confidence interval, 1.214‑74.819; P=0.032). The present study demonstrated that the grading of differentiated squamous cell carcinoma, pRb and c‑Met expression are the most useful prognostic factors for the prediction of recurrent LSCC. These might be further applied as potential markers for clinical use.
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Copy and paste a formatted citation
Spandidos Publications style
Thanasan S, Ruangritchankul K, Kitkumthorn N, Keelawat S and Mahattanasakul P: Protein expression analysis for predicting recurrent laryngeal squamous cell carcinoma. Biomed Rep 20: 15, 2024.
APA
Thanasan, S., Ruangritchankul, K., Kitkumthorn, N., Keelawat, S., & Mahattanasakul, P. (2024). Protein expression analysis for predicting recurrent laryngeal squamous cell carcinoma. Biomedical Reports, 20, 15. https://doi.org/10.3892/br.2023.1702
MLA
Thanasan, S., Ruangritchankul, K., Kitkumthorn, N., Keelawat, S., Mahattanasakul, P."Protein expression analysis for predicting recurrent laryngeal squamous cell carcinoma". Biomedical Reports 20.1 (2024): 15.
Chicago
Thanasan, S., Ruangritchankul, K., Kitkumthorn, N., Keelawat, S., Mahattanasakul, P."Protein expression analysis for predicting recurrent laryngeal squamous cell carcinoma". Biomedical Reports 20, no. 1 (2024): 15. https://doi.org/10.3892/br.2023.1702
Copy and paste a formatted citation
x
Spandidos Publications style
Thanasan S, Ruangritchankul K, Kitkumthorn N, Keelawat S and Mahattanasakul P: Protein expression analysis for predicting recurrent laryngeal squamous cell carcinoma. Biomed Rep 20: 15, 2024.
APA
Thanasan, S., Ruangritchankul, K., Kitkumthorn, N., Keelawat, S., & Mahattanasakul, P. (2024). Protein expression analysis for predicting recurrent laryngeal squamous cell carcinoma. Biomedical Reports, 20, 15. https://doi.org/10.3892/br.2023.1702
MLA
Thanasan, S., Ruangritchankul, K., Kitkumthorn, N., Keelawat, S., Mahattanasakul, P."Protein expression analysis for predicting recurrent laryngeal squamous cell carcinoma". Biomedical Reports 20.1 (2024): 15.
Chicago
Thanasan, S., Ruangritchankul, K., Kitkumthorn, N., Keelawat, S., Mahattanasakul, P."Protein expression analysis for predicting recurrent laryngeal squamous cell carcinoma". Biomedical Reports 20, no. 1 (2024): 15. https://doi.org/10.3892/br.2023.1702
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